Kcna6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcna6
Entrez Gene ID	64358
Full Name	potassium voltage-gated channel subfamily A member 6
Synonyms	Kv1.6
General protein information	Preferred Names potassium voltage-gated channel subfamily A member 6 Names potassium voltage-gated channel subfamily A member 6 RCK2 kv2 potassium channel, voltage gated shaker related subfamily A, member 6 potassium channel-Kv2 potassium voltage gated channel, shaker related subfamily, member 6 voltage-gated potassium channel subunit Kv1.6 voltage-gated potassium channel subunit Kv2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42
Summary	voltage-gated potassium channel [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_023954.1	NP_076444.1	potassium voltage-gated channel subfamily A member 6

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Kcna6	NP_076444.1
Danio rerio (zebrafish)	LOC100536252	XP_003201808.1
Canis lupus familiaris (dog)	KCNA6	XP_005637498.1
Xenopus tropicalis (tropical clawed frog)	LOC100492986	XP_004912861.1
	KCNA6	XP_001101937.1
Gallus gallus (chicken)	LOC100858067	XP_003643199.2
Homo sapiens (human)	KCNA6	NP_002226.1
Pan troglodytes (chimpanzee)	KCNA6	XP_001159166.1
Bos taurus (cattle)	KCNA6	NP_001193342.1
Mus musculus (house mouse)	Kcna6	NP_038596.1

Gene Ontology
Bibliography

Related articles in PubMed

The Kv1.3 potassium channel is localized to the cis-Golgi and Kv1.6 is localized to the endoplasmic reticulum in rat astrocytes.
Zhu J, Yan J, Thornhill WB
The FEBS journal281(15)3433-45(2014 Aug)

Developmental changes in the expression of ?v1 potassium channels in rat vestibular ganglion cells.
Iwasaki S, Nakajima T, Chihara Y, Inoue A, Fujimoto C, Yamasoba T
Brain research142929-35(2012 Jan)

Position-dependent attenuation by Kv1.6 of N-type inactivation of Kv1.4-containing channels.
Al-Sabi A, Kaza S, Le Berre M, O'Hara L, Bodeker M, Wang J, Dolly JO
The Biochemical journal438(2)389-96(2011 Sep)

Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow.
Fulton S, Thibault D, Mendez JA, Lahaie N, Tirotta E, Borrelli E, Bouvier M, Tempel BL, Trudeau LE
The Journal of biological chemistry286(11)9360-72(2011 Mar)

Two opposing roles of 4-AP-sensitive K+ current in initiation and invasion of spikes in rat mesencephalic trigeminal neurons.
Saito M, Murai Y, Sato H, Bae YC, Akaike T, Takada M, Kang Y
Journal of neurophysiology96(4)1887-901(2006 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Kv1.6 is localized to the endoplasmic reticulum in rat astrocytes.
Title: The Kv1.3 potassium channel is localized to the cis-Golgi and Kv1.6 is localized to the endoplasmic reticulum in rat astrocytes.

down-regulation of the Kv1.6 protein and mRNA may be associated with maturation of excitable properties of primary vestibular neurons
Title: Developmental changes in the expression of ?v1 potassium channels in rat vestibular ganglion cells.

N-type inactivation prevention (NIP) domain function was shown to require positioning of Kv1.6 adjacent to the Kv1.4 subunit.
Title: Position-dependent attenuation by Kv1.6 of N-type inactivation of Kv1.4-containing channels.

Consistent with these findings, strong immunoreactivities for Kv1.1 and Kv1.6, among 4-AP-sensitive and low-voltage-activated Kv1 family examined, were detected in the soma but not in the stem axon of MTN neurons.
Title: Two opposing roles of 4-AP-sensitive K+ current in initiation and invasion of spikes in rat mesencephalic trigeminal neurons.

The following Kcna6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcna6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13214	NM_023954.1 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily A member 6 (Kcna6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcna6 ( NM_023954.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_076444.1 Rattus norvegicus potassium voltage-gated channel subfamily A member 6 (Kcna6), mRNA.

