CASP3 cDNA ORF clone, Sus scrofa(pig)

Gene
Clones
gRNAs

Summary

Gene Symbol	CASP3
Entrez Gene ID	397244
Full Name	caspase 3
Gene Type	protein-coding
Organism	Sus scrofa(pig)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005671704.2	XP_005671761.2	caspase-3
NM_214131.1	NP_999296.1	caspase-3

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Apoptosis induced by lipid-associated membrane proteins from Mycoplasma hyopneumoniae in a porcine lung epithelial cell line with the involvement of caspase 3 and the MAPK pathway.
Ni B, Bai FF, Wei Y, Liu MJ, Feng ZX, Xiong QY, Hua LZ, Shao GQ
Genetics and molecular research : GMR14(3)11429-43(2015 Sep)

Sirt1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine preadipocytes.
Pang WJ, Xiong Y, Wang Y, Tong Q, Yang GS
Experimental cell research319(5)670-83(2013 Mar)

Zearalenone induces apoptosis and necrosis in porcine granulosa cells via a caspase-3- and caspase-9-dependent mitochondrial signaling pathway.
Zhu L, Yuan H, Guo C, Lu Y, Deng S, Yang Y, Wei Q, Wen L, He Z
Journal of cellular physiology227(5)1814-20(2012 May)

Presence of cleaved caspase 3 in swine embryos of different developmental capacities produced by parthenogenetic activation.
Coutinho AR, Assump??o ME, Bordignon V
Molecular reproduction and development78(9)673-83(2011 Sep)

Resuscitation of newborn piglets. short-term influence of FiO2 on matrix metalloproteinases, caspase-3 and BDNF.
Solberg R, L?berg EM, Andresen JH, Wright MS, Charrat E, Khrestchatisky M, Rivera S, Saugstad OD
PloS one5(12)e14261(2010 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study demonstrated that LAMPs from M. hyopneumoniae can induce apoptosis in St. Jude porcine lung epithelial cell line through the activation of caspase 3, caspase 8, cyt c, Bax, and p38 MAPK.
Title: Apoptosis induced by lipid-associated membrane proteins from Mycoplasma hyopneumoniae in a porcine lung epithelial cell line with the involvement of caspase 3 and the MAPK pathway.

Results suggest that zearalenone induces apoptosis and necrosis of porcine granulosa cells in a dose-dependent manner via a caspase-3- and caspase-9-dependent mitochondrial pathway.
Title: Zearalenone induces apoptosis and necrosis in porcine granulosa cells via a caspase-3- and caspase-9-dependent mitochondrial signaling pathway.

Caspase-3 (CC3) was shown to be more abundant in early-cleaving and more developmentally competent embryos compared to late-cleaving and less developmentally competent embryos.
Title: Presence of cleaved caspase 3 in swine embryos of different developmental capacities produced by parthenogenetic activation.

FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 and MMP-2, caspase-3 and BDNF
Title: Resuscitation of newborn piglets. short-term influence of FiO2 on matrix metalloproteinases, caspase-3 and BDNF.

Ischemic preconditioning exerts a powerful protective effect against hepatic ischemia-reperfusion injury in the early phase of reperfusion, which may be mediated by preservation of mitochondrial structure and inhibition of caspase-3 activity.
Title: Ischemic preconditioning protects the pig liver by preserving the mitochondrial structure and downregulating caspase-3 activity.

The following CASP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CASP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSe00558	NM_214131.1 Latest version!	Sus scrofa caspase 3 (CASP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OSe43764	XM_005671704.2 Latest version!	Sus scrofa caspase 3, apoptosis-related cysteine peptidase (CASP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CASP3 ( NM_214131.1 ) cDNA ORF clone, Sus scrofa(pig) -> NP_999296.1 Sus scrofa caspase 3 (CASP3), mRNA.

Price & Availability↑

CloneID	OSe00558
Clone ID Related Accession (Same CDS sequence)	NM_214131.1
Accession Version	NM_214131.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Sus scrofa(pig)
Product	caspase-3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB029345.1. ##Evidence-Data-START## Transcript exon combination :: AB029345.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1487420, SAMEA1876824 [ECO:0000350] ##Evidence-Data-END##

ATGGAGAACA ATAAAACCTC CGTGGATTCA AAATCCATTA AAACTTTGGA GACAAAGATC 
TTACATGGAA GCAAATCAAT GGACTCTGGA ATATCCTTGG ATGTCAGTTA CAAAATGGAT 
TATCCTGAAA TGGGTTTATG TATAATAATT AATAATAAGA ACTTTGATAA AAATACCGGA 
ATGGCATGTC GATCTGGTAC AGATGTGGAT GCTGCAAATC TCAGGGAGAC CTTCACAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTTT GGAGTTAATG 
CACAGTGTTT CTAAAGAAGA CCATAGCAAA AGGAGCAGTT TTATTTGCGT GCTTCTAAGC 
CATGGTGAAG AAGGAAAAAT TTTTGGAACA AATGGACCTG TTGATCTGAA AAAATTAACA 
AGTTTCTTCA GAGGGGACTG CTGTAGAACT CTAACTGGCA AACCCAAACT TTTCATAATT 
CAGGCCTGCC GAGGCACAGA ATTGGACTGT GGGATTGAGA CGGACAGTGG GACTGAAGAT 
GACATGGCGT GTCAGAAAAT ACCAGTTGAG GCAGACTTCT TGTATGCATA TTCTACAGCA 
CCTGGTTACT ATTCCTGGCG AAATTCAAAG GACGGATCCT GGTTCATCCA GTCACTTTGT 
GCAGCGCTGA AACAGTATGT TCACAAGCTT GAGCTTATGC ACATTCTTAC TCGGGTTAAC 
CGAAAGGTAG CAGTAGAATT CGAGTCCTTT TCTACTGACT CTACTTTTCA TGCAAAGAAA 
CAGATTCCAT GTATTGTGTC CATGCTCACA AAAGAACTCT ACTTTTATCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_999296.1
CDS	1..834
Translation	MENNKTSVDSKSIKTLETKILHGSKSMDSGISLDVSYKMDYPEMGLCIIINNKNFDKNTGMACRSGTDVDAANLRETFTNLKYEVRNKNDLTREEILELMHSVSKEDHSKRSSFICVLLSHGEEGKIFGTNGPVDLKKLTSFFRGDCCRTLTGKPKLFIIQACRGTELDCGIETDSGTEDDMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAALKQYVHKLELMHILTRVNRKVAVEFESFSTDSTFHAKKQIPCIVSMLTKELYFYH

Target ORF information:

RefSeq Version	NM_214131.1
Organism	Sus scrofa(pig)
Definition	Sus scrofa caspase 3 (CASP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_214131.1

ORF Insert Sequence:

ATGGAGAACA ATAAAACCTC CGTGGATTCA AAATCCATTA AAACTTTGGA GACAAAGATC 
TTACATGGAA GCAAATCAAT GGACTCTGGA ATATCCTTGG ATGTCAGTTA CAAAATGGAT 
TATCCTGAAA TGGGTTTATG TATAATAATT AATAATAAGA ACTTTGATAA AAATACCGGA 
ATGGCATGTC GATCTGGTAC AGATGTGGAT GCTGCAAATC TCAGGGAGAC CTTCACAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTTT GGAGTTAATG 
CACAGTGTTT CTAAAGAAGA CCATAGCAAA AGGAGCAGTT TTATTTGCGT GCTTCTAAGC 
CATGGTGAAG AAGGAAAAAT TTTTGGAACA AATGGACCTG TTGATCTGAA AAAATTAACA 
AGTTTCTTCA GAGGGGACTG CTGTAGAACT CTAACTGGCA AACCCAAACT TTTCATAATT 
CAGGCCTGCC GAGGCACAGA ATTGGACTGT GGGATTGAGA CGGACAGTGG GACTGAAGAT 
GACATGGCGT GTCAGAAAAT ACCAGTTGAG GCAGACTTCT TGTATGCATA TTCTACAGCA 
CCTGGTTACT ATTCCTGGCG AAATTCAAAG GACGGATCCT GGTTCATCCA GTCACTTTGT 
GCAGCGCTGA AACAGTATGT TCACAAGCTT GAGCTTATGC ACATTCTTAC TCGGGTTAAC 
CGAAAGGTAG CAGTAGAATT CGAGTCCTTT TCTACTGACT CTACTTTTCA TGCAAAGAAA 
CAGATTCCAT GTATTGTGTC CATGCTCACA AAAGAACTCT ACTTTTATCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASP3 ( XM_005671704.2 ) cDNA ORF clone, Sus scrofa(pig) -> XP_005671761.2 Sus scrofa caspase 3, apoptosis-related cysteine peptidase (CASP3), mRNA.

Price & Availability↑

CloneID	OSe43764
Clone ID Related Accession (Same CDS sequence)	XM_005671704.2
Accession Version	XM_005671704.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-09-10
Organism	Sus scrofa(Pig)
Product	caspase-3
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003612194.1) and transcript sequence (AB029345.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 11, 2015 this sequence version replaced XM_005671704.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Sus scrofa Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## assembly gap :: added 235 transcript bases to patch genome assembly gap ##RefSeq-Attributes-END##

