AT4G10010 cDNA ORF clone, Arabidopsis thaliana(thale cress)

The following AT4G10010 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AT4G10010 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OAb14499 NM_117069.2
Latest version!
Arabidopsis thaliana Protein kinase superfamily protein (AT4G10010), mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $258.30
$369.00
OAb39105 NM_001340648.1
Latest version!
Arabidopsis thaliana Protein kinase superfamily protein (AT4G10010), mRNA. pcDNA3.1-C-(k)DYK or customized vector 14-16 $342.30
$489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

  • Reference Sequences (Refseq)
    CloneID OAb14499
    Clone ID Related Accession (Same CDS sequence) NM_117069.2
    Accession Version NM_117069.2 Latest version! Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 1410bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2019-02-13
    Organism Arabidopsis thaliana(thale cress)
    Product Protein kinase superfamily protein
    Comment Comment: REVIEWED REFSEQ: This record has been curated by TAIR and Araport. This record is derived from an annotated genomic sequence (NC_003075). On May 13, 2003 this sequence version replaced NM_117069.1.

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    ATGGTAGCAA TGAAGAAGGT CAGGTTCGTT AATATGGATC CGGAAAGCGT GAGATTCATG 
    GCTAGAGAAA TCAACATCTT GCGGAAACTA GACCATCCAA ACGTTATGAA GCTTGAATGT
    CTTGTGACCT CTAAACTCTC TGGTAGCTTG TACCTTGTGT TTGAGTACAT GGAGCATGAT
    CTTTCCGGTC TCGCTCTTAG ACCCGGTGTA AAATTTACTG AATCTCAGAT CAAATGTTAC
    ATGAAACAAT TGCTTAGCGG GCTTGAGCAC TGCCACAGCC GTGGAATCCT CCACCGCGAC
    ATTAAGGGTC CAAATCTCTT GGTAAACAAT GATGGAGTCC TCAAGATTGG AGATTTTGGT
    CTGGCGAATA TCTATCATCC AGAACAAGAT CAACCTTTGA CGAGCCGTGT AGTAACCTTG
    TGGTACAGAG CCCCTGAGCT TCTACTGGGA GCTACAGAAT ATGGTCCAGG GATAGATTTG
    TGGAGTGTTG GTTGCATTCT CACAGAACTG TTTTTAGGGA AACCAATCAT GCCGGGAAGA
    ACAGAGGTGG AGCAAATGCA TAAGATCTTC AAGTTTTGTG GTTCACCAAG TGATGATTAC
    TGGCAAAAGA CAAAGCTACC ACTTGCAACA AGTTTCAAGC CGCAACAACC TTATAAACGT
    GTCCTTCTAG AGACTTTCAA GAACTTACCA CCTTCTGCTC TAGCTCTTGT TGACAAACTT
    CTATCCTTAG AACCAGCGAA GCGTGGCACG GCTTCTTCGA CACTAAGTAG CAAGTTCTTC
    ACTATGGAAC CACTCCCTTG TAATGTATCA AGTTTGCCAA AGTATCCTCC AAGCAAGGAA
    CTTGATGCAA AGGTCCGTGA TGAAGAAGCA AGAAGGAAAA AGTCTGAAAC GGTGAAGGGT
    CGTGGACCTG AATCTGTGAG ACGAGGTTCG AGAGACTTCA AGAGTACTGC TACAACACCA
    GAGTTCGTTG CTTCAGGGCA GTCAAAAGAC ACAATCACCA CCAAGAGATT CAATCCTCAG
    GAAGACAGTA GAACAGGCTT GAGAGGCGAC AGAGATCAGA AAGGCTTTTC TCATACCAAT
    TCAATGATTC ATCCAAGCAT AACAGCAACA TGGAGTAAAA ATGAGAGCTG TAGGAACAAT
    GTAGTTGAGC TAAAGGCTAC TCGATCAAGC AATGTGCCCA TGACTGGGAG ATACTTGTCT
    CCTTCACATA AAGAAGATGT AGCCGTACAA ACCACAACGA CATACGTACG CAAGAAGAAC
    AGAATGCATT GTTCGGGACC ATTGATGCCT CCTGGTGGAA ACATTGAGGA CATATTGAAA
    GACCATGAGA GACAAATCCA AGAAGCTGTA AGGAAATCAC GGCTTGAGAA ATCTGCTACA
    AGGAAAAATA ACAAAACATG TGTAAAGTGA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq NP_192739.2
    CDS442..1851
    Translation

    Target ORF information:

    RefSeq Version NM_117069.2
    Organism Arabidopsis thaliana(thale cress)
    Definition Arabidopsis thaliana Protein kinase superfamily protein (AT4G10010), mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    NM_117069.2

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    ATGGTAGCAA TGAAGAAGGT CAGGTTCGTT AATATGGATC CGGAAAGCGT GAGATTCATG 
    GCTAGAGAAA TCAACATCTT GCGGAAACTA GACCATCCAA ACGTTATGAA GCTTGAATGT
    CTTGTGACCT CTAAACTCTC TGGTAGCTTG TACCTTGTGT TTGAGTACAT GGAGCATGAT
    CTTTCCGGTC TCGCTCTTAG ACCCGGTGTA AAATTTACTG AATCTCAGAT CAAATGTTAC
    ATGAAACAAT TGCTTAGCGG GCTTGAGCAC TGCCACAGCC GTGGAATCCT CCACCGCGAC
    ATTAAGGGTC CAAATCTCTT GGTAAACAAT GATGGAGTCC TCAAGATTGG AGATTTTGGT
    CTGGCGAATA TCTATCATCC AGAACAAGAT CAACCTTTGA CGAGCCGTGT AGTAACCTTG
    TGGTACAGAG CCCCTGAGCT TCTACTGGGA GCTACAGAAT ATGGTCCAGG GATAGATTTG
    TGGAGTGTTG GTTGCATTCT CACAGAACTG TTTTTAGGGA AACCAATCAT GCCGGGAAGA
    ACAGAGGTGG AGCAAATGCA TAAGATCTTC AAGTTTTGTG GTTCACCAAG TGATGATTAC
    TGGCAAAAGA CAAAGCTACC ACTTGCAACA AGTTTCAAGC CGCAACAACC TTATAAACGT
    GTCCTTCTAG AGACTTTCAA GAACTTACCA CCTTCTGCTC TAGCTCTTGT TGACAAACTT
    CTATCCTTAG AACCAGCGAA GCGTGGCACG GCTTCTTCGA CACTAAGTAG CAAGTTCTTC
    ACTATGGAAC CACTCCCTTG TAATGTATCA AGTTTGCCAA AGTATCCTCC AAGCAAGGAA
    CTTGATGCAA AGGTCCGTGA TGAAGAAGCA AGAAGGAAAA AGTCTGAAAC GGTGAAGGGT
    CGTGGACCTG AATCTGTGAG ACGAGGTTCG AGAGACTTCA AGAGTACTGC TACAACACCA
    GAGTTCGTTG CTTCAGGGCA GTCAAAAGAC ACAATCACCA CCAAGAGATT CAATCCTCAG
    GAAGACAGTA GAACAGGCTT GAGAGGCGAC AGAGATCAGA AAGGCTTTTC TCATACCAAT
    TCAATGATTC ATCCAAGCAT AACAGCAACA TGGAGTAAAA ATGAGAGCTG TAGGAACAAT
    GTAGTTGAGC TAAAGGCTAC TCGATCAAGC AATGTGCCCA TGACTGGGAG ATACTTGTCT
    CCTTCACATA AAGAAGATGT AGCCGTACAA ACCACAACGA CATACGTACG CAAGAAGAAC
    AGAATGCATT GTTCGGGACC ATTGATGCCT CCTGGTGGAA ACATTGAGGA CATATTGAAA
    GACCATGAGA GACAAATCCA AGAAGCTGTA AGGAAATCAC GGCTTGAGAA ATCTGCTACA
    AGGAAAAATA ACAAAACATG TGTAAAGTGA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    CloneID OAb39105
    Clone ID Related Accession (Same CDS sequence) NM_001340648.1
    Accession Version NM_001340648.1 Latest version! Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 1950bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2019-02-13
    Organism Arabidopsis thaliana(thale cress)
    Product Protein kinase superfamily protein
    Comment Comment: REVIEWED REFSEQ: This record has been curated by TAIR and Araport. This record is derived from an annotated genomic sequence (NC_003075).

