ATP7A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATP7A
Entrez Gene ID	538
Full Name	ATPase copper transporting alpha
Synonyms	DSMAX,MK,MNK,SMAX3
General protein information	Preferred Names ATPase copper transporting alpha Names copper-transporting ATPase 1 ATPase, Cu++ transporting, alpha polypeptide Cu++-transporting P-type ATPase Menkes disease-associated protein copper pump 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq21.1
Summary	This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed. [provided by RefSeq, Aug 2013].
Disorder MIM:	300011
Disorder Html:	Menkes disease, 309400 (3); Occipital horn syndrome, 304150 (3); Spinal muscular atrophy, distal, X-linked 3, 300489 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001282224.1	NP_001269153.1	copper-transporting ATPase 1 isoform 2
NM_000052.7	NP_000043.4	copper-transporting ATPase 1 isoform 1
NM_000052.6	NP_000043.4	copper-transporting ATPase 1 isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ATP7A	XP_005641578.1
Bos taurus (cattle)	ATP7A	NP_001179781.1
Caenorhabditis elegans (roundworm)	cua-1	NP_001255202.1
Schizosaccharomyces pombe (fission yeast)	ccc2	NP_595829.1
Rattus norvegicus (Norway rat)	Atp7a	NP_434690.1
Gallus gallus (chicken)	ATP7A	XP_004940860.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011754	XP_552490.3
Magnaporthe oryzae (rice blast fungus)	MGG_03724	XP_003716156.1
Neurospora crassa	NCU08341	XP_965244.1
Homo sapiens (human)	ATP7A	NP_000043.4
Saccharomyces cerevisiae (baker's yeast)	CCC2	NP_010556.1
Mus musculus (house mouse)	Atp7a	NP_001103227.1
Drosophila melanogaster (fruit fly)	ATP7	NP_001259466.1
Arabidopsis thaliana (thale cress)	HMA5	NP_176533.1
Oryza sativa (rice)	Os04g0556000	NP_001053522.2
Pan troglodytes (chimpanzee)	ATP7A	XP_003954073.1
Danio rerio (zebrafish)	atp7a	NP_001036185.1
Kluyveromyces lactis	KLLA0F07447g	XP_455418.1

Gene Ontology
Bibliography

Related articles in PubMed

Association between polymorphisms in CTR1, CTR2, ATP7A, and ATP7B and platinum resistance in epithelial ovarian cancer.
Li T, Peng J, Zeng F, Zhang K, Liu J, Li X, Ouyang Q, Wang G, Wang L, Liu Z, Liu Y
International journal of clinical pharmacology and therapeutics55(10)774-780(2017 Oct)

ATP7A-related copper transport diseases-emerging concepts and future trends.
Kaler SG
Nature reviews. Neurology7(1)15-29(2011 Jan)

Evidence for a Menkes-like protein with a nuclear targeting sequence.
Reddy MC, Majumdar S, Harris ED
The Biochemical journal350 Pt 3855-63(2000 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

11 single-nucleotide polymorphisms (SNPs) in CTR1, CTR2, ATP7A, and ATP7B were genotyped in these patients.
Title: Association between polymorphisms in CTR1, CTR2, ATP7A, and ATP7B and platinum resistance in epithelial ovarian cancer.

Deletion spanning exons 8 to 12 of the ATP7A gene is associated with a family affected with Menkes disease.
Title: [Analysis of clinical features and genetic mutations in a Chinese family affected with Menkes disease].

the mechanism of copper-dependent regulation of ATP7B and ATP7A, the roles of individual MBDs, and the relationship between the regulatory and catalytic copper binding are still unknown. We describe the structure and dynamics of the MBDs, review the current knowledge about their functional roles and propose a mechanism of regulation of ATP7B by copper-dependent changes in the dynamics and conformation of the MBD chain.
Title: Dynamics of the metal binding domains and regulation of the human copper transporters ATP7B and ATP7A.

The authors conclude that the ATP7A interactome encompasses a novel Golgi-localized conserved oligomeric Golgi (COG) complex-dependent mechanism to specify neuronal development and survival.
Title: The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors.

MNK orchestrates counterbalancing forces that regulate mTORC1 enzymatic activity.
Title: MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.

The following ATP7A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP7A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20659	NM_001282224.1 Latest version!	Homo sapiens ATPase copper transporting alpha (ATP7A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$727.30 $1039.00
OHu20992	NM_000052.7 Latest version!	Homo sapiens ATPase copper transporting alpha (ATP7A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$811.30 $1159.00
View Old Accession Versions >>
OHu20992	NM_000052.6	Homo sapiens ATPase copper transporting alpha (ATP7A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$811.30 $1159.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATP7A ( NM_001282224.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269153.1 Homo sapiens ATPase copper transporting alpha (ATP7A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20659
Clone ID Related Accession (Same CDS sequence)	NM_001282224.1
Accession Version	NM_001282224.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4269bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	copper-transporting ATPase 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL356235.22, DB164588.1, L06476.1, AB117973.1, AK299449.1, AL645821.2 and BU753163.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. This variant is supported by data in PMIDs 7490081 and 10970802. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: PMID: 7490081 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGATCCAA GTATGGGTGT GAATTCTGTT ACCATTTCTG TTGAGGGTAT GACTTGCAAT 
TCCTGTGTTT GGACCATTGA GCAGCAGATT GGAAAAGTGA ATGGTGTGCA TCACATTAAG 
GTATCACTGG AAGAAAAAAA TGCAACTATT ATTTATGACC CTAAACTACA GACTCCAAAG 
ACCCTACAGG AAGCTATTGA TGACATGGGC TTTGATGCTG TTATCCATAA TCCTGACCCT 
CTCCCTGTTT TAACTGACAC CTTGTTTCTG ACTGTTACGG CGTCACTGAC TTTGCCATGG 
GACCATATCC AAAGCACATT GCTGAAGACC AAGGGTGTGA CAGACATTAA AATTTACCCT 
CAGAAAAGAA CTGTAGCAGT GACAATAATC CCTTCTATAG TGAATGCCAA TCAGATAAAA 
GAGCTGGTTC CAGAACTCAG TTTAGATACT GGGACACTGG AGAAAAAGTC AGGAGCTTGT 
GAAGATCATA GTATGGCTCA AGCTGGTGAA GTCGTGCTGA AGATGAAAGT GGAAGGGATG 
ACCTGCCATT CATGTACTAG CACTATTGAA GGAAAAATTG GGAAACTGCA AGGTGTTCAG 
CGAATTAAAG TCTCCCTGGA CAATCAAGAA GCTACTATTG TTTATCAACC TCATCTTATC 
TCAGTAGAGG AAATGAAAAA GCAGATTGAA GCTATGGGCT TTCCAGCATT TGTCAAAAAG 
CAGCCCAAGT ACCTCAAATT GGGAGCTATT GATGTAGAAC GTCTAAAGAA CACACCAGTT 
AAATCCTCAG AAGGGTCACA GCAAAGGAGT CCATCATATA CCAATGATTC AACAGCCACT 
TTCATCATTG ATGGCATGCA TTGTAAATCA TGTGTGTCAA ATATTGAAAG TACTTTATCT 
GCACTCCAAT ATGTAAGCAG CATAGTAGTT TCTTTAGAGA ATAGGTCTGC CATTGTGAAG 
TATAATGCAA GCTCAGTCAC TCCAGAATCC CTGAGAAAAG CAATAGAGGC TGTATCACCG 
GGGCTATATA GAGTTAGTAT CACAAGTGAA GTTGAGAGTA CCTCAAACTC TCCCTCCAGC 
TCATCTCTTC AGAAGATTCC TTTGAATGTA GTTAGCCAGC CTCTGACACA AGAAACTGTG 
ATAAACATTG ATGGCATGAC TTGTAATTCC TGTGTGCAGT CTATTGAGGG TGTCATATCA 
AAAAAGCCAG GTGTAAAATC CATACGAGTC TCCCTTGCAA ATAGCAATGG GACTGTTGAG 
TATGATCCTC TACTAACCTC TCCAGAAACG TTGAGAGGAG CAATAGAAGA CATGGGATTT 
GATGCTACCT TGTCAGACAC GAATGAGCCG TTGGTAGTAA TAGCTCAGCC TTCATCGGAA 
ATGCCGCTTT TGACTTCAAC TAATGAATTT TATACTAAAG GGATGACACC AGTTCAAGAC 
AAGGAGGAAG GAAAGAATTC ATCTAAGTGT TACATACAGG TCACTGGCAT GACTTGCGCT 
TCCTGTGTAG CAAACATTGA ACGGAATTTA AGGCGGGAAG AAGGAATATA TTCTATACTT 
GTGGCCCTGA TGGCTGGCAA GGCAGAAGTA AGGTATAATC CTGCTGTTAT ACAACCCCCA 
ATGATAGCAG AGTTCATCCG AGAACTTGGA TTTGGAGCCA CTGTGATAGA AAATGCTGAT 
GAAGGAGATG GTGTTTTGGA ACTTGTTGTG AGGGGAATGA CGTGTGCCTC CTGCGTACAT 
AAAATAGAGT CTAGTCTCAC AAAACACAGA GGGATCCTAT ACTGCTCCGT GGCCCTGGCA 
ACCAACAAAG CACATATTAA ATATGACCCA GAAATTATTG GTCCTAGAGA TATTATCCAT 
ACAATTGAAA GCTTAGGTTT TGAAGCTTCT TTGGTCAAGA AGGATCGGTC AGCAAGTCAC 
TTAGATCATA AACGAGAAAT AAGACAATGG AGACGGTCTT TTCTTGTGAG TCTGTTTTTC 
TGTATTCCTG TAATGGGGCT GATGATATAT ATGATGGTTA TGGACCACCA CTTTGCAACT 
CTTCACCATA ATCAAAACAT GAGTAAAGAA GAAATGATCA ACCTTCATTC TTCTATGTTC 
CTGGAGCGCC AGATTCTTCC AGGATTGTCT GTTATGAATT TGCTGTCCTT TTTATTGTGT 
GTACCTGTAC AGGGCAAAAC ATCAGAGGCT CTTGCAAAGT TAATTTCACT ACAAGCTACA 
GAAGCAACTA TTGTAACTCT TGATTCTGAT AATATCCTCC TCAGTGAAGA ACAAGTGGAT 
GTGGAACTTG TACAACGTGG AGATATCATT AAAGTAGTTC CAGGAGGCAA ATTTCCAGTG 
GATGGTCGTG TTATTGAAGG ACATTCTATG GTAGATGAGT CCCTCATCAC AGGGGAGGCA 
ATGCCTGTGG CTAAGAAACC TGGCAGCACA GTGATTGCTG GTTCCATTAA CCAGAACGGG 
TCACTGCTTA TCTGCGCAAC ACATGTTGGA GCAGACACAA CCCTTTCTCA AATTGTCAAA 
CTTGTGGAAG AGGCACAAAC ATCAAAGGCT CCTATCCAGC AGTTTGCAGA CAAACTCAGT 
GGCTATTTTG TTCCTTTTAT TGTTTTTGTT TCCATTGCCA CCCTCTTGGT ATGGATTGTA 
ATTGGATTTC TGAATTTTGA AATTGTGGAA ACCTACTTTC CTGGCTACAA TAGAAGTATC 
TCCCGAACAG AAACGATAAT ACGATTTGCT TTCCAAGCCT CTATCACAGT TCTGTGTATT 
GCATGTCCCT GTTCACTGGG ACTGGCCACT CCAACTGCTG TGATGGTGGG TACAGGAGTA 
GGTGCTCAAA ATGGCATACT AATAAAAGGT GGAGAGCCAT TGGAGATGGC TCATAAGGTA 
AAGGTAGTGG TATTTGATAA GACTGGAACC ATTACTCACG GAACCCCAGT GGTGAATCAA 
GTAAAGGTTC TAACTGAAAG TAACAGAATA TCACACCATA AAATCTTGGC CATTGTGGGA 
ACTGCTGAAA GTAACAGTGA ACACCCTCTA GGAACAGCCA TAACCAAATA TTGCAAACAG 
GAGCTGGACA CTGAAACCTT GGGTACCTGC ATAGATTTCC AGGTTGTGCC AGGCTGTGGT 
ATTAGCTGTA AAGTCACCAA TATTGAAGGC TTGCTACATA AGAATAACTG GAATATAGAG 
GACAATAATA TTAAAAATGC ATCCCTGGTT CAAATTGATG CCAGTAATGA ACAGTCATCA 
ACTTCGTCTT CCATGATTAT TGATGCCCAG ATCTCAAATG CTCTTAATGC TCAGCAGTAT 
AAAGTCCTCA TTGGTAACCG GGAGTGGATG ATTAGAAATG GTCTTGTCAT TAATAACGAT 
GTAAATGATT TCATGACTGA ACATGAGAGA AAAGGTCGGA CTGCTGTATT AGTAGCAGTT 
GATGATGAGC TGTGTGGCTT GATAGCCATT GCAGACACAG TGAAGCCTGA AGCAGAACTG 
GCTATCCATA TTCTGAAATC TATGGGCTTA GAAGTAGTTC TGATGACTGG AGACAACAGT 
AAAACAGCTA GATCTATTGC TTCTCAGGTT GGCATTACTA AGGTGTTTGC TGAAGTTCTA 
CCTTCTCACA AGGTTGCTAA AGTGAAGCAA CTTCAAGAGG AGGGGAAACG GGTAGCAATG 
GTGGGAGATG GAATCAATGA CTCCCCAGCT CTGGCAATGG CTAATGTGGG AATTGCTATT 
GGCACAGGCA CAGATGTAGC CATTGAAGCA GCTGATGTGG TTTTGATAAG GAATGATCTT 
CTGGATGTAG TGGCAAGTAT TGACTTATCA AGAAAGACAG TCAAGAGGAT TCGGATAAAT 
TTTGTCTTTG CTCTAATTTA TAATCTGGTT GGAATTCCCA TAGCTGCTGG AGTTTTTATG 
CCCATTGGTT TGGTTTTGCA GCCCTGGATG GGATCTGCAG CAATGGCTGC TTCATCTGTT 
TCTGTAGTAC TTTCTTCTCT CTTCCTTAAA CTTTACAGGA AACCAACTTA CGAGAGTTAT 
GAACTGCCTG CCCGGAGCCA GATAGGACAG AAGAGTCCTT CAGAAATCAG CGTTCATGTT 
GGAATAGATG ATACCTCAAG GAATTCTCCT AAACTGGGTT TGCTGGACCG GATTGTTAAT 
TATAGCAGAG CCTCTATAAA CTCACTACTG TCTGATAAAC GCTCCCTAAA CAGTGTTGTT 
ACCAGTGAAC CTGACAAGCA CTCACTCCTG GTGGGAGACT TCAGGGAAGA TGATGACACT 
GCATTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269153.1
CDS	202..4470
Translation	MDPSMGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPKTLQEAIDDMGFDAVIHNPDPLPVLTDTLFLTVTASLTLPWDHIQSTLLKTKGVTDIKIYPQKRTVAVTIIPSIVNANQIKELVPELSLDTGTLEKKSGACEDHSMAQAGEVVLKMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVSLDNQEATIVYQPHLISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYTNDSTATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVLELVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKKDRSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPARSQIGQKSPSEISVHVGIDDTSRNSPKLGLLDRIVNYSRASINSLLSDKRSLNSVVTSEPDKHSLLVGDFREDDDTAL

Target ORF information:

RefSeq Version	NM_001282224.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase copper transporting alpha (ATP7A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282224.1

ORF Insert Sequence:

ATGGATCCAA GTATGGGTGT GAATTCTGTT ACCATTTCTG TTGAGGGTAT GACTTGCAAT 
TCCTGTGTTT GGACCATTGA GCAGCAGATT GGAAAAGTGA ATGGTGTGCA TCACATTAAG 
GTATCACTGG AAGAAAAAAA TGCAACTATT ATTTATGACC CTAAACTACA GACTCCAAAG 
ACCCTACAGG AAGCTATTGA TGACATGGGC TTTGATGCTG TTATCCATAA TCCTGACCCT 
CTCCCTGTTT TAACTGACAC CTTGTTTCTG ACTGTTACGG CGTCACTGAC TTTGCCATGG 
GACCATATCC AAAGCACATT GCTGAAGACC AAGGGTGTGA CAGACATTAA AATTTACCCT 
CAGAAAAGAA CTGTAGCAGT GACAATAATC CCTTCTATAG TGAATGCCAA TCAGATAAAA 
GAGCTGGTTC CAGAACTCAG TTTAGATACT GGGACACTGG AGAAAAAGTC AGGAGCTTGT 
GAAGATCATA GTATGGCTCA AGCTGGTGAA GTCGTGCTGA AGATGAAAGT GGAAGGGATG 
ACCTGCCATT CATGTACTAG CACTATTGAA GGAAAAATTG GGAAACTGCA AGGTGTTCAG 
CGAATTAAAG TCTCCCTGGA CAATCAAGAA GCTACTATTG TTTATCAACC TCATCTTATC 
TCAGTAGAGG AAATGAAAAA GCAGATTGAA GCTATGGGCT TTCCAGCATT TGTCAAAAAG 
CAGCCCAAGT ACCTCAAATT GGGAGCTATT GATGTAGAAC GTCTAAAGAA CACACCAGTT 
AAATCCTCAG AAGGGTCACA GCAAAGGAGT CCATCATATA CCAATGATTC AACAGCCACT 
TTCATCATTG ATGGCATGCA TTGTAAATCA TGTGTGTCAA ATATTGAAAG TACTTTATCT 
GCACTCCAAT ATGTAAGCAG CATAGTAGTT TCTTTAGAGA ATAGGTCTGC CATTGTGAAG 
TATAATGCAA GCTCAGTCAC TCCAGAATCC CTGAGAAAAG CAATAGAGGC TGTATCACCG 
GGGCTATATA GAGTTAGTAT CACAAGTGAA GTTGAGAGTA CCTCAAACTC TCCCTCCAGC 
TCATCTCTTC AGAAGATTCC TTTGAATGTA GTTAGCCAGC CTCTGACACA AGAAACTGTG 
ATAAACATTG ATGGCATGAC TTGTAATTCC TGTGTGCAGT CTATTGAGGG TGTCATATCA 
AAAAAGCCAG GTGTAAAATC CATACGAGTC TCCCTTGCAA ATAGCAATGG GACTGTTGAG 
TATGATCCTC TACTAACCTC TCCAGAAACG TTGAGAGGAG CAATAGAAGA CATGGGATTT 
GATGCTACCT TGTCAGACAC GAATGAGCCG TTGGTAGTAA TAGCTCAGCC TTCATCGGAA 
ATGCCGCTTT TGACTTCAAC TAATGAATTT TATACTAAAG GGATGACACC AGTTCAAGAC 
AAGGAGGAAG GAAAGAATTC ATCTAAGTGT TACATACAGG TCACTGGCAT GACTTGCGCT 
TCCTGTGTAG CAAACATTGA ACGGAATTTA AGGCGGGAAG AAGGAATATA TTCTATACTT 
GTGGCCCTGA TGGCTGGCAA GGCAGAAGTA AGGTATAATC CTGCTGTTAT ACAACCCCCA 
ATGATAGCAG AGTTCATCCG AGAACTTGGA TTTGGAGCCA CTGTGATAGA AAATGCTGAT 
GAAGGAGATG GTGTTTTGGA ACTTGTTGTG AGGGGAATGA CGTGTGCCTC CTGCGTACAT 
AAAATAGAGT CTAGTCTCAC AAAACACAGA GGGATCCTAT ACTGCTCCGT GGCCCTGGCA 
ACCAACAAAG CACATATTAA ATATGACCCA GAAATTATTG GTCCTAGAGA TATTATCCAT 
ACAATTGAAA GCTTAGGTTT TGAAGCTTCT TTGGTCAAGA AGGATCGGTC AGCAAGTCAC 
TTAGATCATA AACGAGAAAT AAGACAATGG AGACGGTCTT TTCTTGTGAG TCTGTTTTTC 
TGTATTCCTG TAATGGGGCT GATGATATAT ATGATGGTTA TGGACCACCA CTTTGCAACT 
CTTCACCATA ATCAAAACAT GAGTAAAGAA GAAATGATCA ACCTTCATTC TTCTATGTTC 
CTGGAGCGCC AGATTCTTCC AGGATTGTCT GTTATGAATT TGCTGTCCTT TTTATTGTGT 
GTACCTGTAC AGGGCAAAAC ATCAGAGGCT CTTGCAAAGT TAATTTCACT ACAAGCTACA 
GAAGCAACTA TTGTAACTCT TGATTCTGAT AATATCCTCC TCAGTGAAGA ACAAGTGGAT 
GTGGAACTTG TACAACGTGG AGATATCATT AAAGTAGTTC CAGGAGGCAA ATTTCCAGTG 
GATGGTCGTG TTATTGAAGG ACATTCTATG GTAGATGAGT CCCTCATCAC AGGGGAGGCA 
ATGCCTGTGG CTAAGAAACC TGGCAGCACA GTGATTGCTG GTTCCATTAA CCAGAACGGG 
TCACTGCTTA TCTGCGCAAC ACATGTTGGA GCAGACACAA CCCTTTCTCA AATTGTCAAA 
CTTGTGGAAG AGGCACAAAC ATCAAAGGCT CCTATCCAGC AGTTTGCAGA CAAACTCAGT 
GGCTATTTTG TTCCTTTTAT TGTTTTTGTT TCCATTGCCA CCCTCTTGGT ATGGATTGTA 
ATTGGATTTC TGAATTTTGA AATTGTGGAA ACCTACTTTC CTGGCTACAA TAGAAGTATC 
TCCCGAACAG AAACGATAAT ACGATTTGCT TTCCAAGCCT CTATCACAGT TCTGTGTATT 
GCATGTCCCT GTTCACTGGG ACTGGCCACT CCAACTGCTG TGATGGTGGG TACAGGAGTA 
GGTGCTCAAA ATGGCATACT AATAAAAGGT GGAGAGCCAT TGGAGATGGC TCATAAGGTA 
AAGGTAGTGG TATTTGATAA GACTGGAACC ATTACTCACG GAACCCCAGT GGTGAATCAA 
GTAAAGGTTC TAACTGAAAG TAACAGAATA TCACACCATA AAATCTTGGC CATTGTGGGA 
ACTGCTGAAA GTAACAGTGA ACACCCTCTA GGAACAGCCA TAACCAAATA TTGCAAACAG 
GAGCTGGACA CTGAAACCTT GGGTACCTGC ATAGATTTCC AGGTTGTGCC AGGCTGTGGT 
ATTAGCTGTA AAGTCACCAA TATTGAAGGC TTGCTACATA AGAATAACTG GAATATAGAG 
GACAATAATA TTAAAAATGC ATCCCTGGTT CAAATTGATG CCAGTAATGA ACAGTCATCA 
ACTTCGTCTT CCATGATTAT TGATGCCCAG ATCTCAAATG CTCTTAATGC TCAGCAGTAT 
AAAGTCCTCA TTGGTAACCG GGAGTGGATG ATTAGAAATG GTCTTGTCAT TAATAACGAT 
GTAAATGATT TCATGACTGA ACATGAGAGA AAAGGTCGGA CTGCTGTATT AGTAGCAGTT 
GATGATGAGC TGTGTGGCTT GATAGCCATT GCAGACACAG TGAAGCCTGA AGCAGAACTG 
GCTATCCATA TTCTGAAATC TATGGGCTTA GAAGTAGTTC TGATGACTGG AGACAACAGT 
AAAACAGCTA GATCTATTGC TTCTCAGGTT GGCATTACTA AGGTGTTTGC TGAAGTTCTA 
CCTTCTCACA AGGTTGCTAA AGTGAAGCAA CTTCAAGAGG AGGGGAAACG GGTAGCAATG 
GTGGGAGATG GAATCAATGA CTCCCCAGCT CTGGCAATGG CTAATGTGGG AATTGCTATT 
GGCACAGGCA CAGATGTAGC CATTGAAGCA GCTGATGTGG TTTTGATAAG GAATGATCTT 
CTGGATGTAG TGGCAAGTAT TGACTTATCA AGAAAGACAG TCAAGAGGAT TCGGATAAAT 
TTTGTCTTTG CTCTAATTTA TAATCTGGTT GGAATTCCCA TAGCTGCTGG AGTTTTTATG 
CCCATTGGTT TGGTTTTGCA GCCCTGGATG GGATCTGCAG CAATGGCTGC TTCATCTGTT 
TCTGTAGTAC TTTCTTCTCT CTTCCTTAAA CTTTACAGGA AACCAACTTA CGAGAGTTAT 
GAACTGCCTG CCCGGAGCCA GATAGGACAG AAGAGTCCTT CAGAAATCAG CGTTCATGTT 
GGAATAGATG ATACCTCAAG GAATTCTCCT AAACTGGGTT TGCTGGACCG GATTGTTAAT 
TATAGCAGAG CCTCTATAAA CTCACTACTG TCTGATAAAC GCTCCCTAAA CAGTGTTGTT 
ACCAGTGAAC CTGACAAGCA CTCACTCCTG GTGGGAGACT TCAGGGAAGA TGATGACACT 
GCATTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP7A ( NM_000052.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_000043.4 Homo sapiens ATPase copper transporting alpha (ATP7A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20992
Clone ID Related Accession (Same CDS sequence)	NM_000052.7 , NM_000052.6
Accession Version	NM_000052.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4503bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	copper-transporting ATPase 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL356235.22, DB164588.1, L06476.1, AB117973.1, AK299449.1, AL645821.2 and BU753163.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_000052.6. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L06133.1, SRR1803613.139233.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000341514.11/ ENSP00000345728.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATCCAA GTATGGGTGT GAATTCTGTT ACCATTTCTG TTGAGGGTAT GACTTGCAAT 
TCCTGTGTTT GGACCATTGA GCAGCAGATT GGAAAAGTGA ATGGTGTGCA TCACATTAAG 
GTATCACTGG AAGAAAAAAA TGCAACTATT ATTTATGACC CTAAACTACA GACTCCAAAG 
ACCCTACAGG AAGCTATTGA TGACATGGGC TTTGATGCTG TTATCCATAA TCCTGACCCT 
CTCCCTGTTT TAACTGACAC CTTGTTTCTG ACTGTTACGG CGTCACTGAC TTTGCCATGG 
GACCATATCC AAAGCACATT GCTGAAGACC AAGGGTGTGA CAGACATTAA AATTTACCCT 
CAGAAAAGAA CTGTAGCAGT GACAATAATC CCTTCTATAG TGAATGCCAA TCAGATAAAA 
GAGCTGGTTC CAGAACTCAG TTTAGATACT GGGACACTGG AGAAAAAGTC AGGAGCTTGT 
GAAGATCATA GTATGGCTCA AGCTGGTGAA GTCGTGCTGA AGATGAAAGT GGAAGGGATG 
ACCTGCCATT CATGTACTAG CACTATTGAA GGAAAAATTG GGAAACTGCA AGGTGTTCAG 
CGAATTAAAG TCTCCCTGGA CAATCAAGAA GCTACTATTG TTTATCAACC TCATCTTATC 
TCAGTAGAGG AAATGAAAAA GCAGATTGAA GCTATGGGCT TTCCAGCATT TGTCAAAAAG 
CAGCCCAAGT ACCTCAAATT GGGAGCTATT GATGTAGAAC GTCTAAAGAA CACACCAGTT 
AAATCCTCAG AAGGGTCACA GCAAAGGAGT CCATCATATA CCAATGATTC AACAGCCACT 
TTCATCATTG ATGGCATGCA TTGTAAATCA TGTGTGTCAA ATATTGAAAG TACTTTATCT 
GCACTCCAAT ATGTAAGCAG CATAGTAGTT TCTTTAGAGA ATAGGTCTGC CATTGTGAAG 
TATAATGCAA GCTCAGTCAC TCCAGAATCC CTGAGAAAAG CAATAGAGGC TGTATCACCG 
GGGCTATATA GAGTTAGTAT CACAAGTGAA GTTGAGAGTA CCTCAAACTC TCCCTCCAGC 
TCATCTCTTC AGAAGATTCC TTTGAATGTA GTTAGCCAGC CTCTGACACA AGAAACTGTG 
ATAAACATTG ATGGCATGAC TTGTAATTCC TGTGTGCAGT CTATTGAGGG TGTCATATCA 
AAAAAGCCAG GTGTAAAATC CATACGAGTC TCCCTTGCAA ATAGCAATGG GACTGTTGAG 
TATGATCCTC TACTAACCTC TCCAGAAACG TTGAGAGGAG CAATAGAAGA CATGGGATTT 
GATGCTACCT TGTCAGACAC GAATGAGCCG TTGGTAGTAA TAGCTCAGCC TTCATCGGAA 
ATGCCGCTTT TGACTTCAAC TAATGAATTT TATACTAAAG GGATGACACC AGTTCAAGAC 
AAGGAGGAAG GAAAGAATTC ATCTAAGTGT TACATACAGG TCACTGGCAT GACTTGCGCT 
TCCTGTGTAG CAAACATTGA ACGGAATTTA AGGCGGGAAG AAGGAATATA TTCTATACTT 
GTGGCCCTGA TGGCTGGCAA GGCAGAAGTA AGGTATAATC CTGCTGTTAT ACAACCCCCA 
ATGATAGCAG AGTTCATCCG AGAACTTGGA TTTGGAGCCA CTGTGATAGA AAATGCTGAT 
