Gene Symbol | plk-1 |
Entrez Gene ID | 176143 |
Full Name | Serine/threonine-protein kinase plk-1 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » plk-1 cDNA ORF clone
Gene Symbol | plk-1 |
Entrez Gene ID | 176143 |
Full Name | Serine/threonine-protein kinase plk-1 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_001026002.2 | NP_001021173.1 | Serine/threonine-protein kinase plk-1 |
NM_001026003.3 | NP_001021174.1 | Serine/threonine-protein kinase plk-1 |
NM_001026003.2 | NP_001021174.1 | Serine/threonine-protein kinase plk-1 |
NM_001026002.3 | NP_001021173.1 | Serine/threonine-protein kinase plk-1 |
Danio rerio (zebrafish) | plk1 | NP_001003890.3 |
Caenorhabditis elegans (roundworm) | plk-2 | NP_491036.1 |
Saccharomyces cerevisiae (baker's yeast) | CDC5 | NP_013714.1 |
Drosophila melanogaster (fruit fly) | polo | NP_001014592.1 |
Kluyveromyces lactis | KLLA0C06138g | XP_452471.1 |
Eremothecium gossypii | AGOS_ACL006W | NP_983398.2 |
Pan troglodytes (chimpanzee) | PLK1 | XP_001163623.2 |
Caenorhabditis elegans (roundworm) | plk-1 | NP_001021173.1 |
Xenopus tropicalis (tropical clawed frog) | plk1 | NP_998844.1 |
Homo sapiens (human) | PLK1 | NP_005021.2 |
PLK1 | XP_001092070.1 | |
Bos taurus (cattle) | PLK1 | NP_001033262.1 |
Rattus norvegicus (Norway rat) | Plk1 | NP_058796.1 |
Gallus gallus (chicken) | PLK1 | NP_001025810.1 |
Canis lupus familiaris (dog) | PLK1 | XP_547091.3 |
Mus musculus (house mouse) | Plk1 | NP_035251.3 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP004239 | XP_313155.3 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
PLK1 inhibition mitigates autophagy in cancer cells both under nutrient starvation and sufficiency, and a role of PLK1 in autophagy is also observed in the invertebrate model organism Caenorhabditis elegans.
Title: PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy.
These results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry.
Title: Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells.
Our data further show that PLK-1 is needed for nuclear envelope breakdown during early embryogenesis
Title: Caenorhabditis elegans polo-like kinase PLK-1 is required for merging parental genomes into a single nucleus.
PLK-1 substitutes for Mps1 in controlling spindle checkpoint initiation in C. elegans.
Title: Natural Loss of Mps1 Kinase in Nematodes Uncovers a Role for Polo-like Kinase 1 in Spindle Checkpoint Initiation.
CDK-1 activates PLK-1 via SPAT-1 phosphorylation to promote entry into mitosis.
Title: Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos.
The following plk-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the plk-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa341039 | |
Clone ID Related Accession (Same CDS sequence) | NM_001026002.2 , NM_001026002.3 | |
Accession Version | NM_001026002.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1947bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Serine/threonine-protein kinase plk-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Jun 26, 2012 this sequence version replaced NM_001026002.1. COMPLETENESS: incomplete on both ends. |
1 | ATGAATCGAC TTCCCAACAT TGCAAAACCC CCACAAAAGT CCAACCAAAG AAAGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001021173.1 |
CDS | 1..1947 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001026002.2 |
1 | ATGAATCGAC TTCCCAACAT TGCAAAACCC CCACAAAAGT CCAACCAAAG AAAGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa341039 | |
Clone ID Related Accession (Same CDS sequence) | NM_001026002.2 , NM_001026002.3 | |
Accession Version | NM_001026002.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1947bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Serine/threonine-protein kinase plk-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_001026002.2. COMPLETENESS: incomplete on the 5' end. |
1 | ATGAATCGAC TTCCCAACAT TGCAAAACCC CCACAAAAGT CCAACCAAAG AAAGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001021173.1 |
CDS | 1..1947 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001026002.3 |
1 | ATGAATCGAC TTCCCAACAT TGCAAAACCC CCACAAAAGT CCAACCAAAG AAAGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa341040 | |
Clone ID Related Accession (Same CDS sequence) | NM_001026003.3 , NM_001026003.2 | |
Accession Version | NM_001026003.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1950bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Serine/threonine-protein kinase plk-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_001026003.2. COMPLETENESS: incomplete on the 5' end. |
1 | ATGAATCGAC TTCCCAACAT TGCAAAACCC CCACAAAAGT CCAACCAAAG AAAGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001021174.1 |
CDS | 1..1950 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001026003.3 |
1 | ATGAATCGAC TTCCCAACAT TGCAAAACCC CCACAAAAGT CCAACCAAAG AAAGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa341040 | |
Clone ID Related Accession (Same CDS sequence) | NM_001026003.3 , NM_001026003.2 | |
Accession Version | NM_001026003.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1950bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Serine/threonine-protein kinase plk-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Jun 26, 2012 this sequence version replaced NM_001026003.1. COMPLETENESS: incomplete on both ends. |
1 | ATGAATCGAC TTCCCAACAT TGCAAAACCC CCACAAAAGT CCAACCAAAG AAAGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001021174.1 |
CDS | 1..1950 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001026003.2 |
1 | ATGAATCGAC TTCCCAACAT TGCAAAACCC CCACAAAAGT CCAACCAAAG AAAGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |