smtlb cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	smtlb
Entrez Gene ID	553408
Full Name	somatolactin beta
Synonyms	slb
General protein information	Preferred Names somatolactin beta Names somatolactin beta
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
XM_009305601.2	XP_009303876.1	somatolactin beta isoform X1
NM_001037674.1	NP_001032763.1	somatolactin beta precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	smtla	NP_001032795.1
Danio rerio (zebrafish)	smtlb	NP_001032763.1

Gene Ontology
Bibliography

Related articles in PubMed

Functional characterization of GH-like homolog in amphioxus reveals an ancient origin of GH/GH receptor system.
Li M, Gao Z, Ji D, Zhang S
Endocrinology155(12)4818-30(2014 Dec)

The involvement of cholesterol in sepsis and tolerance to lipopolysaccharide highlighted by the transcriptome analysis of zebrafish (Danio rerio).
Dios S, Balseiro P, Costa MM, Romero A, Bolta?a S, Roher N, Mackenzie S, Figueras A, Novoa B
Zebrafish11(5)421-33(2014 Oct)

The African coelacanth genome provides insights into tetrapod evolution.
Amemiya CT, Alf?ldi J, Lee AP, Fan S, Philippe H, Maccallum I, Braasch I, Manousaki T, Schneider I, Rohner N, Organ C, Chalopin D, Smith JJ, Robinson M, Dorrington RA, Gerdol M, Aken B, Biscotti MA, Barucca M, Baurain D, Berlin AM, Blatch GL, Buonocore F, Burmester T, Campbell MS, Canapa A, Cannon JP, Christoffels A, De Moro G, Edkins AL, Fan L, Fausto AM, Feiner N, Forconi M, Gamieldien J, Gnerre S, Gnirke A, Goldstone JV, Haerty W, Hahn ME, Hesse U, Hoffmann S, Johnson J, Karchner SI, Kuraku S, Lara M, Levin JZ, Litman GW, Mauceli E, Miyake T, Mueller MG, Nelson DR, Nitsche A, Olmo E, Ota T, Pallavicini A, Panji S, Picone B, Ponting CP, Prohaska SJ, Przybylski D, Saha NR, Ravi V, Ribeiro FJ, Sauka-Spengler T, Scapigliati G, Searle SM, Sharpe T, Simakov O, Stadler PF, Stegeman JJ, Sumiyama K, Tabbaa D, Tafer H, Turner-Maier J, van Heusden P, White S, Williams L, Yandell M, Brinkmann H, Volff JN, Tabin CJ, Shubin N, Schartl M, Jaffe DB, Postlethwait JH, Venkatesh B, Di Palma F, Lander ES, Meyer A, Lindblad-Toh K
Nature496(7445)311-6(2013 Apr)

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.
Baraban SC, Dinday MT, Hortopan GA
Nature communications42410(2013)

The HMG-box transcription factor Sox4b is required for pituitary expression of gata2a and specification of thyrotrope and gonadotrope cells in zebrafish.
Quiroz Y, Lopez M, Mavropoulos A, Motte P, Martial JA, Hammerschmidt M, Muller M
Molecular endocrinology (Baltimore, Md.)26(6)1014-27(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

overexpression of SLalpha and SLbeta enhanced transcription of IGFs, insulin, leptin, sterol regulatory element binding protein 1, and fatty acid synthase, as well as expression of vitellogenin and proopiomelanocortin in transgenic larvae
Title: A study of somatolactin actions by ectopic expression in transgenic zebrafish larvae.

SLbeta knockdown embryos were defective in gas bladder inflation.
Title: The effects of the members of growth hormone family knockdown in zebrafish development.

slbeta expression defines a new, additional cell type in the pituitary that depends on pit1 and aal for its differentiation
Title: Expression of the somatolactin beta gene during zebrafish embryonic development.

The following smtlb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the smtlb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa00695	NM_001037674.1 Latest version!	Danio rerio somatolactin beta (smtlb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
ODa41944	XM_009305601.2 Latest version!	Danio rerio somatolactin beta (smtlb), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

smtlb ( NM_001037674.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001032763.1 Danio rerio somatolactin beta (smtlb), mRNA.

