SET5 cDNA ORF clone, Saccharomyces cerevisiae S288C

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.
Johnston M, Andrews S, Brinkman R, Cooper J, Ding H, Dover J, Du Z, Favello A, Fulton L, Gattung S
Science (New York, N.Y.)265(5181)2077-82(1994 Sep)

Set5 functions with Set1 to promote gene repression at telomeres.
Title: The histone methyltransferases Set5 and Set1 have overlapping functions in gene silencing and telomere maintenance.

Results revealed the novel functions of SET5 and PPR1 for the improvement of yeast acetic acid tolerance, and also implicated them in oxidative stress defense and energy metabolism in Saccharomyces cerevisiae.
Title: Improved growth and ethanol fermentation of Saccharomyces cerevisiae in the presence of acetic acid by overexpression of SET5 and PPR1.

The study uncovers novel pathways in which the methyltransferase Set5 participates and, more importantly, reveals a partnership between Set1 and Set5 in transcriptional repression near repetitive DNA elements in budding yeast.
Title: Set5 and Set1 cooperate to repress gene expression at telomeres and retrotransposons.

Genetic studies revealed that Set5 functions in cellular processes that also rely on the global chromatin modifying complexes COMPASS and NuA4, which methylate H3 lysine 4 and acetylate H4 lysines 5, 8 and 12, respectively.
Title: New marks on the block: Set5 methylates H4 lysines 5, 8 and 12.

identify Set5 as the first histone H4 methyltransferase, which monomethylates the critical H4 lysine residues 5, 8 and 12 in budding yeast
Title: Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses.