Tbr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tbr1
Entrez Gene ID	680427
Full Name	T-box, brain, 1
General protein information	Preferred Names T-box, brain, 1 Names T-box brain protein 1 T-box brain gene 1 T-box, brain, 1-like
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q21

mRNA and Protein(s)

mRNA	Protein	Name
NM_001191070.2	NP_001177999.2	T-box brain protein 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tbr1	NP_033348.2
Homo sapiens (human)	TBR1	NP_006584.1
Pan troglodytes (chimpanzee)	TBR1	XP_001150172.1
Bos taurus (cattle)	TBR1	NP_001178978.1
Rattus norvegicus (Norway rat)	Tbr1	NP_001177999.1
Canis lupus familiaris (dog)	TBR1	XP_545492.2
Gallus gallus (chicken)	TBR1	XP_003641686.1
Danio rerio (zebrafish)	tbr1b	NP_001108562.1
Xenopus tropicalis (tropical clawed frog)	tbr1	NP_001072587.1

Gene Ontology
Bibliography

Related articles in PubMed

N-acetylcysteine attenuates lipopolysaccharide-induced impairment in lamination of Ctip2-and Tbr1- expressing cortical neurons in the developing rat fetal brain.
Chao MW, Chen CP, Yang YH, Chuang YC, Chu TY, Tseng CY
Scientific reports632373(2016 Aug)

De novo TBR1 mutations in sporadic autism disrupt protein functions.
Deriziotis P, O'Roak BJ, Graham SA, Estruch SB, Dimitropoulou D, Bernier RA, Gerdts J, Shendure J, Eichler EE, Fisher SE
Nature communications54954(2014 Sep)

Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality.
Huang TN, Chuang HC, Chou WH, Chen CY, Wang HF, Chou SJ, Hsueh YP
Nature neuroscience17(2)240-7(2014 Feb)

A network of genetic repression and derepression specifies projection fates in the developing neocortex.
Srinivasan K, Leone DP, Bateson RK, Dobreva G, Kohwi Y, Kohwi-Shigematsu T, Grosschedl R, McConnell SK
Proceedings of the National Academy of Sciences of the United States of America109(47)19071-8(2012 Nov)

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.
Bedogni F, Hodge RD, Elsen GE, Nelson BR, Daza RA, Beyer RP, Bammler TK, Rubenstein JL, Hevner RF
Proceedings of the National Academy of Sciences of the United States of America107(29)13129-34(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Tbr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tbr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa63216	NM_001191070.2 Latest version!	Rattus norvegicus T-box brain transcription factor 1 (Tbr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tbr1 ( NM_001191070.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001177999.2 Rattus norvegicus T-box brain transcription factor 1 (Tbr1), mRNA.

Price & Availability↑

CloneID	ORa63216
Clone ID Related Accession (Same CDS sequence)	NM_001191070.2
Accession Version	NM_001191070.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2046bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-12
Organism	Rattus norvegicus(Norway rat)
Product	T-box brain protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAHX01022237.1, BF281828.1 and AAHX01022238.1. On Aug 7, 2016 this sequence version replaced NM_001191070.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no transcript was available for the full length of the gene. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052297, SAMEA2689595 [ECO:0000350] ##Evidence-Data-END##

ATGCAGCTGG AGCATTGCCT CTCTCCTTCT ATCATGCTCT CCAAGAAATT TCTCAATGTG 
AGCAGCAGCT ACCCACATTC GGGCGGATCT GAGCTTGTCT TGCATGATCA TCCCATTATC 
TCGACCACTG ACAACCTGGA GAGAAGTTCA CCTTTGAAAA AAATTACCAG GGGGATGACG 
AATCAGTCAG ATACAGACAA TTTTCCTGAC TCCAAGGACT CACCAGGGGA CGTCCAGAGA 
AGTAAACTCT CTCCTGTCTT GGACGGGGTC TCTGAGCTTC GTCACAGTTT CGATGGCTCT 
GCTGCAGATC GTTACCTCCT CTCTCAGTCC AGCCAGCCAC AGTCTGCGGC CACCGCTCCC 
AGTGCCATGT TCCCGTACCC CGGCCAGCAC GGACCGGCGC ATCCCGCCTT CTCCATCGGC 
AGCCCCAGTC GCTACATGGC CCACCACCCG GTCATCACCA ACGGAGCTTA CAACAGCCTG 
CTGTCCAACT CTTCGCCGCA GGGCTACCCC ACCGCCGGCT ACCCCTACCC ACAGCAGTAC 
GGCCACTCCT ACCAAGGAGC CCCATTCTAC CAGTTCTCCT CCACCCAGCC CGGGTTGGTG 
CCCGGCAAGG CGCAGGTATA CCTGTGCAAC AGGCCACTTT GGCTGAAATT TCATCGGCAT 
CAAACGGAGA TGATCATCAC TAAACAGGGA AGGCGCATGT TTCCCTTTTT GAGTTTTAAC 
ATTTCTGGTC TCGATCCCAC CGCTCATTAC AATATTTTTG TGGATGTGAT TTTGGCGGAT 
CCCAATCACT GGAGGTTTCA AGGAGGCAAA TGGGTTCCTT GTGGCAAAGC GGACACCAAT 
GTGCAAGGAA ACCGGGTCTA TATGCATCCG GATTCCCCCA ACACTGGGGC TCACTGGATG 
CGGCAAGAAA TCTCGTTTGG AAAATTAAAA CTTACCAACA ACAAGGGAGC ATCAAACAAC 
AATGGGCAGA TGGTGGTTTT ACAGTCCCTG CACAAGTACC AGCCCCGTCT GCACGTGGTG 
GAAGTGAATG AGGACGGCAC AGAGGACACC AGCCAGCCAG GCCGCGTCCA GACGTTCACT 
TTCCCAGAGA CTCAGTTCAT CGCTGTCACC GCCTATCAGA ACACCGATAT TACACAACTA 
AAAATAGATC ATAACCCCTT TGCAAAAGGA TTTCGAGATA ACTATGACAC GATCTACACG 
GGCTGCGACA TGGACCGCTT GACCCCGTCG CCCAACGACT CTCCGCGCTC TCAGATCGTG 
CCCGGCGCTC GCTACGCCAT GGCCGGCTCT TTCCTGCAAG ATCAATTCGT GAGCAACTAC 
GCCAAGGCCC GCTTCCACCC GGGCGCCGGC GCGGGCCCCG GGCCTGGCAC GGACCGCAGC 
GTGCCGCACA CCAACGGGCT ACTGTCCCCG CAACAGGCCG AGGACCCGGG CGCGCCGTCG 
CCGCAGCGCT GGTTCGTGAC GCCGGCCAAC AACCGGCTGG ACTTCGCGGC CTCGGCCTAC 
GATACGGCCA CGGACTTCGC CGGCAACGCG GCCACGCTGC TGTCGTACGC GGCCGCGGGC 
GTGAAGGCGC TGCCGCTGCA GGCCGCGGGC TGCACGGGCC GCCCGCTCGG CTACTACGCC 
GACCCTTCCG GCTGGGGCGC GCGCAGCCCT CCGCAGTACT GCGGCGCCAA GTCGGGCTCC 
GTGCTCCCCT GCTGGCCCAA CAGCGCTGCG GCCGCCGCGC GCATGGCGGG CGCCAACCCC 
TACTTAGGCG AGGAGGCCGA GGGCCTGGCG GCCGAGCGCT CTCCGCTGGC GCCCGCCGCC 
GAGGACGCCA AGCCCAAGGA CCTGTCCGAC TCCAGCTGGA TCGAGACGCC CTCCTCGATC 
AAGTCCATCG ACTCGAGCGA CTCGGGGATT TACGAGCAGG CCAAGCGGAG GCGGATCTCT 
CCGGCCGACA CGCCGGTGTC CGAGAGCTCG TCCCCACTCA AGAGCGAGGT GCTGGCCCAG 
CGGGACTGCG AGAAGAACTG CGCCAAGGAC ATAGGCGGCT ACTATGGCTT CTACTCGCAC 
AGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001177999.2
CDS	256..2301
Translation	MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTDNLERSSPLKKITRGMTNQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSAADRYLLSQSSQPQSAATAPSAMFPYPGQHGPAHPAFSIGSPSRYMAHHPVITNGAYNSLLSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAGAGPGPGTDRSVPHTNGLLSPQQAEDPGAPSPQRWFVTPANNRLDFAASAYDTATDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGAKSGSVLPCWPNSAAAAARMAGANPYLGEEAEGLAAERSPLAPAAEDAKPKDLSDSSWIETPSSIKSIDSSDSGIYEQAKRRRISPADTPVSESSSPLKSEVLAQRDCEKNCAKDIGGYYGFYSHS

Target ORF information:

RefSeq Version	NM_001191070.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus T-box brain transcription factor 1 (Tbr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001191070.2

ORF Insert Sequence:

ATGCAGCTGG AGCATTGCCT CTCTCCTTCT ATCATGCTCT CCAAGAAATT TCTCAATGTG 
AGCAGCAGCT ACCCACATTC GGGCGGATCT GAGCTTGTCT TGCATGATCA TCCCATTATC 
TCGACCACTG ACAACCTGGA GAGAAGTTCA CCTTTGAAAA AAATTACCAG GGGGATGACG 
AATCAGTCAG ATACAGACAA TTTTCCTGAC TCCAAGGACT CACCAGGGGA CGTCCAGAGA 
AGTAAACTCT CTCCTGTCTT GGACGGGGTC TCTGAGCTTC GTCACAGTTT CGATGGCTCT 
GCTGCAGATC GTTACCTCCT CTCTCAGTCC AGCCAGCCAC AGTCTGCGGC CACCGCTCCC 
AGTGCCATGT TCCCGTACCC CGGCCAGCAC GGACCGGCGC ATCCCGCCTT CTCCATCGGC 
AGCCCCAGTC GCTACATGGC CCACCACCCG GTCATCACCA ACGGAGCTTA CAACAGCCTG 
CTGTCCAACT CTTCGCCGCA GGGCTACCCC ACCGCCGGCT ACCCCTACCC ACAGCAGTAC 
GGCCACTCCT ACCAAGGAGC CCCATTCTAC CAGTTCTCCT CCACCCAGCC CGGGTTGGTG 
CCCGGCAAGG CGCAGGTATA CCTGTGCAAC AGGCCACTTT GGCTGAAATT TCATCGGCAT 
CAAACGGAGA TGATCATCAC TAAACAGGGA AGGCGCATGT TTCCCTTTTT GAGTTTTAAC 
ATTTCTGGTC TCGATCCCAC CGCTCATTAC AATATTTTTG TGGATGTGAT TTTGGCGGAT 
CCCAATCACT GGAGGTTTCA AGGAGGCAAA TGGGTTCCTT GTGGCAAAGC GGACACCAAT 
GTGCAAGGAA ACCGGGTCTA TATGCATCCG GATTCCCCCA ACACTGGGGC TCACTGGATG 
CGGCAAGAAA TCTCGTTTGG AAAATTAAAA CTTACCAACA ACAAGGGAGC ATCAAACAAC 
AATGGGCAGA TGGTGGTTTT ACAGTCCCTG CACAAGTACC AGCCCCGTCT GCACGTGGTG 
GAAGTGAATG AGGACGGCAC AGAGGACACC AGCCAGCCAG GCCGCGTCCA GACGTTCACT 
TTCCCAGAGA CTCAGTTCAT CGCTGTCACC GCCTATCAGA ACACCGATAT TACACAACTA 
AAAATAGATC ATAACCCCTT TGCAAAAGGA TTTCGAGATA ACTATGACAC GATCTACACG 
GGCTGCGACA TGGACCGCTT GACCCCGTCG CCCAACGACT CTCCGCGCTC TCAGATCGTG 
CCCGGCGCTC GCTACGCCAT GGCCGGCTCT TTCCTGCAAG ATCAATTCGT GAGCAACTAC 
GCCAAGGCCC GCTTCCACCC GGGCGCCGGC GCGGGCCCCG GGCCTGGCAC GGACCGCAGC 
GTGCCGCACA CCAACGGGCT ACTGTCCCCG CAACAGGCCG AGGACCCGGG CGCGCCGTCG 
CCGCAGCGCT GGTTCGTGAC GCCGGCCAAC AACCGGCTGG ACTTCGCGGC CTCGGCCTAC 
GATACGGCCA CGGACTTCGC CGGCAACGCG GCCACGCTGC TGTCGTACGC GGCCGCGGGC 
GTGAAGGCGC TGCCGCTGCA GGCCGCGGGC TGCACGGGCC GCCCGCTCGG CTACTACGCC 
GACCCTTCCG GCTGGGGCGC GCGCAGCCCT CCGCAGTACT GCGGCGCCAA GTCGGGCTCC 
GTGCTCCCCT GCTGGCCCAA CAGCGCTGCG GCCGCCGCGC GCATGGCGGG CGCCAACCCC 
TACTTAGGCG AGGAGGCCGA GGGCCTGGCG GCCGAGCGCT CTCCGCTGGC GCCCGCCGCC 
GAGGACGCCA AGCCCAAGGA CCTGTCCGAC TCCAGCTGGA TCGAGACGCC CTCCTCGATC 
AAGTCCATCG ACTCGAGCGA CTCGGGGATT TACGAGCAGG CCAAGCGGAG GCGGATCTCT 
CCGGCCGACA CGCCGGTGTC CGAGAGCTCG TCCCCACTCA AGAGCGAGGT GCTGGCCCAG 
CGGGACTGCG AGAAGAACTG CGCCAAGGAC ATAGGCGGCT ACTATGGCTT CTACTCGCAC 
AGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

N-acetylcysteine attenuates lipopolysaccharide-induced impairment in lamination of Ctip2-and Tbr1- expressing cortical neurons in the developing rat fetal brain.
Scientific reports632373(2016 Aug)
Chao MW,Chen CP,Yang YH,Chuang YC,Chu TY,Tseng CY

De novo TBR1 mutations in sporadic autism disrupt protein functions.
Nature communications54954(2014 Sep)
Deriziotis P,O'Roak BJ,Graham SA,Estruch SB,Dimitropoulou D,Bernier RA,Gerdts J,Shendure J,Eichler EE,Fisher SE

Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality.
Nature neuroscience17(2)240-7(2014 Feb)
Huang TN,Chuang HC,Chou WH,Chen CY,Wang HF,Chou SJ,Hsueh YP

A network of genetic repression and derepression specifies projection fates in the developing neocortex.
Proceedings of the National Academy of Sciences of the United States of America109(47)19071-8(2012 Nov)
Srinivasan K,Leone DP,Bateson RK,Dobreva G,Kohwi Y,Kohwi-Shigematsu T,Grosschedl R,McConnell SK

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.
Proceedings of the National Academy of Sciences of the United States of America107(29)13129-34(2010 Jul)
Bedogni F,Hodge RD,Elsen GE,Nelson BR,Daza RA,Beyer RP,Bammler TK,Rubenstein JL,Hevner RF

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Tbr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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