Price & Availability↑

CloneID	ODa00695
Clone ID Related Accession (Same CDS sequence)	NM_001037674.1
Accession Version	NM_001037674.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-07-02
Organism	Danio rerio(zebrafish)
Product	somatolactin beta precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY221126.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY221126.1, BC121735.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476728, SAMEA4476780 [ECO:0000348] ##Evidence-Data-END##

ATGAAGAAAG CTACAGCTCT ACAGGTTTGT GTGGTGGTTC TGGTCTGCTT AAAGAAGGCT 
GTGATCGGAT CTCCAGTGGA GTGTCCAGAC CAAGAGATTG GAGGGACGTC CTGCACAATC 
TCAGCGGAGA AGCTTCTGGA CCGAGCCGTT CAACATGCTG AGCTCATTTA CCGCTTCTCG 
GAGGAAGCCA AGTTGCTGTT TGACGAGTTG CTCGACTTAT TCGGAGGTAT GAATCAGTAT 
ATTCCTGGAG GGGCTGTGTG TGCTCCCAAA ACGGTGCCGG TTCCTTTGTC TAAAAGCGAA 
ATTCAACAGA TTTCCGACCG ATGGCTTCTG CACTCAGTCC TGATTCTGGT TCAGTTCTGG 
ATTGAGCCAT TGGTGAATCT ACAGAAATCT CTGGAGAACT ATAAAAGTGC CCCAATCGGA 
CTTCTTAGCA GGAACCAATG GATAGCTAGC AAACTATCAA GCCTAGAGGA GGGGCTGTTG 
GTTCTTATTA GACAGATTTT GGGTGAAGGA GGCTTGGTGT TGGGTCCTCC AGAAGATGTA 
TCGGATAACA CTCTCTCTGT CGATGCTTTC GAGACAGTGA GACGAGACTA CAGTGTGATC 
TACTGCTTCC GAAAAGACGC ACACAAGATT CAGACGTTTC TCAAACTCCT GAAGTGCCGC 
CAGGTTGACA GGGAAAACTG CTCCCTCTTC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032763.1
CDS	36..728
Translation	MKKATALQVCVVVLVCLKKAVIGSPVECPDQEIGGTSCTISAEKLLDRAVQHAELIYRFSEEAKLLFDELLDLFGGMNQYIPGGAVCAPKTVPVPLSKSEIQQISDRWLLHSVLILVQFWIEPLVNLQKSLENYKSAPIGLLSRNQWIASKLSSLEEGLLVLIRQILGEGGLVLGPPEDVSDNTLSVDAFETVRRDYSVIYCFRKDAHKIQTFLKLLKCRQVDRENCSLF

Target ORF information:

RefSeq Version	NM_001037674.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio somatolactin beta (smtlb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037674.1

ORF Insert Sequence:

ATGAAGAAAG CTACAGCTCT ACAGGTTTGT GTGGTGGTTC TGGTCTGCTT AAAGAAGGCT 
GTGATCGGAT CTCCAGTGGA GTGTCCAGAC CAAGAGATTG GAGGGACGTC CTGCACAATC 
TCAGCGGAGA AGCTTCTGGA CCGAGCCGTT CAACATGCTG AGCTCATTTA CCGCTTCTCG 
GAGGAAGCCA AGTTGCTGTT TGACGAGTTG CTCGACTTAT TCGGAGGTAT GAATCAGTAT 
ATTCCTGGAG GGGCTGTGTG TGCTCCCAAA ACGGTGCCGG TTCCTTTGTC TAAAAGCGAA 
ATTCAACAGA TTTCCGACCG ATGGCTTCTG CACTCAGTCC TGATTCTGGT TCAGTTCTGG 
ATTGAGCCAT TGGTGAATCT ACAGAAATCT CTGGAGAACT ATAAAAGTGC CCCAATCGGA 
CTTCTTAGCA GGAACCAATG GATAGCTAGC AAACTATCAA GCCTAGAGGA GGGGCTGTTG 
GTTCTTATTA GACAGATTTT GGGTGAAGGA GGCTTGGTGT TGGGTCCTCC AGAAGATGTA 
TCGGATAACA CTCTCTCTGT CGATGCTTTC GAGACAGTGA GACGAGACTA CAGTGTGATC 
TACTGCTTCC GAAAAGACGC ACACAAGATT CAGACGTTTC TCAAACTCCT GAAGTGCCGC 
CAGGTTGACA GGGAAAACTG CTCCCTCTTC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

