Gene Symbol | DOT1 |
Entrez Gene ID | 852050 |
Full Name | histone methyltransferase DOT1 |
Synonyms | KMT4,PCH1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » DOT1 cDNA ORF clone
Gene Symbol | DOT1 |
Entrez Gene ID | 852050 |
Full Name | histone methyltransferase DOT1 |
Synonyms | KMT4,PCH1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001180748.1 | NP_010728.1 | histone methyltransferase DOT1 |
Eremothecium gossypii | AGOS_AER326C | NP_985182.2 |
Saccharomyces cerevisiae (baker's yeast) | DOT1 | NP_010728.1 |
Kluyveromyces lactis | KLLA0B01287g | XP_451588.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Jacq C, Alt-M?rbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Bl?cker H, Blugeon C, Boskovic J, Brandt P, Br?ckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P
Nature387(6632 Suppl)75-8(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties
Title: Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.
Dot1 has a role in histone H3K79 methylation that promotes the formation of meiotic double-strand breaks in the absence of histone H3K4 methylation
Title: Dot1-dependent histone H3K79 methylation promotes the formation of meiotic double-strand breaks in the absence of histone H3K4 methylation in budding yeast.
Dot1-dependent H3K79me also promotes Hop1 activation and its proper distribution along zip1 meiotic chromosomes, at least in part, by regulating Pch2 localization
Title: Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor.
histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79.
Title: Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79.
loss of Dot1 did not globally alter Sir2 or Sir3 occupancy in subtelomeric regions, but only led to some telomere-specific changes
Title: Dot1 and histone H3K79 methylation in natural telomeric and HM silencing.
The following DOT1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DOT1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi01513 | |
Clone ID Related Accession (Same CDS sequence) | NM_001180748.1 | |
Accession Version | NM_001180748.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1749bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | histone methyltransferase DOT1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001136). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGGGCGGTC AAGAAAGTAT ATCAAATAAT AACTCAGACT CATTCATTAT GTCGTCCCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_010728.1 |
CDS | 1..1749 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001180748.1 |
1 | ATGGGCGGTC AAGAAAGTAT ATCAAATAAT AACTCAGACT CATTCATTAT GTCGTCCCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. |
Life with 6000 genes. |