Gene Symbol | IRE1 |
Entrez Gene ID | 856478 |
Full Name | bifunctional endoribonuclease/protein kinase IRE1 |
Synonyms | ERN1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » IRE1 cDNA ORF clone
Gene Symbol | IRE1 |
Entrez Gene ID | 856478 |
Full Name | bifunctional endoribonuclease/protein kinase IRE1 |
Synonyms | ERN1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001179209.1 | NP_011946.1 | bifunctional endoribonuclease/protein kinase IRE1 |
Eremothecium gossypii | AGOS_ADR293C | NP_984389.2 |
Schizosaccharomyces pombe (fission yeast) | ire1 | NP_593384.1 |
Neurospora crassa | NCU02202 | XP_959521.1 |
Kluyveromyces lactis | KLLA0D13266g | XP_453654.1 |
Saccharomyces cerevisiae (baker's yeast) | IRE1 | NP_011946.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_15988 | XP_003708741.1 |
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.
Johnston M, Andrews S, Brinkman R, Cooper J, Ding H, Dover J, Du Z, Favello A, Fulton L, Gattung S
Science (New York, N.Y.)265(5181)2077-82(1994 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The most conserved transducer of ER stress, Ire1, uses an amphipathic helix to sense membrane aberrancies and control unfolded protein response activity.
Title: Activation of the Unfolded Protein Response by Lipid Bilayer Stress.
the AMPK Snf1p and ER stress kinase Ire1p regulated the HOG pathway.
Title: Metabolic respiration induces AMPK- and Ire1p-dependent activation of the p38-Type HOG MAPK pathway.
Deletion of MYO1 impairs the cluster formation of Ire1.
Title: F-actin and a type-II myosin are required for efficient clustering of the ER stress sensor Ire1.
Results show that the kinase domain autophosphorylatse the auto-inhibitory region in order to relieve auto-inhibition and that ADP acts as a switch to activate the kinase extension nuclease domain-catalyzed HAC1 mRNA cleavage.
Title: An ire1-phk1 chimera reveals a dispensable role of autokinase activity in endoplasmic reticulum stress response.
Here we show that in yeast cells, the ER-stress sensor Ire1 was activated upon zinc deficiency
Title: Zinc depletion activates the endoplasmic reticulum-stress sensor Ire1 via pleiotropic mechanisms.
The following IRE1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IRE1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi05278 | |
Clone ID Related Accession (Same CDS sequence) | NM_001179209.1 | |
Accession Version | NM_001179209.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3348bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | bifunctional endoribonuclease/protein kinase IRE1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001140). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Veresion :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGCGTCTAC TTCGAAGAAA CATGTTAGTA TTGACACTGC TCGTTTGTGT GTTTTCATCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_011946.1 |
CDS | 1..3348 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001179209.1 |
1 | ATGCGTCTAC TTCGAAGAAA CATGTTAGTA TTGACACTGC TCGTTTGTGT GTTTTCATCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Life with 6000 genes. |
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII. |