Atic cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atic
Entrez Gene ID	81643
Full Name	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
General protein information	Preferred Names 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Names bifunctional purine biosynthesis protein PURH
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q33
Summary	catalyzes the final two steps of de novo purine biosynthesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031014.2	NP_112276.2	bifunctional purine biosynthesis protein PURH

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ATIC	XP_001150761.1
Danio rerio (zebrafish)	atic	NP_001076265.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001423	XP_321707.4
Neurospora crassa	NCU02629	XP_964054.1
Homo sapiens (human)	ATIC	NP_004035.2
Drosophila melanogaster (fruit fly)	CG11089	NP_651305.1
Caenorhabditis elegans (roundworm)	C55F2.1	NP_741452.2
Eremothecium gossypii	AGOS_AFR213C	NP_985760.2
Schizosaccharomyces pombe (fission yeast)	ade10	NP_588027.1
Magnaporthe oryzae (rice blast fungus)	MGG_04435	XP_003713530.1
Bos taurus (cattle)	ATIC	NP_001068722.1
Mus musculus (house mouse)	Atic	NP_080471.2
Rattus norvegicus (Norway rat)	Atic	NP_112276.2
Canis lupus familiaris (dog)	ATIC	XP_545634.2
Gallus gallus (chicken)	ATIC	NP_990509.1
Saccharomyces cerevisiae (baker's yeast)	ADE17	NP_013839.1
Xenopus tropicalis (tropical clawed frog)	atic	NP_001005460.1
	LOC694819	XP_002808069.1
Kluyveromyces lactis	KLLA0F17655g	XP_455873.1
Arabidopsis thaliana (thale cress)	AT2G35040	NP_001189681.1
Oryza sativa (rice)	Os08g0206600	NP_001061240.1

Gene Ontology
Bibliography

Related articles in PubMed

The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.
Boutchueng-Djidjou M, Collard-Simard G, Fortier S, H?bert SS, Kelly I, Landry CR, Faure RL
Molecular & cellular proteomics : MCP14(4)1079-92(2015 Apr)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

Trafficking of intracellular folates.
Stover PJ, Field MS
Advances in nutrition (Bethesda, Md.)2(4)325-31(2011 Jul)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data identified ATIC as a physical partner of internalized insulin receptor (IR) in purified Golgi-endosomes (G/E) fractions of rat's liver. They show that ATIC later accumulates in G/E . SiRNA-mediated partial knockdown of ATIC decreased tyrosine phosphorylation of IR and regulated IR endocytosis in HEK293 cells. Treatment with ATIC substrate AICAR, which is an allosteric activator of AMPK, increased IR endocytosis.
Title: The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.

The following Atic gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atic cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07385	NM_031014.2 Latest version!	Rattus norvegicus 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (Atic), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$349.30 $499.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atic ( NM_031014.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112276.2 Rattus norvegicus 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (Atic), mRNA.

