Musk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Musk
Entrez Gene ID	81725
Full Name	muscle associated receptor tyrosine kinase
Synonyms	Nsk1
General protein information	Preferred Names muscle associated receptor tyrosine kinase Names muscle, skeletal receptor tyrosine protein kinase muscle specific kinase (neural fold/somite kinase 1) muscle, skeletal, receptor tyrosine kinase muscle-specific kinase receptor muscle-specific tyrosine kinase receptor MuSK muscle-specific tyrosine protein kinase receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q24
Summary	receptor tyrosine kinase expressed in myotomes, developing muscle and localized to the neuromuscular junction in the adult; expression is induced in response to injury or immobilization [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031061.1	NP_112323.1	muscle, skeletal receptor tyrosine protein kinase precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MUSK	XP_001146498.1
Gallus gallus (chicken)	MUSK	NP_989439.1
Danio rerio (zebrafish)	musk	NP_001004503.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006988	XP_308783.2
Mus musculus (house mouse)	Musk	NP_001032204.2
Drosophila melanogaster (fruit fly)	Nrk	NP_477255.1
	MUSK	XP_001106626.1
Canis lupus familiaris (dog)	MUSK	XP_538784.4
Bos taurus (cattle)	MUSK	NP_001179281.1
Homo sapiens (human)	MUSK	NP_005583.1
Rattus norvegicus (Norway rat)	Musk	NP_112323.1
Xenopus tropicalis (tropical clawed frog)	musk	XP_002940313.2

Gene Ontology
Bibliography

Related articles in PubMed

Identification of a Dutch founder mutation in MUSK causing fetal akinesia deformation sequence.
Tan-Sindhunata MB, Mathijssen IB, Smit M, Baas F, de Vries JI, van der Voorn JP, Kluijt I, Hagen MA, Blom EW, Sistermans E, Meijers-Heijboer H, Waisfisz Q, Weiss MM, Groffen AJ
European journal of human genetics : EJHG23(9)1151-7(2015 Sep)

The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface.
Witzemann V, Chevessier F, Pacifici PG, Yampolsky P
Mechanisms of development130(6-8)402-11(2013 Jun-Aug)

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Ghai R, Bugarcic A, Liu H, Norwood SJ, Skeldal S, Coulson EJ, Li SS, Teasdale RD, Collins BM
Proceedings of the National Academy of Sciences of the United States of America110(8)E643-52(2013 Feb)

The formation of complex acetylcholine receptor clusters requires MuSK kinase activity and structural information from the MuSK extracellular domain.
Mazhar S, Herbst R
Molecular and cellular neurosciences49(4)475-86(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MuSK kinase activity is necessary for substrate-dependent acetylcholine receptor cluster formation
Title: The formation of complex acetylcholine receptor clusters requires MuSK kinase activity and structural information from the MuSK extracellular domain.

The crystal structure of the Dok7 PH-PTB domains in complex with a phosphopeptide representing the Dok7-binding site on MuSK, is presented.
Title: The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization.

The structure reveals a five-disulfide-bridged domain similar to CRDs of Frizzled proteins but with a divergent C-terminal region.
Title: Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK.

results identify a synapse-associated E3 ubiquitin ligase as an important regulator of MuSK signaling
Title: Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction.

In summary, the presence of MuSK on retinal astrocytes suggests a novel role of MuSK signalling pathways in the CNS.
Title: Identification of developmentally regulated expression of MuSK in astrocytes of the rodent retina.

The following Musk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Musk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07492	NM_031061.1 Latest version!	Rattus norvegicus muscle associated receptor tyrosine kinase (Musk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Musk ( NM_031061.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112323.1 Rattus norvegicus muscle associated receptor tyrosine kinase (Musk), mRNA.

