sesn2 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	sesn2
Entrez Gene ID	100149745
Full Name	sestrin 2
General protein information	Preferred Names sestrin 2 Names sestrin 2
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005159759.3	XP_005159816.1	sestrin 2 isoform X1
NM_001079975.2	NP_001073444.1	sestrin 2

Pathways from BioSystems

Homologies

	SESN2	XP_001113030.1
Canis lupus familiaris (dog)	SESN2	XP_544461.2
Bos taurus (cattle)	SESN2	NP_001019678.1
Homo sapiens (human)	SESN2	NP_113647.1
Mus musculus (house mouse)	Sesn2	NP_659156.1
Pan troglodytes (chimpanzee)	SESN2	XP_524552.3
Danio rerio (zebrafish)	sesn2	NP_001073444.1
Rattus norvegicus (Norway rat)	Sesn2	NP_001102828.1
Xenopus tropicalis (tropical clawed frog)	sesn2	NP_001073030.1

Gene Ontology
Bibliography

Related articles in PubMed

mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis.
Scheldeman C, Mills JD, Siekierska A, Serra I, Copmans D, Iyer AM, Whalley BJ, Maes J, Jansen AC, Lagae L, Aronica E, de Witte PAM
Neurobiology of disease108225-237(2017 Dec)

TP53 Modulates Oxidative Stress in Gata1
Kramer AC, Weber J, Zhang Y, Tolar J, Gibbens YY, Shevik M, Lund TC
Stem cell reports8(2)360-372(2017 02)

Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling.
Zhou X, Yue GG, Liu M, Zuo Z, Lee JK, Li M, Tsui SK, Fung KP, Sun H, Pu J, Lau CB
Oncotarget7(50)82820-82835(2016 Dec)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

High-throughput RNA sequencing reveals the effects of 2,2',4,4' -tetrabromodiphenyl ether on retina and bone development of zebrafish larvae.
Xu T, Zhao J, Yin D, Zhao Q, Dong B
BMC genomics1623(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following sesn2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the sesn2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa31436	NM_001079975.2 Latest version!	Danio rerio sestrin 2 (sesn2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
ODa24441	XM_005159759.3 Latest version!	Danio rerio sestrin 2 (sesn2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

sesn2 ( NM_001079975.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001073444.1 Danio rerio sestrin 2 (sesn2), mRNA.

Price & Availability↑

CloneID	ODa31436
Clone ID Related Accession (Same CDS sequence)	NM_001079975.2
Accession Version	NM_001079975.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1335bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-30
Organism	Danio rerio(zebrafish)
Product	sestrin 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH536404.1, EH536519.1, EE708471.1, EH474112.1 and EH557777.1. On or before Oct 18, 2009 this sequence version replaced XM_001918598.1, NM_001079975.1. ##Evidence-Data-START## Transcript exon combination :: GDQQ01020222.1, GDQH01007846.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END##