ATGGCGAACA CTAAAAACTC AGTGGATTCA AAATCCATTA AAACTTTGGA GACAAAGATC 
TTACATGGAA GCAAATCAGT GGACTCTGGA ATATCCTTGG ATGTCAGTTA CAAAATGGAT 
TATCCTGAAA TGGGTTTATG TATAATAATT AATAATAAGA ACTTTGATAA AAATACCGGA 
ATGGCATGTC GATCTGGTAC AGATGTGGAT GCTGCAAATC TCAGGGAGAC CTTCACAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTTT GGAGTTAATG 
CACAGTGTTT CTAAAGAAGA CCATAGTAAA AGGAGCAGTT TTATTTGCGT GCTTCTAAGC 
CATGGTGAAG AAGGAAAAAT TTTTGGAACA AATGGACCTG TTGATCTGAA AAAATTAACA 
AGTTTCTTCA GAGGGGACTG TTGTAGAACT CTAACTGGCA AACCCAAACT TTTCATAATT 
CAGGCCTGCC GAGGCACAGA ATTGGACTGT GGGATTGAGA CGGACAGTGG GACTGAAGAT 
GACATGGCGT GTCAGAAAAT ACCAGTTGAG GCAGACTTCT TGTATGCATA TTCTACAGCA 
CCTGGTTACT ATTCCTGGCG AAATTCAAAG GACGGATCCT GGTTCATCCA GTCACTTTGT 
GCAGCGCTGA AACAGTATGT TCACAAGCTT GAGCTTATGC ACATTCTTAC TCGGGTTAAC 
CGAAAGGTAG CAGTAGAATT CGAGTCCTTT TCTACTGACT CTACTTTTCA TGCAAAGAAA 
CAGATTCCAT GTATTGTGTC CATGCTCACA AAAGAACTCT ACTTTTATCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005671761.2
CDS	17..850
Translation	MANTKNSVDSKSIKTLETKILHGSKSVDSGISLDVSYKMDYPEMGLCIIINNKNFDKNTGMACRSGTDVDAANLRETFTNLKYEVRNKNDLTREEILELMHSVSKEDHSKRSSFICVLLSHGEEGKIFGTNGPVDLKKLTSFFRGDCCRTLTGKPKLFIIQACRGTELDCGIETDSGTEDDMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAALKQYVHKLELMHILTRVNRKVAVEFESFSTDSTFHAKKQIPCIVSMLTKELYFYH

Target ORF information:

RefSeq Version	XM_005671704.2
Organism	Sus scrofa(Pig)
Definition	Sus scrofa caspase 3, apoptosis-related cysteine peptidase (CASP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005671704.2

ORF Insert Sequence:

ATGGCGAACA CTAAAAACTC AGTGGATTCA AAATCCATTA AAACTTTGGA GACAAAGATC 
TTACATGGAA GCAAATCAGT GGACTCTGGA ATATCCTTGG ATGTCAGTTA CAAAATGGAT 
TATCCTGAAA TGGGTTTATG TATAATAATT AATAATAAGA ACTTTGATAA AAATACCGGA 
ATGGCATGTC GATCTGGTAC AGATGTGGAT GCTGCAAATC TCAGGGAGAC CTTCACAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTTT GGAGTTAATG 
CACAGTGTTT CTAAAGAAGA CCATAGTAAA AGGAGCAGTT TTATTTGCGT GCTTCTAAGC 
CATGGTGAAG AAGGAAAAAT TTTTGGAACA AATGGACCTG TTGATCTGAA AAAATTAACA 
AGTTTCTTCA GAGGGGACTG TTGTAGAACT CTAACTGGCA AACCCAAACT TTTCATAATT 
CAGGCCTGCC GAGGCACAGA ATTGGACTGT GGGATTGAGA CGGACAGTGG GACTGAAGAT 
GACATGGCGT GTCAGAAAAT ACCAGTTGAG GCAGACTTCT TGTATGCATA TTCTACAGCA 
CCTGGTTACT ATTCCTGGCG AAATTCAAAG GACGGATCCT GGTTCATCCA GTCACTTTGT 
GCAGCGCTGA AACAGTATGT TCACAAGCTT GAGCTTATGC ACATTCTTAC TCGGGTTAAC 
CGAAAGGTAG CAGTAGAATT CGAGTCCTTT TCTACTGACT CTACTTTTCA TGCAAAGAAA 
CAGATTCCAT GTATTGTGTC CATGCTCACA AAAGAACTCT ACTTTTATCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Apoptosis induced by lipid-associated membrane proteins from Mycoplasma hyopneumoniae in a porcine lung epithelial cell line with the involvement of caspase 3 and the MAPK pathway.
Genetics and molecular research : GMR14(3)11429-43(2015 Sep)
Ni B,Bai FF,Wei Y,Liu MJ,Feng ZX,Xiong QY,Hua LZ,Shao GQ

Sirt1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine preadipocytes.
Experimental cell research319(5)670-83(2013 Mar)
Pang WJ,Xiong Y,Wang Y,Tong Q,Yang GS

Zearalenone induces apoptosis and necrosis in porcine granulosa cells via a caspase-3- and caspase-9-dependent mitochondrial signaling pathway.
Journal of cellular physiology227(5)1814-20(2012 May)
Zhu L,Yuan H,Guo C,Lu Y,Deng S,Yang Y,Wei Q,Wen L,He Z

Presence of cleaved caspase 3 in swine embryos of different developmental capacities produced by parthenogenetic activation.
Molecular reproduction and development78(9)673-83(2011 Sep)
Coutinho AR,Assump??o ME,Bordignon V

Resuscitation of newborn piglets. short-term influence of FiO2 on matrix metalloproteinases, caspase-3 and BDNF.
PloS one5(12)e14261(2010 Dec)
Solberg R,L?berg EM,Andresen JH,Wright MS,Charrat E,Khrestchatisky M,Rivera S,Saugstad OD

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CASP3 cDNA ORF clone, Sus scrofa(pig)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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