Gene Symbol | vhl-1 |
Entrez Gene ID | 181321 |
Full Name | von Hippel-Lindau tumor suppressor homolog |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » vhl-1 cDNA ORF clone
Gene Symbol | vhl-1 |
Entrez Gene ID | 181321 |
Full Name | von Hippel-Lindau tumor suppressor homolog |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_077488.3 | NP_509889.1 | von Hippel-Lindau tumor suppressor homolog |
NM_077488.5 | NP_509889.1 | von Hippel-Lindau tumor suppressor homolog |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
loss of VHL-1 increased life span; deletion of HIF-1 was epistatic to VHL-1, indicating HIF-1 acts downstream of VHL-1 to modulate aging; VHL-1 & HIF-1 control longevity by a mechanism distinct from dietary restriction & insulin-like signaling
Title: Proteasomal regulation of the hypoxic response modulates aging in C. elegans.
The Caenorhabditis elegans rhy-1 gene inhibits hif-1 activity in a negative feedback loop that does not include vhl-1.
Title: The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1.
there is a discrete HIF-1-independent function of VHL-1 that is connected with extracellular matrix function
Title: Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans.
The following vhl-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the vhl-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa350152 | |
Clone ID Related Accession (Same CDS sequence) | NM_077488.3 , NM_077488.5 | |
Accession Version | NM_077488.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 525bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | von Hippel-Lindau tumor suppressor homolog | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). On Jun 26, 2012 this sequence version replaced NM_077488.2. COMPLETENESS: incomplete on both ends. |
1 | ATGTCAGACG GTTCGATGGA TGATGATGGA AGGTTATTTC CTGACTTGGG CTCATCAACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_509889.1 |
CDS | 1..525 |
Translation |
Target ORF information:
Target ORF information:
|
NM_077488.3 |
1 | ATGTCAGACG GTTCGATGGA TGATGATGGA AGGTTATTTC CTGACTTGGG CTCATCAACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa350152 | |
Clone ID Related Accession (Same CDS sequence) | NM_077488.3 , NM_077488.5 | |
Accession Version | NM_077488.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 525bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | von Hippel-Lindau tumor suppressor homolog | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). On Oct 18, 2019 this sequence version replaced NM_077488.4. |
1 | ATGTCAGACG GTTCGATGGA TGATGATGGA AGGTTATTTC CTGACTTGGG CTCATCAACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_509889.1 |
CDS | 14..538 |
Translation |
Target ORF information:
Target ORF information:
|
NM_077488.5 |
1 | ATGTCAGACG GTTCGATGGA TGATGATGGA AGGTTATTTC CTGACTTGGG CTCATCAACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |