Lect1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lect1
Entrez Gene ID	81512
Full Name	chondromodulin
Synonyms	Chm-1,Lect1
General protein information	Preferred Names chondromodulin Names leukocyte cell-derived chemotaxin 1 chM-I chondromodulin-1 chondromodulin-I leukocyte cell derived chemotaxin 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15q12
Summary	human homolog is a cartilage-specific glycoprotein that stimulates growth of chondrocytes and inhibits tube formation of endothelial cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_030854.1	NP_110481.1	leukocyte cell-derived chemotaxin 1
XM_006252346.2	XP_006252408.1	leukocyte cell-derived chemotaxin 1 isoform X1

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	lect1	NP_001090798.1
Pan troglodytes (chimpanzee)	LECT1	XP_001136784.2
	LECT1	XP_001084639.2
Bos taurus (cattle)	LECT1	NP_776694.1
Gallus gallus (chicken)	LECT1	NP_990141.1
Canis lupus familiaris (dog)	LECT1	XP_851994.1
Mus musculus (house mouse)	Lect1	NP_034831.2
Rattus norvegicus (Norway rat)	Lect1	NP_110481.1
Homo sapiens (human)	LECT1	NP_008946.1
Danio rerio (zebrafish)	lect1	NP_001119920.1

Gene Ontology
Bibliography

Related articles in PubMed

Proteomic analysis of chondromodulin-I-induced differentiation of mesenchymal stem cells into chondrocytes.
Xing SC, Du LX, Zhou W, Hu YQ, Feng Y, Liang HF, Sang L, Qi M, Zhai LJ, Wang ZQ
Journal of proteomics1591-18(2017 04)

The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development.
Miura S, Kondo J, Takimoto A, Sano-Takai H, Guo L, Shukunami C, Tanaka H, Hiraki Y
PloS one9(4)e94239(2014)

Identification of differentially expressed genes in mandibular condylar and tibial growth cartilages using laser microdissection and fluorescent differential display: chondromodulin-I (ChM-1) and tenomodulin (TeM) are differentially expressed in mandibular condylar and other growth cartilages.
Watahiki J, Yamaguchi T, Enomoto A, Irie T, Yoshie K, Tachikawa T, Maki K
Bone42(6)1053-60(2008 Jun)

Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis.
Yoshioka M, Yuasa S, Matsumura K, Kimura K, Shiomi T, Kimura N, Shukunami C, Okada Y, Mukai M, Shin H, Yozu R, Sata M, Ogawa S, Hiraki Y, Fukuda K
Nature medicine12(10)1151-9(2006 Oct)

Chondromodulin-I expression in the growth plate of young uremic rats.
Amil B, Fernandez-Fuente M, Molinos I, Rodriguez J, Carbajo-P?rez E, Garcia E, Yamamoto T, Santos F
Kidney international66(1)51-9(2004 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results demonstrate novel information about the molecular mechanism by which ChM-I induce MSCs to differentiate into chondrocytes.
Title: Proteomic analysis of chondromodulin-I-induced differentiation of mesenchymal stem cells into chondrocytes.

intact 20-25 kDa ChM-I is stored as a component of extracellular matrix in the avascular cartilage zones, but it is inactivated by a single N-terminal proteolytic cleavage in the hypertrophic zone of growth-plate cartilage
Title: The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development.

Data show that chondromodulin-I (ChM-1) and tenomodulin (TeM) are differentially expressed in mandibular condylar and other growth cartilages.
Title: Identification of differentially expressed genes in mandibular condylar and tibial growth cartilages using laser microdissection and fluorescent differential display: chondromodulin-I (ChM-1) and tenomodulin (TeM) are differentially expressed in mandibular condylar and other growth cartilages.

In experimental uremia, expansion of growth cartilage does not result from increased or persistent expression of ChM-I or from reduced VEGF expression at the cartilage-metaphyseal bone interphase.
Title: Chondromodulin-I expression in the growth plate of young uremic rats.

Chm-1 expression was studied in articular cartilage and compared with that in the growth plate.
Title: Chondromodulin-I expression in rat articular cartilage.

The following Lect1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lect1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07208	NM_030854.1 Latest version!	Rattus norvegicus chondromodulin (Cnmd), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa36869	XM_006252346.2 Latest version!	Rattus norvegicus leukocyte cell derived chemotaxin 1 (Lect1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lect1 ( NM_030854.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_110481.1 Rattus norvegicus chondromodulin (Cnmd), mRNA.

Price & Availability↑

CloneID	ORa07208
Clone ID Related Accession (Same CDS sequence)	NM_030854.1
Accession Version	NM_030854.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	leukocyte cell-derived chemotaxin 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF051425.1. ##Evidence-Data-START## Transcript exon combination :: AF051425.1, BC127493.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACAGAGA ACTCGGACAA AGTTCCTATC ACCATGGTAG GACCTGAAGA CGTTGAGTTT 
TGCAGTCCCC CGGCATATGC CACTGTGACC GTGAAGCCCT CCGGGAGCCC TACACGGCTG 
CTCAAGGTGG GAGCTGTGGT TCTCATTTCT GGCGCGGTGC TGCTGCTCTT CGGGGCCATT 
GGGGCCTTCT ACTTCTGGAA GGGAAATGAC AATCACATTT ACAACGTCCA TTACACCATG 
AGTATCAATG GGAGACTACA AGACGCGTCC ATGGAGATAG ATGCTGCCAA CAACTTGGAG 
ACCTTTAAAA TGGGAAGCGG AGCGGAGGAA GCGATTGAAG TTAATGATTT CCAAAATGGC 
ATCACTGGGA TCCGTTTTGC TGGAGGAGAG AAGTGCTACA TCAAAGCACA GGTGAAGGCT 
CGCATCCCTG AGGTCAGCAC TGGGACCAAG CAGAGCATCT CTGAACTGGA AGGCAAGATC 
ATGCCAGTCA AATATGAAGA GAATTCTCTG ATTTGGGTGG CCGTGGACCA GCCTGTAAAG 
GACAACAGCT TCCTGAGTTC TAAAATCCTC GAATTCTGTG GCGACCTGCC TATTTTCTGG 
CTTAAGCCCA TGTATCCGAA AGAAATCCCA AGAGAGAGAA GAGAAGTAGT GAGAAGCAGT 
GCTCCCTCTA CCACAAGGAG ACCACACAGC GAACCTCGAG GCAACGCAGG CCCTGGAAGA 
CTGAGTAACA GAACCAGACC CAGCGTTCAG GATGACGAAG AACCTTTCAA CCCTGACAAT 
CCTTACCACC AGCAGGAAGG AGAGAGCATG ACCTTTGACC CTAGACTGGA TCACGAAGGA 
ATCTGCTGTA TAGAGTGCAG ACGGAGCTAC ACCCACTGCC AGAAGATCTG CGAACCGCTG 
GGAGGTTACT ACCCGTGGCC TTATAATTAC CAAGGGTGTC GCTCAGCCTG CAGAGTGGTC 
ATGCCGTGCA GCTGGTGGGT TGCCCGCATC TTGGGCATGG TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110481.1
CDS	127..1131
Translation	MTENSDKVPITMVGPEDVEFCSPPAYATVTVKPSGSPTRLLKVGAVVLISGAVLLLFGAIGAFYFWKGNDNHIYNVHYTMSINGRLQDASMEIDAANNLETFKMGSGAEEAIEVNDFQNGITGIRFAGGEKCYIKAQVKARIPEVSTGTKQSISELEGKIMPVKYEENSLIWVAVDQPVKDNSFLSSKILEFCGDLPIFWLKPMYPKEIPRERREVVRSSAPSTTRRPHSEPRGNAGPGRLSNRTRPSVQDDEEPFNPDNPYHQQEGESMTFDPRLDHEGICCIECRRSYTHCQKICEPLGGYYPWPYNYQGCRSACRVVMPCSWWVARILGMV

Target ORF information:

RefSeq Version	NM_030854.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus chondromodulin (Cnmd), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030854.1

ORF Insert Sequence:

ATGACAGAGA ACTCGGACAA AGTTCCTATC ACCATGGTAG GACCTGAAGA CGTTGAGTTT 
TGCAGTCCCC CGGCATATGC CACTGTGACC GTGAAGCCCT CCGGGAGCCC TACACGGCTG 
CTCAAGGTGG GAGCTGTGGT TCTCATTTCT GGCGCGGTGC TGCTGCTCTT CGGGGCCATT 
GGGGCCTTCT ACTTCTGGAA GGGAAATGAC AATCACATTT ACAACGTCCA TTACACCATG 
AGTATCAATG GGAGACTACA AGACGCGTCC ATGGAGATAG ATGCTGCCAA CAACTTGGAG 
ACCTTTAAAA TGGGAAGCGG AGCGGAGGAA GCGATTGAAG TTAATGATTT CCAAAATGGC 
ATCACTGGGA TCCGTTTTGC TGGAGGAGAG AAGTGCTACA TCAAAGCACA GGTGAAGGCT 
CGCATCCCTG AGGTCAGCAC TGGGACCAAG CAGAGCATCT CTGAACTGGA AGGCAAGATC 
ATGCCAGTCA AATATGAAGA GAATTCTCTG ATTTGGGTGG CCGTGGACCA GCCTGTAAAG 
GACAACAGCT TCCTGAGTTC TAAAATCCTC GAATTCTGTG GCGACCTGCC TATTTTCTGG 
CTTAAGCCCA TGTATCCGAA AGAAATCCCA AGAGAGAGAA GAGAAGTAGT GAGAAGCAGT 
GCTCCCTCTA CCACAAGGAG ACCACACAGC GAACCTCGAG GCAACGCAGG CCCTGGAAGA 
CTGAGTAACA GAACCAGACC CAGCGTTCAG GATGACGAAG AACCTTTCAA CCCTGACAAT 
CCTTACCACC AGCAGGAAGG AGAGAGCATG ACCTTTGACC CTAGACTGGA TCACGAAGGA 
ATCTGCTGTA TAGAGTGCAG ACGGAGCTAC ACCCACTGCC AGAAGATCTG CGAACCGCTG 
GGAGGTTACT ACCCGTGGCC TTATAATTAC CAAGGGTGTC GCTCAGCCTG CAGAGTGGTC 
ATGCCGTGCA GCTGGTGGGT TGCCCGCATC TTGGGCATGG TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lect1 ( XM_006252346.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006252408.1 Rattus norvegicus leukocyte cell derived chemotaxin 1 (Lect1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa36869
Clone ID Related Accession (Same CDS sequence)	XM_006252346.2
Accession Version	XM_006252346.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	leukocyte cell-derived chemotaxin 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006252346.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACAGAGA ACTCGGACAA AGTTCCTATC ACCATGGTAG GACCTGAAGA CGTTGAGTTT 
TGCAGTCCCC CGGCATATGC CACTGTGACC GTGAAGCCCT CCGGGAGCCC TACACGGCTG 
CTCAAGGTGG GAGCTGTGGT TCTCATTTCT GGCGCGGTGC TGCTGCTCTT CGGGGCCATT 
GGGGCCTTCT ACTTCTGGAA GGGAAATGAC AATCACATTT ACAACGTCCA TTACACCATG 
AGTATCAATG GGAGACTACA AGACGCGTCC ATGGAGATAG ATGCTGCCAA CAACTTGGAG 
ACCTTTAAAA TGGGAAGCGG AGCGGAGGAA GCGATTGAAG TTAATGATTT CCAAAATGGC 
ATCACTGGGA TCCGTTTTGC TGGAGGAGAG AAGTGCTACA TCAAAGCACA GGTGAAGGCT 
CGCATCCCTG AGGTCAGCAC TGGGACCAAG CAGAGCATCT CTGAACTGGA AGGCAAGATC 
ATGCCAGTCA AATATGAAGA GAATTCTCTG ATTTGGGTGG CCGTGGACCA GCCTGTGAAG 
GACAACAGCT TCCTGAGTTC TAAAATCCTC GAATTCTGTG GCGACCTGCC TATTTTCTGG 
CTTAAGCCCA TGTATCCGAA AGAAATCCCA AGAGAGAGAA GAGAAGTAGT GAGAAGCAGT 
GCTCCCTCTA CCACAAGGAG ACCACACAGC GAACCTCGAG GCAACGCAGG CCCTGGAAGA 
CTGAGTAACA GAACCAGACC CAGCGTTCAG GATGACGAAG AACCTTTCAA CCCTGACAAT 
CCTTACCACC AGGAAGGAGA GAGCATGACC TTTGACCCTA GACTGGATCA CGAAGGAATC 
TGCTGTATAG AGTGCAGACG GAGCTACATC CACTGCCAGA AGATCTGCGA ACCGCTGGGA 
GGTTACTACC CGTGGCCTTA TAATTACCAA GGGTGTCGCT CAGCCTGCAG AGTGGTCATG 
CCGTGCAGCT GGTGGGTTGC CCGCATCTTG GGCATGGTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006252408.1
CDS	203..1204
Translation	MTENSDKVPITMVGPEDVEFCSPPAYATVTVKPSGSPTRLLKVGAVVLISGAVLLLFGAIGAFYFWKGNDNHIYNVHYTMSINGRLQDASMEIDAANNLETFKMGSGAEEAIEVNDFQNGITGIRFAGGEKCYIKAQVKARIPEVSTGTKQSISELEGKIMPVKYEENSLIWVAVDQPVKDNSFLSSKILEFCGDLPIFWLKPMYPKEIPRERREVVRSSAPSTTRRPHSEPRGNAGPGRLSNRTRPSVQDDEEPFNPDNPYHQEGESMTFDPRLDHEGICCIECRRSYIHCQKICEPLGGYYPWPYNYQGCRSACRVVMPCSWWVARILGMV

Target ORF information:

RefSeq Version	XM_006252346.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus leukocyte cell derived chemotaxin 1 (Lect1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006252346.2

ORF Insert Sequence:

ATGACAGAGA ACTCGGACAA AGTTCCTATC ACCATGGTAG GACCTGAAGA CGTTGAGTTT 
TGCAGTCCCC CGGCATATGC CACTGTGACC GTGAAGCCCT CCGGGAGCCC TACACGGCTG 
CTCAAGGTGG GAGCTGTGGT TCTCATTTCT GGCGCGGTGC TGCTGCTCTT CGGGGCCATT 
GGGGCCTTCT ACTTCTGGAA GGGAAATGAC AATCACATTT ACAACGTCCA TTACACCATG 
AGTATCAATG GGAGACTACA AGACGCGTCC ATGGAGATAG ATGCTGCCAA CAACTTGGAG 
ACCTTTAAAA TGGGAAGCGG AGCGGAGGAA GCGATTGAAG TTAATGATTT CCAAAATGGC 
ATCACTGGGA TCCGTTTTGC TGGAGGAGAG AAGTGCTACA TCAAAGCACA GGTGAAGGCT 
CGCATCCCTG AGGTCAGCAC TGGGACCAAG CAGAGCATCT CTGAACTGGA AGGCAAGATC 
ATGCCAGTCA AATATGAAGA GAATTCTCTG ATTTGGGTGG CCGTGGACCA GCCTGTGAAG 
GACAACAGCT TCCTGAGTTC TAAAATCCTC GAATTCTGTG GCGACCTGCC TATTTTCTGG 
CTTAAGCCCA TGTATCCGAA AGAAATCCCA AGAGAGAGAA GAGAAGTAGT GAGAAGCAGT 
GCTCCCTCTA CCACAAGGAG ACCACACAGC GAACCTCGAG GCAACGCAGG CCCTGGAAGA 
CTGAGTAACA GAACCAGACC CAGCGTTCAG GATGACGAAG AACCTTTCAA CCCTGACAAT 
CCTTACCACC AGGAAGGAGA GAGCATGACC TTTGACCCTA GACTGGATCA CGAAGGAATC 
TGCTGTATAG AGTGCAGACG GAGCTACATC CACTGCCAGA AGATCTGCGA ACCGCTGGGA 
GGTTACTACC CGTGGCCTTA TAATTACCAA GGGTGTCGCT CAGCCTGCAG AGTGGTCATG 
CCGTGCAGCT GGTGGGTTGC CCGCATCTTG GGCATGGTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proteomic analysis of chondromodulin-I-induced differentiation of mesenchymal stem cells into chondrocytes.
Journal of proteomics1591-18(2017 04)
Xing SC,Du LX,Zhou W,Hu YQ,Feng Y,Liang HF,Sang L,Qi M,Zhai LJ,Wang ZQ

The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development.
PloS one9(4)e94239(2014)
Miura S,Kondo J,Takimoto A,Sano-Takai H,Guo L,Shukunami C,Tanaka H,Hiraki Y

Identification of differentially expressed genes in mandibular condylar and tibial growth cartilages using laser microdissection and fluorescent differential display: chondromodulin-I (ChM-1) and tenomodulin (TeM) are differentially expressed in mandibular condylar and other growth cartilages.
Bone42(6)1053-60(2008 Jun)
Watahiki J,Yamaguchi T,Enomoto A,Irie T,Yoshie K,Tachikawa T,Maki K

Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis.
Nature medicine12(10)1151-9(2006 Oct)
Yoshioka M,Yuasa S,Matsumura K,Kimura K,Shiomi T,Kimura N,Shukunami C,Okada Y,Mukai M,Shin H,Yozu R,Sata M,Ogawa S,Hiraki Y,Fukuda K

Chondromodulin-I expression in the growth plate of young uremic rats.
Kidney international66(1)51-9(2004 Jul)
Amil B,Fernandez-Fuente M,Molinos I,Rodriguez J,Carbajo-P?rez E,Garcia E,Yamamoto T,Santos F

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Lect1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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