Price & Availability↑

CloneID	ORa13214
Clone ID Related Accession (Same CDS sequence)	NM_023954.1
Accession Version	NM_023954.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1593bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily A member 6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07062058.1 and CB581370.1. On or before Jul 16, 2009 this sequence version replaced XM_575671.2, XM_001067110.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ212954.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: translation inferred from conservation ##RefSeq-Attributes-END##

ATGAGATCGG AGAAATCCCT GACGCTGGCG GCGCCGGGGG AGGTCCGTGG GCCGGAGGGG 
GAGCAACAGG ATGCGGGTGA GTTCCAGGAG GCCGAGGGCG GCGGCGGCTG CTGTAGTAGT 
GAGAGGCTGG TGATCAACAT CTCTGGGCTG CGCTACGAGA CGCAGCTGCG CACCTTGTCG 
CTGTTCCCTG ACACGCTGCT AGGAGACCCT GGCCGCAGAG TCCGCTTCTT TGACCCCTTG 
AGGAATGAGT ACTTCTTTGA CCGCAACCGA CCCAGCTTCG ACGCTATCCT TTATTACTAC 
CAGTCGGGGG GTCGCCTGCG CAGGCCGGTT AACGTGCCCC TTGACATCTT TATGGAAGAG 
ATTCGCTTCT ATCAGTTGGG AGATGAAGCC CTGGCGGCCT TCCGGGAGGA TGAGGGTTGC 
CTGCCCGAAG GTGGTGAGGA TGAGAAGCCA CTCCCCTCCC AGCCTTTCCA GCGACAGGTC 
TGGCTCCTCT TTGAGTATCC GGAGAGTTCT GGGCCCGCCC GAGGCATTGC CATCGTCTCA 
GTGTTGGTCA TCCTCATCTC CATTGTCATC TTTTGCCTGG AGACCTTGCC TCAGTTCCGT 
GCAGATGGGC GCGGTGGAAG CAACGAGGGG AGTGGGACCC GCATGTCCCC GGCCTCCAGG 
GGGAGCCACG AGGAGGAAGA TGAAGACGAG GATTCCTATG CATTTCCTGG TAGCATTCCC 
TCTGGGGGGT TGGGGACCGG AGGAACTTCT TCATTTAGTA CTCTCGGGGG TTCCTTCTTC 
ACAGACCCCT TCTTCCTGGT GGAAACTCTG TGTATCGTCT GGTTCACCTT TGAGCTCCTG 
GTGCGCTTCT CTGCCTGTCC CAGCAAGGCG GCCTTCTTTC GCAATATCAT GAACATCATT 
GACTTGGTGG CCATCTTCCC CTACTTTATC ACCCTGGGCA CCGAGCTAGT GCAACGTCAC 
GAGCAGCAGC CTGTGAGTGG TGGCAGTGGT CAGAATGGGC AGCAGGCCAT GTCCCTAGCC 
ATCCTCAGGG TGATCCGCCT GGTCCGGGTG TTTCGGATCT TCAAGCTCTC CCGCCACTCC 
AAGGGGTTGC AGATCCTGGG TAAGACCTTG CAAGCATCCA TGCGGGAGCT CGGGCTACTC 
ATCTTCTTCC TCTTCATTGG AGTCATCCTC TTCTCCAGCG CTGTCTACTT CGCAGAGGCA 
GATGACGTTG ACTCGCTCTT CCCTAGCATC CCAGATGCCT TTTGGTGGGC TGTGGTTACA 
ATGACCACAG TAGGTTATGG GGACATGTAC CCCATGACGG TGGGAGGCAA GATTGTGGGC 
TCACTGTGTG CCATTGCTGG GGTCCTCACC ATTGCATTAC CGGTACCGGT CATTGTCTCC 
AATTTCAACT ACTTCTACCA CCGAGAGACG GAGCAGGAGG AACAAGGCCA GTATACCCAC 
GTCACTTGTG GGCAGCCTAC ACCGGACCTG AAGGCAACGG ACAATGGGCT TGGCAAACCT 
GACTTTGCGG AGGCTTCACG GGAACGGCGG TCCAGCTACC TTCCAACTCC ACATCGAGCT 
TATGCAGAGA AAAGGATGCT CACCGAGGTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076444.1
CDS	1647..3239
Translation	MRSEKSLTLAAPGEVRGPEGEQQDAGEFQEAEGGGGCCSSERLVINISGLRYETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFMEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRADGRGGSNEGSGTRMSPASRGSHEEEDEDEDSYAFPGSIPSGGLGTGGTSSFSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKAAFFRNIMNIIDLVAIFPYFITLGTELVQRHEQQPVSGGSGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDVDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHVTCGQPTPDLKATDNGLGKPDFAEASRERRSSYLPTPHRAYAEKRMLTEV

