CCC2 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene
Clones
gRNAs

Summary

Gene Symbol	CCC2
Entrez Gene ID	851862
Full Name	Cu(2+)-transporting P-type ATPase CCC2
Gene Type	protein-coding
Organism	Saccharomyces cerevisiae S288C

mRNA and Protein(s)

mRNA	Protein	Name
NM_001180578.1	NP_010556.1	Cu(2+)-transporting P-type ATPase CCC2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ATP7A	XP_005641578.1
Bos taurus (cattle)	ATP7A	NP_001179781.1
Caenorhabditis elegans (roundworm)	cua-1	NP_001255202.1
Schizosaccharomyces pombe (fission yeast)	ccc2	NP_595829.1
Rattus norvegicus (Norway rat)	Atp7a	NP_434690.1
Gallus gallus (chicken)	ATP7A	XP_004940860.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011754	XP_552490.3
Magnaporthe oryzae (rice blast fungus)	MGG_03724	XP_003716156.1
Neurospora crassa	NCU08341	XP_965244.1
Homo sapiens (human)	ATP7A	NP_000043.4
Saccharomyces cerevisiae (baker's yeast)	CCC2	NP_010556.1
Mus musculus (house mouse)	Atp7a	NP_001103227.1
Drosophila melanogaster (fruit fly)	ATP7	NP_001259466.1
Arabidopsis thaliana (thale cress)	HMA5	NP_176533.1
Oryza sativa (rice)	Os04g0556000	NP_001053522.2
Pan troglodytes (chimpanzee)	ATP7A	XP_003954073.1
Danio rerio (zebrafish)	atp7a	NP_001036185.1
Kluyveromyces lactis	KLLA0F07447g	XP_455418.1

Gene Ontology
Bibliography

Related articles in PubMed

The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Jacq C, Alt-M?rbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Bl?cker H, Blugeon C, Boskovic J, Brandt P, Br?ckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P
Nature387(6632 Suppl)75-8(1997 May)

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ser(258) and Ser(971) are under long-range intramolecular, reciprocal and concerted control, in a sequential process that is crucial for catalysis and copper transport in the yeast copper ATPase
Title: Two serine residues control sequential steps during catalysis of the yeast copper ATPase through different mechanisms that involve kinase-mediated phosphorylations.

evidence of a dual role for the Ccc2 N-terminus, namely to receive copper from Atx1 and to convey copper to another domain of Ccc2, thereby activating the ATPase
Title: Dissecting the role of the N-terminal metal-binding domains in activating the yeast copper ATPase in vivo.

Cyclic AMP-dependent protein kinase (PKA) regulates Ccc2p with PKA-mediated phosphorylation of a conserved serine (Ser258) being crucial for catalysis.
Title: Cyclic AMP-dependent protein kinase controls energy interconversion during the catalytic cycle of the yeast copper-ATPase.

structurally characterized the adduct between the copper chaperone Atx1 and the first copper(I)-binding domain of the Ccc2 ATPase
Title: The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction.

The following CCC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSi01351	NM_001180578.1 Latest version!	Saccharomyces cerevisiae S288C Cu(2+)-transporting P-type ATPase CCC2 (CCC2), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$629.30 $899.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCC2 ( NM_001180578.1 ) cDNA ORF clone, Saccharomyces cerevisiae S288C -> NP_010556.1 Saccharomyces cerevisiae S288C Cu(2+)-transporting P-type ATPase CCC2 (CCC2), partial mRNA.

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CloneID	OSi01351
Clone ID Related Accession (Same CDS sequence)	NM_001180578.1
Accession Version	NM_001180578.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3015bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-31
Organism	Saccharomyces cerevisiae S288C
Product	Cu(2+)-transporting P-type ATPase CCC2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001136). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends.

ATGAGAGAAG TGATACTTGC TGTACATGGA ATGACATGCA GCGCCTGTAC TAATACAATC 
AATACGCAGT TACGAGCTTT AAAGGGTGTA ACAAAATGTG ATATTAGTTT AGTGACTAAT 
GAGTGCCAGG TGACATACGA TAACGAGGTT ACCGCCGATT CTATTAAGGA AATTATAGAG 
GATTGTGGAT TTGACTGTGA GATACTAAGA GATTCTGAAA TTACAGCCAT AAGTACGAAG 
GAAGGACTAC TGAGTGTACA AGGTATGACC TGTGGGTCTT GTGTTTCTAC AGTCACCAAA 
CAAGTGGAAG GCATTGAGGG TGTTGAATCG GTAGTCGTTT CCTTGGTAAC GGAAGAGTGC 
CATGTTATTT ATGAACCGTC CAAGACAACG CTAGAAACCG CCAGAGAAAT GATTGAAGAC 
TGTGGATTTG ACTCAAATAT TATTATGGAT GGCAACGGGA ATGCAGACAT GACCGAAAAA 
ACGGTGATCT TGAAAGTAAC TAAGGCTTTC GAGGACGAAT CCCCACTCAT ACTTTCTTCA 
GTAAGCGAAA GGTTTCAATT TTTGTTAGAC CTAGGTGTAA AATCGATAGA AATTTCTGAT 
GATATGCACA CACTCACCAT AAAATACTGT TGTAACGAAC TCGGCATTAG AGATTTATTG 
AGGCACCTTG AGAGGACCGG ATATAAATTC ACTGTATTTT CCAATTTAGA TAATACTACC 
CAGTTAAGGC TTCTCTCTAA AGAGGACGAG ATAAGATTCT GGAAAAAAAA CAGCATAAAA 
TCCACCCTTT TGGCTATAAT ATGTATGCTA TTGTATATGA TTGTCCCTAT GATGTGGCCA 
ACAATTGTTC AGGACCGCAT ATTCCCTTAC AAAGAAACCT CCTTTGTTAG AGGTCTGTTC 
TACAGAGATA TTTTGGGTGT AATATTGGCA AGCTATATTC AGTTCAGCGT TGGTTTTTAC 
TTTTACAAGG CAGCATGGGC ATCTTTAAAG CACGGTTCAG GAACCATGGA TACACTAGTT 
TGTGTTTCCA CTACTTGTGC ATACACATTT TCTGTGTTTT CTTTAGTTCA CAATATGTTC 
CATCCCTCAA GTACTGGCAA ACTCCCAAGG ATCGTTTTCG ACACATCAAT CATGATCATT 
TCATATATTT CCATCGGGAA ATATTTGGAA ACTTTAGCTA AATCACAAAC ATCAACCGCA 
CTTTCTAAAT TAATTCAGCT CACTCCATCG GTGTGTTCAA TTATATCTGA CGTGGAGCGG 
AATGAAACCA AGGAAATTCC CATAGAATTA TTGCAAGTGA ACGATATAGT GGAGATTAAA 
CCAGGGATGA AAATTCCTGC TGATGGCATC ATAACAAGAG GTGAATCTGA AATTGACGAG 
TCGTTAATGA CAGGCGAATC CATTTTGGTG CCCAAGAAAA CTGGTTTTCC GGTTATTGCT 
GGTTCTGTTA ATGGACCTGG ACATTTCTAC TTCAGAACTA CTACCGTTGG GGAGGAAACT 
AAATTAGCAA ATATTATCAA GGTAATGAAA GAAGCACAAT TGAGTAAAGC TCCCATTCAG 
GGGTATGCAG ATTATTTAGC CTCTATTTTT GTTCCGGGGA TCCTAATTTT GGCAGTATTG 
ACTTTCTTTA TTTGGTGTTT TATTTTAAAC ATCTCGGCTA ATCCTCCCGT CGCTTTCACC 
GCAAATACTA AGGCTGATAA TTTTTTTATT TGCTTACAAA CTGCTACTTC TGTTGTCATC 
GTCGCATGCC CATGTGCATT GGGACTTGCC ACGCCGACTG CTATAATGGT GGGTACAGGG 
GTTGGAGCTC AGAATGGTGT CTTAATAAAG GGCGGAGAAG TATTGGAAAA ATTCAATAGT 
ATTACTACTT TTGTTTTTGA TAAAACAGGT ACCTTAACTA CAGGTTTTAT GGTTGTGAAA 
AAGTTCCTTA AAGATTCAAA TTGGGTTGGA AACGTGGATG AAGACGAAGT TCTCGCCTGT 