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    ATGGGCTGCA TTTGCTCAAA AGGAACTGCA GAAGAAGAAG TTAGTGACCA ACATGAGAAA 
    CCAAAAGAGA ATTGGAACAA AACGTCCTCA GTTCAATTGA TTGCTCCTGT AACTTCCAAG
    AAAGATGAGT TTTCACATAA ATCCGTTGAT GGAAGCTCTG GTGGACGTAA AGCTGATGGT
    TTAGCACATA AACCATCCGC TAGAGCTAGT GGATTGATTG TTCCTGTAGA TGATAGTGAC
    GGTAAAACAG TAATTGTAGA GAGACCTACA AGGTGTCACA GGAGATGGCC AACTGCAGAT
    ATTGGAACAG GAGGAGGAGG ATTCAATATT TTTCCACCGA GTAATATTCC CACAAGTGTT
    CCACATAGCC CTGAGGCCGA GCTTATTGCA GCTGGATGGC CTTCTTGGTT AACTTCTGTT
    GCAGGTGAAG CCATCAAAGG TTGGGTTCCA CGACGAGCAG AGTCTTTTGA GAAGCTGGAC
    AAAATTGGAC AAGGGACTTA CAGTAGCGTG TACAGAGCCC GGGATCTTGA GACCGGTAAA
    ATGGTAGCAA TGAAGAAGGT CAGGTTCGTT AATATGGATC CGGAAAGCGT GAGATTCATG
    GCTAGAGAAA TCAACATCTT GCGGAAACTA GACCATCCAA ACGTTATGAA GCTTGAATGT
    CTTGTGACCT CTAAACTCTC TGGTAGCTTG TACCTTGTGT TTGAGTACAT GGAGCATGAT
    CTTTCCGGTC TCGCTCTTAG ACCCGGTGTA AAATTTACTG AATCTCAGAT CAAATGTTAC
    ATGAAACAAT TGCTTAGCGG GCTTGAGCAC TGCCACAGCC GTGGAATCCT CCACCGCGAC
    ATTAAGGGTC CAAATCTCTT GGTAAACAAT GATGGAGTCC TCAAGATTGG AGATTTTGGT
    CTGGCGAATA TCTATCATCC AGAACAAGAT CAACCTTTGA CGAGCCGTGT AGTAACCTTG
    TGGTACAGAG CCCCTGAGCT TCTACTGGGA GCTACAGAAT ATGGTCCAGG GATAGATTTG
    TGGAGTGTTG GTTGCATTCT CACAGAACTG TTTTTAGGGA AACCAATCAT GCCGGGAAGA
    ACAGAGGTGG AGCAAATGCA TAAGATCTTC AAGTTTTGTG GTTCACCAAG TGATGATTAC
    TGGCAAAAGA CAAAGCTACC ACTTGCAACA AGTTTCAAGC CGCAACAACC TTATAAACGT
    GTCCTTCTAG AGACTTTCAA GAACTTACCA CCTTCTGCTC TAGCTCTTGT TGACAAACTT
    CTATCCTTAG AACCAGCGAA GCGTGGCACG GCTTCTTCGA CACTAAGTAG CAAGTTCTTC
    ACTATGGAAC CACTCCCTTG TAATGTATCA AGTTTGCCAA AGTATCCTCC AAGCAAGGAA
    CTTGATGCAA AGGTCCGTGA TGAAGAAGCA AGAAGGAAAA AGTCTGAAAC GGTGAAGGGT
    CGTGGACCTG AATCTGTGAG ACGAGGTTCG AGAGACTTCA AGAGTACTGC TACAACACCA
    GAGTTCGTTG CTTCAGGGCA GTCAAAAGAC ACAATCACCA CCAAGAGATT CAATCCTCAG
    GAAGACAGTA GAACAGGCTT GAGAGGCGAC AGAGATCAGA AAGGCTTTTC TCATACCAAT
    TCAATGATTC ATCCAAGCAT AACAGCAACA TGGAGTAAAA ATGAGAGCTG TAGGAACAAT
    GTAGTTGAGC TAAAGGCTAC TCGATCAAGC AATGTGCCCA TGACTGGGAG ATACTTGTCT
    CCTTCACATA AAGAAGATGT AGCCGTACAA ACCACAACGA CATACGTACG CAAGAAGAAC
    AGAATGCATT GTTCGGGACC ATTGATGCCT CCTGGTGGAA ACATTGAGGA CATATTGAAA
    GACCATGAGA GACAAATCCA AGAAGCTGTA AGGAAATCAC GGCTTGAGAA ATCTGCTACA
    AGGAAAAATA ACAAAACATG TGTAAAGTGA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq NP_001328367.1
    CDS595..2544
    Translation