GAAGGAGATG GTGTTTTGGA ACTTGTTGTG AGGGGAATGA CGTGTGCCTC CTGCGTACAT 
AAAATAGAGT CTAGTCTCAC AAAACACAGA GGGATCCTAT ACTGCTCCGT GGCCCTGGCA 
ACCAACAAAG CACATATTAA ATATGACCCA GAAATTATTG GTCCTAGAGA TATTATCCAT 
ACAATTGAAA GCTTAGGTTT TGAAGCTTCT TTGGTCAAGA AGGATCGGTC AGCAAGTCAC 
TTAGATCATA AACGAGAAAT AAGACAATGG AGACGGTCTT TTCTTGTGAG TCTGTTTTTC 
TGTATTCCTG TAATGGGGCT GATGATATAT ATGATGGTTA TGGACCACCA CTTTGCAACT 
CTTCACCATA ATCAAAACAT GAGTAAAGAA GAAATGATCA ACCTTCATTC TTCTATGTTC 
CTGGAGCGCC AGATTCTTCC AGGATTGTCT GTTATGAATT TGCTGTCCTT TTTATTGTGT 
GTACCTGTAC AGTTTTTCGG AGGCTGGTAC TTCTACATTC AGGCTTATAA AGCACTGAAG 
CATAAGACAG CAAATATGGA CGTACTGATT GTGCTGGCAA CCACCATTGC ATTTGCCTAC 
TCTTTGATTA TTCTTCTAGT TGCAATGTAT GAGAGAGCCA AAGTGAACCC TATTACTTTC 
TTTGACACAC CCCCTATGCT GTTTGTGTTT ATTGCACTAG GCCGATGGCT GGAACATATA 
GCAAAGGGCA AAACATCAGA GGCTCTTGCA AAGTTAATTT CACTACAAGC TACAGAAGCA 
ACTATTGTAA CTCTTGATTC TGATAATATC CTCCTCAGTG AAGAACAAGT GGATGTGGAA 
CTTGTACAAC GTGGAGATAT CATTAAAGTA GTTCCAGGAG GCAAATTTCC AGTGGATGGT 
CGTGTTATTG AAGGACATTC TATGGTAGAT GAGTCCCTCA TCACAGGGGA GGCAATGCCT 
GTGGCTAAGA AACCTGGCAG CACAGTGATT GCTGGTTCCA TTAACCAGAA CGGGTCACTG 
CTTATCTGCG CAACACATGT TGGAGCAGAC ACAACCCTTT CTCAAATTGT CAAACTTGTG 
GAAGAGGCAC AAACATCAAA GGCTCCTATC CAGCAGTTTG CAGACAAACT CAGTGGCTAT 
TTTGTTCCTT TTATTGTTTT TGTTTCCATT GCCACCCTCT TGGTATGGAT TGTAATTGGA 
TTTCTGAATT TTGAAATTGT GGAAACCTAC TTTCCTGGCT ACAATAGAAG TATCTCCCGA 
ACAGAAACGA TAATACGATT TGCTTTCCAA GCCTCTATCA CAGTTCTGTG TATTGCATGT 
CCCTGTTCAC TGGGACTGGC CACTCCAACT GCTGTGATGG TGGGTACAGG AGTAGGTGCT 
CAAAATGGCA TACTAATAAA AGGTGGAGAG CCATTGGAGA TGGCTCATAA GGTAAAGGTA 
GTGGTATTTG ATAAGACTGG AACCATTACT CACGGAACCC CAGTGGTGAA TCAAGTAAAG 
GTTCTAACTG AAAGTAACAG AATATCACAC CATAAAATCT TGGCCATTGT GGGAACTGCT 
GAAAGTAACA GTGAACACCC TCTAGGAACA GCCATAACCA AATATTGCAA ACAGGAGCTG 
GACACTGAAA CCTTGGGTAC CTGCATAGAT TTCCAGGTTG TGCCAGGCTG TGGTATTAGC 
TGTAAAGTCA CCAATATTGA AGGCTTGCTA CATAAGAATA ACTGGAATAT AGAGGACAAT 
AATATTAAAA ATGCATCCCT GGTTCAAATT GATGCCAGTA ATGAACAGTC ATCAACTTCG 
TCTTCCATGA TTATTGATGC CCAGATCTCA AATGCTCTTA ATGCTCAGCA GTATAAAGTC 
CTCATTGGTA ACCGGGAGTG GATGATTAGA AATGGTCTTG TCATTAATAA CGATGTAAAT 
GATTTCATGA CTGAACATGA GAGAAAAGGT CGGACTGCTG TATTAGTAGC AGTTGATGAT 
GAGCTGTGTG GCTTGATAGC CATTGCAGAC ACAGTGAAGC CTGAAGCAGA ACTGGCTATC 
CATATTCTGA AATCTATGGG CTTAGAAGTA GTTCTGATGA CTGGAGACAA CAGTAAAACA 
GCTAGATCTA TTGCTTCTCA GGTTGGCATT ACTAAGGTGT TTGCTGAAGT TCTACCTTCT 
CACAAGGTTG CTAAAGTGAA GCAACTTCAA GAGGAGGGGA AACGGGTAGC AATGGTGGGA 
GATGGAATCA ATGACTCCCC AGCTCTGGCA ATGGCTAATG TGGGAATTGC TATTGGCACA 
GGCACAGATG TAGCCATTGA AGCAGCTGAT GTGGTTTTGA TAAGGAATGA TCTTCTGGAT 
GTAGTGGCAA GTATTGACTT ATCAAGAAAG ACAGTCAAGA GGATTCGGAT AAATTTTGTC 
TTTGCTCTAA TTTATAATCT GGTTGGAATT CCCATAGCTG CTGGAGTTTT TATGCCCATT 
GGTTTGGTTT TGCAGCCCTG GATGGGATCT GCAGCAATGG CTGCTTCATC TGTTTCTGTA 
GTACTTTCTT CTCTCTTCCT TAAACTTTAC AGGAAACCAA CTTACGAGAG TTATGAACTG 
CCTGCCCGGA GCCAGATAGG ACAGAAGAGT CCTTCAGAAA TCAGCGTTCA TGTTGGAATA 
GATGATACCT CAAGGAATTC TCCTAAACTG GGTTTGCTGG ACCGGATTGT TAATTATAGC 
AGAGCCTCTA TAAACTCACT ACTGTCTGAT AAACGCTCCC TAAACAGTGT TGTTACCAGT 
GAACCTGACA AGCACTCACT CCTGGTGGGA GACTTCAGGG AAGATGATGA CACTGCATTA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000043.4
CDS	165..4667
Translation	MDPSMGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPKTLQEAIDDMGFDAVIHNPDPLPVLTDTLFLTVTASLTLPWDHIQSTLLKTKGVTDIKIYPQKRTVAVTIIPSIVNANQIKELVPELSLDTGTLEKKSGACEDHSMAQAGEVVLKMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVSLDNQEATIVYQPHLISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYTNDSTATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVLELVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKKDRSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPARSQIGQKSPSEISVHVGIDDTSRNSPKLGLLDRIVNYSRASINSLLSDKRSLNSVVTSEPDKHSLLVGDFREDDDTAL

