Gene Symbol | WSS1 |
Entrez Gene ID | 856536 |
Full Name | metalloendopeptidase WSS1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » WSS1 cDNA ORF clone
Gene Symbol | WSS1 |
Entrez Gene ID | 856536 |
Full Name | metalloendopeptidase WSS1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001179264.1 | NP_012002.1 | metalloendopeptidase WSS1 |
Kluyveromyces lactis | KLLA0F27863g | XP_456319.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_01341 | XP_003714265.1 |
Saccharomyces cerevisiae (baker's yeast) | WSS1 | NP_012002.1 |
Neurospora crassa | NCU02060 | XP_964016.1 |
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.
Johnston M, Andrews S, Brinkman R, Cooper J, Ding H, Dover J, Du Z, Favello A, Fulton L, Gattung S
Science (New York, N.Y.)265(5181)2077-82(1994 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
e show that SPRTN is a DNA-dependent mammalian protease required for resolving cytotoxic DNA-protein crosslinks (DPCs)- a function that had only been attributed to the metalloprotease Wss1 in budding yeast. We provide genetic evidence that SPRTN and Wss1 function distinctly in vivo to resolve DPCs
Title: SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks.
Upon DNA damage Wss1/Cdc48/Doa1 ternary complex is recruited to sumoylated targets and catalyzes SUMO chain extension through a newly recognized SUMO ligase activity.
Title: Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates.
Data suggest that Wss1 contributes to survival of DNA-protein crosslink (DPC)-harboring cells by acting on DPCs proteolytically. Wss1 enables replication of DPC-containing DNA and thus promotes genome integrity.
Title: A DNA-dependent protease involved in DNA-protein crosslink repair.
In dividing cells, Wss1 is exclusively present in the mother cell.
Title: The Saccharomyces cerevisiae Wss1 protein is only present in mother cells.
Involement of WSS1 in the DNA damage response.
Title: Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response.
The following WSS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the WSS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi05331 | |
Clone ID Related Accession (Same CDS sequence) | NM_001179264.1 | |
Accession Version | NM_001179264.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | metalloendopeptidase WSS1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001140). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Veresion :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGAAGACAG AAGGAATAAA AAGCCCATCG GCAAAATACC ATGATATGGC GGGCTCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_012002.1 |
CDS | 1..810 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGAAGACAG AAGGAATAAA AAGCCCATCG GCAAAATACC ATGATATGGC GGGCTCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Life with 6000 genes. |
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII. |