Mkln1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mkln1
Entrez Gene ID	83536
Full Name	muskelin 1
General protein information	Preferred Names muskelin 1 Names muskelin muskelin 1, intracellular mediator containing kelch motifs
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q22
Summary	human homolog may mediate cell spreading via communication with extracellular matrix component thrombospondin-1 [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031359.1	NP_112649.1	muskelin

Pathways from BioSystems

Homologies

Homo sapiens (human)	MKLN1	NP_037387.2
Canis lupus familiaris (dog)	MKLN1	XP_005628424.1
Schizosaccharomyces pombe (fission yeast)	mde6	NP_594297.2
	MKLN1	XP_001098817.1
Bos taurus (cattle)	MKLN1	NP_001091468.1
Gallus gallus (chicken)	MKLN1	NP_001025944.1
Danio rerio (zebrafish)	mkln1	NP_997859.1
Drosophila melanogaster (fruit fly)	muskelin	NP_610801.1
Rattus norvegicus (Norway rat)	Mkln1	NP_112649.1
Mus musculus (house mouse)	Mkln1	NP_038819.1
Pan troglodytes (chimpanzee)	MKLN1	XP_519385.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004884	XP_314298.3
Xenopus tropicalis (tropical clawed frog)	mkln1	XP_002931895.1

Gene Ontology
Bibliography

Related articles in PubMed

The LisH motif of muskelin is crucial for oligomerization and governs intracellular localization.
Delto CF, Heisler FF, Kuper J, Sander B, Kneussel M, Schindelin H
Structure (London, England : 1993)23(2)364-73(2015 Feb)

Characterization of the novel interaction between muskelin and TBX20, a critical cardiogenic transcription factor.
Debenedittis P, Harmelink C, Chen Y, Wang Q, Jiao K
Biochemical and biophysical research communications409(2)338-43(2011 Jun)

Novel role of the muskelin-RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation.
Valiyaveettil M, Bentley AA, Gursahaney P, Hussien R, Chakravarti R, Kureishy N, Prag S, Adams JC
The Journal of cell biology182(4)727-39(2008 Aug)

RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex.
Kobayashi N, Yang J, Ueda A, Suzuki T, Tomaru K, Takeno M, Okuda K, Ishigatsubo Y
Gene396(2)236-47(2007 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mkln1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mkln1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07915	NM_031359.1 Latest version!	Rattus norvegicus muskelin 1 (Mkln1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$433.30 $619.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mkln1 ( NM_031359.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112649.1 Rattus norvegicus muskelin 1 (Mkln1), mRNA.

Price & Availability↑

CloneID	ORa07915
Clone ID Related Accession (Same CDS sequence)	NM_031359.1
Accession Version	NM_031359.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2208bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	muskelin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB046442.1. ##Evidence-Data-START## Transcript exon combination :: AB046442.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCTG GCGGGGCTGT TGCTGCGGCG CCCGAGTGCC GGCTTCTGCC CTACGCGCTG 
CATAAGTGGA GCTCCTTCTC CTCCACCTAC CTTCCCGAGA ACATTTTAGT GGATAAACCA 
AATGATCAGT CTTCCAGATG GTCTTCAGAG AGCAACTATC CTCCCCAGTA CTTGATTCTG 
AAGCTTGAAA GGCCTGCTAT AGTTCAGAAT ATTACATTTG GAAAATATGA GAAAACTCAT 
GTCTGCAATT TGAAGAAATT CAAAGTTTTC GGTGGAATGA ATGAAGAAAA TATGACAGAG 
CTGCTGTCCA GCGGCTTGAA GAATGATTAT AACAAAGAGA CATTTACCTT GAAACATAAA 
ATTGATGAAC AGATGTTCCC TTGTCGATTC ATTAAAATTG TTCCACTTTT GTCCTGGGGG 
CCCAGCTTTA ATTTTAGCAT CTGGTATGTT GAACTCAGTG GCATTGATGA TCCTGATATA 
GTGCAGCCCT GTCTGAACTG GTACAGCAAG TACCGCGAAC AGGAAGCCAT TCGCCTTTGT 
CTAAAACACT TCAGACAACA CAACTATACA GAGGCTTTTG AATCCCTGCA GAAGAAAACC 
AAGATTGCAC TGGAGCATCC AATGTTGACA GATATGCACG ACAAATTGGT GTTAAAGGGT 
GACTTTGATG CTTGCGAGGA GTTGATTGAA AAAGCGGTAA ATGATGGCTT GTTCAATCAG 
TATATCAGTC AACAGGAGTA TAAGCCACGG TGGAGTCAGA TTATTCCTAA GAGCACCAAA 
GGTGATGGAG AAGATAACCG TCCAGGAATG AGAGGGGGCC ATCAGATGGT CATTGATGTT 
CAGACAGAGA CTGTTTATTT GTTTGGTGGC TGGGATGGAA CACAAGATCT TGCTGACTTC 
TGGGCATACA GTGTGAAGGA GAACCAGTGG ACATGTATTT CTAGAGACAC TGAGAAAGAG 
AATGGTCCTA GTGCCAGATC ATGTCATAAA ATGTGCATTG ATATTCAGCG GAGACAAATC 
TACACATTGG GCCGTTACTT GGATTCCTCT GTGAGGAACA GCAAATCTCT GAAAAGTGAT 
TTCTACCGTT ACGACATTGA CACCAACACC TGGATGTTAC TAAGTGAAGA CACTGCTGCC 
GACGGTGGAC CAAAATTGGT GTTTGATCAT CAGATGTGTA TGGACTCAGA AAAGCATATG 
ATCTATACCT TTGGTGGTAG GATTTTGACA TGTAATGGCA GTGTAGATGA CAGCAGAGCC 
AGTGAACCAC AATTCAGTGG GCTGTTTGCA TTCAACTGCC AGTGTCAAAC CTGGAAACTT 
CTTCGAGAGG ACTCCTGTAA CGCAGGCCCT GAGGACATCC AGTCTCGGAT TGGACACTGC 
ATGCTGTTCC ACTCGAAAAA CCGTTGTTTA TACGTGTTTG GTGGCCAGAG ATCTAAGACC 
TATTTGAATG ATTTTTTTAG TTATGATGTG GACTCTGATC ATGTAGACAT AATTTCAGAT 
GGCACCAAGA AAGACTCTGG AATGGTTCCA ATGACCGGAT TCACACAGAG AGCAACTATT 
GATCCAGAAC TGAATGAAAT ACATGTTTTA TCCGGACTTA GCAAAGACAA AGAAAAGAGG 
GAAGAGAATG TCAGAAATTC ATTCTGGATT TATGACATTG TGAGGAATAG CTGGTCTTGT 
GTCTATAAGA ATGATCAAGC TGCAAAAGAG AATCTGAGTA AAAGTCTTCA GGAAGAAGAA 
CCATGTCCAA GGTTTGCCCA TCAGCTCGTT TATGATGAAT TACACAAGGT TCATTATTTA 
TTTGGTGGGA ATCCAGGAAA GTCTTGCTCT CCAAAGATGA GACTAGATGA CTTCTGGTCG 
CTGAAGTTGT GCAGACCTTC GAAGGACTAC TTACTGAGGC ATTGCAAGTA CCTCATCAGG 
AAGCACAGGT TTGAAGAAAA GGCCCAGATG GATCCCCTTA GTGCTCTGAA GTATTTACAG 
AATGATCTTT ATATAACTGT GGATCATTCG GACCCAGAAG AGACAAAAGA GTTTCAACTC 
CTAGCCTCAG CCCTGTTCAA ATCTGGCTCA GATTTCACAG CTTTAGGCTT TTCAGACGTG 
GATCACACCT ATGCTCAGAG AACTCAGCTC TTTGACACCT TAGTGAATTT CTTTCCTGAC 
AGCATGACTC CTCCTAAGGG CAACCTGGTA GACCTCATCA CACTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112649.1
CDS	1..2208
Translation	MAAGGAVAAAPECRLLPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDMHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKENLSKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYLIRKHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL

Target ORF information:

RefSeq Version	NM_031359.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus muskelin 1 (Mkln1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031359.1

ORF Insert Sequence:

