NAB2 cDNA ORF clone, Saccharomyces cerevisiae S288C

The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.
Tettelin H, Agostoni Carbone ML, Albermann K, Albers M, Arroyo J, Backes U, Barreiros T, Bertani I, Bjourson AJ, Br?ckner M, Bruschi CV, Carignani G, Castagnoli L, Cerdan E, Clemente ML, Coblenz A, Coglievina M, Coissac E, Defoor E, Del Bino S, Delius H, Delneri D, de Wergifosse P, Dujon B, Kleine K
Nature387(6632 Suppl)81-4(1997 May)

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

Binding A11G RNA induces dimerization of Zn fingers 5-7 mediated by the novel spatial arrangement of the fingers promoting each RNA chain binding two protein chains. The dimerization of Nab2 induced by RNA binding provides a basis for understanding its function in both poly(A) tail length regulation and in the compaction of mature transcripts to facilitate nuclear export.
Title: Structural basis for the dimerization of Nab2 generated by RNA binding provides insight into its contribution to both poly(A) tail length determination and transcript compaction in Saccharomyces cerevisiae.

Studies provide evidence Nab2 is important for efficient RNAPIII transcription initiation in addition to its known functions in gene expression, i.e., poly(A) tail length control, mRNP biogenesis, and nuclear mRNA export.
Title: Falling for the dark side of transcription: Nab2 fosters RNA polymerase III transcription.

Nab2 increases TFIIIB binding to the promoter, thereby stimulating RNAPIII transcription.
Title: The poly(A)-binding protein Nab2 functions in RNA polymerase III transcription.

absence of Nab2p results in robust nuclear mRNA decay by the ribonucleolytic RNA exosome.
Title: The Nuclear PolyA-Binding Protein Nab2p Is Essential for mRNA Production.

Nab2p tandem zinc finger TZF34 exhibits a distinctive two-fold symmetry of the zinc centers with mutual recognition of histidine ligands.
Title: Two singular types of CCCH tandem zinc finger in Nab2p contribute to polyadenosine RNA recognition.