him-6 cDNA ORF clone, Caenorhabditis elegans

Gene
Clones
gRNAs

Summary

Gene Symbol	him-6
Entrez Gene ID	178201
Full Name	Bloom syndrome protein homolog
Gene Type	protein-coding
Organism	Caenorhabditis elegans

mRNA and Protein(s)

mRNA	Protein	Name
NM_069989.6	NP_502390.2	Bloom syndrome protein homolog
NM_069989.5	NP_502390.2	Bloom syndrome protein homolog

Pathways from BioSystems

Homologies

Caenorhabditis elegans (roundworm)	him-6	NP_502390.2
Arabidopsis thaliana (thale cress)	RECQI1	NP_187225.2
Oryza sativa (rice)	Os11g0672700	NP_001068436.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002967	XP_311930.4

Gene Ontology
Bibliography

Related articles in PubMed

Genome sequence of the nematode C. elegans: a platform for investigating biology.

Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our results suggest that SMC-5/6 and HIM-6 can synergistically regulate recombination intermediate metabolism and suppress ectopic recombination by controlling chromosome architecture during meiosis.
Title: The SMC-5/6 Complex and the HIM-6 (BLM) Helicase Synergistically Promote Meiotic Recombination Intermediate Processing and Chromosome Maturation during Caenorhabditis elegans Meiosis.

him-6 mutants are competent to load the MutSgamma complex at crossing over sites, to generate intermediates that enable meiosis progression, and to regulate crossing over. HIM-6 prevents formation of MutSgamma-independent interhomolog associations.
Title: DNA helicase HIM-6/BLM both promotes MutS?-dependent crossovers and antagonizes MutS?-independent interhomolog associations during caenorhabditis elegans meiosis.

HIM-6 has DNA-dependent ATPase activity HIM-6 and helicase activity that proceeds in the 3'-5' direction and needs at least five 3' overhanging nucleotides. HIM-6 is also able to unwind DNA structures including D-loops and Holliday junctions.
Title: Characterization of the Caenorhabditis elegans HIM-6/BLM helicase: unwinding recombination intermediates.

Our results are consistent with the existence of at least two redundant meiotic resolvase activities: one requiring HIM-6 and XPF-1, and the other dependent on SLX-1 and MUS-81.
Title: Combinatorial regulation of meiotic holliday junction resolution in C. elegans by HIM-6 (BLM) helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 nucleases.

HIM-6 has a role in preventing DNA lesions
Title: Bloom syndrome ortholog HIM-6 maintains genomic stability in C. elegans.

The following him-6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the him-6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OCa342367	NM_069989.6 Latest version!	Caenorhabditis elegans Bloom syndrome protein homolog (him-6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
View Old Accession Versions >>
OCa342367	NM_069989.5	Caenorhabditis elegans Bloom syndrome protein homolog (him-6), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$510.30 $729.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

him-6 ( NM_069989.6 ) cDNA ORF clone, Caenorhabditis elegans -> NP_502390.2 Caenorhabditis elegans Bloom syndrome protein homolog (him-6), mRNA.

Price & Availability↑

CloneID	OCa342367
Clone ID Related Accession (Same CDS sequence)	NM_069989.6 , NM_069989.5
Accession Version	NM_069989.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2967bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Caenorhabditis elegans
Product	Bloom syndrome protein homolog
Comment	Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003282). On Sep 4, 2019 this sequence version replaced NM_069989.5.

