DEFB1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEFB1
Entrez Gene ID	611241
Full Name	defensin beta 1
Synonyms	CBD1
General protein information	Preferred Names defensin beta 1 Names beta-defensin 1
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001113713.1	NP_001107185.1	beta-defensin 1 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Canine ?-defensin-1 (CBD1) gene as a possible marker for Leishmania infantum infection in dogs.
da Silva LG, Costa-J?nior CRL, Figueiredo-J?nior CAS, Leal-Balbino TC, Crovella S, Otranto D, Balbino VQ, Dantas-Torres F
Parasites & vectors10(1)199(2017 Apr)

Altered cutaneous expression of beta-defensins in dogs with atopic dermatitis.
van Damme CM, Willemse T, van Dijk A, Haagsman HP, Veldhuizen EJ
Molecular immunology46(13)2449-55(2009 Aug)

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Patil AA, Cai Y, Sang Y, Blecha F, Zhang G
Physiological genomics23(1)5-17(2005 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study demonstrates a possible association between SNPs in the CBD1 gene and Leishmania infantum infection in dogs
Title: Canine ?-defensin-1 (CBD1) gene as a possible marker for Leishmania infantum infection in dogs.

Data show thatc ontrary to cBD1, expression of cBD103 was slightly (2-fold) downregulated in skin of atopic dogs.
Title: Altered cutaneous expression of beta-defensins in dogs with atopic dermatitis.

The following DEFB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe33830	NM_001113713.1 Latest version!	Canis lupus familiaris defensin beta 1 (DEFB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEFB1 ( NM_001113713.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001107185.1 Canis lupus familiaris defensin beta 1 (DEFB1), mRNA.

Price & Availability↑

CloneID	OCe33830
Clone ID Related Accession (Same CDS sequence)	NM_001113713.1
Accession Version	NM_001113713.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 210bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-22
Organism	Canis lupus familiaris(dog)
Product	beta-defensin 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ011970.1. On Jun 4, 2008 this sequence version replaced XM_848880.1. ##Evidence-Data-START## Transcript exon combination :: DQ011970.1, DN333983.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4547742, SAMEA4547745 [ECO:0000348] ##Evidence-Data-END##

ATGAGGCCTC TCTACTTGCT GCTGCTGCTT CTGTGCCTTC TCTTCTCCTA CCTGCCCCCA 
GGTGCTGGCT TCCTTACGGG TATCGGCCAG AGGTCTGACC AGTACATCTG TGCCAGGAAA 
GGAGGCACCT GCAACTTCTC CCCTTGCCCG CTCTTTACCA GGATCGATGG CACCTGTTAC 
CGCGGGAAGG CCAAGTGCTG CATGCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001107185.1
CDS	153..362
Translation	MRPLYLLLLLLCLLFSYLPPGAGFLTGIGQRSDQYICARKGGTCNFSPCPLFTRIDGTCYRGKAKCCMP

Target ORF information:

RefSeq Version	NM_001113713.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris defensin beta 1 (DEFB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001113713.1

ORF Insert Sequence:

ATGAGGCCTC TCTACTTGCT GCTGCTGCTT CTGTGCCTTC TCTTCTCCTA CCTGCCCCCA 
GGTGCTGGCT TCCTTACGGG TATCGGCCAG AGGTCTGACC AGTACATCTG TGCCAGGAAA 
GGAGGCACCT GCAACTTCTC CCCTTGCCCG CTCTTTACCA GGATCGATGG CACCTGTTAC 
CGCGGGAAGG CCAAGTGCTG CATGCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Canine ?-defensin-1 (CBD1) gene as a possible marker for Leishmania infantum infection in dogs.
Parasites & vectors10(1)199(2017 Apr)
da Silva LG,Costa-J?nior CRL,Figueiredo-J?nior CAS,Leal-Balbino TC,Crovella S,Otranto D,Balbino VQ,Dantas-Torres F

Altered cutaneous expression of beta-defensins in dogs with atopic dermatitis.
Molecular immunology46(13)2449-55(2009 Aug)
van Damme CM,Willemse T,van Dijk A,Haagsman HP,Veldhuizen EJ

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Physiological genomics23(1)5-17(2005 Sep)
Patil AA,Cai Y,Sang Y,Blecha F,Zhang G