Target ORF information:

RefSeq Version	NM_000052.7
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase copper transporting alpha (ATP7A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000052.7

ORF Insert Sequence:

ATGGATCCAA GTATGGGTGT GAATTCTGTT ACCATTTCTG TTGAGGGTAT GACTTGCAAT 
TCCTGTGTTT GGACCATTGA GCAGCAGATT GGAAAAGTGA ATGGTGTGCA TCACATTAAG 
GTATCACTGG AAGAAAAAAA TGCAACTATT ATTTATGACC CTAAACTACA GACTCCAAAG 
ACCCTACAGG AAGCTATTGA TGACATGGGC TTTGATGCTG TTATCCATAA TCCTGACCCT 
CTCCCTGTTT TAACTGACAC CTTGTTTCTG ACTGTTACGG CGTCACTGAC TTTGCCATGG 
GACCATATCC AAAGCACATT GCTGAAGACC AAGGGTGTGA CAGACATTAA AATTTACCCT 
CAGAAAAGAA CTGTAGCAGT GACAATAATC CCTTCTATAG TGAATGCCAA TCAGATAAAA 
GAGCTGGTTC CAGAACTCAG TTTAGATACT GGGACACTGG AGAAAAAGTC AGGAGCTTGT 
GAAGATCATA GTATGGCTCA AGCTGGTGAA GTCGTGCTGA AGATGAAAGT GGAAGGGATG 
ACCTGCCATT CATGTACTAG CACTATTGAA GGAAAAATTG GGAAACTGCA AGGTGTTCAG 
CGAATTAAAG TCTCCCTGGA CAATCAAGAA GCTACTATTG TTTATCAACC TCATCTTATC 
TCAGTAGAGG AAATGAAAAA GCAGATTGAA GCTATGGGCT TTCCAGCATT TGTCAAAAAG 
CAGCCCAAGT ACCTCAAATT GGGAGCTATT GATGTAGAAC GTCTAAAGAA CACACCAGTT 
AAATCCTCAG AAGGGTCACA GCAAAGGAGT CCATCATATA CCAATGATTC AACAGCCACT 
TTCATCATTG ATGGCATGCA TTGTAAATCA TGTGTGTCAA ATATTGAAAG TACTTTATCT 
GCACTCCAAT ATGTAAGCAG CATAGTAGTT TCTTTAGAGA ATAGGTCTGC CATTGTGAAG 
TATAATGCAA GCTCAGTCAC TCCAGAATCC CTGAGAAAAG CAATAGAGGC TGTATCACCG 
GGGCTATATA GAGTTAGTAT CACAAGTGAA GTTGAGAGTA CCTCAAACTC TCCCTCCAGC 
TCATCTCTTC AGAAGATTCC TTTGAATGTA GTTAGCCAGC CTCTGACACA AGAAACTGTG 
ATAAACATTG ATGGCATGAC TTGTAATTCC TGTGTGCAGT CTATTGAGGG TGTCATATCA 
AAAAAGCCAG GTGTAAAATC CATACGAGTC TCCCTTGCAA ATAGCAATGG GACTGTTGAG 
TATGATCCTC TACTAACCTC TCCAGAAACG TTGAGAGGAG CAATAGAAGA CATGGGATTT 
GATGCTACCT TGTCAGACAC GAATGAGCCG TTGGTAGTAA TAGCTCAGCC TTCATCGGAA 
ATGCCGCTTT TGACTTCAAC TAATGAATTT TATACTAAAG GGATGACACC AGTTCAAGAC 
AAGGAGGAAG GAAAGAATTC ATCTAAGTGT TACATACAGG TCACTGGCAT GACTTGCGCT 
TCCTGTGTAG CAAACATTGA ACGGAATTTA AGGCGGGAAG AAGGAATATA TTCTATACTT 
GTGGCCCTGA TGGCTGGCAA GGCAGAAGTA AGGTATAATC CTGCTGTTAT ACAACCCCCA 
ATGATAGCAG AGTTCATCCG AGAACTTGGA TTTGGAGCCA CTGTGATAGA AAATGCTGAT 
GAAGGAGATG GTGTTTTGGA ACTTGTTGTG AGGGGAATGA CGTGTGCCTC CTGCGTACAT 
AAAATAGAGT CTAGTCTCAC AAAACACAGA GGGATCCTAT ACTGCTCCGT GGCCCTGGCA 
ACCAACAAAG CACATATTAA ATATGACCCA GAAATTATTG GTCCTAGAGA TATTATCCAT 
ACAATTGAAA GCTTAGGTTT TGAAGCTTCT TTGGTCAAGA AGGATCGGTC AGCAAGTCAC 
TTAGATCATA AACGAGAAAT AAGACAATGG AGACGGTCTT TTCTTGTGAG TCTGTTTTTC 
TGTATTCCTG TAATGGGGCT GATGATATAT ATGATGGTTA TGGACCACCA CTTTGCAACT 
CTTCACCATA ATCAAAACAT GAGTAAAGAA GAAATGATCA ACCTTCATTC TTCTATGTTC 
CTGGAGCGCC AGATTCTTCC AGGATTGTCT GTTATGAATT TGCTGTCCTT TTTATTGTGT 
GTACCTGTAC AGTTTTTCGG AGGCTGGTAC TTCTACATTC AGGCTTATAA AGCACTGAAG 
CATAAGACAG CAAATATGGA CGTACTGATT GTGCTGGCAA CCACCATTGC ATTTGCCTAC 
TCTTTGATTA TTCTTCTAGT TGCAATGTAT GAGAGAGCCA AAGTGAACCC TATTACTTTC 
TTTGACACAC CCCCTATGCT GTTTGTGTTT ATTGCACTAG GCCGATGGCT GGAACATATA 
GCAAAGGGCA AAACATCAGA GGCTCTTGCA AAGTTAATTT CACTACAAGC TACAGAAGCA 
ACTATTGTAA CTCTTGATTC TGATAATATC CTCCTCAGTG AAGAACAAGT GGATGTGGAA 
CTTGTACAAC GTGGAGATAT CATTAAAGTA GTTCCAGGAG GCAAATTTCC AGTGGATGGT 
CGTGTTATTG AAGGACATTC TATGGTAGAT GAGTCCCTCA TCACAGGGGA GGCAATGCCT 
GTGGCTAAGA AACCTGGCAG CACAGTGATT GCTGGTTCCA TTAACCAGAA CGGGTCACTG 
CTTATCTGCG CAACACATGT TGGAGCAGAC ACAACCCTTT CTCAAATTGT CAAACTTGTG 
GAAGAGGCAC AAACATCAAA GGCTCCTATC CAGCAGTTTG CAGACAAACT CAGTGGCTAT 
TTTGTTCCTT TTATTGTTTT TGTTTCCATT GCCACCCTCT TGGTATGGAT TGTAATTGGA 
TTTCTGAATT TTGAAATTGT GGAAACCTAC TTTCCTGGCT ACAATAGAAG TATCTCCCGA 
ACAGAAACGA TAATACGATT TGCTTTCCAA GCCTCTATCA CAGTTCTGTG TATTGCATGT 
CCCTGTTCAC TGGGACTGGC CACTCCAACT GCTGTGATGG TGGGTACAGG AGTAGGTGCT 
CAAAATGGCA TACTAATAAA AGGTGGAGAG CCATTGGAGA TGGCTCATAA GGTAAAGGTA 
GTGGTATTTG ATAAGACTGG AACCATTACT CACGGAACCC CAGTGGTGAA TCAAGTAAAG 
GTTCTAACTG AAAGTAACAG AATATCACAC CATAAAATCT TGGCCATTGT GGGAACTGCT 
GAAAGTAACA GTGAACACCC TCTAGGAACA GCCATAACCA AATATTGCAA ACAGGAGCTG 
GACACTGAAA CCTTGGGTAC CTGCATAGAT TTCCAGGTTG TGCCAGGCTG TGGTATTAGC 
TGTAAAGTCA CCAATATTGA AGGCTTGCTA CATAAGAATA ACTGGAATAT AGAGGACAAT 
AATATTAAAA ATGCATCCCT GGTTCAAATT GATGCCAGTA ATGAACAGTC ATCAACTTCG 
TCTTCCATGA TTATTGATGC CCAGATCTCA AATGCTCTTA ATGCTCAGCA GTATAAAGTC 
CTCATTGGTA ACCGGGAGTG GATGATTAGA AATGGTCTTG TCATTAATAA CGATGTAAAT 
GATTTCATGA CTGAACATGA GAGAAAAGGT CGGACTGCTG TATTAGTAGC AGTTGATGAT 
GAGCTGTGTG GCTTGATAGC CATTGCAGAC ACAGTGAAGC CTGAAGCAGA ACTGGCTATC 
CATATTCTGA AATCTATGGG CTTAGAAGTA GTTCTGATGA CTGGAGACAA CAGTAAAACA 
GCTAGATCTA TTGCTTCTCA GGTTGGCATT ACTAAGGTGT TTGCTGAAGT TCTACCTTCT 
CACAAGGTTG CTAAAGTGAA GCAACTTCAA GAGGAGGGGA AACGGGTAGC AATGGTGGGA 
GATGGAATCA ATGACTCCCC AGCTCTGGCA ATGGCTAATG TGGGAATTGC TATTGGCACA 
GGCACAGATG TAGCCATTGA AGCAGCTGAT GTGGTTTTGA TAAGGAATGA TCTTCTGGAT 
GTAGTGGCAA GTATTGACTT ATCAAGAAAG ACAGTCAAGA GGATTCGGAT AAATTTTGTC 
TTTGCTCTAA TTTATAATCT GGTTGGAATT CCCATAGCTG CTGGAGTTTT TATGCCCATT 
GGTTTGGTTT TGCAGCCCTG GATGGGATCT GCAGCAATGG CTGCTTCATC TGTTTCTGTA 
GTACTTTCTT CTCTCTTCCT TAAACTTTAC AGGAAACCAA CTTACGAGAG TTATGAACTG 
CCTGCCCGGA GCCAGATAGG ACAGAAGAGT CCTTCAGAAA TCAGCGTTCA TGTTGGAATA 
GATGATACCT CAAGGAATTC TCCTAAACTG GGTTTGCTGG ACCGGATTGT TAATTATAGC 
AGAGCCTCTA TAAACTCACT ACTGTCTGAT AAACGCTCCC TAAACAGTGT TGTTACCAGT 
GAACCTGACA AGCACTCACT CCTGGTGGGA GACTTCAGGG AAGATGATGA CACTGCATTA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP7A ( NM_000052.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_000043.4 Homo sapiens ATPase copper transporting alpha (ATP7A), transcript variant 1, mRNA.