ATGATAAAAA ATCGTGAAAT CGAAGTTGCA CCACCCCGTC GAACAATTCA ATTCGGCGGA 
TACACTTTCG TTGAACCCGA TTTGAATTTT AAAGCGCCAA TATTTTCGTG TTGCGGTTCG 
ATTCGAGACC CATCTTGTGA AGAAAGAGAG GAGGAATATA TCGATAATGG TCACGATGAA 
GAGCCGCCCG TAGAAGTAAA TCGTATTCAG GAATCGACAA GTTTTGACGA ACCGGTGAGC 
TCGCCGCCAC GTTATCGACC ATCAGAGAAT CCGGGTCCAA GTTCAAGCAG CTACGAGCCA 
GGTCACTACA GTTTCAATGA ATATCAACAA TTTCCAAGTC GTCCACAAAA GCGGCTAGTA 
GATCCTCCGA TTGTCGATTT AGACGAAGAA CCTCCGATTG TCGATTTAGA CGATAGTTTT 
GATAATTTCC ACGTCGGCAG TACATCGGAA GAAGTGGTTT CAGGAGATAT TGCTCCAGAA 
GAAGAAGAAG AAGAAGGTCA CGATAGTTTC GACGATTTTG AATCCGTGCC GGCTCAGCCA 
CCATCCAAGA ACACACTAGC CAGTTTGCAA AAGTCCGATT CAGAAATCGC TTTAAATCAG 
CAGAGACACG ATATGCACGG CAGATTCCGA GGATTTTTAC AGGACGACAG TGAAGAATTC 
AGTGATGAAG TTGGACTTCT CGGTGCTGAT ATGAACAAAG AACTATATGA CACATTAAAA 
TCGAAATTTG GATTCAATCA GTTCCGTCAT CGCCAGAAAC AATGTATCCT TTCTACATTA 
ATGGGCCACG ACACCTTTGT TCTTATGCCA ACTGGCGCGG GAAAAAGTTT GTGCTACCAA 
TTGCCAGCTG TCATTCTTCC CGGAGTTACT GTCGTCGTAT CACCACTTCG TTCGCTGATT 
GAGGATCAGA AAATGAAAAT GAAGGAGTTG GGAATTGGTT GTGAAGCTCT AACCGCCGAC 
CTCGGTGCTC CAGCCCAAGA GAAAATTTAT GCTGAACTCG GCTCAGGAAA TCCGTCTATA 
AAACTTTTAT ATGTAACACC GGAGAAGATT AGCGCTTCTG GTCGTCTCAA TTCAGTATTC 
TTCGATCTTC ATCGTCGTGG ACTTCTCGCT AGATTCGTCA TCGACGAAGC ACATTGTGTT 
TCTCAATGGG GGCACGATTT CAGGCCGGAC TACACGAAAT TAAGCTCGTT ACGGGAGAAA 
TATGCTAATC CACCAGTTCC TATAATTGCT CTCACTGCAA CTGCAACACC TAAAATTGTG 
ACTGATGCCA GAGATCATCT GAAAATGCAA AATTCGAAGC TTTTCATCAG CTCCTTTGTT 
CGAGATAATC TGAAATACGA TTTAATCCCG AAAGCAGCAA GATCGCTGAT CAATGTTGTT 
GAGAAAATGA AACAATTGTA TCCAGGAAAA TCTGGAATTG TTTATTGCTT GTCTAGAAAA 
GAATGTGAAA CGGTTCAAAT GATGCTCACC AAGGCAGGTC TCTCTGCAGA AGTCTATCAT 
GCTGGTCTAA ATGACAATCT TCGAGTTTCT GTTCAAAGAA GTTGGATCGC CAACAAATTC 
GACGTGATCT GTGCGACAAT TGCATTTGGA ATGGGGATTG ATAAACCAGA TGTACGATTT 
GTGATCCATT ACAGTTTGCC AAAATCAATC GAAGGTTACT ATCAAGAGAC GGGTCGCGCT 
GGAAGAGATG GAATGCCCAG TTATTGTTTG ATGCTTTACT CGTATCACGA TTCGATTCGA 
TTGAGGCGAA TGATTGAAGA GGGAAACACT ACGACTGGCG TTCGATCAAT GCATCTCAAT 
AATGTTCTTC AAGTTGTCGC TTACTGTGAG AATGTATCGG TTTGCAGAAG AAAAATGCTC 
GTGGAGCATT TTGGAGAGGT CTATGATGAA CAATCGTGTC GAAATAGCAA AACTCCTTGT 
GACATTTGTG AAAGGCAACG GAAGAATGCT GAAGCCATTC GTCTTTTCGA TGTTTCTACT 
GATGCATTGT CTATTTTGAA ATGCTTACCA CGTATGCAGA AAGCTACGTT AAAATACATA 
TCCGAACTTT ATCGCGGTGC TCTCATCAAA AAGTCTCAGG AACAAGCTAT GCGTCTAGGA 
CACACAAAAC TTCCGTTCTA CTCGAAAGGT CAAGGAATGT CAGAGCAGGA TGCATTGAGA 
TTTGTTCGAA AGCTGGTTAT TGAAGGATAT ATACACGAAC GGCTATATTC GGTTCCAAAT 
CAGGCAGCTG CAGTTTTTGC GTATGCAGAG CTGACGGAAG CTGGACGAGA TTTAGCAAAT 
GGAAAAAAAA CTGCAAAAGT CTATCTCCAC ATTGTCACTT GTGAAAGAAA GCGAAAGAAT 
GCTGGCCTCA TCGAATTATC CAATATGAAT ATCGTCTCAG AAGCCCAGGC ACTAAAAGAA 
CGTCATATGG TTAAACATGG AGATGTTTTT ACGAGATGTC TTCAAGATTT GACTCATCTT 
ATTACTGCAG TTGCCGAGAG TTCTGGATTA TCCGGTCCTT ATTCAATTGT GTCCCGAGAA 
GGAATCGAAC AAATCGCTGC TCTTCTTCCA CGGACGAATT CGGATCTTTT GAGAATTGAT 
TCCATGACCC AGATTAAAGT TACAAAGTAT GGCCGTCTAA TCATGGAGCT TCTAGCAACT 
TACTGGAAAC AGGTTGATGA ACGAGAGGAA GAAGAAATGC GAAACCAGCT TGACAAATTG 
AAAAGCGGAG AAATTGTGAT GGGTGGTTTC GCCACATTAC AATCGGATCC AGGTTTTCCA 
TCTGTACCCT ACATGAAGCC ACTTGGAGGA GGAGGAGGAT GCAGGGGAAG AGGAAAGAAG 
AGGGCATTTT CTGGCTTTTC CTCCGGTCGA GCAACGAAGA AGCCACGCGC AACTGCTCCA 
TCGGCACGTG GCAAGACAAG CGGACGAGGC GGGGCAAAAC CAGCTACTTC ACTCAAACGG 
AACATGTATC CAGCTACATC GATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_502390.2
CDS	8..2974
Translation	MIKNREIEVAPPRRTIQFGGYTFVEPDLNFKAPIFSCCGSIRDPSCEEREEEYIDNGHDEEPPVEVNRIQESTSFDEPVSSPPRYRPSENPGPSSSSYEPGHYSFNEYQQFPSRPQKRLVDPPIVDLDEEPPIVDLDDSFDNFHVGSTSEEVVSGDIAPEEEEEEGHDSFDDFESVPAQPPSKNTLASLQKSDSEIALNQQRHDMHGRFRGFLQDDSEEFSDEVGLLGADMNKELYDTLKSKFGFNQFRHRQKQCILSTLMGHDTFVLMPTGAGKSLCYQLPAVILPGVTVVVSPLRSLIEDQKMKMKELGIGCEALTADLGAPAQEKIYAELGSGNPSIKLLYVTPEKISASGRLNSVFFDLHRRGLLARFVIDEAHCVSQWGHDFRPDYTKLSSLREKYANPPVPIIALTATATPKIVTDARDHLKMQNSKLFISSFVRDNLKYDLIPKAARSLINVVEKMKQLYPGKSGIVYCLSRKECETVQMMLTKAGLSAEVYHAGLNDNLRVSVQRSWIANKFDVICATIAFGMGIDKPDVRFVIHYSLPKSIEGYYQETGRAGRDGMPSYCLMLYSYHDSIRLRRMIEEGNTTTGVRSMHLNNVLQVVAYCENVSVCRRKMLVEHFGEVYDEQSCRNSKTPCDICERQRKNAEAIRLFDVSTDALSILKCLPRMQKATLKYISELYRGALIKKSQEQAMRLGHTKLPFYSKGQGMSEQDALRFVRKLVIEGYIHERLYSVPNQAAAVFAYAELTEAGRDLANGKKTAKVYLHIVTCERKRKNAGLIELSNMNIVSEAQALKERHMVKHGDVFTRCLQDLTHLITAVAESSGLSGPYSIVSREGIEQIAALLPRTNSDLLRIDSMTQIKVTKYGRLIMELLATYWKQVDEREEEEMRNQLDKLKSGEIVMGGFATLQSDPGFPSVPYMKPLGGGGGCRGRGKKRAFSGFSSGRATKKPRATAPSARGKTSGRGGAKPATSLKRNMYPATSM

Target ORF information:

RefSeq Version	NM_069989.6
Organism	Caenorhabditis elegans
Definition	Caenorhabditis elegans Bloom syndrome protein homolog (him-6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_069989.6

ORF Insert Sequence:

ATGATAAAAA ATCGTGAAAT CGAAGTTGCA CCACCCCGTC GAACAATTCA ATTCGGCGGA 
TACACTTTCG TTGAACCCGA TTTGAATTTT AAAGCGCCAA TATTTTCGTG TTGCGGTTCG 
ATTCGAGACC CATCTTGTGA AGAAAGAGAG GAGGAATATA TCGATAATGG TCACGATGAA 
GAGCCGCCCG TAGAAGTAAA TCGTATTCAG GAATCGACAA GTTTTGACGA ACCGGTGAGC 
TCGCCGCCAC GTTATCGACC ATCAGAGAAT CCGGGTCCAA GTTCAAGCAG CTACGAGCCA 
GGTCACTACA GTTTCAATGA ATATCAACAA TTTCCAAGTC GTCCACAAAA GCGGCTAGTA 
GATCCTCCGA TTGTCGATTT AGACGAAGAA CCTCCGATTG TCGATTTAGA CGATAGTTTT 
GATAATTTCC ACGTCGGCAG TACATCGGAA GAAGTGGTTT CAGGAGATAT TGCTCCAGAA 
GAAGAAGAAG AAGAAGGTCA CGATAGTTTC GACGATTTTG AATCCGTGCC GGCTCAGCCA 
CCATCCAAGA ACACACTAGC CAGTTTGCAA AAGTCCGATT CAGAAATCGC TTTAAATCAG 
CAGAGACACG ATATGCACGG CAGATTCCGA GGATTTTTAC AGGACGACAG TGAAGAATTC 
AGTGATGAAG TTGGACTTCT CGGTGCTGAT ATGAACAAAG AACTATATGA CACATTAAAA 
TCGAAATTTG GATTCAATCA GTTCCGTCAT CGCCAGAAAC AATGTATCCT TTCTACATTA 
ATGGGCCACG ACACCTTTGT TCTTATGCCA ACTGGCGCGG GAAAAAGTTT GTGCTACCAA 
TTGCCAGCTG TCATTCTTCC CGGAGTTACT GTCGTCGTAT CACCACTTCG TTCGCTGATT 
GAGGATCAGA AAATGAAAAT GAAGGAGTTG GGAATTGGTT GTGAAGCTCT AACCGCCGAC 
CTCGGTGCTC CAGCCCAAGA GAAAATTTAT GCTGAACTCG GCTCAGGAAA TCCGTCTATA 
AAACTTTTAT ATGTAACACC GGAGAAGATT AGCGCTTCTG GTCGTCTCAA TTCAGTATTC 
TTCGATCTTC ATCGTCGTGG ACTTCTCGCT AGATTCGTCA TCGACGAAGC ACATTGTGTT 
TCTCAATGGG GGCACGATTT CAGGCCGGAC TACACGAAAT TAAGCTCGTT ACGGGAGAAA 
TATGCTAATC CACCAGTTCC TATAATTGCT CTCACTGCAA CTGCAACACC TAAAATTGTG 
ACTGATGCCA GAGATCATCT GAAAATGCAA AATTCGAAGC TTTTCATCAG CTCCTTTGTT 
CGAGATAATC TGAAATACGA TTTAATCCCG AAAGCAGCAA GATCGCTGAT CAATGTTGTT 
GAGAAAATGA AACAATTGTA TCCAGGAAAA TCTGGAATTG TTTATTGCTT GTCTAGAAAA 
GAATGTGAAA CGGTTCAAAT GATGCTCACC AAGGCAGGTC TCTCTGCAGA AGTCTATCAT 
GCTGGTCTAA ATGACAATCT TCGAGTTTCT GTTCAAAGAA GTTGGATCGC CAACAAATTC 
GACGTGATCT GTGCGACAAT TGCATTTGGA ATGGGGATTG ATAAACCAGA TGTACGATTT 
GTGATCCATT ACAGTTTGCC AAAATCAATC GAAGGTTACT ATCAAGAGAC GGGTCGCGCT 
GGAAGAGATG GAATGCCCAG TTATTGTTTG ATGCTTTACT CGTATCACGA TTCGATTCGA 
TTGAGGCGAA TGATTGAAGA GGGAAACACT ACGACTGGCG TTCGATCAAT GCATCTCAAT 
AATGTTCTTC AAGTTGTCGC TTACTGTGAG AATGTATCGG TTTGCAGAAG AAAAATGCTC 
GTGGAGCATT TTGGAGAGGT CTATGATGAA CAATCGTGTC GAAATAGCAA AACTCCTTGT 
GACATTTGTG AAAGGCAACG GAAGAATGCT GAAGCCATTC GTCTTTTCGA TGTTTCTACT 
GATGCATTGT CTATTTTGAA ATGCTTACCA CGTATGCAGA AAGCTACGTT AAAATACATA 
TCCGAACTTT ATCGCGGTGC TCTCATCAAA AAGTCTCAGG AACAAGCTAT GCGTCTAGGA 
CACACAAAAC TTCCGTTCTA CTCGAAAGGT CAAGGAATGT CAGAGCAGGA TGCATTGAGA 
TTTGTTCGAA AGCTGGTTAT TGAAGGATAT ATACACGAAC GGCTATATTC GGTTCCAAAT 
CAGGCAGCTG CAGTTTTTGC GTATGCAGAG CTGACGGAAG CTGGACGAGA TTTAGCAAAT 
GGAAAAAAAA CTGCAAAAGT CTATCTCCAC ATTGTCACTT GTGAAAGAAA GCGAAAGAAT 
GCTGGCCTCA TCGAATTATC CAATATGAAT ATCGTCTCAG AAGCCCAGGC ACTAAAAGAA 
CGTCATATGG TTAAACATGG AGATGTTTTT ACGAGATGTC TTCAAGATTT GACTCATCTT 
ATTACTGCAG TTGCCGAGAG TTCTGGATTA TCCGGTCCTT ATTCAATTGT GTCCCGAGAA 
GGAATCGAAC AAATCGCTGC TCTTCTTCCA CGGACGAATT CGGATCTTTT GAGAATTGAT 
TCCATGACCC AGATTAAAGT TACAAAGTAT GGCCGTCTAA TCATGGAGCT TCTAGCAACT 
TACTGGAAAC AGGTTGATGA ACGAGAGGAA GAAGAAATGC GAAACCAGCT TGACAAATTG 
AAAAGCGGAG AAATTGTGAT GGGTGGTTTC GCCACATTAC AATCGGATCC AGGTTTTCCA 
TCTGTACCCT ACATGAAGCC ACTTGGAGGA GGAGGAGGAT GCAGGGGAAG AGGAAAGAAG 
AGGGCATTTT CTGGCTTTTC CTCCGGTCGA GCAACGAAGA AGCCACGCGC AACTGCTCCA 
TCGGCACGTG GCAAGACAAG CGGACGAGGC GGGGCAAAAC CAGCTACTTC ACTCAAACGG 
AACATGTATC CAGCTACATC GATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

