Pdgfd cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pdgfd
Entrez Gene ID	66018
Full Name	platelet derived growth factor D
Synonyms	Scdgfb,rSCDGF-B
General protein information	Preferred Names platelet derived growth factor D Names platelet-derived growth factor D PDGF-D SCDGF-B iris-expressed growth factor platelet-derived growth factor, D polypeptide spinal cord-derived growth factor B spinal-cord derived growth factor-B protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q11
Summary	a growth factor with mitogenic activity in the central nervous system [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_023962.2	NP_076452.1	platelet-derived growth factor D precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PDGFD	XP_536595.3
Homo sapiens (human)	PDGFD	NP_079484.1
	PDGFD	XP_001099616.1
Mus musculus (house mouse)	Pdgfd	NP_082200.1
Gallus gallus (chicken)	PDGFD	NP_001264740.1
Bos taurus (cattle)	PDGFD	NP_001077175.1
Rattus norvegicus (Norway rat)	Pdgfd	NP_076452.1
Pan troglodytes (chimpanzee)	PDGFD	XP_522165.2
Danio rerio (zebrafish)	LOC100535718	XP_003200146.2
Xenopus tropicalis (tropical clawed frog)	LOC100492060	XP_002934980.2

Gene Ontology
Bibliography

Related articles in PubMed

Platelet-derived growth factor blockade on cardiac remodeling following infarction.
Liu C, Zhao W, Meng W, Zhao T, Chen Y, Ahokas RA, Liu H, Sun Y
Molecular and cellular biochemistry397(1-2)295-304(2014 Dec)

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M
Circulation research113(10)1138-47(2013 Oct)

Platelet-derived growth factor-D promotes fibrogenesis of cardiac fibroblasts.
Zhao T, Zhao W, Chen Y, Li VS, Meng W, Sun Y
American journal of physiology. Heart and circulatory physiology304(12)H1719-26(2013 Jun)

Platelet-derived growth factor-D induces expression of cyclooxygenase-2 in rat mesangial cells through activation of PI3K/PKB and PKCs.
Park YK, Jang BC, Choi M
International journal of molecular medicine31(2)447-52(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

observations indicated that PDGF can contribute to the development of cardiac interstitial fibrosis in the noninfarcted myocardium, but does not alter scar formation in the infarcted myocardium.
Title: Platelet-derived growth factor blockade on cardiac remodeling following infarction.

Activities of PI3K/PKB and PKCs are critical for the Pdgfd - induced COX-2 expression in rat mesangial cells.
Title: Platelet-derived growth factor-D induces expression of cyclooxygenase-2 in rat mesangial cells through activation of PI3K/PKB and PKCs.

Podocyte-specific PDGF-D overexpression caused mesangioproliferative disease, glomerulosclerosis, and crescentic glomerulonephritis. Podocyte-specific PDGF-D overexpression induced paracrine mesangial cell proliferation upstream of the filtration flow.
Title: Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D.

alloimmune response induces PDGF-A, PDGF-C, and PDGF-D expression in the graft vasculature;PDGF-D mediated profibrotic and proarteriosclerotic effects in transplanted hearts involving the TGF-[beta]1 pathway
Title: PDGF-A, -C, and -D but not PDGF-B increase TGF-beta1 and chronic rejection in rat cardiac allografts.

All 3 residues in Sp1 (Thr668, Ser670, and Thr681) are required for Sp1-dependent platelet-derived growth factor-D activation in response to angiotensin II
Title: Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1.

The following Pdgfd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pdgfd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06649	NM_023962.2 Latest version!	Rattus norvegicus platelet derived growth factor D (Pdgfd), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pdgfd ( NM_023962.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_076452.1 Rattus norvegicus platelet derived growth factor D (Pdgfd), mRNA.

Price & Availability↑

CloneID	ORa06649
Clone ID Related Accession (Same CDS sequence)	NM_023962.2
Accession Version	NM_023962.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	platelet-derived growth factor D precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB052170.2. On or before Jun 25, 2006 this sequence version replaced XM_001070182.1, NM_023962.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB052170.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCACCGGC TCATCTTAGT CTCCATTCTT GTGTGTGCGA ACTTTTGCTG CTATCGGGAC 
ACTTTTGCGA CTCCGCAGAG CGCATCCATC AAAGCTTTGC GCAATGCCAA CCTCAGGAGA 
GATGAGAGCA ATCACCTCAC AGACTTGTAC CGGAGAGATG AGAACATTCG GGTGACAGGC 
ACTGGCCACG TGCAGAGTCC TCGCTTCCCC AACAGCTACC CGAGGAACCT GCTCCTGACA 
TGGCGGCTCC ATTCCCAGGA GAAAACACGG ATACAGCTGG CCTTTGACCA TCAATTTGGA 
CTGGAGGAAG CAGAAAATGA CATTTGTAGG TATGACTTTG TGGAAGTTGA AGATGTCTCA 
GAAAGCAGCA CCGTTGTCAG AGGAAGATGG TGTGGCCATA AGGAGATCCC TCCAAGGATA 
ACTTCAAGAA CAAACCAGAT TAAAATCACA TTTCAGTCTG ATGACTATTT TGTGGCAAAA 
CCTGGATTCA AGATTTATTA TTCATTTGTG GAAGATTTCC AACCTGAAGC AGCCTCAGAG 
ATCAACTGGG AATCAGTCAC AAGTTCTTTC TCTGGGGTGT CCTATCACTC TCCATCAGTA 
ATGGACTCCA CTCTCACTGC CGATGCCCTG GACAAAGCTA TTGCAGAATT CGATACTGTA 
GAAGATCTGC TTAAGTACTT CAATCCAGCG TCTTGGCAAG ATGATCTGGA GAATTTGTAC 
ATGGACACCC CTCGTTATAG AGGCAGGTCA TACCATGAAC GGAAGTCTAA AGTGGACCTG 
GACAGGCTCA ATGATGATGT CAAGCGTTAC AGTTGCACTC CCAGGAATCA CTCGGTGAAT 
CTCAGGGAGG AGTTGAAGCT GACCAACGCA GTCTTCTTCC CACGATGCCT CCTTGTGCAG 
CGCTGTGGTG GCAACTGTGG TTGCGGAACT CTCAACTGGA AGTCCTGCAC GTGCAGCTCA 
GGGAAGACAG TAAAGAAGTA TCATGAGGTA CTGAAGTTTG AGCCTGGACA TTTCAAAAGA 
AGGGGCAAAG CTAAGAATAT GGCTCTTGTC GATATCCAGT TGGATCATCA TGAGCGATGT 
GACTGCATCT GCAGCTCAAG ACCACCTCGA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076452.1
CDS	117..1229
Translation	MHRLILVSILVCANFCCYRDTFATPQSASIKALRNANLRRDESNHLTDLYRRDENIRVTGTGHVQSPRFPNSYPRNLLLTWRLHSQEKTRIQLAFDHQFGLEEAENDICRYDFVEVEDVSESSTVVRGRWCGHKEIPPRITSRTNQIKITFQSDDYFVAKPGFKIYYSFVEDFQPEAASEINWESVTSSFSGVSYHSPSVMDSTLTADALDKAIAEFDTVEDLLKYFNPASWQDDLENLYMDTPRYRGRSYHERKSKVDLDRLNDDVKRYSCTPRNHSVNLREELKLTNAVFFPRCLLVQRCGGNCGCGTLNWKSCTCSSGKTVKKYHEVLKFEPGHFKRRGKAKNMALVDIQLDHHERCDCICSSRPPR

Target ORF information:

RefSeq Version	NM_023962.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus platelet derived growth factor D (Pdgfd), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023962.2