ATAAAAGCAA CGGAATCCAT TAGTGACCAT CCAGTTTCGA AAGCAATTAT ACGTTATTGT 
GATGGTTTGA ACTGTAATAA GGCTTTAAAT GCCGTTGTTT TAGAAAGCGA ATACGTGCTT 
GGAAAGGGAA TAGTCTCAAA GTGTCAAGTT AATGGAAATA CTTATGATAT TTGTATTGGG 
AACGAGGCGC TGATTTTGGA GGATGCATTA AAAAAATCCG GATTTATTAA CAGTAATGTC 
GACCAAGGAA ACACTGTATC ATACGTATCA GTAAACGGGC ATGTGTTTGG CTTGTTCGAG 
ATTAATGATG AAGTTAAACA TGATTCTTAC GCAACAGTTC AGTATCTACA AAGAAATGGA 
TATGAAACGT ATATGATTAC TGGCGATAAT AACTCAGCAG CAAAAAGAGT CGCTAGAGAA 
GTAGGTATAA GCTTCGAAAA TGTTTACAGC GATGTGTCAC CCACAGGCAA ATGTGATCTC 
GTGAAAAAAA TTCAAGATAA AGAAGGTAAT AACAAGGTTG CTGTTGTTGG CGATGGCATT 
AACGACGCTC CCGCTTTAGC ACTGAGTGAT CTAGGTATTG CCATTTCAAC AGGTACGGAG 
ATTGCTATTG AAGCAGCTGA TATTGTTATA CTGTGCGGTA ATGATCTGAA TACTAATAGT 
TTGAGAGGAC TGGCCAACGC CATCGATATT TCACTAAAAA CGTTCAAAAG AATAAAGCTG 
AATTTGTTCT GGGCACTTTG CTATAATATA TTCATGATTC CGATTGCTAT GGGTGTGCTC 
ATTCCTTGGG GCATAACTCT TCCTCCAATG CTCGCCGGTT TAGCGATGGC ATTCAGCTCG 
GTCAGTGTCG TTCTAAGTTC ATTGATGTTG AAGAAGTGGA CTCCACCGGA TATTGAATCA 
CATGGGATTT CAGATTTCAA GTCCAAATTT TCGATTGGGA ATTTTTGGTC AAGGCTTTTT 
TCTACGCGGG CTATTGCAGG TGAGCAAGAC ATAGAATCAC AGGCCGGACT AATGTCAAAC 
GAAGAAGTCT TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_010556.1
CDS	1..3015
Translation	MREVILAVHGMTCSACTNTINTQLRALKGVTKCDISLVTNECQVTYDNEVTADSIKEIIEDCGFDCEILRDSEITAISTKEGLLSVQGMTCGSCVSTVTKQVEGIEGVESVVVSLVTEECHVIYEPSKTTLETAREMIEDCGFDSNIIMDGNGNADMTEKTVILKVTKAFEDESPLILSSVSERFQFLLDLGVKSIEISDDMHTLTIKYCCNELGIRDLLRHLERTGYKFTVFSNLDNTTQLRLLSKEDEIRFWKKNSIKSTLLAIICMLLYMIVPMMWPTIVQDRIFPYKETSFVRGLFYRDILGVILASYIQFSVGFYFYKAAWASLKHGSGTMDTLVCVSTTCAYTFSVFSLVHNMFHPSSTGKLPRIVFDTSIMIISYISIGKYLETLAKSQTSTALSKLIQLTPSVCSIISDVERNETKEIPIELLQVNDIVEIKPGMKIPADGIITRGESEIDESLMTGESILVPKKTGFPVIAGSVNGPGHFYFRTTTVGEETKLANIIKVMKEAQLSKAPIQGYADYLASIFVPGILILAVLTFFIWCFILNISANPPVAFTANTKADNFFICLQTATSVVIVACPCALGLATPTAIMVGTGVGAQNGVLIKGGEVLEKFNSITTFVFDKTGTLTTGFMVVKKFLKDSNWVGNVDEDEVLACIKATESISDHPVSKAIIRYCDGLNCNKALNAVVLESEYVLGKGIVSKCQVNGNTYDICIGNEALILEDALKKSGFINSNVDQGNTVSYVSVNGHVFGLFEINDEVKHDSYATVQYLQRNGYETYMITGDNNSAAKRVAREVGISFENVYSDVSPTGKCDLVKKIQDKEGNNKVAVVGDGINDAPALALSDLGIAISTGTEIAIEAADIVILCGNDLNTNSLRGLANAIDISLKTFKRIKLNLFWALCYNIFMIPIAMGVLIPWGITLPPMLAGLAMAFSSVSVVLSSLMLKKWTPPDIESHGISDFKSKFSIGNFWSRLFSTRAIAGEQDIESQAGLMSNEEVL

Target ORF information:

RefSeq Version	NM_001180578.1
Organism	Saccharomyces cerevisiae S288C
Definition	Saccharomyces cerevisiae S288C Cu(2+)-transporting P-type ATPase CCC2 (CCC2), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001180578.1

ORF Insert Sequence:

ATGAGAGAAG TGATACTTGC TGTACATGGA ATGACATGCA GCGCCTGTAC TAATACAATC 
AATACGCAGT TACGAGCTTT AAAGGGTGTA ACAAAATGTG ATATTAGTTT AGTGACTAAT 
GAGTGCCAGG TGACATACGA TAACGAGGTT ACCGCCGATT CTATTAAGGA AATTATAGAG 
GATTGTGGAT TTGACTGTGA GATACTAAGA GATTCTGAAA TTACAGCCAT AAGTACGAAG 
GAAGGACTAC TGAGTGTACA AGGTATGACC TGTGGGTCTT GTGTTTCTAC AGTCACCAAA 
CAAGTGGAAG GCATTGAGGG TGTTGAATCG GTAGTCGTTT CCTTGGTAAC GGAAGAGTGC 
CATGTTATTT ATGAACCGTC CAAGACAACG CTAGAAACCG CCAGAGAAAT GATTGAAGAC 
TGTGGATTTG ACTCAAATAT TATTATGGAT GGCAACGGGA ATGCAGACAT GACCGAAAAA 
ACGGTGATCT TGAAAGTAAC TAAGGCTTTC GAGGACGAAT CCCCACTCAT ACTTTCTTCA 
GTAAGCGAAA GGTTTCAATT TTTGTTAGAC CTAGGTGTAA AATCGATAGA AATTTCTGAT 
GATATGCACA CACTCACCAT AAAATACTGT TGTAACGAAC TCGGCATTAG AGATTTATTG 
AGGCACCTTG AGAGGACCGG ATATAAATTC ACTGTATTTT CCAATTTAGA TAATACTACC 
CAGTTAAGGC TTCTCTCTAA AGAGGACGAG ATAAGATTCT GGAAAAAAAA CAGCATAAAA 
TCCACCCTTT TGGCTATAAT ATGTATGCTA TTGTATATGA TTGTCCCTAT GATGTGGCCA 
ACAATTGTTC AGGACCGCAT ATTCCCTTAC AAAGAAACCT CCTTTGTTAG AGGTCTGTTC 
TACAGAGATA TTTTGGGTGT AATATTGGCA AGCTATATTC AGTTCAGCGT TGGTTTTTAC 
TTTTACAAGG CAGCATGGGC ATCTTTAAAG CACGGTTCAG GAACCATGGA TACACTAGTT 
TGTGTTTCCA CTACTTGTGC ATACACATTT TCTGTGTTTT CTTTAGTTCA CAATATGTTC 
CATCCCTCAA GTACTGGCAA ACTCCCAAGG ATCGTTTTCG ACACATCAAT CATGATCATT 
TCATATATTT CCATCGGGAA ATATTTGGAA ACTTTAGCTA AATCACAAAC ATCAACCGCA 
CTTTCTAAAT TAATTCAGCT CACTCCATCG GTGTGTTCAA TTATATCTGA CGTGGAGCGG 
AATGAAACCA AGGAAATTCC CATAGAATTA TTGCAAGTGA ACGATATAGT GGAGATTAAA 
CCAGGGATGA AAATTCCTGC TGATGGCATC ATAACAAGAG GTGAATCTGA AATTGACGAG 
TCGTTAATGA CAGGCGAATC CATTTTGGTG CCCAAGAAAA CTGGTTTTCC GGTTATTGCT 
GGTTCTGTTA ATGGACCTGG ACATTTCTAC TTCAGAACTA CTACCGTTGG GGAGGAAACT 
AAATTAGCAA ATATTATCAA GGTAATGAAA GAAGCACAAT TGAGTAAAGC TCCCATTCAG 
GGGTATGCAG ATTATTTAGC CTCTATTTTT GTTCCGGGGA TCCTAATTTT GGCAGTATTG 
ACTTTCTTTA TTTGGTGTTT TATTTTAAAC ATCTCGGCTA ATCCTCCCGT CGCTTTCACC 
GCAAATACTA AGGCTGATAA TTTTTTTATT TGCTTACAAA CTGCTACTTC TGTTGTCATC 
GTCGCATGCC CATGTGCATT GGGACTTGCC ACGCCGACTG CTATAATGGT GGGTACAGGG 
GTTGGAGCTC AGAATGGTGT CTTAATAAAG GGCGGAGAAG TATTGGAAAA ATTCAATAGT 
ATTACTACTT TTGTTTTTGA TAAAACAGGT ACCTTAACTA CAGGTTTTAT GGTTGTGAAA 
AAGTTCCTTA AAGATTCAAA TTGGGTTGGA AACGTGGATG AAGACGAAGT TCTCGCCTGT 
ATAAAAGCAA CGGAATCCAT TAGTGACCAT CCAGTTTCGA AAGCAATTAT ACGTTATTGT 
GATGGTTTGA ACTGTAATAA GGCTTTAAAT GCCGTTGTTT TAGAAAGCGA ATACGTGCTT 
GGAAAGGGAA TAGTCTCAAA GTGTCAAGTT AATGGAAATA CTTATGATAT TTGTATTGGG 
AACGAGGCGC TGATTTTGGA GGATGCATTA AAAAAATCCG GATTTATTAA CAGTAATGTC 
GACCAAGGAA ACACTGTATC ATACGTATCA GTAAACGGGC ATGTGTTTGG CTTGTTCGAG 
ATTAATGATG AAGTTAAACA TGATTCTTAC GCAACAGTTC AGTATCTACA AAGAAATGGA 
TATGAAACGT ATATGATTAC TGGCGATAAT AACTCAGCAG CAAAAAGAGT CGCTAGAGAA 
GTAGGTATAA GCTTCGAAAA TGTTTACAGC GATGTGTCAC CCACAGGCAA ATGTGATCTC 
GTGAAAAAAA TTCAAGATAA AGAAGGTAAT AACAAGGTTG CTGTTGTTGG CGATGGCATT 
AACGACGCTC CCGCTTTAGC ACTGAGTGAT CTAGGTATTG CCATTTCAAC AGGTACGGAG 
ATTGCTATTG AAGCAGCTGA TATTGTTATA CTGTGCGGTA ATGATCTGAA TACTAATAGT 
TTGAGAGGAC TGGCCAACGC CATCGATATT TCACTAAAAA CGTTCAAAAG AATAAAGCTG 
AATTTGTTCT GGGCACTTTG CTATAATATA TTCATGATTC CGATTGCTAT GGGTGTGCTC 
ATTCCTTGGG GCATAACTCT TCCTCCAATG CTCGCCGGTT TAGCGATGGC ATTCAGCTCG 
GTCAGTGTCG TTCTAAGTTC ATTGATGTTG AAGAAGTGGA CTCCACCGGA TATTGAATCA 
CATGGGATTT CAGATTTCAA GTCCAAATTT TCGATTGGGA ATTTTTGGTC AAGGCTTTTT 
TCTACGCGGG CTATTGCAGG TGAGCAAGAC ATAGAATCAC AGGCCGGACT AATGTCAAAC 
GAAGAAGTCT TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Nature387(6632 Suppl)75-8(1997 May)
Jacq C,Alt-M?rbe J,Andre B,Arnold W,Bahr A,Ballesta JP,Bargues M,Baron L,Becker A,Biteau N,Bl?cker H,Blugeon C,Boskovic J,Brandt P,Br?ckner M,Buitrago MJ,Coster F,Delaveau T,del Rey F,Dujon B,Eide LG,Garcia-Cantalejo JM,Goffeau A,Gomez-Peris A,Zaccaria P

Life with 6000 genes.
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Goffeau A,Barrell BG,Bussey H,Davis RW,Dujon B,Feldmann H,Galibert F,Hoheisel JD,Jacq C,Johnston M,Louis EJ,Mewes HW,Murakami Y,Philippsen P,Tettelin H,Oliver SG

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CCC2 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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