BIR1 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene
Clones
gRNAs

Summary

Gene Symbol	BIR1
Entrez Gene ID	853551
Full Name	Bir1p
Gene Type	protein-coding
Organism	Saccharomyces cerevisiae S288C

mRNA and Protein(s)

mRNA	Protein	Name
NM_001181746.3	NP_012622.3	Bir1p

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.
Galibert F, Alexandraki D, Baur A, Boles E, Chalwatzis N, Chuat JC, Coster F, Cziepluch C, De Haan M, Domdey H, Durand P, Entian KD, Gatius M, Goffeau A, Grivell LA, Hennemann A, Herbert CJ, Heumann K, Hilger F, Hollenberg CP, Huang ME, Jacq C, Jauniaux JC, Katsoulou C, Karpfinger-Hartl L
The EMBO journal15(9)2031-49(1996 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that Bir1 is needed to permit efficient chromosome biorientation.
Title: Efficient chromosome biorientation and the tension checkpoint in Saccharomyces cerevisiae both require Bir1.

The establishment of tension removes Ipl1, Bir1, and Sli15, and their kinetochore detachment activity, from the vicinity of kinetochores and allows cells to proceed through the tension checkpoint.
Title: Bir1 is required for the tension checkpoint.

The interaction between Bir1p and Sli15p is specifically involved in regulating septin dynamics during anaphase.
Title: A Bir1p Sli15p kinetochore passenger complex regulates septin organization during anaphase.

Using an in vitro approach based on the sequence-specific budding yeast centromere, a complex of the chromosomal passenger proteins Bir1 and Sli15 (Survivin and INCENP) that links centromeres to microtubules was identified.
Title: A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension.

Data show that Bir1p is a substrate for Nma111p, which is the homologue of the human pro-apoptotic serine protease Omi/HtrA2 and which is known to mediate apoptosis in yeast.
Title: The inhibitor-of-apoptosis protein Bir1p protects against apoptosis in S. cerevisiae and is a substrate for the yeast homologue of Omi/HtrA2.

The following BIR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BIR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSi02782	NM_001181746.3 Latest version!	Saccharomyces cerevisiae S288C Bir1p (BIR1), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$510.30 $729.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BIR1 ( NM_001181746.3 ) cDNA ORF clone, Saccharomyces cerevisiae S288C -> NP_012622.3 Saccharomyces cerevisiae S288C Bir1p (BIR1), partial mRNA.

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CloneID	OSi02782
Clone ID Related Accession (Same CDS sequence)	NM_001181746.3
Accession Version	NM_001181746.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2865bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-31
Organism	Saccharomyces cerevisiae S288C
Product	Bir1p
Comment	Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001142). On Jul 30, 2012 this sequence version replaced NM_001181746.2. ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends.

ATGGATGGTC AAATAGATAA AATGGAGAAG CGATATAGCA TGACCAAACT GGAGAATAGG 
TTAAGGACTT TCCAAGATGG TGTTGCACTT GAAAAAAAAA AGTTAAAGTG GAGTTTTAAA 
GTTATTCCGT ATCAGGCAAT GGCCAAGCTT GGATTTTACT TTGATCCAGT GATCGATCCT 
AAGACATCTA AACTGAAAAA AGACTCTGTA AGATGTTGCT ATTGTCATCG TCAAACATAC 
AATGTGAGAG ACTGCAGATC CAAAAGAAAA GATGTTCTTG AGACTCTAAG CAATATAATG 
AGGCAACATC TGACTGTTAC TGATAACAAA CAAGTTTGCC TCCTTATTTA CTTGCGCAAT 
AAGCTATTGA CGGACTATAG CTTCCATATG GGGGTTTCGG ACTGGAAAAA TGACAAGTAC 
TTCAGCAATC CAGATGATGA AAACGTGATA AACCTAAGAA AATTTACTTT TCAAGATAAC 
TGGCCTCACA GTGGTTCTCA AAATGAACAT CCGCTGGGTA TAGAAAAGAT GGTGAATGCA 
GGACTCATGC GATACGACTC CAGCATAGAA GGCTTAGGCG ATCCAAGCAT GGATAAAACA 
CTTATGAACG ATACCTGTTA TTGTATTTAT TGCAAACAGT TGTTACAAGG TTGGTCAATA 
AATGACGATC CGATGAGCCG ACATTATAAG GTTTCTCAAA ATGGGAACTG TTATTTCTTT 
CAGACACGTA ATCGATTTGA GAGAATAAAA AATGACAATG ACAGTATCAC GAAAAATTGC 
GAAGTCTCTC CAACTTTAGG CGAAAATGGG AAAAGAGAAG TGATCAACAC GAAAACCGCT 
TCTCAAAGGC AGTGTCCTTT ATTTGAGTCA CCTCCATCTA GTACTGGTCC TCAACTTGAC 
GATTATAATG AGAAGACAGA TATATCTGTT ATTCAACATA ATATAAGTGT GCTTGATGGA 
GCACAAGGCG AAAATGTAAA ACGTAATAGT GTGGAAGAAA AAGAACAAAT CAACATGGAA 
AATGGAAGCA CTACATTAGA AGAGGGCAAT ATAAATCGTG ATGTTTTAGC AGATAAGAAA 
GAAGTTATTT CGACACCAAC TGCAAAAGAA ATCAAACGTC CAAATGTCCA GCTAACCCAA 
TCATCGTCAC CTATAAAAAA GAAAAGAAAG TTTAAGAGAA TATCGCCTAG AAAAATCTTT 
GATGAGGAAG ATAGCGAACA CTCCCTTAAT AATAATTCTG CCAACGGAGA CAACAAAGAT 
AAGGATTTGG TTATAGATTT TACAAGCCAT ATCATAAAAA ATAGAGATGT AGGGAGAAAG 
AATGCTATTT TAGATGACAG CACAGATGAA TTCAGTTTCA GTAACCAAGG ACATAACACA 
TTTGACATAC CTATACCAAC CTCATCACAT TTGCTCAAAG GTATAGATTC AGATAATGAC 
AATGTTATAC GAGAAGATGA TACTGGCATA AATACAGACA CAAAAGGAGC GTCTTCTAAA 
CACGAAAAAT TTTCTGTTAA TTCTGAAGAA GATTTAAATT TCAGTGAAGT GAAACTCACA 
GGTAGAGACA GTAGTACTAA TATTCTTATA AGAACGCAAA TTGTAGATCA GAATTTGGGT 
GATATCGACA GAGATAAGGT CCCCAATGGT GGATCCCCAG AAGTTCCAAA GACACATGAG 
TTAATTAGAG ATAACTCTGA AAAGAGGGAA GCACAAAACG GGGAATTTCG ACATCAAAAA 
GATTCAACTG TACGGCAATC TCCAGATATA TTACATTCTA ATAAAAGTGG TGATAATTCC 
AGTAATATTA CCGCAATACC CAAAGAGGAA CAAAGGAGAG GCAATAGCAA AACATCCAGC 
ATTCCCGCTG ATATTCATCC TAAACCAAGG AAAAACTTGC AAGAACCAAG AAGCCTATCA 