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CloneID	OHu20992
Clone ID Related Accession (Same CDS sequence)	NM_000052.7 , NM_000052.6
Accession Version	NM_000052.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4503bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	copper-transporting ATPase 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL356235.22, DB164588.1, L06476.1, AB117973.1, AK299449.1, AL645821.2 and BU753163.1. This sequence is a reference standard in the RefSeqGene project. On Aug 24, 2013 this sequence version replaced NM_000052.5. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L06133.1, SRR1803613.139233.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATCCAA GTATGGGTGT GAATTCTGTT ACCATTTCTG TTGAGGGTAT GACTTGCAAT 
TCCTGTGTTT GGACCATTGA GCAGCAGATT GGAAAAGTGA ATGGTGTGCA TCACATTAAG 
GTATCACTGG AAGAAAAAAA TGCAACTATT ATTTATGACC CTAAACTACA GACTCCAAAG 
ACCCTACAGG AAGCTATTGA TGACATGGGC TTTGATGCTG TTATCCATAA TCCTGACCCT 
CTCCCTGTTT TAACTGACAC CTTGTTTCTG ACTGTTACGG CGTCACTGAC TTTGCCATGG 
GACCATATCC AAAGCACATT GCTGAAGACC AAGGGTGTGA CAGACATTAA AATTTACCCT 
CAGAAAAGAA CTGTAGCAGT GACAATAATC CCTTCTATAG TGAATGCCAA TCAGATAAAA 
GAGCTGGTTC CAGAACTCAG TTTAGATACT GGGACACTGG AGAAAAAGTC AGGAGCTTGT 
GAAGATCATA GTATGGCTCA AGCTGGTGAA GTCGTGCTGA AGATGAAAGT GGAAGGGATG 
ACCTGCCATT CATGTACTAG CACTATTGAA GGAAAAATTG GGAAACTGCA AGGTGTTCAG 
CGAATTAAAG TCTCCCTGGA CAATCAAGAA GCTACTATTG TTTATCAACC TCATCTTATC 
TCAGTAGAGG AAATGAAAAA GCAGATTGAA GCTATGGGCT TTCCAGCATT TGTCAAAAAG 
CAGCCCAAGT ACCTCAAATT GGGAGCTATT GATGTAGAAC GTCTAAAGAA CACACCAGTT 
AAATCCTCAG AAGGGTCACA GCAAAGGAGT CCATCATATA CCAATGATTC AACAGCCACT 
TTCATCATTG ATGGCATGCA TTGTAAATCA TGTGTGTCAA ATATTGAAAG TACTTTATCT 
GCACTCCAAT ATGTAAGCAG CATAGTAGTT TCTTTAGAGA ATAGGTCTGC CATTGTGAAG 
TATAATGCAA GCTCAGTCAC TCCAGAATCC CTGAGAAAAG CAATAGAGGC TGTATCACCG 
GGGCTATATA GAGTTAGTAT CACAAGTGAA GTTGAGAGTA CCTCAAACTC TCCCTCCAGC 
TCATCTCTTC AGAAGATTCC TTTGAATGTA GTTAGCCAGC CTCTGACACA AGAAACTGTG 
ATAAACATTG ATGGCATGAC TTGTAATTCC TGTGTGCAGT CTATTGAGGG TGTCATATCA 
AAAAAGCCAG GTGTAAAATC CATACGAGTC TCCCTTGCAA ATAGCAATGG GACTGTTGAG 
TATGATCCTC TACTAACCTC TCCAGAAACG TTGAGAGGAG CAATAGAAGA CATGGGATTT 
GATGCTACCT TGTCAGACAC GAATGAGCCG TTGGTAGTAA TAGCTCAGCC TTCATCGGAA 
ATGCCGCTTT TGACTTCAAC TAATGAATTT TATACTAAAG GGATGACACC AGTTCAAGAC 
AAGGAGGAAG GAAAGAATTC ATCTAAGTGT TACATACAGG TCACTGGCAT GACTTGCGCT 
TCCTGTGTAG CAAACATTGA ACGGAATTTA AGGCGGGAAG AAGGAATATA TTCTATACTT 
GTGGCCCTGA TGGCTGGCAA GGCAGAAGTA AGGTATAATC CTGCTGTTAT ACAACCCCCA 
ATGATAGCAG AGTTCATCCG AGAACTTGGA TTTGGAGCCA CTGTGATAGA AAATGCTGAT 
GAAGGAGATG GTGTTTTGGA ACTTGTTGTG AGGGGAATGA CGTGTGCCTC CTGCGTACAT 
AAAATAGAGT CTAGTCTCAC AAAACACAGA GGGATCCTAT ACTGCTCCGT GGCCCTGGCA 
ACCAACAAAG CACATATTAA ATATGACCCA GAAATTATTG GTCCTAGAGA TATTATCCAT 
ACAATTGAAA GCTTAGGTTT TGAAGCTTCT TTGGTCAAGA AGGATCGGTC AGCAAGTCAC 
TTAGATCATA AACGAGAAAT AAGACAATGG AGACGGTCTT TTCTTGTGAG TCTGTTTTTC 
TGTATTCCTG TAATGGGGCT GATGATATAT ATGATGGTTA TGGACCACCA CTTTGCAACT 
CTTCACCATA ATCAAAACAT GAGTAAAGAA GAAATGATCA ACCTTCATTC TTCTATGTTC 
CTGGAGCGCC AGATTCTTCC AGGATTGTCT GTTATGAATT TGCTGTCCTT TTTATTGTGT 
GTACCTGTAC AGTTTTTCGG AGGCTGGTAC TTCTACATTC AGGCTTATAA AGCACTGAAG 
CATAAGACAG CAAATATGGA CGTACTGATT GTGCTGGCAA CCACCATTGC ATTTGCCTAC 
TCTTTGATTA TTCTTCTAGT TGCAATGTAT GAGAGAGCCA AAGTGAACCC TATTACTTTC 
TTTGACACAC CCCCTATGCT GTTTGTGTTT ATTGCACTAG GCCGATGGCT GGAACATATA 
GCAAAGGGCA AAACATCAGA GGCTCTTGCA AAGTTAATTT CACTACAAGC TACAGAAGCA 
ACTATTGTAA CTCTTGATTC TGATAATATC CTCCTCAGTG AAGAACAAGT GGATGTGGAA 
CTTGTACAAC GTGGAGATAT CATTAAAGTA GTTCCAGGAG GCAAATTTCC AGTGGATGGT 
CGTGTTATTG AAGGACATTC TATGGTAGAT GAGTCCCTCA TCACAGGGGA GGCAATGCCT 
GTGGCTAAGA AACCTGGCAG CACAGTGATT GCTGGTTCCA TTAACCAGAA CGGGTCACTG 
CTTATCTGCG CAACACATGT TGGAGCAGAC ACAACCCTTT CTCAAATTGT CAAACTTGTG 
GAAGAGGCAC AAACATCAAA GGCTCCTATC CAGCAGTTTG CAGACAAACT CAGTGGCTAT 
TTTGTTCCTT TTATTGTTTT TGTTTCCATT GCCACCCTCT TGGTATGGAT TGTAATTGGA 
TTTCTGAATT TTGAAATTGT GGAAACCTAC TTTCCTGGCT ACAATAGAAG TATCTCCCGA 
ACAGAAACGA TAATACGATT TGCTTTCCAA GCCTCTATCA CAGTTCTGTG TATTGCATGT 
CCCTGTTCAC TGGGACTGGC CACTCCAACT GCTGTGATGG TGGGTACAGG AGTAGGTGCT 
CAAAATGGCA TACTAATAAA AGGTGGAGAG CCATTGGAGA TGGCTCATAA GGTAAAGGTA 
GTGGTATTTG ATAAGACTGG AACCATTACT CACGGAACCC CAGTGGTGAA TCAAGTAAAG 
GTTCTAACTG AAAGTAACAG AATATCACAC CATAAAATCT TGGCCATTGT GGGAACTGCT 
GAAAGTAACA GTGAACACCC TCTAGGAACA GCCATAACCA AATATTGCAA ACAGGAGCTG 
GACACTGAAA CCTTGGGTAC CTGCATAGAT TTCCAGGTTG TGCCAGGCTG TGGTATTAGC 
TGTAAAGTCA CCAATATTGA AGGCTTGCTA CATAAGAATA ACTGGAATAT AGAGGACAAT 
AATATTAAAA ATGCATCCCT GGTTCAAATT GATGCCAGTA ATGAACAGTC ATCAACTTCG 
TCTTCCATGA TTATTGATGC CCAGATCTCA AATGCTCTTA ATGCTCAGCA GTATAAAGTC 
CTCATTGGTA ACCGGGAGTG GATGATTAGA AATGGTCTTG TCATTAATAA CGATGTAAAT 
GATTTCATGA CTGAACATGA GAGAAAAGGT CGGACTGCTG TATTAGTAGC AGTTGATGAT 
GAGCTGTGTG GCTTGATAGC CATTGCAGAC ACAGTGAAGC CTGAAGCAGA ACTGGCTATC 
CATATTCTGA AATCTATGGG CTTAGAAGTA GTTCTGATGA CTGGAGACAA CAGTAAAACA 
GCTAGATCTA TTGCTTCTCA GGTTGGCATT ACTAAGGTGT TTGCTGAAGT TCTACCTTCT 
CACAAGGTTG CTAAAGTGAA GCAACTTCAA GAGGAGGGGA AACGGGTAGC AATGGTGGGA 
GATGGAATCA ATGACTCCCC AGCTCTGGCA ATGGCTAATG TGGGAATTGC TATTGGCACA 
GGCACAGATG TAGCCATTGA AGCAGCTGAT GTGGTTTTGA TAAGGAATGA TCTTCTGGAT 
GTAGTGGCAA GTATTGACTT ATCAAGAAAG ACAGTCAAGA GGATTCGGAT AAATTTTGTC 
TTTGCTCTAA TTTATAATCT GGTTGGAATT CCCATAGCTG CTGGAGTTTT TATGCCCATT 
GGTTTGGTTT TGCAGCCCTG GATGGGATCT GCAGCAATGG CTGCTTCATC TGTTTCTGTA 
GTACTTTCTT CTCTCTTCCT TAAACTTTAC AGGAAACCAA CTTACGAGAG TTATGAACTG 
CCTGCCCGGA GCCAGATAGG ACAGAAGAGT CCTTCAGAAA TCAGCGTTCA TGTTGGAATA 
GATGATACCT CAAGGAATTC TCCTAAACTG GGTTTGCTGG ACCGGATTGT TAATTATAGC 
AGAGCCTCTA TAAACTCACT ACTGTCTGAT AAACGCTCCC TAAACAGTGT TGTTACCAGT 
GAACCTGACA AGCACTCACT CCTGGTGGGA GACTTCAGGG AAGATGATGA CACTGCATTA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000043.4
CDS	202..4704
Translation	MDPSMGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPKTLQEAIDDMGFDAVIHNPDPLPVLTDTLFLTVTASLTLPWDHIQSTLLKTKGVTDIKIYPQKRTVAVTIIPSIVNANQIKELVPELSLDTGTLEKKSGACEDHSMAQAGEVVLKMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVSLDNQEATIVYQPHLISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYTNDSTATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVLELVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKKDRSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPARSQIGQKSPSEISVHVGIDDTSRNSPKLGLLDRIVNYSRASINSLLSDKRSLNSVVTSEPDKHSLLVGDFREDDDTAL