    Target ORF information:

    RefSeq Version NM_001340648.1
    Organism Arabidopsis thaliana(thale cress)
    Definition Arabidopsis thaliana Protein kinase superfamily protein (AT4G10010), mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    NM_001340648.1

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    ATGGGCTGCA TTTGCTCAAA AGGAACTGCA GAAGAAGAAG TTAGTGACCA ACATGAGAAA 
    CCAAAAGAGA ATTGGAACAA AACGTCCTCA GTTCAATTGA TTGCTCCTGT AACTTCCAAG
    AAAGATGAGT TTTCACATAA ATCCGTTGAT GGAAGCTCTG GTGGACGTAA AGCTGATGGT
    TTAGCACATA AACCATCCGC TAGAGCTAGT GGATTGATTG TTCCTGTAGA TGATAGTGAC
    GGTAAAACAG TAATTGTAGA GAGACCTACA AGGTGTCACA GGAGATGGCC AACTGCAGAT
    ATTGGAACAG GAGGAGGAGG ATTCAATATT TTTCCACCGA GTAATATTCC CACAAGTGTT
    CCACATAGCC CTGAGGCCGA GCTTATTGCA GCTGGATGGC CTTCTTGGTT AACTTCTGTT
    GCAGGTGAAG CCATCAAAGG TTGGGTTCCA CGACGAGCAG AGTCTTTTGA GAAGCTGGAC
    AAAATTGGAC AAGGGACTTA CAGTAGCGTG TACAGAGCCC GGGATCTTGA GACCGGTAAA
    ATGGTAGCAA TGAAGAAGGT CAGGTTCGTT AATATGGATC CGGAAAGCGT GAGATTCATG
    GCTAGAGAAA TCAACATCTT GCGGAAACTA GACCATCCAA ACGTTATGAA GCTTGAATGT
    CTTGTGACCT CTAAACTCTC TGGTAGCTTG TACCTTGTGT TTGAGTACAT GGAGCATGAT
    CTTTCCGGTC TCGCTCTTAG ACCCGGTGTA AAATTTACTG AATCTCAGAT CAAATGTTAC
    ATGAAACAAT TGCTTAGCGG GCTTGAGCAC TGCCACAGCC GTGGAATCCT CCACCGCGAC
    ATTAAGGGTC CAAATCTCTT GGTAAACAAT GATGGAGTCC TCAAGATTGG AGATTTTGGT
    CTGGCGAATA TCTATCATCC AGAACAAGAT CAACCTTTGA CGAGCCGTGT AGTAACCTTG
    TGGTACAGAG CCCCTGAGCT TCTACTGGGA GCTACAGAAT ATGGTCCAGG GATAGATTTG
    TGGAGTGTTG GTTGCATTCT CACAGAACTG TTTTTAGGGA AACCAATCAT GCCGGGAAGA
    ACAGAGGTGG AGCAAATGCA TAAGATCTTC AAGTTTTGTG GTTCACCAAG TGATGATTAC
    TGGCAAAAGA CAAAGCTACC ACTTGCAACA AGTTTCAAGC CGCAACAACC TTATAAACGT
    GTCCTTCTAG AGACTTTCAA GAACTTACCA CCTTCTGCTC TAGCTCTTGT TGACAAACTT
    CTATCCTTAG AACCAGCGAA GCGTGGCACG GCTTCTTCGA CACTAAGTAG CAAGTTCTTC
    ACTATGGAAC CACTCCCTTG TAATGTATCA AGTTTGCCAA AGTATCCTCC AAGCAAGGAA
    CTTGATGCAA AGGTCCGTGA TGAAGAAGCA AGAAGGAAAA AGTCTGAAAC GGTGAAGGGT
    CGTGGACCTG AATCTGTGAG ACGAGGTTCG AGAGACTTCA AGAGTACTGC TACAACACCA
    GAGTTCGTTG CTTCAGGGCA GTCAAAAGAC ACAATCACCA CCAAGAGATT CAATCCTCAG
    GAAGACAGTA GAACAGGCTT GAGAGGCGAC AGAGATCAGA AAGGCTTTTC TCATACCAAT
    TCAATGATTC ATCCAAGCAT AACAGCAACA TGGAGTAAAA ATGAGAGCTG TAGGAACAAT
    GTAGTTGAGC TAAAGGCTAC TCGATCAAGC AATGTGCCCA TGACTGGGAG ATACTTGTCT
    CCTTCACATA AAGAAGATGT AGCCGTACAA ACCACAACGA CATACGTACG CAAGAAGAAC
    AGAATGCATT GTTCGGGACC ATTGATGCCT CCTGGTGGAA ACATTGAGGA CATATTGAAA
    GACCATGAGA GACAAATCCA AGAAGCTGTA AGGAAATCAC GGCTTGAGAA ATCTGCTACA
    AGGAAAAATA ACAAAACATG TGTAAAGTGA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