him-6 ( NM_069989.5 ) cDNA ORF clone, Caenorhabditis elegans -> NP_502390.2 Caenorhabditis elegans Bloom syndrome protein homolog (him-6), partial mRNA.

Price & Availability↑

CloneID	OCa342367
Clone ID Related Accession (Same CDS sequence)	NM_069989.6 , NM_069989.5
Accession Version	NM_069989.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2967bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-08
Organism	Caenorhabditis elegans
Product	Bloom syndrome protein homolog
Comment	Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003282). On Jun 26, 2012 this sequence version replaced NM_069989.4. COMPLETENESS: incomplete on both ends.

ATGATAAAAA ATCGTGAAAT CGAAGTTGCA CCACCCCGTC GAACAATTCA ATTCGGCGGA 
TACACTTTCG TTGAACCCGA TTTGAATTTT AAAGCGCCAA TATTTTCGTG TTGCGGTTCG 
ATTCGAGACC CATCTTGTGA AGAAAGAGAG GAGGAATATA TCGATAATGG TCACGATGAA 
GAGCCGCCCG TAGAAGTAAA TCGTATTCAG GAATCGACAA GTTTTGACGA ACCGGTGAGC 
TCGCCGCCAC GTTATCGACC ATCAGAGAAT CCGGGTCCAA GTTCAAGCAG CTACGAGCCA 
GGTCACTACA GTTTCAATGA ATATCAACAA TTTCCAAGTC GTCCACAAAA GCGGCTAGTA 
GATCCTCCGA TTGTCGATTT AGACGAAGAA CCTCCGATTG TCGATTTAGA CGATAGTTTT 
GATAATTTCC ACGTCGGCAG TACATCGGAA GAAGTGGTTT CAGGAGATAT TGCTCCAGAA 
GAAGAAGAAG AAGAAGGTCA CGATAGTTTC GACGATTTTG AATCCGTGCC GGCTCAGCCA 
CCATCCAAGA ACACACTAGC CAGTTTGCAA AAGTCCGATT CAGAAATCGC TTTAAATCAG 
CAGAGACACG ATATGCACGG CAGATTCCGA GGATTTTTAC AGGACGACAG TGAAGAATTC 
AGTGATGAAG TTGGACTTCT CGGTGCTGAT ATGAACAAAG AACTATATGA CACATTAAAA 
TCGAAATTTG GATTCAATCA GTTCCGTCAT CGCCAGAAAC AATGTATCCT TTCTACATTA 
ATGGGCCACG ACACCTTTGT TCTTATGCCA ACTGGCGCGG GAAAAAGTTT GTGCTACCAA 
TTGCCAGCTG TCATTCTTCC CGGAGTTACT GTCGTCGTAT CACCACTTCG TTCGCTGATT 
GAGGATCAGA AAATGAAAAT GAAGGAGTTG GGAATTGGTT GTGAAGCTCT AACCGCCGAC 
CTCGGTGCTC CAGCCCAAGA GAAAATTTAT GCTGAACTCG GCTCAGGAAA TCCGTCTATA 
AAACTTTTAT ATGTAACACC GGAGAAGATT AGCGCTTCTG GTCGTCTCAA TTCAGTATTC 
TTCGATCTTC ATCGTCGTGG ACTTCTCGCT AGATTCGTCA TCGACGAAGC ACATTGTGTT 
TCTCAATGGG GGCACGATTT CAGGCCGGAC TACACGAAAT TAAGCTCGTT ACGGGAGAAA 
TATGCTAATC CACCAGTTCC TATAATTGCT CTCACTGCAA CTGCAACACC TAAAATTGTG 
ACTGATGCCA GAGATCATCT GAAAATGCAA AATTCGAAGC TTTTCATCAG CTCCTTTGTT 
CGAGATAATC TGAAATACGA TTTAATCCCG AAAGCAGCAA GATCGCTGAT CAATGTTGTT 
GAGAAAATGA AACAATTGTA TCCAGGAAAA TCTGGAATTG TTTATTGCTT GTCTAGAAAA 
GAATGTGAAA CGGTTCAAAT GATGCTCACC AAGGCAGGTC TCTCTGCAGA AGTCTATCAT 
GCTGGTCTAA ATGACAATCT TCGAGTTTCT GTTCAAAGAA GTTGGATCGC CAACAAATTC 
GACGTGATCT GTGCGACAAT TGCATTTGGA ATGGGGATTG ATAAACCAGA TGTACGATTT 
GTGATCCATT ACAGTTTGCC AAAATCAATC GAAGGTTACT ATCAAGAGAC GGGTCGCGCT 