Price & Availability↑

CloneID	ORa07385
Clone ID Related Accession (Same CDS sequence)	NM_031014.2
Accession Version	NM_031014.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1779bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	bifunctional purine biosynthesis protein PURH
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC072496.1. On Jun 13, 2004 this sequence version replaced NM_031014.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC072496.1, D89514.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTTCCT CCCAGCTTGC CCTGTTCAGT GTGTCTGACA AAACTGGCCT CGTGGAATTT 
GCCAGAAACC TCGCGTCTCT TGGTTTGAGT TTGGTCGCTT CTGGAGGCAC GGCAAAAGCG 
ATCAGGGATG CTGGCCTGGC AGTGAGAGAT GTGTCTGAGC TAACTGGGTT CCCTGAAATG 
TTAGGGGGGC GTGTGAAAAC CTTGCATCCT GCAGTCCATG CTGGAATCTT AGCACGCAAT 
ATTCCAGAAG ATGCTGCTGA CATGGCCAGG CTTGATTTCA ACCTCATAAG AGTTGTTGTC 
TGTAACCTGT ACCCGTTCGT GAAGACTGTG GCTTCTCCAG ATGTAACCGT TGAGGCAGCT 
GTTGAGCAAA TTGACATTGG TGGCGTGACC TTACTGAGAG CTGCAGCCAA AAACCATGCT 
CGAGTGACAG TTGTGTGTGA GCCAGAGGAC TATGGTGCGG TGGCTGCAGA GATGCAGGGC 
TCTGGTAATA AGGACACCTC CCTGGAGACC AGGCGCCACT TGGCATTGAA GGCATTCACG 
CATACCGCTC AATATGATGA AGCGATTTCG GATTACTTCA GGAGACAGTA CAGTAAAGGA 
ATTTCTCAGA TGCCCTTGAG GTATGGGATG AACCCCCATC AGACTCCTGC CCAGCTGTAT 
ACACTGAAGC CCAAGCTTCC CATCACAGTT CTCAACGGAG CCCCAGGATT CATAAACCTC 
TGCGATGCTT TGAATGCCTG GCAGCTGGTG ACAGAGCTGA GAGGAGCAGT AGACATTCCA 
GCTGCGGCGT CTTTCAAGCA CGTCAGCCCA GCAGGTGCTG CTGTTGGGGT TCCACTCAGT 
GAGGACGAAG CCAGAGTCTG CATGGTCTAT GACCTCTATC CGACCCTCAC GCCCCTGGCC 
ATTGCATATG CAAGAGCAAG AGGAGCTGAT AGGATGTCTT CATTTGGTGA TTTTGTTGCA 
TTATCTGATG TTTGTGATGT CCCAACTGCA AAAATTATCT CCAGAGAAGT GTCAGATGGT 
ATTGTTGCCC CAGGATATGA GGAAGAGGCC TTGAAAATAC TTTCTAAAAA GAAAAATGGA 
AGCTACTGTG TTCTTCAGAT GGACCAGTCC TACAAACCGG ATGAAAATGA AGTTCGAACG 
CTCTTTGGTC TTCGTTTAAG CCAGAAGAGA AATAATGGTG TTGTTGACAA GTCGTTGTTT 
AGCAATATTG TCACCAAGAA TAAAGATCTG CCGGAATCTG CTCTCCGAGA CCTCATTGTC 
GCCACCATCG CTGTCAAGTA TACTCAGTCT AATTCGGTGT GCTATGCCAA GGACGGGCAG 
GTTATTGGCA TCGGAGCAGG ACAGCAGTCT CGGATACACT GTACACGCCT TGCAGGTGAT 
AAGGCAAACT CTTGGTGGCT TCGGCACCAT CCACGAGTGC TTTCCATGAA GTTTAAAGCT 
GGGGTGAAGA GAGCAGAAGT CTCCAATGCC ATCGATCAGT ATGTGACCGG CACCATTGGT 
GAGGGTGAAG ACCTGGTGAA ATGGAAAGCA CTGTTTGAAG AGGTTCCTGA GTTACTCACT 
GAGGCGGAGA AGAAGGAATG GGTGGACAAG CTGAGTGGCG TGTCTGTCAG TTCCGATGCT 
TTCTTTCCTT TCAGGGATAA TGTAGACCGA GCGAAAAGGA GTGGTGTGGC CTACATTGTT 
GCTCCATCCG GATCTACTGC TGACAAGGTT GTGATCGAGG CGTGTGACGA GCTGGGGATC 
GTGTTGGCTC ATACAGATCT GCGTCTCTTC CACCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112276.2
CDS	63..1841
Translation	MASSQLALFSVSDKTGLVEFARNLASLGLSLVASGGTAKAIRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDAADMARLDFNLIRVVVCNLYPFVKTVASPDVTVEAAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYGAVAAEMQGSGNKDTSLETRRHLALKAFTHTAQYDEAISDYFRRQYSKGISQMPLRYGMNPHQTPAQLYTLKPKLPITVLNGAPGFINLCDALNAWQLVTELRGAVDIPAAASFKHVSPAGAAVGVPLSEDEARVCMVYDLYPTLTPLAIAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNGSYCVLQMDQSYKPDENEVRTLFGLRLSQKRNNGVVDKSLFSNIVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAGVKRAEVSNAIDQYVTGTIGEGEDLVKWKALFEEVPELLTEAEKKEWVDKLSGVSVSSDAFFPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACDELGIVLAHTDLRLFHH

Target ORF information:

RefSeq Version	NM_031014.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (Atic), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031014.2

ORF Insert Sequence:

ATGGCTTCCT CCCAGCTTGC CCTGTTCAGT GTGTCTGACA AAACTGGCCT CGTGGAATTT 
GCCAGAAACC TCGCGTCTCT TGGTTTGAGT TTGGTCGCTT CTGGAGGCAC GGCAAAAGCG 
ATCAGGGATG CTGGCCTGGC AGTGAGAGAT GTGTCTGAGC TAACTGGGTT CCCTGAAATG 
TTAGGGGGGC GTGTGAAAAC CTTGCATCCT GCAGTCCATG CTGGAATCTT AGCACGCAAT 
ATTCCAGAAG ATGCTGCTGA CATGGCCAGG CTTGATTTCA ACCTCATAAG AGTTGTTGTC 
TGTAACCTGT ACCCGTTCGT GAAGACTGTG GCTTCTCCAG ATGTAACCGT TGAGGCAGCT 
GTTGAGCAAA TTGACATTGG TGGCGTGACC TTACTGAGAG CTGCAGCCAA AAACCATGCT 
CGAGTGACAG TTGTGTGTGA GCCAGAGGAC TATGGTGCGG TGGCTGCAGA GATGCAGGGC 
TCTGGTAATA AGGACACCTC CCTGGAGACC AGGCGCCACT TGGCATTGAA GGCATTCACG 
CATACCGCTC AATATGATGA AGCGATTTCG GATTACTTCA GGAGACAGTA CAGTAAAGGA 
ATTTCTCAGA TGCCCTTGAG GTATGGGATG AACCCCCATC AGACTCCTGC CCAGCTGTAT 
ACACTGAAGC CCAAGCTTCC CATCACAGTT CTCAACGGAG CCCCAGGATT CATAAACCTC 
TGCGATGCTT TGAATGCCTG GCAGCTGGTG ACAGAGCTGA GAGGAGCAGT AGACATTCCA 
GCTGCGGCGT CTTTCAAGCA CGTCAGCCCA GCAGGTGCTG CTGTTGGGGT TCCACTCAGT 
GAGGACGAAG CCAGAGTCTG CATGGTCTAT GACCTCTATC CGACCCTCAC GCCCCTGGCC 
ATTGCATATG CAAGAGCAAG AGGAGCTGAT AGGATGTCTT CATTTGGTGA TTTTGTTGCA 
TTATCTGATG TTTGTGATGT CCCAACTGCA AAAATTATCT CCAGAGAAGT GTCAGATGGT 
ATTGTTGCCC CAGGATATGA GGAAGAGGCC TTGAAAATAC TTTCTAAAAA GAAAAATGGA 
AGCTACTGTG TTCTTCAGAT GGACCAGTCC TACAAACCGG ATGAAAATGA AGTTCGAACG 
CTCTTTGGTC TTCGTTTAAG CCAGAAGAGA AATAATGGTG TTGTTGACAA GTCGTTGTTT 
AGCAATATTG TCACCAAGAA TAAAGATCTG CCGGAATCTG CTCTCCGAGA CCTCATTGTC 
GCCACCATCG CTGTCAAGTA TACTCAGTCT AATTCGGTGT GCTATGCCAA GGACGGGCAG 
GTTATTGGCA TCGGAGCAGG ACAGCAGTCT CGGATACACT GTACACGCCT TGCAGGTGAT 
AAGGCAAACT CTTGGTGGCT TCGGCACCAT CCACGAGTGC TTTCCATGAA GTTTAAAGCT 
GGGGTGAAGA GAGCAGAAGT CTCCAATGCC ATCGATCAGT ATGTGACCGG CACCATTGGT 
GAGGGTGAAG ACCTGGTGAA ATGGAAAGCA CTGTTTGAAG AGGTTCCTGA GTTACTCACT 
GAGGCGGAGA AGAAGGAATG GGTGGACAAG CTGAGTGGCG TGTCTGTCAG TTCCGATGCT 
TTCTTTCCTT TCAGGGATAA TGTAGACCGA GCGAAAAGGA GTGGTGTGGC CTACATTGTT 
GCTCCATCCG GATCTACTGC TGACAAGGTT GTGATCGAGG CGTGTGACGA GCTGGGGATC 
GTGTTGGCTC ATACAGATCT GCGTCTCTTC CACCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.
Molecular & cellular proteomics : MCP14(4)1079-92(2015 Apr)
Boutchueng-Djidjou M,Collard-Simard G,Fortier S,H?bert SS,Kelly I,Landry CR,Faure RL

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

Trafficking of intracellular folates.
Advances in nutrition (Bethesda, Md.)2(4)325-31(2011 Jul)
Stover PJ,Field MS

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Atic cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報