ATAAGTGGAA AAGTTGTTCC AACAGAAAGA AAATTAGATA ACATCAATAT AGATCTAAAT 
TTTTCGGCGT CCGATTTTTC ACCATCATCA CAATCTGAGC AATCATCAAA AAGCTCAAGC 
GTTATTTCAA CGCCGGTAGC GAGCCCTAAA ATTAATCTCA CACGCAGTTT GCATGCAGTC 
AAAGAGCTTT CTGGCCTCAA AAAAGAAACT GACGATGGTA AGTATTTTAC TAATAAGCAG 
GAAACTATAA AAATACTGGA AGATGTGTCT GTGAAGAATG AGACCCCAAA TAATGAAATG 
TTACTTTTTG AGACTGGAAC CCCGATCGCA TCTCAAGAAA ACAAGTCAAG AAAATTATTT 
GATGAAGAGT TTTCTGGGAA GGAATTGGAT ATACCTATAG ATTCATCAAC TGTAGAAATA 
AAAAAGGTTA TTAAACCCGA ATTTGAGCCA GTCCCATCAG TTGCAAGGAA TTTGGTGTCT 
GGAACCTCTT CATATCCACG GAATTCACGT TTAGAAGAAC AAAGAAAGGA AACAAGCACA 
AGTTTGGCTG ATAATTCTAA GAAAGGAAGT TCATTTAATG AGGGCAACAA CGAAAAAGAA 
CCGAATGCAG CAGAATGGTT TAAAATTGAT GAAAATAGAC ACCTTGTAAA AAATTACTTC 
CATGATTTGT TAAAATATAT AAATAATAAT GATGCTACGC TAGCTAATGA CAAAGACGGT 
GATCTGGCTT TTTTGATTAA GCAAATGCCT GCAGAAGAGT TGGACATGAC ATTCAACAAT 
TGGGTGAACC TAAAAGTGCA ATCTATTAAG CGCGAATTTA TAGATGACTG TGATAAGAAA 
TTGGACATAT TGAGAAGGGA TTACTATACT GCCACAAATT TTATTGAAAC TTTGGAAGAT 
GACAATCAAT TGATCGATAT TGCTAAGAAA ATGGGCATTT TATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_012622.3
CDS	1..2865
Translation	MDGQIDKMEKRYSMTKLENRLRTFQDGVALEKKKLKWSFKVIPYQAMAKLGFYFDPVIDPKTSKLKKDSVRCCYCHRQTYNVRDCRSKRKDVLETLSNIMRQHLTVTDNKQVCLLIYLRNKLLTDYSFHMGVSDWKNDKYFSNPDDENVINLRKFTFQDNWPHSGSQNEHPLGIEKMVNAGLMRYDSSIEGLGDPSMDKTLMNDTCYCIYCKQLLQGWSINDDPMSRHYKVSQNGNCYFFQTRNRFERIKNDNDSITKNCEVSPTLGENGKREVINTKTASQRQCPLFESPPSSTGPQLDDYNEKTDISVIQHNISVLDGAQGENVKRNSVEEKEQINMENGSTTLEEGNINRDVLADKKEVISTPTAKEIKRPNVQLTQSSSPIKKKRKFKRISPRKIFDEEDSEHSLNNNSANGDNKDKDLVIDFTSHIIKNRDVGRKNAILDDSTDEFSFSNQGHNTFDIPIPTSSHLLKGIDSDNDNVIREDDTGINTDTKGASSKHEKFSVNSEEDLNFSEVKLTGRDSSTNILIRTQIVDQNLGDIDRDKVPNGGSPEVPKTHELIRDNSEKREAQNGEFRHQKDSTVRQSPDILHSNKSGDNSSNITAIPKEEQRRGNSKTSSIPADIHPKPRKNLQEPRSLSISGKVVPTERKLDNINIDLNFSASDFSPSSQSEQSSKSSSVISTPVASPKINLTRSLHAVKELSGLKKETDDGKYFTNKQETIKILEDVSVKNETPNNEMLLFETGTPIASQENKSRKLFDEEFSGKELDIPIDSSTVEIKKVIKPEFEPVPSVARNLVSGTSSYPRNSRLEEQRKETSTSLADNSKKGSSFNEGNNEKEPNAAEWFKIDENRHLVKNYFHDLLKYINNNDATLANDKDGDLAFLIKQMPAEELDMTFNNWVNLKVQSIKREFIDDCDKKLDILRRDYYTATNFIETLEDDNQLIDIAKKMGIL

