vipr2 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	vipr2
Entrez Gene ID	81886
Full Name	vasoactive intestinal peptide receptor 2
Synonyms	pacap,vpac2,vpac2-R
General protein information	Preferred Names vasoactive intestinal peptide receptor 2 Names vasoactive intestinal polypeptide receptor 2 PHI-R PHIR VPAC2R histidine-isoleucine receptor pituitary adenylate cyclase-activating peptide vasoactive intestingal polypeptide receptor type 2
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_131779.1	NP_571854.1	vasoactive intestinal polypeptide receptor 2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	VIPR2	NP_003373.2
Bos taurus (cattle)	VIPR2	NP_001193710.1
Danio rerio (zebrafish)	vipr2	NP_571854.1
Mus musculus (house mouse)	Vipr2	NP_033537.1
Canis lupus familiaris (dog)	VIPR2	XP_854454.2
Pan troglodytes (chimpanzee)	VIPR2	XP_003318991.1
	VIPR2	XP_001094713.1
Rattus norvegicus (Norway rat)	Vipr2	NP_058934.1
Xenopus tropicalis (tropical clawed frog)	vipr2	NP_001120616.1
Gallus gallus (chicken)	VIPR2	NP_001014970.1

Gene Ontology
Bibliography

Related articles in PubMed

Protective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Against Oxidative Stress in Zebrafish Hair Cells.
Kasica N, Podlasz P, Sundvik M, Tamas A, Reglodi D, Kaleczyc J
Neurotoxicity research30(4)633-647(2016 Nov)

Functional Pairing of Class B1 Ligand-GPCR in Cephalochordate Provides Evidence of the Origin of PTH and PACAP/Glucagon Receptor Family.
On JS, Duan C, Chow BK, Lee LT
Molecular biology and evolution32(8)2048-59(2015 Aug)

Structural and functional divergence of growth hormone-releasing hormone receptors in early sarcopterygians: lungfish and Xenopus.
Tam JK, Chow BK, Lee LT
PloS one8(1)e53482(2013)

Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors in the zebrafish ovary: evidence for potentially dual roles of PACAP in controlling final oocyte maturation.
Zhou R, Tsang AH, Lau SW, Ge W
Biology of reproduction85(3)615-25(2011 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study found a protective effect of PACAP-38 on oxidative stress damage in zebrafish hair cells, suggesting PACAP-38 ability to prevent hair cells from apoptosis. PACAP-38 treatment decreased the cleaved caspase-3 level in the hair cells, but somewhat unexpectedly had no influence on p-38 MAPK pathway. PACAP-38 treatment also rescued H2O2-induced reduction in movement.
Title: Protective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Against Oxidative Stress in Zebrafish Hair Cells.

PACAP might play dual roles in regulating follicle growth and maturation through different receptors located in different compartments.
Title: Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors in the zebrafish ovary: evidence for potentially dual roles of PACAP in controlling final oocyte maturation.

These results suggest that, in fish, PACAP and PAC1-R may play a role in brain development.
Title: Expression analysis of PAC1-R and PACAP genes in zebrafish embryos.

zfPACAP38-2 is a potential ovarian factor that mediates gonadotropin actions in paracrine/autocrine manners, and its functional roles are likely, to some extent, related to the ovarian activin/follistatin system.
Title: Cloning, regulation of messenger ribonucleic acid expression, and function of a new isoform of pituitary adenylate cyclase-activating polypeptide in the zebrafish ovary.

The temporal and spatial expression pattern of the ghrh-pacap1 transcript suggests that these hormones may modulate patterning during development.
Title: Developmental changes in the expression of growth hormone-releasing hormone and pituitary adenylate cyclase-activating polypeptide in zebrafish.

The following vipr2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the vipr2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa32550	NM_131779.1 Latest version!	Danio rerio vasoactive intestinal peptide receptor 2 (vipr2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

vipr2 ( NM_131779.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_571854.1 Danio rerio vasoactive intestinal peptide receptor 2 (vipr2), mRNA.

Price & Availability↑

CloneID	ODa32550
Clone ID Related Accession (Same CDS sequence)	NM_131779.1
Accession Version	NM_131779.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1320bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-22
Organism	Danio rerio(zebrafish)
Product	vasoactive intestinal polypeptide receptor 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU069395.1. On Mar 5, 2008 this sequence version replaced XM_686724.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU069395.1, BC162944.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168447, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END##

ATGAGCCTCG TCAACTGTTT GGTTCTTCTT ATAGTTTGGC ACGCGCACTC GGTCAACGGG 
AGACATCCAA ACTGTCAGTT TCTGTATGAG CTGCAGATGG CAGAGAAGGA ATGTTTGGGC 
GATCTAGCAG ACGAGCCTCT TCTGCACACC GAAGGTTGCA GAGGGATGTG GGACAATTTT 
TCCTGCTGGC ACCATGCTGA TGTTGGAAAG GTGGTCGTCA ATAACTGTCC TGCTGCCCTC 
AAAAATTTGT TCACCAGAGA TGGGATCATT AGCAGGAACT GCACTACGGA AGGCTGGTCC 
AACGTGTATC CCAGCATCGA CAGCGTGTGT TTTGCACCCA CAAATACAAA TACAACTATG 
TATGTTTTCT ACACAGTGAT GAAGACTCTT TACACACTAG GACACAGCCT TTCTCTCATC 
GCCCTCATCA CCGGCAGCAC CATCCTCTGT CTCTTCAGAA AACTGCACTG CACCAGGAAC 
TACATCCATC TGAACCTGTT CTTCTCGTTC ATACTGAGGG CCATCGCGGT GCTGGTCAAA 
GATGCCATTT TGTTTTCTCA TGAAAACGGG GAATGTACAG TGCAGCCATC CTTGATGGGT 
TGCAAAGTCA GTCTGGTCAT CCTCAACTAC TTCATCATGG CAAACTTCTA CTGGTTGCTG 
GTTGAAGGAT TGTACTTACA CACCCTACTG ATGGTCATTT TCTCAGAGAA CAGACACTTC 
ATCATTTACC TTCTGATTGG ATGGGGATTC CCCACCGTGT TTGTGATTCC ATGGATTGTG 
TGCAGGATTT ACCTCGAGGA CACAGGATGC TGGGAGAGGA TCGACAATCC GATTCCCTGG 
CGCGTGATCA ACTGGCCAAT CATGGCATCT GTCATTTTAA ACTTCATTCT GTTCATCAGC 
ATCATTCGAA TCCTGGTCCA GAAGCTGAGA TGTCCTGACG TTGGTGGAAA CGACCAGTCC 
CAGTACAGGA GGTTAGCCAA GTCCACACTT CTGCTGATTC CTCTTTTTGG CGTCCACTAT 
ATTGTTTTCG TTTACATCAT AGATGGAAAT GGAGAGAGGG AAAACTATAA AATATTCTTT 
GACCTCGGTC TGGGATCCTT TCAGGGCTTG GTGGTTGCGA TTTTGTATTG CTTTTTGAAT 
AGTGAGGTCC AGAGTGAACT CAAGAGAAAG TGGCGGAGTT TACGTTTAAA GCGCTACATC 
GGCCGCGACT ACCGTCTGCA CAGTTCCTCC ATATCCAGGA ACGGCACAGA AAACATGGCC 
CAATTCCAGC GAAACACCAG AGCCCAGTCC TTCCTGCAGA CAGAGACCAC CGTGGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_571854.1
CDS	2..1321
Translation	MSLVNCLVLLIVWHAHSVNGRHPNCQFLYELQMAEKECLGDLADEPLLHTEGCRGMWDNFSCWHHADVGKVVVNNCPAALKNLFTRDGIISRNCTTEGWSNVYPSIDSVCFAPTNTNTTMYVFYTVMKTLYTLGHSLSLIALITGSTILCLFRKLHCTRNYIHLNLFFSFILRAIAVLVKDAILFSHENGECTVQPSLMGCKVSLVILNYFIMANFYWLLVEGLYLHTLLMVIFSENRHFIIYLLIGWGFPTVFVIPWIVCRIYLEDTGCWERIDNPIPWRVINWPIMASVILNFILFISIIRILVQKLRCPDVGGNDQSQYRRLAKSTLLLIPLFGVHYIVFVYIIDGNGERENYKIFFDLGLGSFQGLVVAILYCFLNSEVQSELKRKWRSLRLKRYIGRDYRLHSSSISRNGTENMAQFQRNTRAQSFLQTETTVV

