Gene Symbol | TUP1 |
Entrez Gene ID | 850445 |
Full Name | chromatin-silencing transcriptional regulator TUP1 |
Synonyms | AAR1,AER2,AMM1,CRT4,CYC9,FLK1,ROX4,SFL2,UMR7 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » TUP1 cDNA ORF clone
Gene Symbol | TUP1 |
Entrez Gene ID | 850445 |
Full Name | chromatin-silencing transcriptional regulator TUP1 |
Synonyms | AAR1,AER2,AMM1,CRT4,CYC9,FLK1,ROX4,SFL2,UMR7 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001178790.1 | NP_010007.1 | chromatin-silencing transcriptional regulator TUP1 |
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
The complete DNA sequence of yeast chromosome III.
Oliver SG, van der Aart QJ, Agostoni-Carbone ML, Aigle M, Alberghina L, Alexandraki D, Antoine G, Anwar R, Ballesta JP, Benit P
Nature357(6373)38-46(1992 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Tup1 regulates GAL1 epigenetic transcriptional memory. Tup1 is necessary for incorporation of both H2A.Z and H3K4me2 at the GAL1 promoter.
Title: Epigenetic Transcriptional Memory of
we identified a transposable element insertion in the promoter region of known flocculation gene FLO1, and, in an additional five clones, we recovered loss-of-function mutations in transcriptional repressor TUP1, which regulates FLO1 and other related genes
Title: Experimental Evolution Reveals Favored Adaptive Routes to Cell Aggregation in Yeast.
CYC8 and TUP1 were required for transcription of the amino acid transporter genes.
Title: Yeast Cyc8p and Tup1p proteins function as coactivators for transcription of Stp1/2p-dependent amino acid transporter genes.
coordinated sumoylation of Gcn4, Tup1 and likely other factors dampens activated transcription by stabilizing Tup1 binding and stimulating Gcn4 and RNAP II removal
Title: Sumoylation controls the timing of Tup1-mediated transcriptional deactivation.
These data suggest that distinctly bound Cyc8-Tup1 cooperates with Hda1p and Rpd3p to establish or maintain an extensive array of strongly positioned, deacetylated nucleosomes over the FLO1 promoter and upstream region which inhibit histone acetylation, block Swi-Snf binding and prevent transcription.
Title: The yeast Cyc8-Tup1 complex cooperates with Hda1p and Rpd3p histone deacetylases to robustly repress transcription of the subtelomeric FLO1 gene.
The following TUP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TUP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi00148 | |
Clone ID Related Accession (Same CDS sequence) | NM_001178790.1 | |
Accession Version | NM_001178790.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2142bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | chromatin-silencing transcriptional regulator TUP1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001135). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGACTGCCA GCGTTTCGAA TACGCAGAAT AAGCTGAATG AGCTTCTCGA TGCCATCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_010007.1 |
CDS | 1..2142 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001178790.1 |
1 | ATGACTGCCA GCGTTTCGAA TACGCAGAAT AAGCTGAATG AGCTTCTCGA TGCCATCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Life with 6000 genes. |
The complete DNA sequence of yeast chromosome III. |