  • PubMed

    Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.
    Nature402(6763)769-77(1999 Dec)
    Mayer K,Sch?ller C,Wambutt R,Murphy G,Volckaert G,Pohl T,D?sterh?ft A,Stiekema W,Entian KD,Terryn N,Harris B,Ansorge W,Brandt P,Grivell L,Rieger M,Weichselgartner M,de Simone V,Obermaier B,Mache R,M?ller M,Kreis M,Delseny M,Puigdomenech P,Watson M,Schmidtheini T,Reichert B,Portatelle D,Perez-Alonso M,Boutry M,Bancroft I,Vos P,Hoheisel J,Zimmermann W,Wedler H,Ridley P,Langham SA,McCullagh B,Bilham L,Robben J,Van der Schueren J,Grymonprez B,Chuang YJ,Vandenbussche F,Braeken M,Weltjens I,Voet M,Bastiaens I,Aert R,Defoor E,Weitzenegger T,Bothe G,Ramsperger U,Hilbert H,Braun M,Holzer E,Brandt A,Peters S,van Staveren M,Dirske W,Mooijman P,Klein Lankhorst R,Rose M,Hauf J,K?tter P,Berneiser S,Hempel S,Feldpausch M,Lamberth S,Van den Daele H,De Keyser A,Buysshaert C,Gielen J,Villarroel R,De Clercq R,Van Montagu M,Rogers J,Cronin A,Quail M,Bray-Allen S,Clark L,Doggett J,Hall S,Kay M,Lennard N,McLay K,Mayes R,Pettett A,Rajandream MA,Lyne M,Benes V,Rechmann S,Borkova D,Bl?cker H,Scharfe M,Grimm M,L?hnert TH,Dose S,de Haan M,Maarse A,Sch?fer M,M?ller-Auer S,Gabel C,Fuchs M,Fartmann B,Granderath K,Dauner D,Herzl A,Neumann S,Argiriou A,Vitale D,Liguori R,Piravandi E,Massenet O,Quigley F,Clabauld G,M?ndlein A,Felber R,Schnabl S,Hiller R,Schmidt W,Lecharny A,Aubourg S,Chefdor F,Cooke R,Berger C,Montfort A,Casacuberta E,Gibbons T,Weber N,Vandenbol M,Bargues M,Terol J,Torres A,Perez-Perez A,Purnelle B,Bent E,Johnson S,Tacon D,Jesse T,Heijnen L,Schwarz S,Scholler P,Heber S,Francs P,Bielke C,Frishman D,Haase D,Lemcke K,Mewes HW,Stocker S,Zaccaria P,Bevan M,Wilson RK,de la Bastide M,Habermann K,Parnell L,Dedhia N,Gnoj L,Schutz K,Huang E,Spiegel L,Sehkon M,Murray J,Sheet P,Cordes M,Abu-Threideh J,Stoneking T,Kalicki J,Graves T,Harmon G,Edwards J,Latreille P,Courtney L,Cloud J,Abbott A,Scott K,Johnson D,Minx P,Bentley D,Fulton B,Miller N,Greco T,Kemp K,Kramer J,Fulton L,Mardis E,Dante M,Pepin K,Hillier L,Nelson J,Spieth J,Ryan E,Andrews S,Geisel C,Layman D,Du H,Ali J,Berghoff A,Jones K,Drone K,Cotton M,Joshu C,Antonoiu B,Zidanic M,Strong C,Sun H,Lamar B,Yordan C,Ma P,Zhong J,Preston R,Vil D,Shekher M,Matero A,Shah R,Swaby IK,O'Shaughnessy A,Rodriguez M,Hoffmann J,Till S,Granat S,Shohdy N,Hasegawa A,Hameed A,Lodhi M,Johnson A,Chen E,Marra M,Martienssen R,McCombie WR