Target ORF information:

RefSeq Version	NM_001181746.3
Organism	Saccharomyces cerevisiae S288C
Definition	Saccharomyces cerevisiae S288C Bir1p (BIR1), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001181746.3

ORF Insert Sequence:

ATGGATGGTC AAATAGATAA AATGGAGAAG CGATATAGCA TGACCAAACT GGAGAATAGG 
TTAAGGACTT TCCAAGATGG TGTTGCACTT GAAAAAAAAA AGTTAAAGTG GAGTTTTAAA 
GTTATTCCGT ATCAGGCAAT GGCCAAGCTT GGATTTTACT TTGATCCAGT GATCGATCCT 
AAGACATCTA AACTGAAAAA AGACTCTGTA AGATGTTGCT ATTGTCATCG TCAAACATAC 
AATGTGAGAG ACTGCAGATC CAAAAGAAAA GATGTTCTTG AGACTCTAAG CAATATAATG 
AGGCAACATC TGACTGTTAC TGATAACAAA CAAGTTTGCC TCCTTATTTA CTTGCGCAAT 
AAGCTATTGA CGGACTATAG CTTCCATATG GGGGTTTCGG ACTGGAAAAA TGACAAGTAC 
TTCAGCAATC CAGATGATGA AAACGTGATA AACCTAAGAA AATTTACTTT TCAAGATAAC 
TGGCCTCACA GTGGTTCTCA AAATGAACAT CCGCTGGGTA TAGAAAAGAT GGTGAATGCA 
GGACTCATGC GATACGACTC CAGCATAGAA GGCTTAGGCG ATCCAAGCAT GGATAAAACA 
CTTATGAACG ATACCTGTTA TTGTATTTAT TGCAAACAGT TGTTACAAGG TTGGTCAATA 
AATGACGATC CGATGAGCCG ACATTATAAG GTTTCTCAAA ATGGGAACTG TTATTTCTTT 
CAGACACGTA ATCGATTTGA GAGAATAAAA AATGACAATG ACAGTATCAC GAAAAATTGC 
GAAGTCTCTC CAACTTTAGG CGAAAATGGG AAAAGAGAAG TGATCAACAC GAAAACCGCT 
TCTCAAAGGC AGTGTCCTTT ATTTGAGTCA CCTCCATCTA GTACTGGTCC TCAACTTGAC 
GATTATAATG AGAAGACAGA TATATCTGTT ATTCAACATA ATATAAGTGT GCTTGATGGA 
GCACAAGGCG AAAATGTAAA ACGTAATAGT GTGGAAGAAA AAGAACAAAT CAACATGGAA 
AATGGAAGCA CTACATTAGA AGAGGGCAAT ATAAATCGTG ATGTTTTAGC AGATAAGAAA 
GAAGTTATTT CGACACCAAC TGCAAAAGAA ATCAAACGTC CAAATGTCCA GCTAACCCAA 
TCATCGTCAC CTATAAAAAA GAAAAGAAAG TTTAAGAGAA TATCGCCTAG AAAAATCTTT 
GATGAGGAAG ATAGCGAACA CTCCCTTAAT AATAATTCTG CCAACGGAGA CAACAAAGAT 
AAGGATTTGG TTATAGATTT TACAAGCCAT ATCATAAAAA ATAGAGATGT AGGGAGAAAG 
AATGCTATTT TAGATGACAG CACAGATGAA TTCAGTTTCA GTAACCAAGG ACATAACACA 
TTTGACATAC CTATACCAAC CTCATCACAT TTGCTCAAAG GTATAGATTC AGATAATGAC 
AATGTTATAC GAGAAGATGA TACTGGCATA AATACAGACA CAAAAGGAGC GTCTTCTAAA 
CACGAAAAAT TTTCTGTTAA TTCTGAAGAA GATTTAAATT TCAGTGAAGT GAAACTCACA 
GGTAGAGACA GTAGTACTAA TATTCTTATA AGAACGCAAA TTGTAGATCA GAATTTGGGT 
GATATCGACA GAGATAAGGT CCCCAATGGT GGATCCCCAG AAGTTCCAAA GACACATGAG 
