TBR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TBR1
Entrez Gene ID	10716
Full Name	T-box, brain 1
Synonyms	TBR-1,TES-56
General protein information	Preferred Names T-box, brain 1 Names T-box brain protein 1 T-brain-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q24.2
Summary	This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Dec 2015].
Disorder MIM:	604616

mRNA and Protein(s)

mRNA	Protein	Name
NM_006593.3	NP_006584.1	T-box brain protein 1
NM_006593.2	NP_006584.1	T-box brain protein 1
NM_006593.4	NP_006584.1	T-box brain protein 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tbr1	NP_033348.2
Homo sapiens (human)	TBR1	NP_006584.1
Pan troglodytes (chimpanzee)	TBR1	XP_001150172.1
Bos taurus (cattle)	TBR1	NP_001178978.1
Rattus norvegicus (Norway rat)	Tbr1	NP_001177999.1
Canis lupus familiaris (dog)	TBR1	XP_545492.2
Gallus gallus (chicken)	TBR1	XP_003641686.1
Danio rerio (zebrafish)	tbr1b	NP_001108562.1
Xenopus tropicalis (tropical clawed frog)	tbr1	NP_001072587.1

Gene Ontology
Bibliography

Related articles in PubMed

De novo TBR1 mutations in sporadic autism disrupt protein functions.
Deriziotis P, O'Roak BJ, Graham SA, Estruch SB, Dimitropoulou D, Bernier RA, Gerdts J, Shendure J, Eichler EE, Fisher SE
Nature communications54954(2014 Sep)

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
Rietveld CA, Esko T, Davies G, Pers TH, Turley P, Benyamin B, Chabris CF, Emilsson V, Johnson AD, Lee JJ, de Leeuw C, Marioni RE, Medland SE, Miller MB, Rostapshova O, van der Lee SJ, Vinkhuyzen AA, Amin N, Conley D, Derringer J, van Duijn CM, Fehrmann R, Franke L, Glaeser EL, Hansell NK, Hayward C, Iacono WG, Ibrahim-Verbaas C, Jaddoe V, Karjalainen J, Laibson D, Lichtenstein P, Liewald DC, Magnusson PK, Martin NG, McGue M, McMahon G, Pedersen NL, Pinker S, Porteous DJ, Posthuma D, Rivadeneira F, Smith BH, Starr JM, Tiemeier H, Timpson NJ, Trzaskowski M, Uitterlinden AG, Verhulst FC, Ward ME, Wright MJ, Davey Smith G, Deary IJ, Johannesson M, Plomin R, Visscher PM, Benjamin DJ, Cesarini D, Koellinger PD
Proceedings of the National Academy of Sciences of the United States of America111(38)13790-4(2014 Sep)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TBR1 homodimerizes; it interacts with FOXP2, a transcription factor implicated in speech/language disorders, and this interaction is disrupted by pathogenic mutations affecting either protein
Title: De novo TBR1 mutations in sporadic autism disrupt protein functions.

Observational study of gene-disease association. (HuGE Navigator)
Title: TbetaR-I(6A) polymorphism is not a tumor susceptibility allele in Macedonian colorectal cancer patients. Correspondence re: B. Pasche et al. Type I TbetaR-I(6A) Is a Candidate Tumor Susceptibility Allele. Cancer Res., 58: 2727-2732, 1998.

The following TBR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TBR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05683	NM_006593.4 Latest version!	Homo sapiens T-box brain transcription factor 1 (TBR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
View Old Accession Versions >>
OHu05683	NM_006593.2	Homo sapiens T-box, brain, 1 (TBR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
OHu05683	NM_006593.3	Homo sapiens T-box, brain 1 (TBR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TBR1 ( NM_006593.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006584.1 Homo sapiens T-box, brain 1 (TBR1), mRNA.

Price & Availability↑

CloneID	OHu05683
Clone ID Related Accession (Same CDS sequence)	NM_006593.3 , NM_006593.2 , NM_006593.4
Accession Version	NM_006593.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2049bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	T-box brain protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA771310.1, U49250.1, BC113418.1, BX114402.1, H41824.1, DA511772.1 and DB550595.1. This sequence is a reference standard in the RefSeqGene project. On Dec 23, 2015 this sequence version replaced NM_006593.2. ##Evidence-Data-START## Transcript exon combination :: U49250.1, BC104844.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCTGG AGCACTGCCT TTCTCCTTCT ATCATGCTCT CCAAGAAATT TCTCAATGTG 
AGCAGCAGCT ACCCACATTC AGGCGGATCC GAGCTTGTCT TGCACGATCA TCCCATTATC 
TCGACCACTG ACAACCTGGA GAGAAGTTCA CCTTTGAAAA AAATTACCAG GGGGATGACG 
AATCAGTCAG ATACAGACAA TTTTCCTGAC TCCAAGGACT CACCAGGGGA CGTCCAGAGA 
AGTAAACTCT CTCCTGTCTT GGACGGGGTC TCTGAGCTTC GTCACAGTTT CGATGGCTCT 
GCTGCAGATC GCTACCTCCT CTCTCAGTCC AGCCAGCCAC AGTCTGCGGC CACTGCTCCC 
AGTGCCATGT TCCCGTACCC CGGCCAGCAC GGACCGGCGC ACCCCGCCTT CTCCATCGGC 
AGCCCTAGCC GCTACATGGC CCACCACCCG GTCATCACCA ACGGAGCCTA CAACAGCCTC 
CTGTCCAACT CCTCGCCGCA GGGATACCCC ACGGCCGGCT ACCCCTACCC ACAGCAGTAC 
GGCCACTCCT ACCAAGGAGC TCCGTTCTAC CAGTTCTCCT CCACCCAGCC GGGGCTGGTG 
CCCGGCAAAG CACAGGTGTA CCTGTGCAAC AGGCCCCTTT GGCTGAAATT TCACCGGCAC 
CAAACGGAGA TGATCATCAC CAAACAGGGA AGGCGCATGT TTCCTTTTTT AAGTTTTAAC 
ATTTCTGGTC TCGATCCCAC GGCTCATTAC AATATTTTTG TGGATGTGAT TTTGGCGGAT 
CCCAATCACT GGAGGTTTCA AGGAGGCAAA TGGGTTCCTT GCGGCAAAGC GGACACCAAT 
GTGCAAGGAA ATCGGGTCTA TATGCATCCG GATTCCCCCA ACACTGGGGC TCACTGGATG 
CGCCAAGAAA TCTCTTTTGG AAAATTAAAA CTTACGAACA ACAAAGGAGC TTCAAATAAC 
AATGGGCAGA TGGTGGTTTT ACAGTCCTTG CACAAGTACC AGCCCCGCCT GCATGTGGTG 
GAAGTGAACG AGGACGGCAC GGAGGACACT AGCCAGCCCG GCCGCGTGCA GACGTTCACT 
TTCCCTGAGA CTCAGTTCAT CGCCGTCACC GCCTACCAGA ACACGGATAT TACACAACTG 
AAAATAGATC ACAACCCTTT TGCAAAAGGA TTTCGGGATA ATTATGACAC GATCTACACC 
GGCTGTGACA TGGACCGCCT GACCCCCTCG CCCAACGACT CGCCGCGCTC GCAGATCGTG 
CCCGGGGCCC GCTACGCCAT GGCCGGCTCT TTCCTGCAGG ACCAGTTCGT GAGCAACTAC 
GCCAAGGCCC GCTTCCACCC GGGCGCGGGC GCGGGCCCCG GGCCGGGTAC GGACCGCAGC 
GTGCCGCACA CCAACGGGCT GCTGTCGCCG CAGCAGGCCG AGGACCCGGG CGCGCCCTCG 
CCGCAACGCT GGTTTGTGAC GCCGGCCAAC AACCGGCTGG ACTTCGCGGC CTCGGCCTAT 
GACACGGCCA CGGACTTCGC GGGCAACGCG GCCACGCTGC TCTCTTACGC GGCGGCGGGC 
GTGAAGGCGC TGCCGCTGCA GGCTGCAGGC TGCACTGGCC GCCCGCTCGG CTACTACGCC 
GACCCGTCGG GCTGGGGCGC CCGCAGTCCC CCGCAGTACT GCGGCACCAA GTCGGGCTCG 
GTGCTGCCCT GCTGGCCCAA CAGCGCCGCG GCCGCCGCGC GCATGGCCGG CGCCAATCCC 
TACCTGGGCG AGGAGGCCGA GGGCCTGGCC GCCGAGCGCT CGCCGCTGCC GCCCGGCGCC 
GCCGAGGACG CCAAGCCCAA GGACCTGTCC GATTCCAGCT GGATCGAGAC GCCCTCCTCG 
ATCAAGTCCA TCGACTCCAG CGACTCGGGG ATTTACGAGC AGGCCAAGCG GAGGCGGATC 
TCGCCGGCCG ACACGCCCGT GTCCGAGAGT TCGTCCCCGC TCAAGAGCGA GGTGCTGGCC 
CAGCGGGACT GCGAGAAGAA CTGCGCCAAG GACATTAGCG GCTACTATGG CTTCTACTCG 
CACAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006584.1
CDS	318..2366
Translation	MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTDNLERSSPLKKITRGMTNQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSAADRYLLSQSSQPQSAATAPSAMFPYPGQHGPAHPAFSIGSPSRYMAHHPVITNGAYNSLLSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAGAGPGPGTDRSVPHTNGLLSPQQAEDPGAPSPQRWFVTPANNRLDFAASAYDTATDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGTKSGSVLPCWPNSAAAAARMAGANPYLGEEAEGLAAERSPLPPGAAEDAKPKDLSDSSWIETPSSIKSIDSSDSGIYEQAKRRRISPADTPVSESSSPLKSEVLAQRDCEKNCAKDISGYYGFYSHS

Target ORF information:

RefSeq Version	NM_006593.3
Organism	Homo sapiens(human)
Definition	Homo sapiens T-box, brain 1 (TBR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006593.3

ORF Insert Sequence:

ATGCAGCTGG AGCACTGCCT TTCTCCTTCT ATCATGCTCT CCAAGAAATT TCTCAATGTG 
AGCAGCAGCT ACCCACATTC AGGCGGATCC GAGCTTGTCT TGCACGATCA TCCCATTATC 
TCGACCACTG ACAACCTGGA GAGAAGTTCA CCTTTGAAAA AAATTACCAG GGGGATGACG 
AATCAGTCAG ATACAGACAA TTTTCCTGAC TCCAAGGACT CACCAGGGGA CGTCCAGAGA 
AGTAAACTCT CTCCTGTCTT GGACGGGGTC TCTGAGCTTC GTCACAGTTT CGATGGCTCT 
GCTGCAGATC GCTACCTCCT CTCTCAGTCC AGCCAGCCAC AGTCTGCGGC CACTGCTCCC 
AGTGCCATGT TCCCGTACCC CGGCCAGCAC GGACCGGCGC ACCCCGCCTT CTCCATCGGC 
AGCCCTAGCC GCTACATGGC CCACCACCCG GTCATCACCA ACGGAGCCTA CAACAGCCTC 
CTGTCCAACT CCTCGCCGCA GGGATACCCC ACGGCCGGCT ACCCCTACCC ACAGCAGTAC 
GGCCACTCCT ACCAAGGAGC TCCGTTCTAC CAGTTCTCCT CCACCCAGCC GGGGCTGGTG 
CCCGGCAAAG CACAGGTGTA CCTGTGCAAC AGGCCCCTTT GGCTGAAATT TCACCGGCAC 
CAAACGGAGA TGATCATCAC CAAACAGGGA AGGCGCATGT TTCCTTTTTT AAGTTTTAAC 
ATTTCTGGTC TCGATCCCAC GGCTCATTAC AATATTTTTG TGGATGTGAT TTTGGCGGAT 
CCCAATCACT GGAGGTTTCA AGGAGGCAAA TGGGTTCCTT GCGGCAAAGC GGACACCAAT 
GTGCAAGGAA ATCGGGTCTA TATGCATCCG GATTCCCCCA ACACTGGGGC TCACTGGATG 
CGCCAAGAAA TCTCTTTTGG AAAATTAAAA CTTACGAACA ACAAAGGAGC TTCAAATAAC 
AATGGGCAGA TGGTGGTTTT ACAGTCCTTG CACAAGTACC AGCCCCGCCT GCATGTGGTG 
GAAGTGAACG AGGACGGCAC GGAGGACACT AGCCAGCCCG GCCGCGTGCA GACGTTCACT 
TTCCCTGAGA CTCAGTTCAT CGCCGTCACC GCCTACCAGA ACACGGATAT TACACAACTG 
AAAATAGATC ACAACCCTTT TGCAAAAGGA TTTCGGGATA ATTATGACAC GATCTACACC 
GGCTGTGACA TGGACCGCCT GACCCCCTCG CCCAACGACT CGCCGCGCTC GCAGATCGTG 
CCCGGGGCCC GCTACGCCAT GGCCGGCTCT TTCCTGCAGG ACCAGTTCGT GAGCAACTAC 
GCCAAGGCCC GCTTCCACCC GGGCGCGGGC GCGGGCCCCG GGCCGGGTAC GGACCGCAGC 
GTGCCGCACA CCAACGGGCT GCTGTCGCCG CAGCAGGCCG AGGACCCGGG CGCGCCCTCG 
CCGCAACGCT GGTTTGTGAC GCCGGCCAAC AACCGGCTGG ACTTCGCGGC CTCGGCCTAT 
GACACGGCCA CGGACTTCGC GGGCAACGCG GCCACGCTGC TCTCTTACGC GGCGGCGGGC 
GTGAAGGCGC TGCCGCTGCA GGCTGCAGGC TGCACTGGCC GCCCGCTCGG CTACTACGCC 
GACCCGTCGG GCTGGGGCGC CCGCAGTCCC CCGCAGTACT GCGGCACCAA GTCGGGCTCG 
GTGCTGCCCT GCTGGCCCAA CAGCGCCGCG GCCGCCGCGC GCATGGCCGG CGCCAATCCC 
TACCTGGGCG AGGAGGCCGA GGGCCTGGCC GCCGAGCGCT CGCCGCTGCC GCCCGGCGCC 
GCCGAGGACG CCAAGCCCAA GGACCTGTCC GATTCCAGCT GGATCGAGAC GCCCTCCTCG 
ATCAAGTCCA TCGACTCCAG CGACTCGGGG ATTTACGAGC AGGCCAAGCG GAGGCGGATC 
TCGCCGGCCG ACACGCCCGT GTCCGAGAGT TCGTCCCCGC TCAAGAGCGA GGTGCTGGCC 
CAGCGGGACT GCGAGAAGAA CTGCGCCAAG GACATTAGCG GCTACTATGG CTTCTACTCG 
CACAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TBR1 ( NM_006593.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006584.1 Homo sapiens T-box, brain, 1 (TBR1), mRNA.

Price & Availability↑

CloneID	OHu05683
Clone ID Related Accession (Same CDS sequence)	NM_006593.3 , NM_006593.2 , NM_006593.4
Accession Version	NM_006593.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2049bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	T-box brain protein 1
Comment

ATGCAGCTGG AGCACTGCCT TTCTCCTTCT ATCATGCTCT CCAAGAAATT TCTCAATGTG 
AGCAGCAGCT ACCCACATTC AGGCGGATCC GAGCTTGTCT TGCACGATCA TCCCATTATC 
TCGACCACTG ACAACCTGGA GAGAAGTTCA CCTTTGAAAA AAATTACCAG GGGGATGACG 
AATCAGTCAG ATACAGACAA TTTTCCTGAC TCCAAGGACT CACCAGGGGA CGTCCAGAGA 
AGTAAACTCT CTCCTGTCTT GGACGGGGTC TCTGAGCTTC GTCACAGTTT CGATGGCTCT 
GCTGCAGATC GCTACCTCCT CTCTCAGTCC AGCCAGCCAC AGTCTGCGGC CACTGCTCCC 
AGTGCCATGT TCCCGTACCC CGGCCAGCAC GGACCGGCGC ACCCCGCCTT CTCCATCGGC 
AGCCCTAGCC GCTACATGGC CCACCACCCG GTCATCACCA ACGGAGCCTA CAACAGCCTC 
CTGTCCAACT CCTCGCCGCA GGGATACCCC ACGGCCGGCT ACCCCTACCC ACAGCAGTAC 
GGCCACTCCT ACCAAGGAGC TCCGTTCTAC CAGTTCTCCT CCACCCAGCC GGGGCTGGTG 
CCCGGCAAAG CACAGGTGTA CCTGTGCAAC AGGCCCCTTT GGCTGAAATT TCACCGGCAC 
CAAACGGAGA TGATCATCAC CAAACAGGGA AGGCGCATGT TTCCTTTTTT AAGTTTTAAC 
ATTTCTGGTC TCGATCCCAC GGCTCATTAC AATATTTTTG TGGATGTGAT TTTGGCGGAT 
CCCAATCACT GGAGGTTTCA AGGAGGCAAA TGGGTTCCTT GCGGCAAAGC GGACACCAAT 
GTGCAAGGAA ATCGGGTCTA TATGCATCCG GATTCCCCCA ACACTGGGGC TCACTGGATG 
CGCCAAGAAA TCTCTTTTGG AAAATTAAAA CTTACGAACA ACAAAGGAGC TTCAAATAAC 
AATGGGCAGA TGGTGGTTTT ACAGTCCTTG CACAAGTACC AGCCCCGCCT GCATGTGGTG 
GAAGTGAACG AGGACGGCAC GGAGGACACT AGCCAGCCCG GCCGCGTGCA GACGTTCACT 
TTCCCTGAGA CTCAGTTCAT CGCCGTCACC GCCTACCAGA ACACGGATAT TACACAACTG 
AAAATAGATC ACAACCCTTT TGCAAAAGGA TTTCGGGATA ATTATGACAC GATCTACACC 
GGCTGTGACA TGGACCGCCT GACCCCCTCG CCCAACGACT CGCCGCGCTC GCAGATCGTG 
CCCGGGGCCC GCTACGCCAT GGCCGGCTCT TTCCTGCAGG ACCAGTTCGT GAGCAACTAC 
GCCAAGGCCC GCTTCCACCC GGGCGCGGGC GCGGGCCCCG GGCCGGGTAC GGACCGCAGC 
GTGCCGCACA CCAACGGGCT GCTGTCGCCG CAGCAGGCCG AGGACCCGGG CGCGCCCTCG 
CCGCAACGCT GGTTTGTGAC GCCGGCCAAC AACCGGCTGG ACTTCGCGGC CTCGGCCTAT 
GACACGGCCA CGGACTTCGC GGGCAACGCG GCCACGCTGC TCTCTTACGC GGCGGCGGGC 
GTGAAGGCGC TGCCGCTGCA GGCTGCAGGC TGCACTGGCC GCCCGCTCGG CTACTACGCC 
GACCCGTCGG GCTGGGGCGC CCGCAGTCCC CCGCAGTACT GCGGCACCAA GTCGGGCTCG 
GTGCTGCCCT GCTGGCCCAA CAGCGCCGCG GCCGCCGCGC GCATGGCCGG CGCCAATCCC 
TACCTGGGCG AGGAGGCCGA GGGCCTGGCC GCCGAGCGCT CGCCGCTGCC GCCCGGCGCC 
GCCGAGGACG CCAAGCCCAA GGACCTGTCC GATTCCAGCT GGATCGAGAC GCCCTCCTCG 
ATCAAGTCCA TCGACTCCAG CGACTCGGGG ATTTACGAGC AGGCCAAGCG GAGGCGGATC 
TCGCCGGCCG ACACGCCCGT GTCCGAGAGT TCGTCCCCGC TCAAGAGCGA GGTGCTGGCC 
CAGCGGGACT GCGAGAAGAA CTGCGCCAAG GACATTAGCG GCTACTATGG CTTCTACTCG 
CACAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_006584.1