GGAAGAGATG GAATGCCCAG TTATTGTTTG ATGCTTTACT CGTATCACGA TTCGATTCGA 
TTGAGGCGAA TGATTGAAGA GGGAAACACT ACGACTGGCG TTCGATCAAT GCATCTCAAT 
AATGTTCTTC AAGTTGTCGC TTACTGTGAG AATGTATCGG TTTGCAGAAG AAAAATGCTC 
GTGGAGCATT TTGGAGAGGT CTATGATGAA CAATCGTGTC GAAATAGCAA AACTCCTTGT 
GACATTTGTG AAAGGCAACG GAAGAATGCT GAAGCCATTC GTCTTTTCGA TGTTTCTACT 
GATGCATTGT CTATTTTGAA ATGCTTACCA CGTATGCAGA AAGCTACGTT AAAATACATA 
TCCGAACTTT ATCGCGGTGC TCTCATCAAA AAGTCTCAGG AACAAGCTAT GCGTCTAGGA 
CACACAAAAC TTCCGTTCTA CTCGAAAGGT CAAGGAATGT CAGAGCAGGA TGCATTGAGA 
TTTGTTCGAA AGCTGGTTAT TGAAGGATAT ATACACGAAC GGCTATATTC GGTTCCAAAT 
CAGGCAGCTG CAGTTTTTGC GTATGCAGAG CTGACGGAAG CTGGACGAGA TTTAGCAAAT 
GGAAAAAAAA CTGCAAAAGT CTATCTCCAC ATTGTCACTT GTGAAAGAAA GCGAAAGAAT 
GCTGGCCTCA TCGAATTATC CAATATGAAT ATCGTCTCAG AAGCCCAGGC ACTAAAAGAA 
CGTCATATGG TTAAACATGG AGATGTTTTT ACGAGATGTC TTCAAGATTT GACTCATCTT 
ATTACTGCAG TTGCCGAGAG TTCTGGATTA TCCGGTCCTT ATTCAATTGT GTCCCGAGAA 
GGAATCGAAC AAATCGCTGC TCTTCTTCCA CGGACGAATT CGGATCTTTT GAGAATTGAT 
TCCATGACCC AGATTAAAGT TACAAAGTAT GGCCGTCTAA TCATGGAGCT TCTAGCAACT 
TACTGGAAAC AGGTTGATGA ACGAGAGGAA GAAGAAATGC GAAACCAGCT TGACAAATTG 
AAAAGCGGAG AAATTGTGAT GGGTGGTTTC GCCACATTAC AATCGGATCC AGGTTTTCCA 
TCTGTACCCT ACATGAAGCC ACTTGGAGGA GGAGGAGGAT GCAGGGGAAG AGGAAAGAAG 
AGGGCATTTT CTGGCTTTTC CTCCGGTCGA GCAACGAAGA AGCCACGCGC AACTGCTCCA 
TCGGCACGTG GCAAGACAAG CGGACGAGGC GGGGCAAAAC CAGCTACTTC ACTCAAACGG 
AACATGTATC CAGCTACATC GATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_502390.2
CDS	1..2967
Translation	MIKNREIEVAPPRRTIQFGGYTFVEPDLNFKAPIFSCCGSIRDPSCEEREEEYIDNGHDEEPPVEVNRIQESTSFDEPVSSPPRYRPSENPGPSSSSYEPGHYSFNEYQQFPSRPQKRLVDPPIVDLDEEPPIVDLDDSFDNFHVGSTSEEVVSGDIAPEEEEEEGHDSFDDFESVPAQPPSKNTLASLQKSDSEIALNQQRHDMHGRFRGFLQDDSEEFSDEVGLLGADMNKELYDTLKSKFGFNQFRHRQKQCILSTLMGHDTFVLMPTGAGKSLCYQLPAVILPGVTVVVSPLRSLIEDQKMKMKELGIGCEALTADLGAPAQEKIYAELGSGNPSIKLLYVTPEKISASGRLNSVFFDLHRRGLLARFVIDEAHCVSQWGHDFRPDYTKLSSLREKYANPPVPIIALTATATPKIVTDARDHLKMQNSKLFISSFVRDNLKYDLIPKAARSLINVVEKMKQLYPGKSGIVYCLSRKECETVQMMLTKAGLSAEVYHAGLNDNLRVSVQRSWIANKFDVICATIAFGMGIDKPDVRFVIHYSLPKSIEGYYQETGRAGRDGMPSYCLMLYSYHDSIRLRRMIEEGNTTTGVRSMHLNNVLQVVAYCENVSVCRRKMLVEHFGEVYDEQSCRNSKTPCDICERQRKNAEAIRLFDVSTDALSILKCLPRMQKATLKYISELYRGALIKKSQEQAMRLGHTKLPFYSKGQGMSEQDALRFVRKLVIEGYIHERLYSVPNQAAAVFAYAELTEAGRDLANGKKTAKVYLHIVTCERKRKNAGLIELSNMNIVSEAQALKERHMVKHGDVFTRCLQDLTHLITAVAESSGLSGPYSIVSREGIEQIAALLPRTNSDLLRIDSMTQIKVTKYGRLIMELLATYWKQVDEREEEEMRNQLDKLKSGEIVMGGFATLQSDPGFPSVPYMKPLGGGGGCRGRGKKRAFSGFSSGRATKKPRATAPSARGKTSGRGGAKPATSLKRNMYPATSM

