Gab2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gab2
Entrez Gene ID	84477
Full Name	GRB2-associated binding protein 2
General protein information	Preferred Names GRB2-associated binding protein 2 Names GRB2-associated-binding protein 2 GRB2-associated binder 2 growth factor receptor bound protein 2-associated protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q32
Summary	adapter for transmitting various signals in response to stimuli through cytokine and growth factor receptors [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017589791.1	XP_017445280.1	GRB2-associated-binding protein 2 isoform X1
NM_053417.1	NP_445869.1	GRB2-associated-binding protein 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gab2	NP_445869.1
Danio rerio (zebrafish)	gab2	XP_692935.3
Homo sapiens (human)	GAB2	NP_536739.1
Bos taurus (cattle)	GAB2	XP_002699116.2
Pan troglodytes (chimpanzee)	GAB2	XP_001164121.2
Canis lupus familiaris (dog)	GAB2	XP_542285.3
Gallus gallus (chicken)	GAB2	XP_001234549.1
	GAB2	XP_001093917.2
Mus musculus (house mouse)	Gab2	NP_034378.2
Xenopus tropicalis (tropical clawed frog)	gab2	XP_002936593.1

Gene Ontology
Bibliography

Related articles in PubMed

Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility.
Zhang X, Lavoie G, Fort L, Huttlin EL, Tcherkezian J, Galan JA, Gu H, Gygi SP, Carreno S, Roux PP
Molecular and cellular biology33(8)1657-70(2013 Apr)

Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.
W?hrle FU, Halbach S, Aumann K, Schwemmers S, Braun S, Auberger P, Schramek D, Penninger JM, La?mann S, Werner M, Waller CF, Pahl HL, Zeiser R, Daly RJ, Brummer T
Leukemia27(1)118-29(2013 Jan)

PKA and GAB2 play central roles in the FSH signaling pathway to PI3K and AKT in ovarian granulosa cells.
Hunzicker-Dunn ME, Lopez-Biladeau B, Law NC, Fiedler SE, Carr DW, Maizels ET
Proceedings of the National Academy of Sciences of the United States of America109(44)E2979-88(2012 Oct)

Inhibition of the antigen-induced activation of RBL-2H3 cells by Gab2 siRNA.
Huang F, Tong X, Deng H, Fu L, Zhang R
Cellular & molecular immunology5(6)433-8(2008 Dec)

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.
Brummer T, Larance M, Herrera Abreu MT, Lyons RJ, Timpson P, Emmerich CH, Fleuren ED, Lehrbach GM, Schramek D, Guilhaus M, James DE, Daly RJ
The EMBO journal27(17)2305-16(2008 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Overexpression of GAB2 enhances FSH-stimulated AKT phosphorylation. GAB2, thus, seems to coordinate signals from the FSH-stimulated rise in cAMP that leads to activation of PI3K/AKT
Title: PKA and GAB2 play central roles in the FSH signaling pathway to PI3K and AKT in ovarian granulosa cells.

Gab2 siRNA could suppress the antigen-induced activation of RBL-2H3 cells and suggested a possible mechanism through inhibition of signaling molecules downstream of Gab2 in the FcepsilonRI-mediated Ca(2+)-independent pathway.
Title: Inhibition of the antigen-induced activation of RBL-2H3 cells by Gab2 siRNA.

Gab2 associated with SHP-2; the activity of Gab2-bound SHP-2 is increased in a Thy-1- and actin-dependent manner.
Title: Involvement of filamentous actin in setting the threshold for degranulation in mast cells.

Gab2 tyrosine phosphorylation; role in epidermal growth factor-induced mitogenesis
Title: Gab2 tyrosine phosphorylation by a pleckstrin homology domain-independent mechanism: role in epidermal growth factor-induced mitogenesis.

comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat
Title: Comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat.

The following Gab2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gab2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09494	NM_053417.1 Latest version!	Rattus norvegicus GRB2-associated binding protein 2 (Gab2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa56875	XM_017589791.1 Latest version!	Rattus norvegicus GRB2-associated binding protein 2 (Gab2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gab2 ( NM_053417.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445869.1 Rattus norvegicus GRB2-associated binding protein 2 (Gab2), mRNA.

Price & Availability↑

CloneID	ORa09494
Clone ID Related Accession (Same CDS sequence)	NM_053417.1
Accession Version	NM_053417.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1998bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	GRB2-associated-binding protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF230367.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF230367.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGCGGCG GCGGCGGCGA CGACGTGGTG TGTACCGGCT GGCTGAGGAA ATCGCCTCCG 
GAAAAGAAGT TGAGGCGCTA TGCCTGGAAG AAACGCTGGT TTATACTGCG GAGTGGCCGG 
ATGAGTGGAG ACCCAGATGT TCTGGAATAC TACAAGAATG AGCACTCCAA GAAACCCCTG 
CGGATCATCA ACCTGAACTT CTGTGAGCAG GTGGATGCAG GCCTGACCTT CAACAAGAAA 
GAGCTACAGG ATAGCTTTGT GTTTGATATC AAGACCAGCG AGCGCACGTT TTACCTGGTG 
GCTGAGACGG AGGCTGACAT GAACAAGTGG GTCCAGAGCA TCTGCCAGAT TTGCGGTTTC 
AATCAAGCCG AAGAGAGCAC AGACTCCCTG AGGAACCTTT CTTCAGCCAG TCACGGTCCC 
CGCTCCTCTC CAGCTGAGTT CAGCTCCAGT CAGCACCTGC TCCGAGAACG GAAGTCCTCA 
GCCCCTTCAC ACTCTAGCCA GCCCACTTTA TTCACATTTG AGCCCCCTAT GACAAGCCAC 
ATGCAGCCTG CCTTGTCCAC CAGTGCACCT CAGGAGTATC TCTACTTGCA CCAGTGCATA 
AGCAGAAGGA CAGAAAACTC AAGGAGTGCC AGCTTCTCTC AGGGCACCCG GCAGAAGAGT 
GATACAGCCG TGCAAAAACT TGCCCAGAGC AATGGACACT GTATCAATGG AGTCAGCAAT 
CAAGTCCATG GTTTCTATAG CCTTCCCAAG CCAAGCCGAC ACAATACAGA ATTCAAAGAC 
AGTACTTATG ATCTCCCGAG GAGCCTGGCG TCACATGGCC ACACCAAGAG CAGCCTCACA 
GGGTCTGAGA CTGATAACGA GGATGTGTAT ACCTTCAAGA TGCCCAGCAA CACCCTGTGT 
CGGGAGTTTG GAGACCTCCT TGTGGACAAT ATGGATGTTC CAACCACCCC TCTCTCAGCC 
TACCAGATCC CTAGAACATT TACACTGGAC AAGAATCACA ATGCCATGAC AGTGGCCACT 
TCTGGAGACT CAGCCATAGC TCCCCCACCC CGGCCACCCA AGCCAAGTCA AGCAGAAACA 
CCTCGATGGG GCAGCCCTCA GCAAAAACCT CCGATCGGCG AGAATAGCAG ATCTGTAGCT 
GCTACTATCC CCAGGCGCAA TACCCTCCCT GCAATGGACA ACAGCCGGCT CCACCGAGCT 
TCCTCCTGTG AGACCTATGA ATACCCAACA CGAGGCAGCG GAGAGAGTGC CAGCTGGTCT 
GCTGAATCTC CAGGAAAGAC TGCCGTGGGT CGATCAGACA GTGCCAGCTC TGATGAAAAT 
TACGTGCCCA TGAACCCAGG TTCTTCTACC CTGCTGGCCA TGGAACGAGC CGGGGACAAT 
TCCCAGAGTG CCTACATACC CATGGGCCCA GGGCCTCATC ACTTTGATCC ACTTGGGTAC 
CCATCCACAG CCCTTCCTAT TCACAGAGGC CCCAGCCGAG GAAGTGAGAT CCAGCCACCC 
CCAGTCAACC GAAACCTCAA ACCTGACCGA AAAGCAAAGC CAACACCCCT TGACCTGAGA 
AACAACACTG TCATCGATGA GCTCCCCTTC AAGTCACCTG TCACCAAGTC TTGGTCCAGG 
ATCAACCACA CCTTTAACTC CAGTTCCTCC CAGTACTGCC GTCCTATCTC CACACAGAGC 
ATCACCAGCA CAGACTCAGG AGACAGTGAG GAGAACTATG TCCCTATGCA AAACCCAGTA 
TCTGCGTCCC CTGTTCCCAG TGGCACTAAC AGCCCAGCTC CCAGGAAGAG TACTGGCAGT 
GTGGATTACC TAGCCCTGGA CTTCCAGCCG GGCTCCCCAA GCCCTCACCG CAAGCCATCC 
ACATCATCTG TCACATCGGA TGAGAAGGTA GACTATGTCC AAGTGGATAA AGAGAAGACA 
CAGGCCCTGC AGAACACCAT GCAGGAGTGG ACAGATGTAC GGCAGTCCTC AGAACCTTCC 
AAGGGTGCCA AGCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445869.1
CDS	1..1998
Translation	MSGGGGDDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNEHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEADMNKWVQSICQICGFNQAEESTDSLRNLSSASHGPRSSPAEFSSSQHLLRERKSSAPSHSSQPTLFTFEPPMTSHMQPALSTSAPQEYLYLHQCISRRTENSRSASFSQGTRQKSDTAVQKLAQSNGHCINGVSNQVHGFYSLPKPSRHNTEFKDSTYDLPRSLASHGHTKSSLTGSETDNEDVYTFKMPSNTLCREFGDLLVDNMDVPTTPLSAYQIPRTFTLDKNHNAMTVATSGDSAIAPPPRPPKPSQAETPRWGSPQQKPPIGENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPTRGSGESASWSAESPGKTAVGRSDSASSDENYVPMNPGSSTLLAMERAGDNSQSAYIPMGPGPHHFDPLGYPSTALPIHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPVTKSWSRINHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPRKSTGSVDYLALDFQPGSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAKL

Target ORF information:

RefSeq Version	NM_053417.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GRB2-associated binding protein 2 (Gab2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053417.1

ORF Insert Sequence:

ATGAGCGGCG GCGGCGGCGA CGACGTGGTG TGTACCGGCT GGCTGAGGAA ATCGCCTCCG 
GAAAAGAAGT TGAGGCGCTA TGCCTGGAAG AAACGCTGGT TTATACTGCG GAGTGGCCGG 
ATGAGTGGAG ACCCAGATGT TCTGGAATAC TACAAGAATG AGCACTCCAA GAAACCCCTG 
CGGATCATCA ACCTGAACTT CTGTGAGCAG GTGGATGCAG GCCTGACCTT CAACAAGAAA 
GAGCTACAGG ATAGCTTTGT GTTTGATATC AAGACCAGCG AGCGCACGTT TTACCTGGTG 
GCTGAGACGG AGGCTGACAT GAACAAGTGG GTCCAGAGCA TCTGCCAGAT TTGCGGTTTC 
AATCAAGCCG AAGAGAGCAC AGACTCCCTG AGGAACCTTT CTTCAGCCAG TCACGGTCCC 
CGCTCCTCTC CAGCTGAGTT CAGCTCCAGT CAGCACCTGC TCCGAGAACG GAAGTCCTCA 
GCCCCTTCAC ACTCTAGCCA GCCCACTTTA TTCACATTTG AGCCCCCTAT GACAAGCCAC 
ATGCAGCCTG CCTTGTCCAC CAGTGCACCT CAGGAGTATC TCTACTTGCA CCAGTGCATA 
AGCAGAAGGA CAGAAAACTC AAGGAGTGCC AGCTTCTCTC AGGGCACCCG GCAGAAGAGT 
GATACAGCCG TGCAAAAACT TGCCCAGAGC AATGGACACT GTATCAATGG AGTCAGCAAT 
CAAGTCCATG GTTTCTATAG CCTTCCCAAG CCAAGCCGAC ACAATACAGA ATTCAAAGAC 
AGTACTTATG ATCTCCCGAG GAGCCTGGCG TCACATGGCC ACACCAAGAG CAGCCTCACA 
GGGTCTGAGA CTGATAACGA GGATGTGTAT ACCTTCAAGA TGCCCAGCAA CACCCTGTGT 
CGGGAGTTTG GAGACCTCCT TGTGGACAAT ATGGATGTTC CAACCACCCC TCTCTCAGCC 
TACCAGATCC CTAGAACATT TACACTGGAC AAGAATCACA ATGCCATGAC AGTGGCCACT 
TCTGGAGACT CAGCCATAGC TCCCCCACCC CGGCCACCCA AGCCAAGTCA AGCAGAAACA 
CCTCGATGGG GCAGCCCTCA GCAAAAACCT CCGATCGGCG AGAATAGCAG ATCTGTAGCT 
GCTACTATCC CCAGGCGCAA TACCCTCCCT GCAATGGACA ACAGCCGGCT CCACCGAGCT 
TCCTCCTGTG AGACCTATGA ATACCCAACA CGAGGCAGCG GAGAGAGTGC CAGCTGGTCT 
GCTGAATCTC CAGGAAAGAC TGCCGTGGGT CGATCAGACA GTGCCAGCTC TGATGAAAAT 
TACGTGCCCA TGAACCCAGG TTCTTCTACC CTGCTGGCCA TGGAACGAGC CGGGGACAAT 
TCCCAGAGTG CCTACATACC CATGGGCCCA GGGCCTCATC ACTTTGATCC ACTTGGGTAC 
CCATCCACAG CCCTTCCTAT TCACAGAGGC CCCAGCCGAG GAAGTGAGAT CCAGCCACCC 
CCAGTCAACC GAAACCTCAA ACCTGACCGA AAAGCAAAGC CAACACCCCT TGACCTGAGA 
AACAACACTG TCATCGATGA GCTCCCCTTC AAGTCACCTG TCACCAAGTC TTGGTCCAGG 
ATCAACCACA CCTTTAACTC CAGTTCCTCC CAGTACTGCC GTCCTATCTC CACACAGAGC 
ATCACCAGCA CAGACTCAGG AGACAGTGAG GAGAACTATG TCCCTATGCA AAACCCAGTA 
TCTGCGTCCC CTGTTCCCAG TGGCACTAAC AGCCCAGCTC CCAGGAAGAG TACTGGCAGT 
GTGGATTACC TAGCCCTGGA CTTCCAGCCG GGCTCCCCAA GCCCTCACCG CAAGCCATCC 
ACATCATCTG TCACATCGGA TGAGAAGGTA GACTATGTCC AAGTGGATAA AGAGAAGACA 
CAGGCCCTGC AGAACACCAT GCAGGAGTGG ACAGATGTAC GGCAGTCCTC AGAACCTTCC 
AAGGGTGCCA AGCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gab2 ( XM_017589791.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017445280.1 Rattus norvegicus GRB2-associated binding protein 2 (Gab2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa56875
Clone ID Related Accession (Same CDS sequence)	XM_017589791.1
Accession Version	XM_017589791.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1995bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	GRB2-associated-binding protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCGGCG GCGGCGACGA CGTGGTGTGT ACCGGCTGGC TGAGGAAATC GCCTCCGGAA 
AAGAAGTTGA GGCGCTATGC CTGGAAGAAA CGCTGGTTTA TACTGCGGAG TGGCCGGATG 
AGTGGAGACC CAGATGTTCT GGAATACTAC AAGAACGAGC ACTCCAAGAA ACCCCTGCGG 
ATCATCAACC TGAACTTCTG TGAGCAGGTG GATGCAGGCC TGACCTTCAA CAAGAAAGAG 
CTACAGGATA GCTTTGTGTT TGATATCAAG ACCAGCGAGC GCACGTTTTA CCTGGTGGCT 
GAGACGGAGG CTGACATGAA CAAGTGGGTC CAGAGCATCT GCCAGATTTG CGGTTTCAAT 
CAAGCCGAAG AGAGCACAGA CTCCCTGAGA AACCTTTCTT CAGCCAGTCA CGGTCCCCGC 
TCCTCTCCAG CTGAGTTCAG CTCCAGTCAG CACCTGCTCC GAGAACGGAA GTCCTCAGCC 
CCTTCACACT CTAGCCAGCC CACTTTATTC ACATTTGAGC CCCCTATGTC AAGCCACATG 
CAGCCTGCCT TGTCCACCAG TGCACCTCAG GAGTATCTCT ACTTGCACCA GTGCATAAGC 
AGAAGGACAG AAAACTCAAG GAGTGCCAGC TTCTCTCAGG GCACCCGGCA GAAGAGTGAT 
ACAGCCGTGC AAAAACTTGC CCAGAGCAAT GGACACTGTA TCAATGGAGT CAGCAATCAA 
GTCCATGGTT TCTATAGCCT TCCCAAGCCA AGCCGACACA ATACAGAATT CAAAGACAGT 
ACTTATGATC TCCCGAGGAG CCTGGCGTCA CATGGCCACA CCAAGAGCAG CCTCACAGGG 
TCTGAGACTG ATAACGAGGA TGTGTATACC TTCAAGATGC CCAGCAACAC CCTGTGTCGG 
GAGTTTGGAG ACCTCCTTGT GGACAATATG GATGTTCCAA CCACCCCTCT CTCAGCCTAC 
CAGATCCCTA GAACATTTAC ACTGGACAAG AATCACAATG CCATGACAGT GGCCACTTCT 
GGAGACTCAG CCATAGCTCC CCCACCCCGG CCACCCAAGC CAAGTCAAGC AGAAACACCT 
CGATGGGGCA GCCCTCAGCA AAAACCTCCG ATCGGCGAGA ATAGCAGATC TGTAGCTGCT 
ACTATCCCCA GGCGCAATAC CCTCCCTGCA ATGGACAACA GCCGGCTCCA CCGAGCTTCC 
TCCTGTGAGA CCTATGAATA CCCAACACGA GGCAGCGGAG AGAGTGCCAG CTGGTCTGCT 
GAATCTCCAG GAAAGACTGC CGTGGGTCGA TCAAACAGTG CCAGCTCTGA TGACAACTAC 
GTGCCCATGA ACCCAGGTTC TTCTACCCTG CTGGCCATGG AACGAGCCGG GGACAATTCC 
CAGAGTGCCT ACATACCCAT GAGCCCAGGG CCTCATCACT TTGATCCACT TGGGTACCCA 
TCCACAGCCC TTCCTATTCA CAGAGGCCCC AGCCGAGGAA GTGAGATCCA GCCACCCCCA 
GTCAACCGAA ACCTCAAACC TGACCGAAAA GCAAAGCCAA CACCCCTTGA CCTGAGAAAC 
AACACTGTCA TCGATGAGCT CCCCTTCAAG TCACCTGTCA CCAAGTCTTG GTCCAGGATC 
AACCACACCT TTAACTCCAG TTCCTCCCAG TACTGCCGTC CTATCTCCAC ACAGAGCATC 
ACCAGCACAG ACTCAGGAGA CAGTGAGGAG AACTATGTCC CTATGCAAAA CCCAGTATCT 
GCGTCCCCTG TTCCCAGTGG CACTAACAGC CCAGCTCCCA GGAAGAGTAC TGGCAGTGTG 
GATTACCTAG CCCTGGACTT CCAGCCGGGC TCCCCAAGCC CTCACCGCAA GCCATCCACA 
TCATCTGTCA CATCGGATGA GAAGGTAGAC TATGTCCAAG TGGATAAAGA GAAGACACAG 
GCCCTGCAGA ACACCATGCA GGAGTGGACA GATGTACGGC AGTCCTCAGA ACCTTCCAAG 
GGTGCCAAGC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017445280.1
CDS	163..2157
Translation	MSGGGDDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNEHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEADMNKWVQSICQICGFNQAEESTDSLRNLSSASHGPRSSPAEFSSSQHLLRERKSSAPSHSSQPTLFTFEPPMSSHMQPALSTSAPQEYLYLHQCISRRTENSRSASFSQGTRQKSDTAVQKLAQSNGHCINGVSNQVHGFYSLPKPSRHNTEFKDSTYDLPRSLASHGHTKSSLTGSETDNEDVYTFKMPSNTLCREFGDLLVDNMDVPTTPLSAYQIPRTFTLDKNHNAMTVATSGDSAIAPPPRPPKPSQAETPRWGSPQQKPPIGENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPTRGSGESASWSAESPGKTAVGRSNSASSDDNYVPMNPGSSTLLAMERAGDNSQSAYIPMSPGPHHFDPLGYPSTALPIHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPVTKSWSRINHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPRKSTGSVDYLALDFQPGSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAKL

Target ORF information:

RefSeq Version	XM_017589791.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GRB2-associated binding protein 2 (Gab2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589791.1

ORF Insert Sequence:

ATGAGCGGCG GCGGCGACGA CGTGGTGTGT ACCGGCTGGC TGAGGAAATC GCCTCCGGAA 
AAGAAGTTGA GGCGCTATGC CTGGAAGAAA CGCTGGTTTA TACTGCGGAG TGGCCGGATG 
AGTGGAGACC CAGATGTTCT GGAATACTAC AAGAACGAGC ACTCCAAGAA ACCCCTGCGG 
ATCATCAACC TGAACTTCTG TGAGCAGGTG GATGCAGGCC TGACCTTCAA CAAGAAAGAG 
CTACAGGATA GCTTTGTGTT TGATATCAAG ACCAGCGAGC GCACGTTTTA CCTGGTGGCT 
GAGACGGAGG CTGACATGAA CAAGTGGGTC CAGAGCATCT GCCAGATTTG CGGTTTCAAT 
CAAGCCGAAG AGAGCACAGA CTCCCTGAGA AACCTTTCTT CAGCCAGTCA CGGTCCCCGC 
TCCTCTCCAG CTGAGTTCAG CTCCAGTCAG CACCTGCTCC GAGAACGGAA GTCCTCAGCC 
CCTTCACACT CTAGCCAGCC CACTTTATTC ACATTTGAGC CCCCTATGTC AAGCCACATG 
CAGCCTGCCT TGTCCACCAG TGCACCTCAG GAGTATCTCT ACTTGCACCA GTGCATAAGC 
AGAAGGACAG AAAACTCAAG GAGTGCCAGC TTCTCTCAGG GCACCCGGCA GAAGAGTGAT 
ACAGCCGTGC AAAAACTTGC CCAGAGCAAT GGACACTGTA TCAATGGAGT CAGCAATCAA 
GTCCATGGTT TCTATAGCCT TCCCAAGCCA AGCCGACACA ATACAGAATT CAAAGACAGT 
ACTTATGATC TCCCGAGGAG CCTGGCGTCA CATGGCCACA CCAAGAGCAG CCTCACAGGG 
TCTGAGACTG ATAACGAGGA TGTGTATACC TTCAAGATGC CCAGCAACAC CCTGTGTCGG 
GAGTTTGGAG ACCTCCTTGT GGACAATATG GATGTTCCAA CCACCCCTCT CTCAGCCTAC 
CAGATCCCTA GAACATTTAC ACTGGACAAG AATCACAATG CCATGACAGT GGCCACTTCT 
GGAGACTCAG CCATAGCTCC CCCACCCCGG CCACCCAAGC CAAGTCAAGC AGAAACACCT 
CGATGGGGCA GCCCTCAGCA AAAACCTCCG ATCGGCGAGA ATAGCAGATC TGTAGCTGCT 
ACTATCCCCA GGCGCAATAC CCTCCCTGCA ATGGACAACA GCCGGCTCCA CCGAGCTTCC 
TCCTGTGAGA CCTATGAATA CCCAACACGA GGCAGCGGAG AGAGTGCCAG CTGGTCTGCT 
GAATCTCCAG GAAAGACTGC CGTGGGTCGA TCAAACAGTG CCAGCTCTGA TGACAACTAC 
GTGCCCATGA ACCCAGGTTC TTCTACCCTG CTGGCCATGG AACGAGCCGG GGACAATTCC 
CAGAGTGCCT ACATACCCAT GAGCCCAGGG CCTCATCACT TTGATCCACT TGGGTACCCA 
TCCACAGCCC TTCCTATTCA CAGAGGCCCC AGCCGAGGAA GTGAGATCCA GCCACCCCCA 
GTCAACCGAA ACCTCAAACC TGACCGAAAA GCAAAGCCAA CACCCCTTGA CCTGAGAAAC 
AACACTGTCA TCGATGAGCT CCCCTTCAAG TCACCTGTCA CCAAGTCTTG GTCCAGGATC 
AACCACACCT TTAACTCCAG TTCCTCCCAG TACTGCCGTC CTATCTCCAC ACAGAGCATC 
ACCAGCACAG ACTCAGGAGA CAGTGAGGAG AACTATGTCC CTATGCAAAA CCCAGTATCT 
GCGTCCCCTG TTCCCAGTGG CACTAACAGC CCAGCTCCCA GGAAGAGTAC TGGCAGTGTG 
GATTACCTAG CCCTGGACTT CCAGCCGGGC TCCCCAAGCC CTCACCGCAA GCCATCCACA 
TCATCTGTCA CATCGGATGA GAAGGTAGAC TATGTCCAAG TGGATAAAGA GAAGACACAG 
GCCCTGCAGA ACACCATGCA GGAGTGGACA GATGTACGGC AGTCCTCAGA ACCTTCCAAG 
GGTGCCAAGC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility.
Molecular and cellular biology33(8)1657-70(2013 Apr)
Zhang X,Lavoie G,Fort L,Huttlin EL,Tcherkezian J,Galan JA,Gu H,Gygi SP,Carreno S,Roux PP

Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.
Leukemia27(1)118-29(2013 Jan)
W?hrle FU,Halbach S,Aumann K,Schwemmers S,Braun S,Auberger P,Schramek D,Penninger JM,La?mann S,Werner M,Waller CF,Pahl HL,Zeiser R,Daly RJ,Brummer T

PKA and GAB2 play central roles in the FSH signaling pathway to PI3K and AKT in ovarian granulosa cells.
Proceedings of the National Academy of Sciences of the United States of America109(44)E2979-88(2012 Oct)
Hunzicker-Dunn ME,Lopez-Biladeau B,Law NC,Fiedler SE,Carr DW,Maizels ET

Inhibition of the antigen-induced activation of RBL-2H3 cells by Gab2 siRNA.
Cellular & molecular immunology5(6)433-8(2008 Dec)
Huang F,Tong X,Deng H,Fu L,Zhang R

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.
The EMBO journal27(17)2305-16(2008 Sep)
Brummer T,Larance M,Herrera Abreu MT,Lyons RJ,Timpson P,Emmerich CH,Fleuren ED,Lehrbach GM,Schramek D,Guilhaus M,James DE,Daly RJ

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Gab2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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