Translation

MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTDNLERSSPLKKITRGMTNQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSAADRYLLSQSSQPQSAATAPSAMFPYPGQHGPAHPAFSIGSPSRYMAHHPVITNGAYNSLLSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAGAGPGPGTDRSVPHTNGLLSPQQAEDPGAPSPQRWFVTPANNRLDFAASAYDTATDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGTKSGSVLPCWPNSAAAAARMAGANPYLGEEAEGLAAERSPLPPGAAEDAKPKDLSDSSWIETPSSIKSIDSSDSGIYEQAKRRRISPADTPVSESSSPLKSEVLAQRDCEKNCAKDISGYYGFYSHS

Target ORF information:

RefSeq Version	NM_006593.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens T-box, brain, 1 (TBR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006593.2

ORF Insert Sequence:

ATGCAGCTGG AGCACTGCCT TTCTCCTTCT ATCATGCTCT CCAAGAAATT TCTCAATGTG 
AGCAGCAGCT ACCCACATTC AGGCGGATCC GAGCTTGTCT TGCACGATCA TCCCATTATC 
TCGACCACTG ACAACCTGGA GAGAAGTTCA CCTTTGAAAA AAATTACCAG GGGGATGACG 
AATCAGTCAG ATACAGACAA TTTTCCTGAC TCCAAGGACT CACCAGGGGA CGTCCAGAGA 
AGTAAACTCT CTCCTGTCTT GGACGGGGTC TCTGAGCTTC GTCACAGTTT CGATGGCTCT 
GCTGCAGATC GCTACCTCCT CTCTCAGTCC AGCCAGCCAC AGTCTGCGGC CACTGCTCCC 
AGTGCCATGT TCCCGTACCC CGGCCAGCAC GGACCGGCGC ACCCCGCCTT CTCCATCGGC 
AGCCCTAGCC GCTACATGGC CCACCACCCG GTCATCACCA ACGGAGCCTA CAACAGCCTC 
CTGTCCAACT CCTCGCCGCA GGGATACCCC ACGGCCGGCT ACCCCTACCC ACAGCAGTAC 
GGCCACTCCT ACCAAGGAGC TCCGTTCTAC CAGTTCTCCT CCACCCAGCC GGGGCTGGTG 
CCCGGCAAAG CACAGGTGTA CCTGTGCAAC AGGCCCCTTT GGCTGAAATT TCACCGGCAC 
CAAACGGAGA TGATCATCAC CAAACAGGGA AGGCGCATGT TTCCTTTTTT AAGTTTTAAC 
ATTTCTGGTC TCGATCCCAC GGCTCATTAC AATATTTTTG TGGATGTGAT TTTGGCGGAT 
CCCAATCACT GGAGGTTTCA AGGAGGCAAA TGGGTTCCTT GCGGCAAAGC GGACACCAAT 
GTGCAAGGAA ATCGGGTCTA TATGCATCCG GATTCCCCCA ACACTGGGGC TCACTGGATG 
CGCCAAGAAA TCTCTTTTGG AAAATTAAAA CTTACGAACA ACAAAGGAGC TTCAAATAAC 
AATGGGCAGA TGGTGGTTTT ACAGTCCTTG CACAAGTACC AGCCCCGCCT GCATGTGGTG 
GAAGTGAACG AGGACGGCAC GGAGGACACT AGCCAGCCCG GCCGCGTGCA GACGTTCACT 
TTCCCTGAGA CTCAGTTCAT CGCCGTCACC GCCTACCAGA ACACGGATAT TACACAACTG 
AAAATAGATC ACAACCCTTT TGCAAAAGGA TTTCGGGATA ATTATGACAC GATCTACACC 
GGCTGTGACA TGGACCGCCT GACCCCCTCG CCCAACGACT CGCCGCGCTC GCAGATCGTG 
CCCGGGGCCC GCTACGCCAT GGCCGGCTCT TTCCTGCAGG ACCAGTTCGT GAGCAACTAC 
GCCAAGGCCC GCTTCCACCC GGGCGCGGGC GCGGGCCCCG GGCCGGGTAC GGACCGCAGC 
GTGCCGCACA CCAACGGGCT GCTGTCGCCG CAGCAGGCCG AGGACCCGGG CGCGCCCTCG 
CCGCAACGCT GGTTTGTGAC GCCGGCCAAC AACCGGCTGG ACTTCGCGGC CTCGGCCTAT 
GACACGGCCA CGGACTTCGC GGGCAACGCG GCCACGCTGC TCTCTTACGC GGCGGCGGGC 
GTGAAGGCGC TGCCGCTGCA GGCTGCAGGC TGCACTGGCC GCCCGCTCGG CTACTACGCC 
GACCCGTCGG GCTGGGGCGC CCGCAGTCCC CCGCAGTACT GCGGCACCAA GTCGGGCTCG 
GTGCTGCCCT GCTGGCCCAA CAGCGCCGCG GCCGCCGCGC GCATGGCCGG CGCCAATCCC 
TACCTGGGCG AGGAGGCCGA GGGCCTGGCC GCCGAGCGCT CGCCGCTGCC GCCCGGCGCC 
GCCGAGGACG CCAAGCCCAA GGACCTGTCC GATTCCAGCT GGATCGAGAC GCCCTCCTCG 
ATCAAGTCCA TCGACTCCAG CGACTCGGGG ATTTACGAGC AGGCCAAGCG GAGGCGGATC 
TCGCCGGCCG ACACGCCCGT GTCCGAGAGT TCGTCCCCGC TCAAGAGCGA GGTGCTGGCC 
CAGCGGGACT GCGAGAAGAA CTGCGCCAAG GACATTAGCG GCTACTATGG CTTCTACTCG 
CACAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TBR1 ( NM_006593.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006584.1 Homo sapiens T-box brain transcription factor 1 (TBR1), mRNA.

Price & Availability↑

CloneID	OHu05683
Clone ID Related Accession (Same CDS sequence)	NM_006593.3 , NM_006593.2 , NM_006593.4
Accession Version	NM_006593.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2049bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-02
Organism	Homo sapiens(human)
Product	T-box brain protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA771310.1, U49250.1, BC113418.1, BX114402.1, H41824.1, DA511772.1, DB550595.1 and AC009487.3. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_006593.3. ##Evidence-Data-START## Transcript exon combination :: U49250.1, BC104844.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000389554.8/ ENSP00000374205.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGCTGG AGCACTGCCT TTCTCCTTCT ATCATGCTCT CCAAGAAATT TCTCAATGTG 
AGCAGCAGCT ACCCACATTC AGGCGGATCC GAGCTTGTCT TGCACGATCA TCCCATTATC 
TCGACCACTG ACAACCTGGA GAGAAGTTCA CCTTTGAAAA AAATTACCAG GGGGATGACG 
AATCAGTCAG ATACAGACAA TTTTCCTGAC TCCAAGGACT CACCAGGGGA CGTCCAGAGA 
AGTAAACTCT CTCCTGTCTT GGACGGGGTC TCTGAGCTTC GTCACAGTTT CGATGGCTCT 
GCTGCAGATC GCTACCTCCT CTCTCAGTCC AGCCAGCCAC AGTCTGCGGC CACTGCTCCC 
AGTGCCATGT TCCCGTACCC CGGCCAGCAC GGACCGGCGC ACCCCGCCTT CTCCATCGGC 
AGCCCTAGCC GCTACATGGC CCACCACCCG GTCATCACCA ACGGAGCCTA CAACAGCCTC 
CTGTCCAACT CCTCGCCGCA GGGATACCCC ACGGCCGGCT ACCCCTACCC ACAGCAGTAC 
GGCCACTCCT ACCAAGGAGC TCCGTTCTAC CAGTTCTCCT CCACCCAGCC GGGGCTGGTG 
CCCGGCAAAG CACAGGTGTA CCTGTGCAAC AGGCCCCTTT GGCTGAAATT TCACCGGCAC 
CAAACGGAGA TGATCATCAC CAAACAGGGA AGGCGCATGT TTCCTTTTTT AAGTTTTAAC 
ATTTCTGGTC TCGATCCCAC GGCTCATTAC AATATTTTTG TGGATGTGAT TTTGGCGGAT 
CCCAATCACT GGAGGTTTCA AGGAGGCAAA TGGGTTCCTT GCGGCAAAGC GGACACCAAT 
GTGCAAGGAA ATCGGGTCTA TATGCATCCG GATTCCCCCA ACACTGGGGC TCACTGGATG 
CGCCAAGAAA TCTCTTTTGG AAAATTAAAA CTTACGAACA ACAAAGGAGC TTCAAATAAC 
AATGGGCAGA TGGTGGTTTT ACAGTCCTTG CACAAGTACC AGCCCCGCCT GCATGTGGTG 
GAAGTGAACG AGGACGGCAC GGAGGACACT AGCCAGCCCG GCCGCGTGCA GACGTTCACT 
TTCCCTGAGA CTCAGTTCAT CGCCGTCACC GCCTACCAGA ACACGGATAT TACACAACTG 
AAAATAGATC ACAACCCTTT TGCAAAAGGA TTTCGGGATA ATTATGACAC GATCTACACC 
GGCTGTGACA TGGACCGCCT GACCCCCTCG CCCAACGACT CGCCGCGCTC GCAGATCGTG 
CCCGGGGCCC GCTACGCCAT GGCCGGCTCT TTCCTGCAGG ACCAGTTCGT GAGCAACTAC 
GCCAAGGCCC GCTTCCACCC GGGCGCGGGC GCGGGCCCCG GGCCGGGTAC GGACCGCAGC 
GTGCCGCACA CCAACGGGCT GCTGTCGCCG CAGCAGGCCG AGGACCCGGG CGCGCCCTCG 
CCGCAACGCT GGTTTGTGAC GCCGGCCAAC AACCGGCTGG ACTTCGCGGC CTCGGCCTAT 
GACACGGCCA CGGACTTCGC GGGCAACGCG GCCACGCTGC TCTCTTACGC GGCGGCGGGC 
GTGAAGGCGC TGCCGCTGCA GGCTGCAGGC TGCACTGGCC GCCCGCTCGG CTACTACGCC 
GACCCGTCGG GCTGGGGCGC CCGCAGTCCC CCGCAGTACT GCGGCACCAA GTCGGGCTCG 
GTGCTGCCCT GCTGGCCCAA CAGCGCCGCG GCCGCCGCGC GCATGGCCGG CGCCAATCCC 
TACCTGGGCG AGGAGGCCGA GGGCCTGGCC GCCGAGCGCT CGCCGCTGCC GCCCGGCGCC 
GCCGAGGACG CCAAGCCCAA GGACCTGTCC GATTCCAGCT GGATCGAGAC GCCCTCCTCG 
ATCAAGTCCA TCGACTCCAG CGACTCGGGG ATTTACGAGC AGGCCAAGCG GAGGCGGATC 
TCGCCGGCCG ACACGCCCGT GTCCGAGAGT TCGTCCCCGC TCAAGAGCGA GGTGCTGGCC 
CAGCGGGACT GCGAGAAGAA CTGCGCCAAG GACATTAGCG GCTACTATGG CTTCTACTCG 
CACAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006584.1
CDS	115..2163
Translation	MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTDNLERSSPLKKITRGMTNQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSAADRYLLSQSSQPQSAATAPSAMFPYPGQHGPAHPAFSIGSPSRYMAHHPVITNGAYNSLLSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAGAGPGPGTDRSVPHTNGLLSPQQAEDPGAPSPQRWFVTPANNRLDFAASAYDTATDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGTKSGSVLPCWPNSAAAAARMAGANPYLGEEAEGLAAERSPLPPGAAEDAKPKDLSDSSWIETPSSIKSIDSSDSGIYEQAKRRRISPADTPVSESSSPLKSEVLAQRDCEKNCAKDISGYYGFYSHS

Target ORF information:

RefSeq Version	NM_006593.4
Organism	Homo sapiens(human)
Definition	Homo sapiens T-box brain transcription factor 1 (TBR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006593.4

ORF Insert Sequence:

ATGCAGCTGG AGCACTGCCT TTCTCCTTCT ATCATGCTCT CCAAGAAATT TCTCAATGTG 
AGCAGCAGCT ACCCACATTC AGGCGGATCC GAGCTTGTCT TGCACGATCA TCCCATTATC 
TCGACCACTG ACAACCTGGA GAGAAGTTCA CCTTTGAAAA AAATTACCAG GGGGATGACG 
AATCAGTCAG ATACAGACAA TTTTCCTGAC TCCAAGGACT CACCAGGGGA CGTCCAGAGA 
AGTAAACTCT CTCCTGTCTT GGACGGGGTC TCTGAGCTTC GTCACAGTTT CGATGGCTCT 
GCTGCAGATC GCTACCTCCT CTCTCAGTCC AGCCAGCCAC AGTCTGCGGC CACTGCTCCC 
AGTGCCATGT TCCCGTACCC CGGCCAGCAC GGACCGGCGC ACCCCGCCTT CTCCATCGGC 
AGCCCTAGCC GCTACATGGC CCACCACCCG GTCATCACCA ACGGAGCCTA CAACAGCCTC 
CTGTCCAACT CCTCGCCGCA GGGATACCCC ACGGCCGGCT ACCCCTACCC ACAGCAGTAC 
GGCCACTCCT ACCAAGGAGC TCCGTTCTAC CAGTTCTCCT CCACCCAGCC GGGGCTGGTG 
CCCGGCAAAG CACAGGTGTA CCTGTGCAAC AGGCCCCTTT GGCTGAAATT TCACCGGCAC 
CAAACGGAGA TGATCATCAC CAAACAGGGA AGGCGCATGT TTCCTTTTTT AAGTTTTAAC 
ATTTCTGGTC TCGATCCCAC GGCTCATTAC AATATTTTTG TGGATGTGAT TTTGGCGGAT 
CCCAATCACT GGAGGTTTCA AGGAGGCAAA TGGGTTCCTT GCGGCAAAGC GGACACCAAT 
GTGCAAGGAA ATCGGGTCTA TATGCATCCG GATTCCCCCA ACACTGGGGC TCACTGGATG 
CGCCAAGAAA TCTCTTTTGG AAAATTAAAA CTTACGAACA ACAAAGGAGC TTCAAATAAC 
AATGGGCAGA TGGTGGTTTT ACAGTCCTTG CACAAGTACC AGCCCCGCCT GCATGTGGTG 
GAAGTGAACG AGGACGGCAC GGAGGACACT AGCCAGCCCG GCCGCGTGCA GACGTTCACT 
TTCCCTGAGA CTCAGTTCAT CGCCGTCACC GCCTACCAGA ACACGGATAT TACACAACTG 
AAAATAGATC ACAACCCTTT TGCAAAAGGA TTTCGGGATA ATTATGACAC GATCTACACC 
GGCTGTGACA TGGACCGCCT GACCCCCTCG CCCAACGACT CGCCGCGCTC GCAGATCGTG 
CCCGGGGCCC GCTACGCCAT GGCCGGCTCT TTCCTGCAGG ACCAGTTCGT GAGCAACTAC 
GCCAAGGCCC GCTTCCACCC GGGCGCGGGC GCGGGCCCCG GGCCGGGTAC GGACCGCAGC 
GTGCCGCACA CCAACGGGCT GCTGTCGCCG CAGCAGGCCG AGGACCCGGG CGCGCCCTCG 
CCGCAACGCT GGTTTGTGAC GCCGGCCAAC AACCGGCTGG ACTTCGCGGC CTCGGCCTAT 
GACACGGCCA CGGACTTCGC GGGCAACGCG GCCACGCTGC TCTCTTACGC GGCGGCGGGC 
GTGAAGGCGC TGCCGCTGCA GGCTGCAGGC TGCACTGGCC GCCCGCTCGG CTACTACGCC 
GACCCGTCGG GCTGGGGCGC CCGCAGTCCC CCGCAGTACT GCGGCACCAA GTCGGGCTCG 
GTGCTGCCCT GCTGGCCCAA CAGCGCCGCG GCCGCCGCGC GCATGGCCGG CGCCAATCCC 
TACCTGGGCG AGGAGGCCGA GGGCCTGGCC GCCGAGCGCT CGCCGCTGCC GCCCGGCGCC 
GCCGAGGACG CCAAGCCCAA GGACCTGTCC GATTCCAGCT GGATCGAGAC GCCCTCCTCG 
ATCAAGTCCA TCGACTCCAG CGACTCGGGG ATTTACGAGC AGGCCAAGCG GAGGCGGATC 
TCGCCGGCCG ACACGCCCGT GTCCGAGAGT TCGTCCCCGC TCAAGAGCGA GGTGCTGGCC 
CAGCGGGACT GCGAGAAGAA CTGCGCCAAG GACATTAGCG GCTACTATGG CTTCTACTCG 
CACAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

De novo TBR1 mutations in sporadic autism disrupt protein functions.
Nature communications54954(2014 Sep)
Deriziotis P,O'Roak BJ,Graham SA,Estruch SB,Dimitropoulou D,Bernier RA,Gerdts J,Shendure J,Eichler EE,Fisher SE

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
Proceedings of the National Academy of Sciences of the United States of America111(38)13790-4(2014 Sep)
Rietveld CA,Esko T,Davies G,Pers TH,Turley P,Benyamin B,Chabris CF,Emilsson V,Johnson AD,Lee JJ,de Leeuw C,Marioni RE,Medland SE,Miller MB,Rostapshova O,van der Lee SJ,Vinkhuyzen AA,Amin N,Conley D,Derringer J,van Duijn CM,Fehrmann R,Franke L,Glaeser EL,Hansell NK,Hayward C,Iacono WG,Ibrahim-Verbaas C,Jaddoe V,Karjalainen J,Laibson D,Lichtenstein P,Liewald DC,Magnusson PK,Martin NG,McGue M,McMahon G,Pedersen NL,Pinker S,Porteous DJ,Posthuma D,Rivadeneira F,Smith BH,Starr JM,Tiemeier H,Timpson NJ,Trzaskowski M,Uitterlinden AG,Verhulst FC,Ward ME,Wright MJ,Davey Smith G,Deary IJ,Johannesson M,Plomin R,Visscher PM,Benjamin DJ,Cesarini D,Koellinger PD

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

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TBR1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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