Target ORF information:

RefSeq Version	NM_069989.5
Organism	Caenorhabditis elegans
Definition	Caenorhabditis elegans Bloom syndrome protein homolog (him-6), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_069989.5

ORF Insert Sequence:

ATGATAAAAA ATCGTGAAAT CGAAGTTGCA CCACCCCGTC GAACAATTCA ATTCGGCGGA 
TACACTTTCG TTGAACCCGA TTTGAATTTT AAAGCGCCAA TATTTTCGTG TTGCGGTTCG 
ATTCGAGACC CATCTTGTGA AGAAAGAGAG GAGGAATATA TCGATAATGG TCACGATGAA 
GAGCCGCCCG TAGAAGTAAA TCGTATTCAG GAATCGACAA GTTTTGACGA ACCGGTGAGC 
TCGCCGCCAC GTTATCGACC ATCAGAGAAT CCGGGTCCAA GTTCAAGCAG CTACGAGCCA 
GGTCACTACA GTTTCAATGA ATATCAACAA TTTCCAAGTC GTCCACAAAA GCGGCTAGTA 
GATCCTCCGA TTGTCGATTT AGACGAAGAA CCTCCGATTG TCGATTTAGA CGATAGTTTT 
GATAATTTCC ACGTCGGCAG TACATCGGAA GAAGTGGTTT CAGGAGATAT TGCTCCAGAA 
GAAGAAGAAG AAGAAGGTCA CGATAGTTTC GACGATTTTG AATCCGTGCC GGCTCAGCCA 
CCATCCAAGA ACACACTAGC CAGTTTGCAA AAGTCCGATT CAGAAATCGC TTTAAATCAG 
CAGAGACACG ATATGCACGG CAGATTCCGA GGATTTTTAC AGGACGACAG TGAAGAATTC 
AGTGATGAAG TTGGACTTCT CGGTGCTGAT ATGAACAAAG AACTATATGA CACATTAAAA 
TCGAAATTTG GATTCAATCA GTTCCGTCAT CGCCAGAAAC AATGTATCCT TTCTACATTA 
ATGGGCCACG ACACCTTTGT TCTTATGCCA ACTGGCGCGG GAAAAAGTTT GTGCTACCAA 
TTGCCAGCTG TCATTCTTCC CGGAGTTACT GTCGTCGTAT CACCACTTCG TTCGCTGATT 
GAGGATCAGA AAATGAAAAT GAAGGAGTTG GGAATTGGTT GTGAAGCTCT AACCGCCGAC 
CTCGGTGCTC CAGCCCAAGA GAAAATTTAT GCTGAACTCG GCTCAGGAAA TCCGTCTATA 
AAACTTTTAT ATGTAACACC GGAGAAGATT AGCGCTTCTG GTCGTCTCAA TTCAGTATTC 
TTCGATCTTC ATCGTCGTGG ACTTCTCGCT AGATTCGTCA TCGACGAAGC ACATTGTGTT 
TCTCAATGGG GGCACGATTT CAGGCCGGAC TACACGAAAT TAAGCTCGTT ACGGGAGAAA 
TATGCTAATC CACCAGTTCC TATAATTGCT CTCACTGCAA CTGCAACACC TAAAATTGTG 
ACTGATGCCA GAGATCATCT GAAAATGCAA AATTCGAAGC TTTTCATCAG CTCCTTTGTT 
CGAGATAATC TGAAATACGA TTTAATCCCG AAAGCAGCAA GATCGCTGAT CAATGTTGTT 
GAGAAAATGA AACAATTGTA TCCAGGAAAA TCTGGAATTG TTTATTGCTT GTCTAGAAAA 
GAATGTGAAA CGGTTCAAAT GATGCTCACC AAGGCAGGTC TCTCTGCAGA AGTCTATCAT 