ORF Insert Sequence:

ATGCACCGGC TCATCTTAGT CTCCATTCTT GTGTGTGCGA ACTTTTGCTG CTATCGGGAC 
ACTTTTGCGA CTCCGCAGAG CGCATCCATC AAAGCTTTGC GCAATGCCAA CCTCAGGAGA 
GATGAGAGCA ATCACCTCAC AGACTTGTAC CGGAGAGATG AGAACATTCG GGTGACAGGC 
ACTGGCCACG TGCAGAGTCC TCGCTTCCCC AACAGCTACC CGAGGAACCT GCTCCTGACA 
TGGCGGCTCC ATTCCCAGGA GAAAACACGG ATACAGCTGG CCTTTGACCA TCAATTTGGA 
CTGGAGGAAG CAGAAAATGA CATTTGTAGG TATGACTTTG TGGAAGTTGA AGATGTCTCA 
GAAAGCAGCA CCGTTGTCAG AGGAAGATGG TGTGGCCATA AGGAGATCCC TCCAAGGATA 
ACTTCAAGAA CAAACCAGAT TAAAATCACA TTTCAGTCTG ATGACTATTT TGTGGCAAAA 
CCTGGATTCA AGATTTATTA TTCATTTGTG GAAGATTTCC AACCTGAAGC AGCCTCAGAG 
ATCAACTGGG AATCAGTCAC AAGTTCTTTC TCTGGGGTGT CCTATCACTC TCCATCAGTA 
ATGGACTCCA CTCTCACTGC CGATGCCCTG GACAAAGCTA TTGCAGAATT CGATACTGTA 
GAAGATCTGC TTAAGTACTT CAATCCAGCG TCTTGGCAAG ATGATCTGGA GAATTTGTAC 
ATGGACACCC CTCGTTATAG AGGCAGGTCA TACCATGAAC GGAAGTCTAA AGTGGACCTG 
GACAGGCTCA ATGATGATGT CAAGCGTTAC AGTTGCACTC CCAGGAATCA CTCGGTGAAT 
CTCAGGGAGG AGTTGAAGCT GACCAACGCA GTCTTCTTCC CACGATGCCT CCTTGTGCAG 
CGCTGTGGTG GCAACTGTGG TTGCGGAACT CTCAACTGGA AGTCCTGCAC GTGCAGCTCA 
GGGAAGACAG TAAAGAAGTA TCATGAGGTA CTGAAGTTTG AGCCTGGACA TTTCAAAAGA 
AGGGGCAAAG CTAAGAATAT GGCTCTTGTC GATATCCAGT TGGATCATCA TGAGCGATGT 
GACTGCATCT GCAGCTCAAG ACCACCTCGA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Platelet-derived growth factor blockade on cardiac remodeling following infarction.
Molecular and cellular biochemistry397(1-2)295-304(2014 Dec)
Liu C,Zhao W,Meng W,Zhao T,Chen Y,Ahokas RA,Liu H,Sun Y

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Circulation research113(10)1138-47(2013 Oct)
Abonnenc M,Nabeebaccus AA,Mayr U,Barallobre-Barreiro J,Dong X,Cuello F,Sur S,Drozdov I,Langley SR,Lu R,Stathopoulou K,Didangelos A,Yin X,Zimmermann WH,Shah AM,Zampetaki A,Mayr M

Platelet-derived growth factor-D promotes fibrogenesis of cardiac fibroblasts.
American journal of physiology. Heart and circulatory physiology304(12)H1719-26(2013 Jun)
Zhao T,Zhao W,Chen Y,Li VS,Meng W,Sun Y

Platelet-derived growth factor-D induces expression of cyclooxygenase-2 in rat mesangial cells through activation of PI3K/PKB and PKCs.
International journal of molecular medicine31(2)447-52(2013 Feb)
Park YK,Jang BC,Choi M

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Pdgfd cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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