Target ORF information:

RefSeq Version	NM_000052.6
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase copper transporting alpha (ATP7A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000052.6

ORF Insert Sequence:

ATGGATCCAA GTATGGGTGT GAATTCTGTT ACCATTTCTG TTGAGGGTAT GACTTGCAAT 
TCCTGTGTTT GGACCATTGA GCAGCAGATT GGAAAAGTGA ATGGTGTGCA TCACATTAAG 
GTATCACTGG AAGAAAAAAA TGCAACTATT ATTTATGACC CTAAACTACA GACTCCAAAG 
ACCCTACAGG AAGCTATTGA TGACATGGGC TTTGATGCTG TTATCCATAA TCCTGACCCT 
CTCCCTGTTT TAACTGACAC CTTGTTTCTG ACTGTTACGG CGTCACTGAC TTTGCCATGG 
GACCATATCC AAAGCACATT GCTGAAGACC AAGGGTGTGA CAGACATTAA AATTTACCCT 
CAGAAAAGAA CTGTAGCAGT GACAATAATC CCTTCTATAG TGAATGCCAA TCAGATAAAA 
GAGCTGGTTC CAGAACTCAG TTTAGATACT GGGACACTGG AGAAAAAGTC AGGAGCTTGT 
GAAGATCATA GTATGGCTCA AGCTGGTGAA GTCGTGCTGA AGATGAAAGT GGAAGGGATG 
ACCTGCCATT CATGTACTAG CACTATTGAA GGAAAAATTG GGAAACTGCA AGGTGTTCAG 
CGAATTAAAG TCTCCCTGGA CAATCAAGAA GCTACTATTG TTTATCAACC TCATCTTATC 
TCAGTAGAGG AAATGAAAAA GCAGATTGAA GCTATGGGCT TTCCAGCATT TGTCAAAAAG 
CAGCCCAAGT ACCTCAAATT GGGAGCTATT GATGTAGAAC GTCTAAAGAA CACACCAGTT 
AAATCCTCAG AAGGGTCACA GCAAAGGAGT CCATCATATA CCAATGATTC AACAGCCACT 
TTCATCATTG ATGGCATGCA TTGTAAATCA TGTGTGTCAA ATATTGAAAG TACTTTATCT 
GCACTCCAAT ATGTAAGCAG CATAGTAGTT TCTTTAGAGA ATAGGTCTGC CATTGTGAAG 
TATAATGCAA GCTCAGTCAC TCCAGAATCC CTGAGAAAAG CAATAGAGGC TGTATCACCG 
GGGCTATATA GAGTTAGTAT CACAAGTGAA GTTGAGAGTA CCTCAAACTC TCCCTCCAGC 
TCATCTCTTC AGAAGATTCC TTTGAATGTA GTTAGCCAGC CTCTGACACA AGAAACTGTG 
ATAAACATTG ATGGCATGAC TTGTAATTCC TGTGTGCAGT CTATTGAGGG TGTCATATCA 
AAAAAGCCAG GTGTAAAATC CATACGAGTC TCCCTTGCAA ATAGCAATGG GACTGTTGAG 
TATGATCCTC TACTAACCTC TCCAGAAACG TTGAGAGGAG CAATAGAAGA CATGGGATTT 
GATGCTACCT TGTCAGACAC GAATGAGCCG TTGGTAGTAA TAGCTCAGCC TTCATCGGAA 
ATGCCGCTTT TGACTTCAAC TAATGAATTT TATACTAAAG GGATGACACC AGTTCAAGAC 
AAGGAGGAAG GAAAGAATTC ATCTAAGTGT TACATACAGG TCACTGGCAT GACTTGCGCT 
TCCTGTGTAG CAAACATTGA ACGGAATTTA AGGCGGGAAG AAGGAATATA TTCTATACTT 
GTGGCCCTGA TGGCTGGCAA GGCAGAAGTA AGGTATAATC CTGCTGTTAT ACAACCCCCA 
ATGATAGCAG AGTTCATCCG AGAACTTGGA TTTGGAGCCA CTGTGATAGA AAATGCTGAT 
GAAGGAGATG GTGTTTTGGA ACTTGTTGTG AGGGGAATGA CGTGTGCCTC CTGCGTACAT 
AAAATAGAGT CTAGTCTCAC AAAACACAGA GGGATCCTAT ACTGCTCCGT GGCCCTGGCA 
ACCAACAAAG CACATATTAA ATATGACCCA GAAATTATTG GTCCTAGAGA TATTATCCAT 
ACAATTGAAA GCTTAGGTTT TGAAGCTTCT TTGGTCAAGA AGGATCGGTC AGCAAGTCAC 
TTAGATCATA AACGAGAAAT AAGACAATGG AGACGGTCTT TTCTTGTGAG TCTGTTTTTC 
TGTATTCCTG TAATGGGGCT GATGATATAT ATGATGGTTA TGGACCACCA CTTTGCAACT 
CTTCACCATA ATCAAAACAT GAGTAAAGAA GAAATGATCA ACCTTCATTC TTCTATGTTC 
CTGGAGCGCC AGATTCTTCC AGGATTGTCT GTTATGAATT TGCTGTCCTT TTTATTGTGT 
GTACCTGTAC AGTTTTTCGG AGGCTGGTAC TTCTACATTC AGGCTTATAA AGCACTGAAG 
CATAAGACAG CAAATATGGA CGTACTGATT GTGCTGGCAA CCACCATTGC ATTTGCCTAC 
TCTTTGATTA TTCTTCTAGT TGCAATGTAT GAGAGAGCCA AAGTGAACCC TATTACTTTC 
TTTGACACAC CCCCTATGCT GTTTGTGTTT ATTGCACTAG GCCGATGGCT GGAACATATA 
GCAAAGGGCA AAACATCAGA GGCTCTTGCA AAGTTAATTT CACTACAAGC TACAGAAGCA 
ACTATTGTAA CTCTTGATTC TGATAATATC CTCCTCAGTG AAGAACAAGT GGATGTGGAA 
CTTGTACAAC GTGGAGATAT CATTAAAGTA GTTCCAGGAG GCAAATTTCC AGTGGATGGT 
CGTGTTATTG AAGGACATTC TATGGTAGAT GAGTCCCTCA TCACAGGGGA GGCAATGCCT 
GTGGCTAAGA AACCTGGCAG CACAGTGATT GCTGGTTCCA TTAACCAGAA CGGGTCACTG 
CTTATCTGCG CAACACATGT TGGAGCAGAC ACAACCCTTT CTCAAATTGT CAAACTTGTG 
GAAGAGGCAC AAACATCAAA GGCTCCTATC CAGCAGTTTG CAGACAAACT CAGTGGCTAT 
TTTGTTCCTT TTATTGTTTT TGTTTCCATT GCCACCCTCT TGGTATGGAT TGTAATTGGA 
TTTCTGAATT TTGAAATTGT GGAAACCTAC TTTCCTGGCT ACAATAGAAG TATCTCCCGA 
ACAGAAACGA TAATACGATT TGCTTTCCAA GCCTCTATCA CAGTTCTGTG TATTGCATGT 
CCCTGTTCAC TGGGACTGGC CACTCCAACT GCTGTGATGG TGGGTACAGG AGTAGGTGCT 
CAAAATGGCA TACTAATAAA AGGTGGAGAG CCATTGGAGA TGGCTCATAA GGTAAAGGTA 
GTGGTATTTG ATAAGACTGG AACCATTACT CACGGAACCC CAGTGGTGAA TCAAGTAAAG 
GTTCTAACTG AAAGTAACAG AATATCACAC CATAAAATCT TGGCCATTGT GGGAACTGCT 
GAAAGTAACA GTGAACACCC TCTAGGAACA GCCATAACCA AATATTGCAA ACAGGAGCTG 
GACACTGAAA CCTTGGGTAC CTGCATAGAT TTCCAGGTTG TGCCAGGCTG TGGTATTAGC 
TGTAAAGTCA CCAATATTGA AGGCTTGCTA CATAAGAATA ACTGGAATAT AGAGGACAAT 
AATATTAAAA ATGCATCCCT GGTTCAAATT GATGCCAGTA ATGAACAGTC ATCAACTTCG 
TCTTCCATGA TTATTGATGC CCAGATCTCA AATGCTCTTA ATGCTCAGCA GTATAAAGTC 
CTCATTGGTA ACCGGGAGTG GATGATTAGA AATGGTCTTG TCATTAATAA CGATGTAAAT 
GATTTCATGA CTGAACATGA GAGAAAAGGT CGGACTGCTG TATTAGTAGC AGTTGATGAT 
GAGCTGTGTG GCTTGATAGC CATTGCAGAC ACAGTGAAGC CTGAAGCAGA ACTGGCTATC 
CATATTCTGA AATCTATGGG CTTAGAAGTA GTTCTGATGA CTGGAGACAA CAGTAAAACA 
GCTAGATCTA TTGCTTCTCA GGTTGGCATT ACTAAGGTGT TTGCTGAAGT TCTACCTTCT 
CACAAGGTTG CTAAAGTGAA GCAACTTCAA GAGGAGGGGA AACGGGTAGC AATGGTGGGA 
GATGGAATCA ATGACTCCCC AGCTCTGGCA ATGGCTAATG TGGGAATTGC TATTGGCACA 
GGCACAGATG TAGCCATTGA AGCAGCTGAT GTGGTTTTGA TAAGGAATGA TCTTCTGGAT 
GTAGTGGCAA GTATTGACTT ATCAAGAAAG ACAGTCAAGA GGATTCGGAT AAATTTTGTC 
TTTGCTCTAA TTTATAATCT GGTTGGAATT CCCATAGCTG CTGGAGTTTT TATGCCCATT 
GGTTTGGTTT TGCAGCCCTG GATGGGATCT GCAGCAATGG CTGCTTCATC TGTTTCTGTA 
GTACTTTCTT CTCTCTTCCT TAAACTTTAC AGGAAACCAA CTTACGAGAG TTATGAACTG 
CCTGCCCGGA GCCAGATAGG ACAGAAGAGT CCTTCAGAAA TCAGCGTTCA TGTTGGAATA 
GATGATACCT CAAGGAATTC TCCTAAACTG GGTTTGCTGG ACCGGATTGT TAATTATAGC 
AGAGCCTCTA TAAACTCACT ACTGTCTGAT AAACGCTCCC TAAACAGTGT TGTTACCAGT 
GAACCTGACA AGCACTCACT CCTGGTGGGA GACTTCAGGG AAGATGATGA CACTGCATTA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association between polymorphisms in CTR1, CTR2, ATP7A, and ATP7B and platinum resistance in epithelial ovarian cancer.
International journal of clinical pharmacology and therapeutics55(10)774-780(2017 Oct)
Li T,Peng J,Zeng F,Zhang K,Liu J,Li X,Ouyang Q,Wang G,Wang L,Liu Z,Liu Y

ATP7A-related copper transport diseases-emerging concepts and future trends.
Nature reviews. Neurology7(1)15-29(2011 Jan)
Kaler SG

Evidence for a Menkes-like protein with a nuclear targeting sequence.
The Biochemical journal350 Pt 3855-63(2000 Sep)
Reddy MC,Majumdar S,Harris ED

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ATP7A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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