GCTGGTCTAA ATGACAATCT TCGAGTTTCT GTTCAAAGAA GTTGGATCGC CAACAAATTC 
GACGTGATCT GTGCGACAAT TGCATTTGGA ATGGGGATTG ATAAACCAGA TGTACGATTT 
GTGATCCATT ACAGTTTGCC AAAATCAATC GAAGGTTACT ATCAAGAGAC GGGTCGCGCT 
GGAAGAGATG GAATGCCCAG TTATTGTTTG ATGCTTTACT CGTATCACGA TTCGATTCGA 
TTGAGGCGAA TGATTGAAGA GGGAAACACT ACGACTGGCG TTCGATCAAT GCATCTCAAT 
AATGTTCTTC AAGTTGTCGC TTACTGTGAG AATGTATCGG TTTGCAGAAG AAAAATGCTC 
GTGGAGCATT TTGGAGAGGT CTATGATGAA CAATCGTGTC GAAATAGCAA AACTCCTTGT 
GACATTTGTG AAAGGCAACG GAAGAATGCT GAAGCCATTC GTCTTTTCGA TGTTTCTACT 
GATGCATTGT CTATTTTGAA ATGCTTACCA CGTATGCAGA AAGCTACGTT AAAATACATA 
TCCGAACTTT ATCGCGGTGC TCTCATCAAA AAGTCTCAGG AACAAGCTAT GCGTCTAGGA 
CACACAAAAC TTCCGTTCTA CTCGAAAGGT CAAGGAATGT CAGAGCAGGA TGCATTGAGA 
TTTGTTCGAA AGCTGGTTAT TGAAGGATAT ATACACGAAC GGCTATATTC GGTTCCAAAT 
CAGGCAGCTG CAGTTTTTGC GTATGCAGAG CTGACGGAAG CTGGACGAGA TTTAGCAAAT 
GGAAAAAAAA CTGCAAAAGT CTATCTCCAC ATTGTCACTT GTGAAAGAAA GCGAAAGAAT 
GCTGGCCTCA TCGAATTATC CAATATGAAT ATCGTCTCAG AAGCCCAGGC ACTAAAAGAA 
CGTCATATGG TTAAACATGG AGATGTTTTT ACGAGATGTC TTCAAGATTT GACTCATCTT 
ATTACTGCAG TTGCCGAGAG TTCTGGATTA TCCGGTCCTT ATTCAATTGT GTCCCGAGAA 
GGAATCGAAC AAATCGCTGC TCTTCTTCCA CGGACGAATT CGGATCTTTT GAGAATTGAT 
TCCATGACCC AGATTAAAGT TACAAAGTAT GGCCGTCTAA TCATGGAGCT TCTAGCAACT 
TACTGGAAAC AGGTTGATGA ACGAGAGGAA GAAGAAATGC GAAACCAGCT TGACAAATTG 
AAAAGCGGAG AAATTGTGAT GGGTGGTTTC GCCACATTAC AATCGGATCC AGGTTTTCCA 
TCTGTACCCT ACATGAAGCC ACTTGGAGGA GGAGGAGGAT GCAGGGGAAG AGGAAAGAAG 
AGGGCATTTT CTGGCTTTTC CTCCGGTCGA GCAACGAAGA AGCCACGCGC AACTGCTCCA 
TCGGCACGTG GCAAGACAAG CGGACGAGGC GGGGCAAAAC CAGCTACTTC ACTCAAACGG 
AACATGTATC CAGCTACATC GATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

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him-6 cDNA ORF clone, Caenorhabditis elegans

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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