Price & Availability↑

CloneID	ORa07492
Clone ID Related Accession (Same CDS sequence)	NM_031061.1
Accession Version	NM_031061.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2607bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	muscle, skeletal receptor tyrosine protein kinase precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U34985.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U34985.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAGAGAGC TCGTCAACAT TCCACTGTTA CAGATGCTCA CCCTGGTTGC CTTCAGCGGG 
ACCGAGAAAC TTCCAAAAGC CCCTGTCATC ACCACGCCTC TTGAAACTGT AGATGCCTTA 
GTTGAAGAAG TGGCGACTTT CATGTGCGCC GTGGAATCCT ACCCTCAGCC TGAAATTTCT 
TGGACCAGAA ATAAAATTCT CATCAAGCTG TTTGACACCC GCTACAGCAT CCGAGAGAAC 
GGTCAGCTCC TCACCATCCT GAGTGTGGAG GACAGTGATG ATGGCATCTA CTGCTGCACA 
GCCAACAATG GAGTGGGAGG AGCGGTGGAA AGTTGTGGCG CCCTGCAAGT GAAGATGAAG 
CCTAAAATAA CTCGTCCTCC CATCAATGTA AAAATAATTG AGGGATTGAA AGCAGTCCTA 
CCGTGCACTA CGATGGGTAA CCCCAAGCCA TCCGTGTCCT GGATTAAGGG GGACAGTGCT 
CTCAGGGAAA ATTCCAGGAT TGCAGTTCTT GAATCTGGGA GTTTAAGGAT CCATAATGTG 
CAAAAGGAAG ACGCAGGACA GTACCGATGT GTGGCAAAAA ACAGCCTGGG CACAGCTTAC 
TCCAAACTGG TGAAGCTGGA AGTGGAGGTT TTTGCAAGAA TCCTGCGTGC TCCTGAATCC 
CACAATGTCA CCTTTGGTTC CTTTGTAACC CTACGCTGCA CAGCAATAGG CATGCCTGTC 
CCCACCATCA GCTGGATTGA AAACGGAAAT GCTGTTTCTT CAGGTTCCAT TCAAGAGAAT 
GTGAAAGACC GAGTGATTGA CTCAAGACTC CAGCTCTTTA TCACAAAGCC AGGACTCTAC 
ACATGCATAG CTACCAATAA GCATGGAGAG AAATTCAGTA CCGCAAAGGC TGCAGCCACT 
GTCAGTATAG CAGAATGGAG CAAATCACAG AAAGAAAGCA AAGGCTACTG TGCCCAGTAC 
AGAGGGGAGG TGTGTGATGC CGTCCTGGTG AAAGACTCTC TTGTCTTCTT CAACACCTCC 
TATCCCGACC CTGAGGAGGC CCAAGAGCTG CTGATCCACA CTGCGTGGAA TGAACTCAAG 
GCTGTGAGCC CACTCTGCCG ACCAGCTGCC GAGGCTCTGC TGTGTAATCA CCTCTTCCAG 
GAGTGCAGCC CTGGAGTGCT ACCTACTCCT ATGCCCATTT GCAGAGAGTA CTGCTTGGCA 
GTAAAGGAGC TCTTCTGTGC AAAGGAATGG CTGGCAATGG AAGGGAAGAC CCACCGCGGA 
CTCTACAGAT CCGGGATGCA TTTCCTCCCG GTCCCGGAGT GCAGCAAGCT TCCCAGCATG 
CACCAGGACC CCACAGCCTG CACAAGACTG CCGTATTTAG ATTATAAAAA AGAAAACATA 
ACAACATTCC CGTCCATAAC GTCCTCCAAG CCGAGCGTGG ACATTCCAAA CCTGCCTGCC 
TCCACGTCTT CCTTCGCCGT CTCGCCTGCG TACTCCATGA CTGTCATCAT CTCCATCATG 
TCCTGCTTTG CGGTGTTTGC TCTCCTCACC ATCACTACTC TCTATTGCTG CCGAAGGAGG 
AGAGAGTGGA AAAATAAGAA AAGAGAGTCG GCAGCGGTGA CCCTCACCAC ATTGCCTTCC 
GAGCTCCTGC TGGACAGGCT GCATCCCAAC CCCATGTACC AGAGGATGCC ACTCCTTCTG 
AATCCCAAGT TGCTCAGCCT GGAGTATCCG AGGAATAACA TCGAGTATGT CAGAGACATC 
GGAGAGGGAG CGTTTGGAAG GGTCTTTCAA GCGAGGGCCC CAGGCTTGCT TCCTTATGAA 
CCCTTCACTA TGGTGGCTGT GAAGATGCTG AAGGAGGAGG CCTCCGCAGA TATGCAGGCA 
GACTTTCAGA GGGAGGCAGC CCTCATGGCG GAGTTTGACA ACCCCAACAT TGTGAAGCTC 
TTAGGTGTGT GTGCTGTTGG GAAGCCAATG TGCCTGCTCT TTGAATATAT GGCCTATGGT 
GACCTCAATG AGTTCCTCCG AAGCATGTCC CCTCACACTG TGTGCAGCCT CAGCCACAGT 
GACCTGTCCA CGAGGGCTCG GGTGTCCAGC CCTGGTCCTC CACCCCTGTC TTGTGCGGAA 
CAGCTCTGTA TTGCCAGGCA AGTGGCAGCT GGCATGGCCT ACCTGTCGGA GCGCAAGTTT 
GTCCATCGGG ACTTAGCTAC CAGGAACTGC CTGGTTGGAG AGAACATGGT GGTGAAAATT 
GCAGACTTTG GCCTCTCTAG GAACATCTAC TCCGCAGACT ACTACAAAGC TGATGGAAAC 
GATGCTATAC CTATCCGCTG GATGCCACCC GAGTCTATCT TCTACAACCG CTACACCACG 
GAGTCAGATG TGTGGGCTTA TGGCGTGGTC CTCTGGGAGA TCTTCTCCTA TGGACTGCAG 
CCCTACTATG GAATGGCCCA TGAGGAGGTC ATTTACTATG TGAGAGATGG TAACATCCTT 
GCCTGCCCTG AGAACTGTCC CTTGGAACTG TACAACCTTA TGCGCCTATG TTGGAGCAAG 
CTGCCTGCAG ACAGACCCAG CTTCTGCAGT ATCCACCGGA TCCTGCAGCG CATGTGCGAG 
AGAGCAGAGG GAACGGTAGG CGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112323.1
CDS	121..2727
Translation	MRELVNIPLLQMLTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSALRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKLVKLEVEVFARILRAPESHNVTFGSFVTLRCTAIGMPVPTISWIENGNAVSSGSIQENVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATVSIAEWSKSQKESKGYCAQYRGEVCDAVLVKDSLVFFNTSYPDPEEAQELLIHTAWNELKAVSPLCRPAAEALLCNHLFQECSPGVLPTPMPICREYCLAVKELFCAKEWLAMEGKTHRGLYRSGMHFLPVPECSKLPSMHQDPTACTRLPYLDYKKENITTFPSITSSKPSVDIPNLPASTSSFAVSPAYSMTVIISIMSCFAVFALLTITTLYCCRRRREWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQRMCERAEGTVGV

Target ORF information:

RefSeq Version	NM_031061.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus muscle associated receptor tyrosine kinase (Musk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031061.1

ORF Insert Sequence:

ATGAGAGAGC TCGTCAACAT TCCACTGTTA CAGATGCTCA CCCTGGTTGC CTTCAGCGGG 
ACCGAGAAAC TTCCAAAAGC CCCTGTCATC ACCACGCCTC TTGAAACTGT AGATGCCTTA 
GTTGAAGAAG TGGCGACTTT CATGTGCGCC GTGGAATCCT ACCCTCAGCC TGAAATTTCT 
TGGACCAGAA ATAAAATTCT CATCAAGCTG TTTGACACCC GCTACAGCAT CCGAGAGAAC 
GGTCAGCTCC TCACCATCCT GAGTGTGGAG GACAGTGATG ATGGCATCTA CTGCTGCACA 
GCCAACAATG GAGTGGGAGG AGCGGTGGAA AGTTGTGGCG CCCTGCAAGT GAAGATGAAG 
CCTAAAATAA CTCGTCCTCC CATCAATGTA AAAATAATTG AGGGATTGAA AGCAGTCCTA 
CCGTGCACTA CGATGGGTAA CCCCAAGCCA TCCGTGTCCT GGATTAAGGG GGACAGTGCT 
CTCAGGGAAA ATTCCAGGAT TGCAGTTCTT GAATCTGGGA GTTTAAGGAT CCATAATGTG 
CAAAAGGAAG ACGCAGGACA GTACCGATGT GTGGCAAAAA ACAGCCTGGG CACAGCTTAC 
TCCAAACTGG TGAAGCTGGA AGTGGAGGTT TTTGCAAGAA TCCTGCGTGC TCCTGAATCC 
CACAATGTCA CCTTTGGTTC CTTTGTAACC CTACGCTGCA CAGCAATAGG CATGCCTGTC 
CCCACCATCA GCTGGATTGA AAACGGAAAT GCTGTTTCTT CAGGTTCCAT TCAAGAGAAT 
GTGAAAGACC GAGTGATTGA CTCAAGACTC CAGCTCTTTA TCACAAAGCC AGGACTCTAC 
ACATGCATAG CTACCAATAA GCATGGAGAG AAATTCAGTA CCGCAAAGGC TGCAGCCACT 
GTCAGTATAG CAGAATGGAG CAAATCACAG AAAGAAAGCA AAGGCTACTG TGCCCAGTAC 
AGAGGGGAGG TGTGTGATGC CGTCCTGGTG AAAGACTCTC TTGTCTTCTT CAACACCTCC 
TATCCCGACC CTGAGGAGGC CCAAGAGCTG CTGATCCACA CTGCGTGGAA TGAACTCAAG 
GCTGTGAGCC CACTCTGCCG ACCAGCTGCC GAGGCTCTGC TGTGTAATCA CCTCTTCCAG 
GAGTGCAGCC CTGGAGTGCT ACCTACTCCT ATGCCCATTT GCAGAGAGTA CTGCTTGGCA 
GTAAAGGAGC TCTTCTGTGC AAAGGAATGG CTGGCAATGG AAGGGAAGAC CCACCGCGGA 
CTCTACAGAT CCGGGATGCA TTTCCTCCCG GTCCCGGAGT GCAGCAAGCT TCCCAGCATG 
CACCAGGACC CCACAGCCTG CACAAGACTG CCGTATTTAG ATTATAAAAA AGAAAACATA 
ACAACATTCC CGTCCATAAC GTCCTCCAAG CCGAGCGTGG ACATTCCAAA CCTGCCTGCC 
TCCACGTCTT CCTTCGCCGT CTCGCCTGCG TACTCCATGA CTGTCATCAT CTCCATCATG 
TCCTGCTTTG CGGTGTTTGC TCTCCTCACC ATCACTACTC TCTATTGCTG CCGAAGGAGG 
AGAGAGTGGA AAAATAAGAA AAGAGAGTCG GCAGCGGTGA CCCTCACCAC ATTGCCTTCC 
GAGCTCCTGC TGGACAGGCT GCATCCCAAC CCCATGTACC AGAGGATGCC ACTCCTTCTG 
AATCCCAAGT TGCTCAGCCT GGAGTATCCG AGGAATAACA TCGAGTATGT CAGAGACATC 
