Gene Symbol | MIP1 |
Entrez Gene ID | 854508 |
Full Name | DNA-directed DNA polymerase gamma MIP1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » MIP1 cDNA ORF clone
Gene Symbol | MIP1 |
Entrez Gene ID | 854508 |
Full Name | DNA-directed DNA polymerase gamma MIP1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001183750.1 | NP_014975.2 | DNA-directed DNA polymerase gamma MIP1 |
Pan troglodytes (chimpanzee) | POLG | XP_523149.2 |
Bos taurus (cattle) | POLG | XP_002696610.2 |
Schizosaccharomyces pombe (fission yeast) | pog1 | NP_588025.2 |
Canis lupus familiaris (dog) | POLG | XP_005618410.1 |
Mus musculus (house mouse) | Polg | NP_059490.2 |
Gallus gallus (chicken) | POLG | XP_425079.4 |
Saccharomyces cerevisiae (baker's yeast) | MIP1 | NP_014975.2 |
POLG | XP_001092360.1 | |
Neurospora crassa | NCU00276 | XP_957747.2 |
Rattus norvegicus (Norway rat) | Polg | NP_445980.1 |
Drosophila melanogaster (fruit fly) | tam | NP_476821.1 |
Eremothecium gossypii | AGOS_ADR357C | NP_984453.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100488393 | XP_002932281.2 |
Homo sapiens (human) | POLG | NP_001119603.1 |
Danio rerio (zebrafish) | polg | XP_001921130.3 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000139 | XP_311006.5 |
Magnaporthe oryzae (rice blast fungus) | MGG_08913 | XP_003713942.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.
Dujon B, Albermann K, Aldea M, Alexandraki D, Ansorge W, Arino J, Benes V, Bohn C, Bolotin-Fukuhara M, Bordonn? R, Boyer J, Camasses A, Casamayor A, Casas C, Ch?ret G, Cziepluch C, Daignan-Fornier B, Dang DV, de Haan M, Delius H, Durand P, Fairhead C, Feldmann H, Gaillon L, Kleine K
Nature387(6632 Suppl)98-102(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Herein the authors found that Rpo41 transcribes RNAs that can be extended by Mip1 on single and double-stranded DNA.
Title: Yeast mitochondrial RNA polymerase primes mitochondrial DNA polymerase at origins of replication and promoter sequences.
Our study also further confirms the utility of yeast Mip1p as a tool for studying human DNA polymerase (pol gamma)variants.
Title: Yeast model analysis of novel polymerase gamma variants found in patients with autosomal recessive mitochondrial disease.
Disrupting exonuclease activity of mutant variants was not associated with increased spontaneous mutagenesis compared with exonuclease-proficient alleles, suggesting that most or all of the mtDNA was replicated by wild type Mip1.
Title: MMS exposure promotes increased MtDNA mutagenesis in the presence of replication-defective disease-associated DNA polymerase ? variants.
disruption of Mip1 exonuclease activity increases mtDNA deletions 160-fold.
Title: The exonuclease activity of the yeast mitochondrial DNA polymerase ? suppresses mitochondrial DNA deletions between short direct repeats in Saccharomyces cerevisiae.
Point mutations in the 3'-5' exonuclease domain of Mip1 result in severe impairment of the polymerase function and DNA binding.
Title: A cluster of pathogenic mutations in the 3'-5' exonuclease domain of DNA polymerase gamma defines a novel module coupling DNA synthesis and degradation.
The following MIP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MIP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi03616 | |
Clone ID Related Accession (Same CDS sequence) | NM_001183750.1 | |
Accession Version | NM_001183750.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3765bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | DNA-directed DNA polymerase gamma MIP1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001147). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGACGAAAT TGATGGTTAG ATCTGAATGC ATGCTGCGAA TGGTGCGGCG GCGGCCGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_014975.2 |
CDS | 1..3765 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001183750.1 |
1 | ATGACGAAAT TGATGGTTAG ATCTGAATGC ATGCTGCGAA TGGTGCGGCG GCGGCCGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XV. |
Life with 6000 genes. |