Clns1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Clns1a
Entrez Gene ID	65160
Full Name	chloride nucleotide-sensitive channel 1A
Synonyms	Clci,Clcni,Icln,pICln
General protein information	Preferred Names chloride nucleotide-sensitive channel 1A Names methylosome subunit pICln Clns 1a chloride channel current inducer chloride channel, nucleotide-sensitive, 1A chloride conductance regulatory protein ICln i(Cln)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q32
Summary	protein involved in cellular chloride transport [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031719.1	NP_113907.1	methylosome subunit pICln
XM_006229792.2	XP_006229854.1	methylosome subunit pICln isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Clns1a	NP_113907.1
Gallus gallus (chicken)	CLNS1A	XP_423253.3
Pan troglodytes (chimpanzee)	CLNS1A	XP_003339258.1
Danio rerio (zebrafish)	icln	NP_571499.2
Xenopus tropicalis (tropical clawed frog)	clns1a	NP_001032339.1
Canis lupus familiaris (dog)	CLNS1A	NP_001003288.1
Bos taurus (cattle)	CLNS1A	NP_001069768.1
Mus musculus (house mouse)	Clns1a	NP_076160.1
Homo sapiens (human)	CLNS1A	NP_001284.1
	CLNS1A	XP_001088333.1

Gene Ontology
Bibliography

Related articles in PubMed

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.
Guderian G, Peter C, Wiesner J, Sickmann A, Schulze-Osthoff K, Fischer U, Grimmler M
The Journal of biological chemistry286(3)1976-86(2011 Jan)

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.
Chari A, Golas MM, Klingenh?ger M, Neuenkirchen N, Sander B, Englbrecht C, Sickmann A, Stark H, Fischer U
Cell135(3)497-509(2008 Oct)

Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior.
Fronz K, Otto S, K?lbel K, K?hn U, Friedrich H, Schierhorn A, Beck-Sickinger AG, Ostareck-Lederer A, Wahle E
The Journal of biological chemistry283(29)20408-20(2008 Jul)

ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4.
F?rst J, Schedlbauer A, Gandini R, Garavaglia ML, Saino S, Gschwentner M, Sarg B, Lindner H, Jakab M, Ritter M, Bazzini C, Botta G, Meyer G, Kontaxis G, Tilly BC, Konrat R, Paulmichl M
The Journal of biological chemistry280(35)31276-82(2005 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ICln associates with the cell membrane after cell swelling
Title: Cell swelling stimulates cytosol to membrane transposition of ICln.

The following Clns1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Clns1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08577	NM_031719.1 Latest version!	Rattus norvegicus chloride nucleotide-sensitive channel 1A (Clns1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa08577	XM_006229792.2 Latest version!	Rattus norvegicus chloride nucleotide-sensitive channel 1A (Clns1a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Clns1a ( NM_031719.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113907.1 Rattus norvegicus chloride nucleotide-sensitive channel 1A (Clns1a), mRNA.

Price & Availability↑

CloneID	ORa08577
Clone ID Related Accession (Same CDS sequence)	NM_031719.1 , XM_006229792.2
Accession Version	NM_031719.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	methylosome subunit pICln
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L26450.1. ##Evidence-Data-START## Transcript exon combination :: L26450.1, BC060555.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCTTTCGC CCGCAATGAG CTTCCTCAAA AGCTTCCCGC CCCCTGGGTC CGCAGATGGA 
CTCCGGCTGC AGCAGCCAGA CACCGAAGCT GTGCTGAACG GGAAGGGGCT CGGCACCGGC 
ACGCTTTACA TTGCGGAGAG CCGCCTGTCT TGGCTAGATG GTTCTGGATT AGGATTCTCA 
CTGGAGTACC CCACCATTAG TTTACATGCG GTATCCAGGG ACCCAAATGC TTATCCTCAA 
GAACATCTGT ATGTCATGGT GAATGCCAGA TTTGGAGAAG AATCAAAAGA ACCTTTCTCT 
GATGAAGATG AGGACGACAA TGATGATGTT GAACCCATTT CTGAGTTTAG ATTTGTGCCC 
AGTGATAAGT CAGCATTGGA GGCGATGTTC ACAGCAATGT GTGAGTGCCA GGCCCTGCAT 
CCAGACCCTG AGGATGAAGA CTCGGATGAC TATGATGGAG AAGAGTATGA TGTGGAAGCA 
CATGAGCAAG GACAGGGGGA CATCCCTACA TTTTACACCT ATGAAGAAGG ACTATCCCAT 
TTAACAGCAG AAGGGCAAGC CACGCTGGAG AGATTAGAAG GAATGCTTTC TCAGTCTGTG 
AGCAGCCAGT ATAATATGGC AGGCGTCCGA ACAGAAGATT CAGTAAGAAC TTACGAAGAT 
GGCATGGAGG TAGAGACCAC ACCAACTGTT GCCGGACAGT TCGAGGATGC AGACGTTGAC 
CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113907.1
CDS	26..751
Translation	MLSPAMSFLKSFPPPGSADGLRLQQPDTEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPTISLHAVSRDPNAYPQEHLYVMVNARFGEESKEPFSDEDEDDNDDVEPISEFRFVPSDKSALEAMFTAMCECQALHPDPEDEDSDDYDGEEYDVEAHEQGQGDIPTFYTYEEGLSHLTAEGQATLERLEGMLSQSVSSQYNMAGVRTEDSVRTYEDGMEVETTPTVAGQFEDADVDH

Target ORF information:

RefSeq Version	NM_031719.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus chloride nucleotide-sensitive channel 1A (Clns1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031719.1

ORF Insert Sequence:

ATGCTTTCGC CCGCAATGAG CTTCCTCAAA AGCTTCCCGC CCCCTGGGTC CGCAGATGGA 
CTCCGGCTGC AGCAGCCAGA CACCGAAGCT GTGCTGAACG GGAAGGGGCT CGGCACCGGC 
ACGCTTTACA TTGCGGAGAG CCGCCTGTCT TGGCTAGATG GTTCTGGATT AGGATTCTCA 
CTGGAGTACC CCACCATTAG TTTACATGCG GTATCCAGGG ACCCAAATGC TTATCCTCAA 
GAACATCTGT ATGTCATGGT GAATGCCAGA TTTGGAGAAG AATCAAAAGA ACCTTTCTCT 
GATGAAGATG AGGACGACAA TGATGATGTT GAACCCATTT CTGAGTTTAG ATTTGTGCCC 
AGTGATAAGT CAGCATTGGA GGCGATGTTC ACAGCAATGT GTGAGTGCCA GGCCCTGCAT 
CCAGACCCTG AGGATGAAGA CTCGGATGAC TATGATGGAG AAGAGTATGA TGTGGAAGCA 
CATGAGCAAG GACAGGGGGA CATCCCTACA TTTTACACCT ATGAAGAAGG ACTATCCCAT 
TTAACAGCAG AAGGGCAAGC CACGCTGGAG AGATTAGAAG GAATGCTTTC TCAGTCTGTG 
AGCAGCCAGT ATAATATGGC AGGCGTCCGA ACAGAAGATT CAGTAAGAAC TTACGAAGAT 
GGCATGGAGG TAGAGACCAC ACCAACTGTT GCCGGACAGT TCGAGGATGC AGACGTTGAC 
CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Clns1a ( XM_006229792.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006229854.1 Rattus norvegicus chloride nucleotide-sensitive channel 1A (Clns1a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa08577
Clone ID Related Accession (Same CDS sequence)	NM_031719.1 , XM_006229792.2
Accession Version	XM_006229792.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	methylosome subunit pICln isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006229792.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTTTCGC CCGCAATGAG CTTCCTCAAA AGCTTCCCGC CCCCTGGGTC CGCAGATGGA 
CTCCGGCTGC AGCAGCCAGA CACCGAAGCT GTGCTGAACG GGAAGGGGCT CGGCACCGGC 
ACGCTTTACA TTGCGGAGAG CCGCCTGTCT TGGCTAGATG GTTCTGGATT AGGATTCTCA 
CTGGAGTACC CCACCATTAG TTTACATGCG GTATCCAGGG ACCCAAATGC TTATCCTCAA 
GAACATCTGT ATGTCATGGT GAATGCCAGA TTTGGAGAAG AATCAAAAGA ACCTTTCTCT 
GATGAAGATG AGGACGACAA TGATGATGTT GAACCCATTT CTGAGTTTAG ATTTGTGCCC 
AGTGATAAGT CAGCATTGGA GGCGATGTTC ACAGCAATGT GTGAGTGCCA GGCCCTGCAT 
CCAGACCCTG AGGATGAAGA CTCGGATGAC TATGATGGAG AAGAGTATGA TGTGGAAGCA 
CATGAGCAAG GACAGGGGGA CATCCCTACA TTTTACACCT ATGAAGAAGG ACTATCCCAT 
TTAACAGCAG AAGGGCAAGC CACGCTGGAG AGATTAGAAG GAATGCTTTC TCAGTCTGTG 
AGCAGCCAGT ATAATATGGC AGGCGTCCGA ACAGAAGATT CAGTAAGAAC TTACGAAGAT 
GGCATGGAGG TAGAGACCAC ACCAACTGTT GCCGGACAGT TCGAGGATGC AGACGTTGAC 
CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006229854.1
CDS	89..814
Translation	MLSPAMSFLKSFPPPGSADGLRLQQPDTEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPTISLHAVSRDPNAYPQEHLYVMVNARFGEESKEPFSDEDEDDNDDVEPISEFRFVPSDKSALEAMFTAMCECQALHPDPEDEDSDDYDGEEYDVEAHEQGQGDIPTFYTYEEGLSHLTAEGQATLERLEGMLSQSVSSQYNMAGVRTEDSVRTYEDGMEVETTPTVAGQFEDADVDH

Target ORF information:

RefSeq Version	XM_006229792.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus chloride nucleotide-sensitive channel 1A (Clns1a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006229792.2

ORF Insert Sequence:

ATGCTTTCGC CCGCAATGAG CTTCCTCAAA AGCTTCCCGC CCCCTGGGTC CGCAGATGGA 
CTCCGGCTGC AGCAGCCAGA CACCGAAGCT GTGCTGAACG GGAAGGGGCT CGGCACCGGC 
ACGCTTTACA TTGCGGAGAG CCGCCTGTCT TGGCTAGATG GTTCTGGATT AGGATTCTCA 
CTGGAGTACC CCACCATTAG TTTACATGCG GTATCCAGGG ACCCAAATGC TTATCCTCAA 
GAACATCTGT ATGTCATGGT GAATGCCAGA TTTGGAGAAG AATCAAAAGA ACCTTTCTCT 
GATGAAGATG AGGACGACAA TGATGATGTT GAACCCATTT CTGAGTTTAG ATTTGTGCCC 
AGTGATAAGT CAGCATTGGA GGCGATGTTC ACAGCAATGT GTGAGTGCCA GGCCCTGCAT 
CCAGACCCTG AGGATGAAGA CTCGGATGAC TATGATGGAG AAGAGTATGA TGTGGAAGCA 
CATGAGCAAG GACAGGGGGA CATCCCTACA TTTTACACCT ATGAAGAAGG ACTATCCCAT 
TTAACAGCAG AAGGGCAAGC CACGCTGGAG AGATTAGAAG GAATGCTTTC TCAGTCTGTG 
AGCAGCCAGT ATAATATGGC AGGCGTCCGA ACAGAAGATT CAGTAAGAAC TTACGAAGAT 
GGCATGGAGG TAGAGACCAC ACCAACTGTT GCCGGACAGT TCGAGGATGC AGACGTTGAC 
CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.
The Journal of biological chemistry286(3)1976-86(2011 Jan)
Guderian G,Peter C,Wiesner J,Sickmann A,Schulze-Osthoff K,Fischer U,Grimmler M

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.
Cell135(3)497-509(2008 Oct)
Chari A,Golas MM,Klingenh?ger M,Neuenkirchen N,Sander B,Englbrecht C,Sickmann A,Stark H,Fischer U

Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior.
The Journal of biological chemistry283(29)20408-20(2008 Jul)
Fronz K,Otto S,K?lbel K,K?hn U,Friedrich H,Schierhorn A,Beck-Sickinger AG,Ostareck-Lederer A,Wahle E

ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4.
The Journal of biological chemistry280(35)31276-82(2005 Sep)
F?rst J,Schedlbauer A,Gandini R,Garavaglia ML,Saino S,Gschwentner M,Sarg B,Lindner H,Jakab M,Ritter M,Bazzini C,Botta G,Meyer G,Kontaxis G,Tilly BC,Konrat R,Paulmichl M

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Clns1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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