ERG6 cDNA ORF clone, Saccharomyces cerevisiae S288C

The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.
Bowman S, Churcher C, Badcock K, Brown D, Chillingworth T, Connor R, Dedman K, Devlin K, Gentles S, Hamlin N, Hunt S, Jagels K, Lye G, Moule S, Odell C, Pearson D, Rajandream M, Rice P, Skelton J, Walsh S, Whitehead S, Barrell B
Nature387(6632 Suppl)90-3(1997 May)

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

Lis1 has two opposing modes of regulating dynein, being capable of inducing both low and high affinity for the microtubule; study shows that these opposing modes depend on the stoichiometry of Lis1 binding to dynein and that this stoichiometry is regulated by the nucleotide state of dynein's AAA3 domain.
Title: Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein.

Data show that the erg6Delta mutant strain is more sensitive to hyperosmotic shocks than is WT.
Title: Nature of sterols affects plasma membrane behavior and yeast survival during dehydration.

In the K6R substituted Hmg2 mutant, the squalene content was approximately 20-fold higher than in the wild-type EGY48 parental strain and ERG6 deletion did not further enhance squalene accumulation.
Title: Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6.

Overexpression of ERG6 and ERG2 led to an increased ergosterol level.
Title: [Regulation role of sterol C-24 methyltransferase and sterol C-8 isomerase in the ergosterol biosynthesis of Saccharomyces cerevisiae].

photolabeling & mutagenesis were performed on 24-C-sterol methyltransferase to elucidate location & role of active site residues involved in AdoMet binding & catalysis; results indicate that one or both of Cys128 & Pro133 are covalently bound to AdoMet
Title: Photoaffinity labeling and mutational analysis of 24-C-sterol methyltransferase defines the AdoMet binding site.