TTAATTAGAG ATAACTCTGA AAAGAGGGAA GCACAAAACG GGGAATTTCG ACATCAAAAA 
GATTCAACTG TACGGCAATC TCCAGATATA TTACATTCTA ATAAAAGTGG TGATAATTCC 
AGTAATATTA CCGCAATACC CAAAGAGGAA CAAAGGAGAG GCAATAGCAA AACATCCAGC 
ATTCCCGCTG ATATTCATCC TAAACCAAGG AAAAACTTGC AAGAACCAAG AAGCCTATCA 
ATAAGTGGAA AAGTTGTTCC AACAGAAAGA AAATTAGATA ACATCAATAT AGATCTAAAT 
TTTTCGGCGT CCGATTTTTC ACCATCATCA CAATCTGAGC AATCATCAAA AAGCTCAAGC 
GTTATTTCAA CGCCGGTAGC GAGCCCTAAA ATTAATCTCA CACGCAGTTT GCATGCAGTC 
AAAGAGCTTT CTGGCCTCAA AAAAGAAACT GACGATGGTA AGTATTTTAC TAATAAGCAG 
GAAACTATAA AAATACTGGA AGATGTGTCT GTGAAGAATG AGACCCCAAA TAATGAAATG 
TTACTTTTTG AGACTGGAAC CCCGATCGCA TCTCAAGAAA ACAAGTCAAG AAAATTATTT 
GATGAAGAGT TTTCTGGGAA GGAATTGGAT ATACCTATAG ATTCATCAAC TGTAGAAATA 
AAAAAGGTTA TTAAACCCGA ATTTGAGCCA GTCCCATCAG TTGCAAGGAA TTTGGTGTCT 
GGAACCTCTT CATATCCACG GAATTCACGT TTAGAAGAAC AAAGAAAGGA AACAAGCACA 
AGTTTGGCTG ATAATTCTAA GAAAGGAAGT TCATTTAATG AGGGCAACAA CGAAAAAGAA 
CCGAATGCAG CAGAATGGTT TAAAATTGAT GAAAATAGAC ACCTTGTAAA AAATTACTTC 
CATGATTTGT TAAAATATAT AAATAATAAT GATGCTACGC TAGCTAATGA CAAAGACGGT 
GATCTGGCTT TTTTGATTAA GCAAATGCCT GCAGAAGAGT TGGACATGAC ATTCAACAAT 
TGGGTGAACC TAAAAGTGCA ATCTATTAAG CGCGAATTTA TAGATGACTG TGATAAGAAA 
TTGGACATAT TGAGAAGGGA TTACTATACT GCCACAAATT TTATTGAAAC TTTGGAAGAT 
GACAATCAAT TGATCGATAT TGCTAAGAAA ATGGGCATTT TATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Life with 6000 genes.
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Goffeau A,Barrell BG,Bussey H,Davis RW,Dujon B,Feldmann H,Galibert F,Hoheisel JD,Jacq C,Johnston M,Louis EJ,Mewes HW,Murakami Y,Philippsen P,Tettelin H,Oliver SG

Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.
The EMBO journal15(9)2031-49(1996 May)
Galibert F,Alexandraki D,Baur A,Boles E,Chalwatzis N,Chuat JC,Coster F,Cziepluch C,De Haan M,Domdey H,Durand P,Entian KD,Gatius M,Goffeau A,Grivell LA,Hennemann A,Herbert CJ,Heumann K,Hilger F,Hollenberg CP,Huang ME,Jacq C,Jauniaux JC,Katsoulou C,Karpfinger-Hartl L

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BIR1 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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