ATGAAGGACG AAGCAGATGA CCTCCCTGAG GTGTTGCCTT CCGGGCCCAG TGCCTTTATT 
CCAACTGAAG AGATTCTGGA GGAAGGATCC ACACATGAAG TGATGTCAGA CGTTTTGTTG 
TCAGAAGGAC GTGCTGATCA TATCAACATG GTGATGGGGC TTCATCCCAC CTACCTGGCC 
TGTTTCCAGC GCACACAGGA TGCTTTGCTC CAGCTGGACG GCCCACTGCC CTTATCATGG 
AGACATTATA TAGTCATTTT GGCGGCTGCT CGTCATCAGT GCTCGTATCT CGTGCAGCAT 
CACAGCTCCG CTTTTCTGCT TGCCGGTGGA GACGAGTCCT GGCTGCGGGG AGTTCACTGT 
GCACCACCGA AAATACAGCA TCTGCAGACA CTCAACAAAC TGCTGGCACA CAGACCCTGG 
ATCATCACCC AGGAGCACAT ACAGGAGTTA GTTTGTCCCG GTGCGGAGGC TCGATGGTCT 
CTTGCGGAGC TGATTCAGGC GGTGGTTTTG ATGACACACG CTCACTCTCT GGCCTCGTTT 
GTCTGGGGTT GCGGGATTCA TCCAGAGCCT GAGCAGACAG AAGATCAGAC GCTTCAGCCG 
TGTTCGCCCA CAGACTCCTG TTGTTCAGTG CGGGGCAAGG CCAGAAATCA GCAGGAGTGG 
TCTGAGGCTG TAAACGAGGT TAAGCTTTTG ATGGAGAGGA TGATGATGGT TCAACAGCAA 
GGTGAAGAGT TTACTCAGGA GGAGATGGTC ACTCGCTTTG AAAGAGAGAG AACGGAGAGT 
TTGCTGGAAC CTGCTGATGT TCAGCGCTCC GTCCTTCCCG ATTGTGTGTC GCGGTTTGTC 
GTGGACGCAG ATTTTACTTA TCAGGATTTT AGTCCTAGAG GAGCACAGGC CCCTCCAACC 
ATGAGAGCTC AGGACTATTC ATGGGAGGAT CACGGCTTCT CTCTGATGAA CCGGCTGTAT 
GGGGAGATGG CGCAGCTTCT GGATGAGAAG TTTCAGGTGG CCTGTGCGCT CACGTATCAC 
ACCATGGCCA TGCACTCACA CGTGGACACA TCCACACTGC GCAAAGCCAT CTGGAACTAC 
ATTCAGTGCA TCTACGGCAT CAGATATGAT GATTACGATT ATGGGGAAGT GAACCAGCTG 
CTGGAGCGCA GTTTAAAAGT CTATGTAAAG ACTGTGGCTT GTCACCCGGA GAAAACCACA 
GCAAGAATGT ACTTCTCGTT TTGGAGGCAG TTTCGACACT CTGAAAAGGT CCATGTGAAC 
CTGTTACTGA TGGAGGCACG AATGCAGGCA GCTTTACTTT ATGCTCTCAG AGCAATTACA 
CGCTACATGA CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001073444.1
CDS	154..1488
Translation	MKDEADDLPEVLPSGPSAFIPTEEILEEGSTHEVMSDVLLSEGRADHINMVMGLHPTYLACFQRTQDALLQLDGPLPLSWRHYIVILAAARHQCSYLVQHHSSAFLLAGGDESWLRGVHCAPPKIQHLQTLNKLLAHRPWIITQEHIQELVCPGAEARWSLAELIQAVVLMTHAHSLASFVWGCGIHPEPEQTEDQTLQPCSPTDSCCSVRGKARNQQEWSEAVNEVKLLMERMMMVQQQGEEFTQEEMVTRFERERTESLLEPADVQRSVLPDCVSRFVVDADFTYQDFSPRGAQAPPTMRAQDYSWEDHGFSLMNRLYGEMAQLLDEKFQVACALTYHTMAMHSHVDTSTLRKAIWNYIQCIYGIRYDDYDYGEVNQLLERSLKVYVKTVACHPEKTTARMYFSFWRQFRHSEKVHVNLLLMEARMQAALLYALRAITRYMT

Target ORF information:

RefSeq Version	NM_001079975.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio sestrin 2 (sesn2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001079975.2

ORF Insert Sequence:

ATGAAGGACG AAGCAGATGA CCTCCCTGAG GTGTTGCCTT CCGGGCCCAG TGCCTTTATT 
CCAACTGAAG AGATTCTGGA GGAAGGATCC ACACATGAAG TGATGTCAGA CGTTTTGTTG 
TCAGAAGGAC GTGCTGATCA TATCAACATG GTGATGGGGC TTCATCCCAC CTACCTGGCC 
TGTTTCCAGC GCACACAGGA TGCTTTGCTC CAGCTGGACG GCCCACTGCC CTTATCATGG 
AGACATTATA TAGTCATTTT GGCGGCTGCT CGTCATCAGT GCTCGTATCT CGTGCAGCAT 
CACAGCTCCG CTTTTCTGCT TGCCGGTGGA GACGAGTCCT GGCTGCGGGG AGTTCACTGT 
GCACCACCGA AAATACAGCA TCTGCAGACA CTCAACAAAC TGCTGGCACA CAGACCCTGG 
ATCATCACCC AGGAGCACAT ACAGGAGTTA GTTTGTCCCG GTGCGGAGGC TCGATGGTCT 
CTTGCGGAGC TGATTCAGGC GGTGGTTTTG ATGACACACG CTCACTCTCT GGCCTCGTTT 
GTCTGGGGTT GCGGGATTCA TCCAGAGCCT GAGCAGACAG AAGATCAGAC GCTTCAGCCG 
TGTTCGCCCA CAGACTCCTG TTGTTCAGTG CGGGGCAAGG CCAGAAATCA GCAGGAGTGG 
TCTGAGGCTG TAAACGAGGT TAAGCTTTTG ATGGAGAGGA TGATGATGGT TCAACAGCAA 
GGTGAAGAGT TTACTCAGGA GGAGATGGTC ACTCGCTTTG AAAGAGAGAG AACGGAGAGT 
TTGCTGGAAC CTGCTGATGT TCAGCGCTCC GTCCTTCCCG ATTGTGTGTC GCGGTTTGTC 
GTGGACGCAG ATTTTACTTA TCAGGATTTT AGTCCTAGAG GAGCACAGGC CCCTCCAACC 
ATGAGAGCTC AGGACTATTC ATGGGAGGAT CACGGCTTCT CTCTGATGAA CCGGCTGTAT 
GGGGAGATGG CGCAGCTTCT GGATGAGAAG TTTCAGGTGG CCTGTGCGCT CACGTATCAC 
ACCATGGCCA TGCACTCACA CGTGGACACA TCCACACTGC GCAAAGCCAT CTGGAACTAC 
ATTCAGTGCA TCTACGGCAT CAGATATGAT GATTACGATT ATGGGGAAGT GAACCAGCTG 
CTGGAGCGCA GTTTAAAAGT CTATGTAAAG ACTGTGGCTT GTCACCCGGA GAAAACCACA 
GCAAGAATGT ACTTCTCGTT TTGGAGGCAG TTTCGACACT CTGAAAAGGT CCATGTGAAC 
CTGTTACTGA TGGAGGCACG AATGCAGGCA GCTTTACTTT ATGCTCTCAG AGCAATTACA 
CGCTACATGA CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

sesn2 ( XM_005159759.3 ) cDNA ORF clone, Danio rerio(zebrafish) -> XP_005159816.1 Danio rerio sestrin 2 (sesn2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ODa24441
Clone ID Related Accession (Same CDS sequence)	XM_005159759.3
Accession Version	XM_005159759.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-23
Organism	Danio rerio(Zebrafish)
Product	sestrin 2 isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007130.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XM_005159759.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCAGACG TTTTGTTGTC AGAAGGACGT GCTGATCATA TCAACATGGT GATGGGGCTT 
CATCCCACCT ACCTGGCCTG TTTCCAGCGC ACACAGGATG CTTTGCTCCA GCTGGACGGC 
CCACTGCCCT TATCATGGAG ACATTATATA GTCATTTTGG CGGCTGCTCG TCATCAGTGC 
TCGTATCTCG TGCAGCATCA CAGCTCCGCT TTTCTGCTTG CCGGTGGAGA CGAGTCCTGG 
CTGCGGGGAG TTCACTGTGC ACCACCGAAA ATACAGCATC TGCAGACACT CAACAAACTG 
CTGGCACACA GACCCTGGAT CATCACCCAG GAGCACATAC AGGAGTTAGT TTGTCCCGGT 
GCGGAGGCTC GATGGTCTCT TGCGGAGCTG ATTCAGGCGG TGGTTTTGAT GACACACGCT 
CACTCTCTGG CCTCGTTTGT CTGGGGTTGC GGGATTCATC CAGAGCCTGA GCAGACAGAA 
GATCAGACGC TTCAGCCGTG TTCGCCCACA GACTCCTGTT GTTCAGTGCG GGGCAAGGCC 
AGAAATCAGC AGGAGTGGTC TGAGGCTGTA AACGAGGTTA AGCTTTTGAT GGAGAGGATG 
ATGATGGTTC AACAGCAAGG TGAAGAGTTT ACTCAGGAGG AGATGGTCAC TCGCTTTGAA 
AGAGAGAGAA CGGAGAGTTT GCTGGAACCT GCTGATGTTC AGCGCTCCGT CCTTCCCGAT 
TGTGTGTCGC GGTTTGTCGT GGACGCAGAT TTTACTTATC AGGATTTTAG TCCTAGAGGA 
GCACAGGCCC CTCCAACCAT GAGAGCTCAG GACTATTCAT GGGAGGATCA CGGCTTCTCT 
CTGATGAACC GGCTGTATGG GGAGATGGCG CAGCTTCTGG ATGAGAAGTT TCAGGTGGCC 
TGTGCGCTCA CGTATCACAC CATGGCCATG CACTCACACG TGGACACATC CACACTGCGC 
AAAGCCATCT GGAACTACAT TCAGTGCATC TACGGCATCA GATATGATGA TTACGATTAT 
GGGGAAGTGA ACCAGCTGCT GGAGCGCAGT TTAAAAGTCT ATGTAAAGAC TGTGGCTTGT 
CACCCGGAGA AAACCACAGC AAGAATGTAC TTCTCGTTTT GGAGGCAGTT TCGACACTCT 
GAAAAGGTCC ATGTGAACCT GTTACTGATG GAGGCACGAA TGCAGGCAGC TTTACTTTAT 
GCTCTCAGAG CAATTACACG CTACATGACC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005159816.1
CDS	192..1424
Translation	MSDVLLSEGRADHINMVMGLHPTYLACFQRTQDALLQLDGPLPLSWRHYIVILAAARHQCSYLVQHHSSAFLLAGGDESWLRGVHCAPPKIQHLQTLNKLLAHRPWIITQEHIQELVCPGAEARWSLAELIQAVVLMTHAHSLASFVWGCGIHPEPEQTEDQTLQPCSPTDSCCSVRGKARNQQEWSEAVNEVKLLMERMMMVQQQGEEFTQEEMVTRFERERTESLLEPADVQRSVLPDCVSRFVVDADFTYQDFSPRGAQAPPTMRAQDYSWEDHGFSLMNRLYGEMAQLLDEKFQVACALTYHTMAMHSHVDTSTLRKAIWNYIQCIYGIRYDDYDYGEVNQLLERSLKVYVKTVACHPEKTTARMYFSFWRQFRHSEKVHVNLLLMEARMQAALLYALRAITRYMT

Target ORF information:

RefSeq Version	XM_005159759.3
Organism	Danio rerio(Zebrafish)
Definition	Danio rerio sestrin 2 (sesn2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005159759.3

ORF Insert Sequence:

ATGTCAGACG TTTTGTTGTC AGAAGGACGT GCTGATCATA TCAACATGGT GATGGGGCTT 
CATCCCACCT ACCTGGCCTG TTTCCAGCGC ACACAGGATG CTTTGCTCCA GCTGGACGGC 
CCACTGCCCT TATCATGGAG ACATTATATA GTCATTTTGG CGGCTGCTCG TCATCAGTGC 
TCGTATCTCG TGCAGCATCA CAGCTCCGCT TTTCTGCTTG CCGGTGGAGA CGAGTCCTGG 
CTGCGGGGAG TTCACTGTGC ACCACCGAAA ATACAGCATC TGCAGACACT CAACAAACTG 
CTGGCACACA GACCCTGGAT CATCACCCAG GAGCACATAC AGGAGTTAGT TTGTCCCGGT 
GCGGAGGCTC GATGGTCTCT TGCGGAGCTG ATTCAGGCGG TGGTTTTGAT GACACACGCT 
CACTCTCTGG CCTCGTTTGT CTGGGGTTGC GGGATTCATC CAGAGCCTGA GCAGACAGAA 
GATCAGACGC TTCAGCCGTG TTCGCCCACA GACTCCTGTT GTTCAGTGCG GGGCAAGGCC 
AGAAATCAGC AGGAGTGGTC TGAGGCTGTA AACGAGGTTA AGCTTTTGAT GGAGAGGATG 
ATGATGGTTC AACAGCAAGG TGAAGAGTTT ACTCAGGAGG AGATGGTCAC TCGCTTTGAA 
AGAGAGAGAA CGGAGAGTTT GCTGGAACCT GCTGATGTTC AGCGCTCCGT CCTTCCCGAT 
TGTGTGTCGC GGTTTGTCGT GGACGCAGAT TTTACTTATC AGGATTTTAG TCCTAGAGGA 
GCACAGGCCC CTCCAACCAT GAGAGCTCAG GACTATTCAT GGGAGGATCA CGGCTTCTCT 
CTGATGAACC GGCTGTATGG GGAGATGGCG CAGCTTCTGG ATGAGAAGTT TCAGGTGGCC 
TGTGCGCTCA CGTATCACAC CATGGCCATG CACTCACACG TGGACACATC CACACTGCGC 
AAAGCCATCT GGAACTACAT TCAGTGCATC TACGGCATCA GATATGATGA TTACGATTAT 
GGGGAAGTGA ACCAGCTGCT GGAGCGCAGT TTAAAAGTCT ATGTAAAGAC TGTGGCTTGT 
CACCCGGAGA AAACCACAGC AAGAATGTAC TTCTCGTTTT GGAGGCAGTT TCGACACTCT 
GAAAAGGTCC ATGTGAACCT GTTACTGATG GAGGCACGAA TGCAGGCAGC TTTACTTTAT 
GCTCTCAGAG CAATTACACG CTACATGACC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis.
Neurobiology of disease108225-237(2017 Dec)
Scheldeman C,Mills JD,Siekierska A,Serra I,Copmans D,Iyer AM,Whalley BJ,Maes J,Jansen AC,Lagae L,Aronica E,de Witte PAM

TP53 Modulates Oxidative Stress in Gata1
Stem cell reports8(2)360-372(2017 02)
Kramer AC,Weber J,Zhang Y,Tolar J,Gibbens YY,Shevik M,Lund TC

Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling.
Oncotarget7(50)82820-82835(2016 Dec)
Zhou X,Yue GG,Liu M,Zuo Z,Lee JK,Li M,Tsui SK,Fung KP,Sun H,Pu J,Lau CB

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

High-throughput RNA sequencing reveals the effects of 2,2',4,4' -tetrabromodiphenyl ether on retina and bone development of zebrafish larvae.
BMC genomics1623(2015 Jan)
Xu T,Zhao J,Yin D,Zhao Q,Dong B

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sesn2 cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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