Target ORF information:

RefSeq Version	NM_131779.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio vasoactive intestinal peptide receptor 2 (vipr2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_131779.1

ORF Insert Sequence:

ATGAGCCTCG TCAACTGTTT GGTTCTTCTT ATAGTTTGGC ACGCGCACTC GGTCAACGGG 
AGACATCCAA ACTGTCAGTT TCTGTATGAG CTGCAGATGG CAGAGAAGGA ATGTTTGGGC 
GATCTAGCAG ACGAGCCTCT TCTGCACACC GAAGGTTGCA GAGGGATGTG GGACAATTTT 
TCCTGCTGGC ACCATGCTGA TGTTGGAAAG GTGGTCGTCA ATAACTGTCC TGCTGCCCTC 
AAAAATTTGT TCACCAGAGA TGGGATCATT AGCAGGAACT GCACTACGGA AGGCTGGTCC 
AACGTGTATC CCAGCATCGA CAGCGTGTGT TTTGCACCCA CAAATACAAA TACAACTATG 
TATGTTTTCT ACACAGTGAT GAAGACTCTT TACACACTAG GACACAGCCT TTCTCTCATC 
GCCCTCATCA CCGGCAGCAC CATCCTCTGT CTCTTCAGAA AACTGCACTG CACCAGGAAC 
TACATCCATC TGAACCTGTT CTTCTCGTTC ATACTGAGGG CCATCGCGGT GCTGGTCAAA 
GATGCCATTT TGTTTTCTCA TGAAAACGGG GAATGTACAG TGCAGCCATC CTTGATGGGT 
TGCAAAGTCA GTCTGGTCAT CCTCAACTAC TTCATCATGG CAAACTTCTA CTGGTTGCTG 
GTTGAAGGAT TGTACTTACA CACCCTACTG ATGGTCATTT TCTCAGAGAA CAGACACTTC 
ATCATTTACC TTCTGATTGG ATGGGGATTC CCCACCGTGT TTGTGATTCC ATGGATTGTG 
TGCAGGATTT ACCTCGAGGA CACAGGATGC TGGGAGAGGA TCGACAATCC GATTCCCTGG 
CGCGTGATCA ACTGGCCAAT CATGGCATCT GTCATTTTAA ACTTCATTCT GTTCATCAGC 
ATCATTCGAA TCCTGGTCCA GAAGCTGAGA TGTCCTGACG TTGGTGGAAA CGACCAGTCC 
CAGTACAGGA GGTTAGCCAA GTCCACACTT CTGCTGATTC CTCTTTTTGG CGTCCACTAT 
ATTGTTTTCG TTTACATCAT AGATGGAAAT GGAGAGAGGG AAAACTATAA AATATTCTTT 
GACCTCGGTC TGGGATCCTT TCAGGGCTTG GTGGTTGCGA TTTTGTATTG CTTTTTGAAT 
AGTGAGGTCC AGAGTGAACT CAAGAGAAAG TGGCGGAGTT TACGTTTAAA GCGCTACATC 
GGCCGCGACT ACCGTCTGCA CAGTTCCTCC ATATCCAGGA ACGGCACAGA AAACATGGCC 
CAATTCCAGC GAAACACCAG AGCCCAGTCC TTCCTGCAGA CAGAGACCAC CGTGGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Protective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Against Oxidative Stress in Zebrafish Hair Cells.
Neurotoxicity research30(4)633-647(2016 Nov)
Kasica N,Podlasz P,Sundvik M,Tamas A,Reglodi D,Kaleczyc J

Functional Pairing of Class B1 Ligand-GPCR in Cephalochordate Provides Evidence of the Origin of PTH and PACAP/Glucagon Receptor Family.
Molecular biology and evolution32(8)2048-59(2015 Aug)
On JS,Duan C,Chow BK,Lee LT

Structural and functional divergence of growth hormone-releasing hormone receptors in early sarcopterygians: lungfish and Xenopus.
PloS one8(1)e53482(2013)
Tam JK,Chow BK,Lee LT

Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors in the zebrafish ovary: evidence for potentially dual roles of PACAP in controlling final oocyte maturation.
Biology of reproduction85(3)615-25(2011 Sep)
Zhou R,Tsang AH,Lau SW,Ge W

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vipr2 cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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