smtlb ( XM_009305601.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> XP_009303876.1 Danio rerio somatolactin beta (smtlb), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ODa41944
Clone ID Related Accession (Same CDS sequence)	XM_009305601.2
Accession Version	XM_009305601.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-23
Organism	Danio rerio(Zebrafish)
Product	somatolactin beta isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007121.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XM_009305601.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGACAGA GAATCAGCGA TGTAAACATG AATAATGTCA CGTTTATACC GGGTAATAGG 
CGAAGATGCA TTTTGGTCGA CCAGATCACA GCTCTACAGG TTTGTGTGGT GGTTCTGGTC 
TGCTTAAAGA AGGCTGTGAT CGGATCTCCA GTGGAGTGTC CAGACCAAGA GATTGGAGGG 
ACGTCCTGCA CAATCTCAGC GGAGAAGCTT CTGGACCGAG CCGTTCAACA TGCTGAGCTC 
ATTTACCGCT TCTCGGAGGA AGCCAAGTTG CTGTTTGACG AGTTGCTCGA CTTATTCGGA 
GGTATGAATC AGTATATTCC TGGAGGGGCT GTGTGTGCTC CCAAAACGGT GCCGGTTCCT 
TTGTCTAAAA GTGAAATTCA ACAGATTTCC GACCGATGGC TTCTGCACTC AGTCCTGATT 
CTGGTTCAGT TCTGGATTGA GCCATTGGTG AATCTACAGA AATCTCTGGA GAACTATAAA 
AGTGCCCCAA TCGGACTTCT TAGCAGGAAC CAATGGATAG CTAGCAAACT ATCAAGCCTA 
GAGGAGGGGC TGTTGGTTCT TATTAGACAG ATTTTGGGTG AAGGAGGCTT GGTGTTGGGT 
CCTCCAGAAG ATGTATCGGA TAACACTCTC TCTGTCGATG CTTTCGAGAC AGTGAGACGA 
GACTACAGTG TGATCTACTG CTTCCGAAAA GACGCACACA AGATTCAGAC GTTTCTCAAA 
CTCCTGAAGT GCCGCCAGGT TGACAGGGAA AACTGCTCCC TCTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_009303876.1
CDS	196..963
Translation	MRQRISDVNMNNVTFIPGNRRRCILVDQITALQVCVVVLVCLKKAVIGSPVECPDQEIGGTSCTISAEKLLDRAVQHAELIYRFSEEAKLLFDELLDLFGGMNQYIPGGAVCAPKTVPVPLSKSEIQQISDRWLLHSVLILVQFWIEPLVNLQKSLENYKSAPIGLLSRNQWIASKLSSLEEGLLVLIRQILGEGGLVLGPPEDVSDNTLSVDAFETVRRDYSVIYCFRKDAHKIQTFLKLLKCRQVDRENCSLF

Target ORF information:

RefSeq Version	XM_009305601.2
Organism	Danio rerio(Zebrafish)
Definition	Danio rerio somatolactin beta (smtlb), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_009305601.2

ORF Insert Sequence:

ATGAGACAGA GAATCAGCGA TGTAAACATG AATAATGTCA CGTTTATACC GGGTAATAGG 
CGAAGATGCA TTTTGGTCGA CCAGATCACA GCTCTACAGG TTTGTGTGGT GGTTCTGGTC 
TGCTTAAAGA AGGCTGTGAT CGGATCTCCA GTGGAGTGTC CAGACCAAGA GATTGGAGGG 
ACGTCCTGCA CAATCTCAGC GGAGAAGCTT CTGGACCGAG CCGTTCAACA TGCTGAGCTC 
ATTTACCGCT TCTCGGAGGA AGCCAAGTTG CTGTTTGACG AGTTGCTCGA CTTATTCGGA 
GGTATGAATC AGTATATTCC TGGAGGGGCT GTGTGTGCTC CCAAAACGGT GCCGGTTCCT 
TTGTCTAAAA GTGAAATTCA ACAGATTTCC GACCGATGGC TTCTGCACTC AGTCCTGATT 
CTGGTTCAGT TCTGGATTGA GCCATTGGTG AATCTACAGA AATCTCTGGA GAACTATAAA 
AGTGCCCCAA TCGGACTTCT TAGCAGGAAC CAATGGATAG CTAGCAAACT ATCAAGCCTA 
GAGGAGGGGC TGTTGGTTCT TATTAGACAG ATTTTGGGTG AAGGAGGCTT GGTGTTGGGT 
CCTCCAGAAG ATGTATCGGA TAACACTCTC TCTGTCGATG CTTTCGAGAC AGTGAGACGA 
GACTACAGTG TGATCTACTG CTTCCGAAAA GACGCACACA AGATTCAGAC GTTTCTCAAA 
CTCCTGAAGT GCCGCCAGGT TGACAGGGAA AACTGCTCCC TCTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional characterization of GH-like homolog in amphioxus reveals an ancient origin of GH/GH receptor system.
Endocrinology155(12)4818-30(2014 Dec)
Li M,Gao Z,Ji D,Zhang S

The involvement of cholesterol in sepsis and tolerance to lipopolysaccharide highlighted by the transcriptome analysis of zebrafish (Danio rerio).
Zebrafish11(5)421-33(2014 Oct)
Dios S,Balseiro P,Costa MM,Romero A,Bolta?a S,Roher N,Mackenzie S,Figueras A,Novoa B

The African coelacanth genome provides insights into tetrapod evolution.
Nature496(7445)311-6(2013 Apr)
Amemiya CT,Alf?ldi J,Lee AP,Fan S,Philippe H,Maccallum I,Braasch I,Manousaki T,Schneider I,Rohner N,Organ C,Chalopin D,Smith JJ,Robinson M,Dorrington RA,Gerdol M,Aken B,Biscotti MA,Barucca M,Baurain D,Berlin AM,Blatch GL,Buonocore F,Burmester T,Campbell MS,Canapa A,Cannon JP,Christoffels A,De Moro G,Edkins AL,Fan L,Fausto AM,Feiner N,Forconi M,Gamieldien J,Gnerre S,Gnirke A,Goldstone JV,Haerty W,Hahn ME,Hesse U,Hoffmann S,Johnson J,Karchner SI,Kuraku S,Lara M,Levin JZ,Litman GW,Mauceli E,Miyake T,Mueller MG,Nelson DR,Nitsche A,Olmo E,Ota T,Pallavicini A,Panji S,Picone B,Ponting CP,Prohaska SJ,Przybylski D,Saha NR,Ravi V,Ribeiro FJ,Sauka-Spengler T,Scapigliati G,Searle SM,Sharpe T,Simakov O,Stadler PF,Stegeman JJ,Sumiyama K,Tabbaa D,Tafer H,Turner-Maier J,van Heusden P,White S,Williams L,Yandell M,Brinkmann H,Volff JN,Tabin CJ,Shubin N,Schartl M,Jaffe DB,Postlethwait JH,Venkatesh B,Di Palma F,Lander ES,Meyer A,Lindblad-Toh K

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.
Nature communications42410(2013)
Baraban SC,Dinday MT,Hortopan GA

The HMG-box transcription factor Sox4b is required for pituitary expression of gata2a and specification of thyrotrope and gonadotrope cells in zebrafish.
Molecular endocrinology (Baltimore, Md.)26(6)1014-27(2012 Jun)
Quiroz Y,Lopez M,Mavropoulos A,Motte P,Martial JA,Hammerschmidt M,Muller M

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smtlb cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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