ATGGCGGCTG GCGGGGCTGT TGCTGCGGCG CCCGAGTGCC GGCTTCTGCC CTACGCGCTG 
CATAAGTGGA GCTCCTTCTC CTCCACCTAC CTTCCCGAGA ACATTTTAGT GGATAAACCA 
AATGATCAGT CTTCCAGATG GTCTTCAGAG AGCAACTATC CTCCCCAGTA CTTGATTCTG 
AAGCTTGAAA GGCCTGCTAT AGTTCAGAAT ATTACATTTG GAAAATATGA GAAAACTCAT 
GTCTGCAATT TGAAGAAATT CAAAGTTTTC GGTGGAATGA ATGAAGAAAA TATGACAGAG 
CTGCTGTCCA GCGGCTTGAA GAATGATTAT AACAAAGAGA CATTTACCTT GAAACATAAA 
ATTGATGAAC AGATGTTCCC TTGTCGATTC ATTAAAATTG TTCCACTTTT GTCCTGGGGG 
CCCAGCTTTA ATTTTAGCAT CTGGTATGTT GAACTCAGTG GCATTGATGA TCCTGATATA 
GTGCAGCCCT GTCTGAACTG GTACAGCAAG TACCGCGAAC AGGAAGCCAT TCGCCTTTGT 
CTAAAACACT TCAGACAACA CAACTATACA GAGGCTTTTG AATCCCTGCA GAAGAAAACC 
AAGATTGCAC TGGAGCATCC AATGTTGACA GATATGCACG ACAAATTGGT GTTAAAGGGT 
GACTTTGATG CTTGCGAGGA GTTGATTGAA AAAGCGGTAA ATGATGGCTT GTTCAATCAG 
TATATCAGTC AACAGGAGTA TAAGCCACGG TGGAGTCAGA TTATTCCTAA GAGCACCAAA 
GGTGATGGAG AAGATAACCG TCCAGGAATG AGAGGGGGCC ATCAGATGGT CATTGATGTT 
CAGACAGAGA CTGTTTATTT GTTTGGTGGC TGGGATGGAA CACAAGATCT TGCTGACTTC 
TGGGCATACA GTGTGAAGGA GAACCAGTGG ACATGTATTT CTAGAGACAC TGAGAAAGAG 
AATGGTCCTA GTGCCAGATC ATGTCATAAA ATGTGCATTG ATATTCAGCG GAGACAAATC 
TACACATTGG GCCGTTACTT GGATTCCTCT GTGAGGAACA GCAAATCTCT GAAAAGTGAT 
TTCTACCGTT ACGACATTGA CACCAACACC TGGATGTTAC TAAGTGAAGA CACTGCTGCC 
GACGGTGGAC CAAAATTGGT GTTTGATCAT CAGATGTGTA TGGACTCAGA AAAGCATATG 
ATCTATACCT TTGGTGGTAG GATTTTGACA TGTAATGGCA GTGTAGATGA CAGCAGAGCC 
AGTGAACCAC AATTCAGTGG GCTGTTTGCA TTCAACTGCC AGTGTCAAAC CTGGAAACTT 
CTTCGAGAGG ACTCCTGTAA CGCAGGCCCT GAGGACATCC AGTCTCGGAT TGGACACTGC 
ATGCTGTTCC ACTCGAAAAA CCGTTGTTTA TACGTGTTTG GTGGCCAGAG ATCTAAGACC 
TATTTGAATG ATTTTTTTAG TTATGATGTG GACTCTGATC ATGTAGACAT AATTTCAGAT 
GGCACCAAGA AAGACTCTGG AATGGTTCCA ATGACCGGAT TCACACAGAG AGCAACTATT 
GATCCAGAAC TGAATGAAAT ACATGTTTTA TCCGGACTTA GCAAAGACAA AGAAAAGAGG 
GAAGAGAATG TCAGAAATTC ATTCTGGATT TATGACATTG TGAGGAATAG CTGGTCTTGT 
GTCTATAAGA ATGATCAAGC TGCAAAAGAG AATCTGAGTA AAAGTCTTCA GGAAGAAGAA 
CCATGTCCAA GGTTTGCCCA TCAGCTCGTT TATGATGAAT TACACAAGGT TCATTATTTA 
TTTGGTGGGA ATCCAGGAAA GTCTTGCTCT CCAAAGATGA GACTAGATGA CTTCTGGTCG 
CTGAAGTTGT GCAGACCTTC GAAGGACTAC TTACTGAGGC ATTGCAAGTA CCTCATCAGG 
AAGCACAGGT TTGAAGAAAA GGCCCAGATG GATCCCCTTA GTGCTCTGAA GTATTTACAG 
AATGATCTTT ATATAACTGT GGATCATTCG GACCCAGAAG AGACAAAAGA GTTTCAACTC 
CTAGCCTCAG CCCTGTTCAA ATCTGGCTCA GATTTCACAG CTTTAGGCTT TTCAGACGTG 
GATCACACCT ATGCTCAGAG AACTCAGCTC TTTGACACCT TAGTGAATTT CTTTCCTGAC 
AGCATGACTC CTCCTAAGGG CAACCTGGTA GACCTCATCA CACTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The LisH motif of muskelin is crucial for oligomerization and governs intracellular localization.
Structure (London, England : 1993)23(2)364-73(2015 Feb)
Delto CF,Heisler FF,Kuper J,Sander B,Kneussel M,Schindelin H

Characterization of the novel interaction between muskelin and TBX20, a critical cardiogenic transcription factor.
Biochemical and biophysical research communications409(2)338-43(2011 Jun)
Debenedittis P,Harmelink C,Chen Y,Wang Q,Jiao K

Novel role of the muskelin-RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation.
The Journal of cell biology182(4)727-39(2008 Aug)
Valiyaveettil M,Bentley AA,Gursahaney P,Hussien R,Chakravarti R,Kureishy N,Prag S,Adams JC

RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex.
Gene396(2)236-47(2007 Jul)
Kobayashi N,Yang J,Ueda A,Suzuki T,Tomaru K,Takeno M,Okuda K,Ishigatsubo Y

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Mkln1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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