GGAGAGGGAG CGTTTGGAAG GGTCTTTCAA GCGAGGGCCC CAGGCTTGCT TCCTTATGAA 
CCCTTCACTA TGGTGGCTGT GAAGATGCTG AAGGAGGAGG CCTCCGCAGA TATGCAGGCA 
GACTTTCAGA GGGAGGCAGC CCTCATGGCG GAGTTTGACA ACCCCAACAT TGTGAAGCTC 
TTAGGTGTGT GTGCTGTTGG GAAGCCAATG TGCCTGCTCT TTGAATATAT GGCCTATGGT 
GACCTCAATG AGTTCCTCCG AAGCATGTCC CCTCACACTG TGTGCAGCCT CAGCCACAGT 
GACCTGTCCA CGAGGGCTCG GGTGTCCAGC CCTGGTCCTC CACCCCTGTC TTGTGCGGAA 
CAGCTCTGTA TTGCCAGGCA AGTGGCAGCT GGCATGGCCT ACCTGTCGGA GCGCAAGTTT 
GTCCATCGGG ACTTAGCTAC CAGGAACTGC CTGGTTGGAG AGAACATGGT GGTGAAAATT 
GCAGACTTTG GCCTCTCTAG GAACATCTAC TCCGCAGACT ACTACAAAGC TGATGGAAAC 
GATGCTATAC CTATCCGCTG GATGCCACCC GAGTCTATCT TCTACAACCG CTACACCACG 
GAGTCAGATG TGTGGGCTTA TGGCGTGGTC CTCTGGGAGA TCTTCTCCTA TGGACTGCAG 
CCCTACTATG GAATGGCCCA TGAGGAGGTC ATTTACTATG TGAGAGATGG TAACATCCTT 
GCCTGCCCTG AGAACTGTCC CTTGGAACTG TACAACCTTA TGCGCCTATG TTGGAGCAAG 
CTGCCTGCAG ACAGACCCAG CTTCTGCAGT ATCCACCGGA TCCTGCAGCG CATGTGCGAG 
AGAGCAGAGG GAACGGTAGG CGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of a Dutch founder mutation in MUSK causing fetal akinesia deformation sequence.
European journal of human genetics : EJHG23(9)1151-7(2015 Sep)
Tan-Sindhunata MB,Mathijssen IB,Smit M,Baas F,de Vries JI,van der Voorn JP,Kluijt I,Hagen MA,Blom EW,Sistermans E,Meijers-Heijboer H,Waisfisz Q,Weiss MM,Groffen AJ

The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface.
Mechanisms of development130(6-8)402-11(2013 Jun-Aug)
Witzemann V,Chevessier F,Pacifici PG,Yampolsky P

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Proceedings of the National Academy of Sciences of the United States of America110(8)E643-52(2013 Feb)
Ghai R,Bugarcic A,Liu H,Norwood SJ,Skeldal S,Coulson EJ,Li SS,Teasdale RD,Collins BM

The formation of complex acetylcholine receptor clusters requires MuSK kinase activity and structural information from the MuSK extracellular domain.
Molecular and cellular neurosciences49(4)475-86(2012 Apr)
Mazhar S,Herbst R

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Musk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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