Gene Symbol | HUL5 |
Entrez Gene ID | 852736 |
Full Name | ubiquitin-ubiquitin ligase HUL5 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » HUL5 cDNA ORF clone
Gene Symbol | HUL5 |
Entrez Gene ID | 852736 |
Full Name | ubiquitin-ubiquitin ligase HUL5 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001181006.1 | NP_011374.1 | ubiquitin-ubiquitin ligase HUL5 |
Saccharomyces cerevisiae (baker's yeast) | HUL5 | NP_011374.1 |
Eremothecium gossypii | AGOS_ADL280W | NP_983816.1 |
Kluyveromyces lactis | KLLA0E14697g | XP_454612.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.
Tettelin H, Agostoni Carbone ML, Albermann K, Albers M, Arroyo J, Backes U, Barreiros T, Bertani I, Bjourson AJ, Br?ckner M, Bruschi CV, Carignani G, Castagnoli L, Cerdan E, Clemente ML, Coblenz A, Coglievina M, Coissac E, Defoor E, Del Bino S, Delius H, Delneri D, de Wergifosse P, Dujon B, Kleine K
Nature387(6632 Suppl)81-4(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Review discusses how the Hul5 protein quality control pathway may specifically target low solubility cytosolic proteins in the cell.[Review]
Title: Hul5 ubiquitin ligase: good riddance to bad proteins.
Hul5 is involved in a cytosolic protein quality control pathway that targets misfolded proteins for degradation.
Title: Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turnover of cytosolic misfolded proteins.
support a role for the ATPase subunits in the unfolding of proteasome substrates before insertion into the catalytic cavity and suggest a role for Hul5 in the processive degradation of proteins that are stalled on the proteasome.
Title: The ubiquitin ligase Hul5 promotes proteasomal processivity.
Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation
Title: Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation.
We report here a proteasome-dependent conjugating activity of Hul5 that endows proteasomes with the capacity to extend ubiquitin chains.
Title: Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities.
The following HUL5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HUL5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi02108 | |
Clone ID Related Accession (Same CDS sequence) | NM_001181006.1 | |
Accession Version | NM_001181006.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2733bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | ubiquitin-ubiquitin ligase HUL5 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001139). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTTAAACT TCACCGGTCA AACAAGGAGA AGAAATGTCA ATTTAGGGAA TAGGACTCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_011374.1 |
CDS | 1..2733 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001181006.1 |
1 | ATGTTAAACT TCACCGGTCA AACAAGGAGA AGAAATGTCA ATTTAGGGAA TAGGACTCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. |
Life with 6000 genes. |