Trpc6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Trpc6
Entrez Gene ID	89823
Full Name	transient receptor potential cation channel, subfamily C, member 6
Synonyms	Trrp6
General protein information	Preferred Names transient receptor potential cation channel, subfamily C, member 6 Names short transient receptor potential channel 6 transient receptor protein 6
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q11
Summary	a G-protein-coupled receptor regulated Ca(2+) channel [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053559.1	NP_446011.1	short transient receptor potential channel 6

Pathways from BioSystems

Homologies

Bos taurus (cattle)	TRPC6	NP_001160044.1
Caenorhabditis elegans (roundworm)	trp-1	NP_001040889.1
Xenopus tropicalis (tropical clawed frog)	trpc6	XP_002935616.2
	TRPM2	XP_002808133.1
Canis lupus familiaris (dog)	TRPC6	XP_546553.3
Danio rerio (zebrafish)	trpc6a	NP_001025453.1
Gallus gallus (chicken)	TRPC6	XP_003640636.1
Danio rerio (zebrafish)	LOC100333090	XP_002665445.2
Mus musculus (house mouse)	Trpc6	NP_038866.2
Homo sapiens (human)	TRPC6	NP_004612.2
Pan troglodytes (chimpanzee)	TRPC6	XP_001150152.1
Rattus norvegicus (Norway rat)	Trpc6	NP_446011.1

Gene Ontology
Bibliography

Related articles in PubMed

TRPC6 expression in neurons is differentially regulated by NR2A- and NR2B-containing NMDA receptors.
Qu Z, Wang Y, Li X, Wu L, Wang Y
Journal of neurochemistry143(3)282-293(2017 Nov)

Increased CaSR and TRPC6 pulmonary vascular expression in the nitrofen-induced model of congenital diaphragmatic hernia.
Nakamura H, Zimmer J, Lim T, Puri P
Pediatric surgery international(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study demonstrated that TRPC6 expression in neurons is regulated by glutamate in a bidirectional manner that is dependent on NR2A and NR2B.
Title: TRPC6 expression in neurons is differentially regulated by NR2A- and NR2B-containing NMDA receptors.

Salvianolic acid B attenuates doxorubicin-induced ER stress by inhibiting TRPC3 and TRPC6 mediated Ca(2+) overload in rat cardiomyocytes.
Title: Salvianolic acid B attenuates doxorubicin-induced ER stress by inhibiting TRPC3 and TRPC6 mediated Ca

Results results demonstrate that sphingosine-1-phosphate induces Ca(2+) signaling in astrocytes via Gq -coupled receptors S1P2 and S1P3 , followed by Ca(2+) influx through TRPC6 that could activate MAPK signaling, which leads to increased secretion of the proinflammatory or neuroprotective chemokine CXCL1
Title: Sphingosine-1-phosphate induces Ca

TGFbeta1 specifically elevates the expression level of TRPC6 mainly through Smad-dependent canonical pathway. The siRNA against TRPC6 abolished TGFbeta1-induced molecular and cellular phenotype changes, including myosin light chain phosphorylation, actin stress fiber formation, and cell migration.
Title: TGF?1 induces stress fiber formation through upregulation of TRPC6 in vascular smooth muscle cells.

Local coupling of TRPC6 to ANO1/TMEM16A channels in smooth muscle cells amplifies vasoconstriction in cerebral arteries.
Title: Local coupling of TRPC6 to ANO1/TMEM16A channels in smooth muscle cells amplifies vasoconstriction in cerebral arteries.

The following Trpc6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Trpc6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12737	NM_053559.1 Latest version!	Rattus norvegicus transient receptor potential cation channel, subfamily C, member 6 (Trpc6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$545.30 $779.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Trpc6 ( NM_053559.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446011.1 Rattus norvegicus transient receptor potential cation channel, subfamily C, member 6 (Trpc6), mRNA.

Price & Availability↑

CloneID	ORa12737
Clone ID Related Accession (Same CDS sequence)	NM_053559.1
Accession Version	NM_053559.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2793bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Rattus norvegicus(Norway rat)
Product	short transient receptor potential channel 6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB051212.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGCCAGA GCCCGGGGTT CGTGACCCGG AGGGGTGGCT CTCCGAAGGC TGCCCCTGGA 
GCCGGCGCGC GGCGCAACGA GAGCCAGGAC TATCTGCTGA TGGACGAGCT GGGAGACGAC 
GGCTACCCAC AGCTCCAGCA GCCACCTTAT GGCTACTATC CCAGCTTCCG GGGTAATGAA 
AACAGACTGA CTCACCGGCG GCAGACAGTT CTTCGTGAGA AGGGAAGAAG GTTGGCTAAT 
CGAGGACCAG CATACATGTT TAATGATCAC TCAACCAGCC TGTCTATTGA GGAGGAACGC 
TTTCTGGATG CAGCTGAATA TGGCAACATC CCAGTGGTGC GGAAGATGCT AGAAGAATGT 
CTCTCCCTCA ATGTTAACTG TGTGGATTAC ATGGGCCAGA ATGCCCTACA GTTGGCGGTG 
GCCAATGAGC ACCTGGAAAT TACAGAGCTG TTACTCAAGA AGGAAAACTT GTCTCGAGTT 
GGGGATGCTT TACTTTTAGC TATCAGTAAA GGTTATGTAC GGATTGTGGA GGCTATTCTC 
AACCATCCAG CTTTTGCTGA AGGCAAGAGG TTGGCGACAA GCCCCAGCCA GTCTGAACTC 
CAGCAAGATG ACTTTTATGC CTATGATGAA GATGGGACAA GATTCTCCCA CGATGTGACC 
CCAATCATTC TGGCTGCTCA TTGCCAGGAA TATGAAATTG TGCATACCCT CCTGAGAAAG 
GGTGCCCGGA TCGAACGGCC TCATGATTAT TTCTGCAAGT GTACAGAATG CAGCCAGAAA 
CAAAAGCATG ACTCCTTCAG CCACTCTAGA TCCAGGATCA ATGCCTACAA AGGGCTGGCA 
AGTCCAGCAT ACCTGTCACT GTCCAGTGAA GATCCAGTCA TGACAGCTTT AGAACTCAGC 
AATGAGCTGG CAGTGCTTGC CAACATTGAG AAAGAGTTCA AGAATGACTA CAGGAAGCTG 
TCCATGCAGT GCAAGGATTT TGTTGTGGGT CTCCTGGACC TCTGCAGAAA CACGGAGGAA 
GTGGAAGCCA TCCTGAACGG GGATGCAGAG ACTCGCCAGC CCGGGGACCT CGCTCGTCCG 
AATCTCAGCC GTTTAAAACT CGCTATTAAA TATGAAGTAA AAAAATTCGT GGCGCATCCG 
AACTGCCAGC AGCAGCTCCT CTCCATATGG TATGAGAACC TCTCTGGTTT ACGGCAGCAG 
ACCATGGCAG TGAAATTCCT CGTGGTCCTC GCTGTCGCCA TTGGACTGCC CTTCCTGGCT 
CTCATATACT GGTGTGCTCC TTGCAGCAAG ATGGGGAAGA TATTACGAGG TCCATTCATG 
AAGTTCGTAG CACATGCGGC CTCCTTCACC ATTTTCCTGG GGCTGCTCGT CATGAATGCA 
GCTGACAGAT TTGAAGGCAC CAAGCTCCTC CCTAATGAAA CCAGCACAGA TAATGCAAGG 
CAGCTGTTCA GGATGAAAAC ATCCTGTTTC TCATGGATGG AGATGCTCAT TATATCCTGG 
GTAATAGGAA TGATATGGGC TGAATGTAAA GAAATCTGGA CTCAAGGCCC CAAAGAATAT 
TTATTTGAGT TGTGGAATAT GCTTGACTTT GGAATGTTAG CAATCTTTGC AGCATCATTC 
ATTGCAAGAT TTATGGCATT CTGGCATGCA TCCAAAGCTC AGAGCATCAT CGATGCAAAT 
GACACTTTAA AGGACTTGAC AAAAGTCACA CTGGGGGACA ACGTCAAATA CTACAATCTG 
GCCAGGATAA AGTGGGACCC TACCGATCCT CAGATCATCT CTGAAGGTCT TTATGCAATC 
GCGGTGGTTT TAAGTTTCTC CAGAATAGCT TACATTTTAC CGGCAAATGA AAGCTTTGGA 
CCTCTGCAGA TTTCACTTGG AAGAACAGTG AAAGATATCT TCAAATTCAT GGTCATATTC 
ATCATGGTGT TTGTAGCCTT TATGATTGGA ATGTTCAACC TCTACTCCTA CTACATTGGT 
GCAAAACAGA ATGAAGCCTT CACAACAGTT GAGGAAAGTT TTAAGACTCT GTTCTGGGCT 
ATATTTGGTC TTTCTGAAGT GAAGTCGGTG GTCATCAACT ACAATCACAA GTTCATTGAG 
AACATAGGCT ATGTTCTGTA TGGAGTCTAT AATGTCACAA TGGTCATTGT TTTGCTAAAT 
ATGTTAATTG CGATGATCAA CAGTTCATTC CAGGAAATTG AGGATGATGC GGATGTGGAG 
TGGAAGTTTG CAAGGGCCAA ATTGTGGTTT TCCTACTTTG AAGAGGGAAG AACACTGCCT 
GTCCCCTTCA ATCTTGTGCC AAGTCCAAAG TCCCTGCTTT ATCTCCTATT GAAATTTAAG 
AAATGGATGT CTGAGCTTAT CCAGGGTCAT AAGAAAGGCT TCCAAGAAGA TGCAGAGATG 
AACAAGAGAA ATGAAGAAAA GAAATTTGGA ATTTTGGGAA GTCATGAAGA CCTTTCAAAA 
TTTTCACTTG ACAGAAATCA GCTGGCACAC AACAAACAAT CAAGTACAAG GAGCTCAGAA 
GATTTCCATT TAAATAGCTT CAGTAATCCT CCAAGACAGT ATCAGAAAAT CATGAAAAGA 
CTCATTAAAA GATACGTACT GCAGGCCCAG ATTGATAAGG AGAGTGATGA AGTGAACGAA 
GGGGAGCTGA AGGAAATTAA GCAGGACATC TCAAGTCTCC GTTATGAACT CCTTGAGGAA 
AAATCACAGA ACACAGAGGA CCTAGCAGAA CTCATTAGAA AGCTTGGGGA GAGACTGTCT 
TTAGAGTCGA AACAAGAGGA AAGCCGCAGA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446011.1
CDS	1..2793
Translation	MSQSPGFVTRRGGSPKAAPGAGARRNESQDYLLMDELGDDGYPQLQQPPYGYYPSFRGNENRLTHRRQTVLREKGRRLANRGPAYMFNDHSTSLSIEEERFLDAAEYGNIPVVRKMLEECLSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCTECSQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYRKLSMQCKDFVVGLLDLCRNTEEVEAILNGDAETRQPGDLARPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWCAPCSKMGKILRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNARQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPTDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLLYLLLKFKKWMSELIQGHKKGFQEDAEMNKRNEEKKFGILGSHEDLSKFSLDRNQLAHNKQSSTRSSEDFHLNSFSNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRKLGERLSLESKQEESRR

Target ORF information:

RefSeq Version	NM_053559.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transient receptor potential cation channel, subfamily C, member 6 (Trpc6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053559.1

ORF Insert Sequence:

ATGAGCCAGA GCCCGGGGTT CGTGACCCGG AGGGGTGGCT CTCCGAAGGC TGCCCCTGGA 
GCCGGCGCGC GGCGCAACGA GAGCCAGGAC TATCTGCTGA TGGACGAGCT GGGAGACGAC 
GGCTACCCAC AGCTCCAGCA GCCACCTTAT GGCTACTATC CCAGCTTCCG GGGTAATGAA 
AACAGACTGA CTCACCGGCG GCAGACAGTT CTTCGTGAGA AGGGAAGAAG GTTGGCTAAT 
CGAGGACCAG CATACATGTT TAATGATCAC TCAACCAGCC TGTCTATTGA GGAGGAACGC 
TTTCTGGATG CAGCTGAATA TGGCAACATC CCAGTGGTGC GGAAGATGCT AGAAGAATGT 
CTCTCCCTCA ATGTTAACTG TGTGGATTAC ATGGGCCAGA ATGCCCTACA GTTGGCGGTG 
GCCAATGAGC ACCTGGAAAT TACAGAGCTG TTACTCAAGA AGGAAAACTT GTCTCGAGTT 
GGGGATGCTT TACTTTTAGC TATCAGTAAA GGTTATGTAC GGATTGTGGA GGCTATTCTC 
AACCATCCAG CTTTTGCTGA AGGCAAGAGG TTGGCGACAA GCCCCAGCCA GTCTGAACTC 
CAGCAAGATG ACTTTTATGC CTATGATGAA GATGGGACAA GATTCTCCCA CGATGTGACC 
CCAATCATTC TGGCTGCTCA TTGCCAGGAA TATGAAATTG TGCATACCCT CCTGAGAAAG 
GGTGCCCGGA TCGAACGGCC TCATGATTAT TTCTGCAAGT GTACAGAATG CAGCCAGAAA 
CAAAAGCATG ACTCCTTCAG CCACTCTAGA TCCAGGATCA ATGCCTACAA AGGGCTGGCA 
AGTCCAGCAT ACCTGTCACT GTCCAGTGAA GATCCAGTCA TGACAGCTTT AGAACTCAGC 
AATGAGCTGG CAGTGCTTGC CAACATTGAG AAAGAGTTCA AGAATGACTA CAGGAAGCTG 
TCCATGCAGT GCAAGGATTT TGTTGTGGGT CTCCTGGACC TCTGCAGAAA CACGGAGGAA 
GTGGAAGCCA TCCTGAACGG GGATGCAGAG ACTCGCCAGC CCGGGGACCT CGCTCGTCCG 
AATCTCAGCC GTTTAAAACT CGCTATTAAA TATGAAGTAA AAAAATTCGT GGCGCATCCG 
AACTGCCAGC AGCAGCTCCT CTCCATATGG TATGAGAACC TCTCTGGTTT ACGGCAGCAG 
ACCATGGCAG TGAAATTCCT CGTGGTCCTC GCTGTCGCCA TTGGACTGCC CTTCCTGGCT 
CTCATATACT GGTGTGCTCC TTGCAGCAAG ATGGGGAAGA TATTACGAGG TCCATTCATG 
AAGTTCGTAG CACATGCGGC CTCCTTCACC ATTTTCCTGG GGCTGCTCGT CATGAATGCA 
GCTGACAGAT TTGAAGGCAC CAAGCTCCTC CCTAATGAAA CCAGCACAGA TAATGCAAGG 
CAGCTGTTCA GGATGAAAAC ATCCTGTTTC TCATGGATGG AGATGCTCAT TATATCCTGG 
GTAATAGGAA TGATATGGGC TGAATGTAAA GAAATCTGGA CTCAAGGCCC CAAAGAATAT 
TTATTTGAGT TGTGGAATAT GCTTGACTTT GGAATGTTAG CAATCTTTGC AGCATCATTC 
ATTGCAAGAT TTATGGCATT CTGGCATGCA TCCAAAGCTC AGAGCATCAT CGATGCAAAT 
GACACTTTAA AGGACTTGAC AAAAGTCACA CTGGGGGACA ACGTCAAATA CTACAATCTG 
GCCAGGATAA AGTGGGACCC TACCGATCCT CAGATCATCT CTGAAGGTCT TTATGCAATC 
GCGGTGGTTT TAAGTTTCTC CAGAATAGCT TACATTTTAC CGGCAAATGA AAGCTTTGGA 
CCTCTGCAGA TTTCACTTGG AAGAACAGTG AAAGATATCT TCAAATTCAT GGTCATATTC 
ATCATGGTGT TTGTAGCCTT TATGATTGGA ATGTTCAACC TCTACTCCTA CTACATTGGT 
GCAAAACAGA ATGAAGCCTT CACAACAGTT GAGGAAAGTT TTAAGACTCT GTTCTGGGCT 
ATATTTGGTC TTTCTGAAGT GAAGTCGGTG GTCATCAACT ACAATCACAA GTTCATTGAG 
AACATAGGCT ATGTTCTGTA TGGAGTCTAT AATGTCACAA TGGTCATTGT TTTGCTAAAT 
ATGTTAATTG CGATGATCAA CAGTTCATTC CAGGAAATTG AGGATGATGC GGATGTGGAG 
TGGAAGTTTG CAAGGGCCAA ATTGTGGTTT TCCTACTTTG AAGAGGGAAG AACACTGCCT 
GTCCCCTTCA ATCTTGTGCC AAGTCCAAAG TCCCTGCTTT ATCTCCTATT GAAATTTAAG 
AAATGGATGT CTGAGCTTAT CCAGGGTCAT AAGAAAGGCT TCCAAGAAGA TGCAGAGATG 
AACAAGAGAA ATGAAGAAAA GAAATTTGGA ATTTTGGGAA GTCATGAAGA CCTTTCAAAA 
TTTTCACTTG ACAGAAATCA GCTGGCACAC AACAAACAAT CAAGTACAAG GAGCTCAGAA 
GATTTCCATT TAAATAGCTT CAGTAATCCT CCAAGACAGT ATCAGAAAAT CATGAAAAGA 
CTCATTAAAA GATACGTACT GCAGGCCCAG ATTGATAAGG AGAGTGATGA AGTGAACGAA 
GGGGAGCTGA AGGAAATTAA GCAGGACATC TCAAGTCTCC GTTATGAACT CCTTGAGGAA 
AAATCACAGA ACACAGAGGA CCTAGCAGAA CTCATTAGAA AGCTTGGGGA GAGACTGTCT 
TTAGAGTCGA AACAAGAGGA AAGCCGCAGA TAG