Target ORF information:

RefSeq Version	NM_023954.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily A member 6 (Kcna6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023954.1

ORF Insert Sequence:

ATGAGATCGG AGAAATCCCT GACGCTGGCG GCGCCGGGGG AGGTCCGTGG GCCGGAGGGG 
GAGCAACAGG ATGCGGGTGA GTTCCAGGAG GCCGAGGGCG GCGGCGGCTG CTGTAGTAGT 
GAGAGGCTGG TGATCAACAT CTCTGGGCTG CGCTACGAGA CGCAGCTGCG CACCTTGTCG 
CTGTTCCCTG ACACGCTGCT AGGAGACCCT GGCCGCAGAG TCCGCTTCTT TGACCCCTTG 
AGGAATGAGT ACTTCTTTGA CCGCAACCGA CCCAGCTTCG ACGCTATCCT TTATTACTAC 
CAGTCGGGGG GTCGCCTGCG CAGGCCGGTT AACGTGCCCC TTGACATCTT TATGGAAGAG 
ATTCGCTTCT ATCAGTTGGG AGATGAAGCC CTGGCGGCCT TCCGGGAGGA TGAGGGTTGC 
CTGCCCGAAG GTGGTGAGGA TGAGAAGCCA CTCCCCTCCC AGCCTTTCCA GCGACAGGTC 
TGGCTCCTCT TTGAGTATCC GGAGAGTTCT GGGCCCGCCC GAGGCATTGC CATCGTCTCA 
GTGTTGGTCA TCCTCATCTC CATTGTCATC TTTTGCCTGG AGACCTTGCC TCAGTTCCGT 
GCAGATGGGC GCGGTGGAAG CAACGAGGGG AGTGGGACCC GCATGTCCCC GGCCTCCAGG 
GGGAGCCACG AGGAGGAAGA TGAAGACGAG GATTCCTATG CATTTCCTGG TAGCATTCCC 
TCTGGGGGGT TGGGGACCGG AGGAACTTCT TCATTTAGTA CTCTCGGGGG TTCCTTCTTC 
ACAGACCCCT TCTTCCTGGT GGAAACTCTG TGTATCGTCT GGTTCACCTT TGAGCTCCTG 
GTGCGCTTCT CTGCCTGTCC CAGCAAGGCG GCCTTCTTTC GCAATATCAT GAACATCATT 
GACTTGGTGG CCATCTTCCC CTACTTTATC ACCCTGGGCA CCGAGCTAGT GCAACGTCAC 
GAGCAGCAGC CTGTGAGTGG TGGCAGTGGT CAGAATGGGC AGCAGGCCAT GTCCCTAGCC 
ATCCTCAGGG TGATCCGCCT GGTCCGGGTG TTTCGGATCT TCAAGCTCTC CCGCCACTCC 
AAGGGGTTGC AGATCCTGGG TAAGACCTTG CAAGCATCCA TGCGGGAGCT CGGGCTACTC 
ATCTTCTTCC TCTTCATTGG AGTCATCCTC TTCTCCAGCG CTGTCTACTT CGCAGAGGCA 
GATGACGTTG ACTCGCTCTT CCCTAGCATC CCAGATGCCT TTTGGTGGGC TGTGGTTACA 
ATGACCACAG TAGGTTATGG GGACATGTAC CCCATGACGG TGGGAGGCAA GATTGTGGGC 
TCACTGTGTG CCATTGCTGG GGTCCTCACC ATTGCATTAC CGGTACCGGT CATTGTCTCC 
AATTTCAACT ACTTCTACCA CCGAGAGACG GAGCAGGAGG AACAAGGCCA GTATACCCAC 
GTCACTTGTG GGCAGCCTAC ACCGGACCTG AAGGCAACGG ACAATGGGCT TGGCAAACCT 
GACTTTGCGG AGGCTTCACG GGAACGGCGG TCCAGCTACC TTCCAACTCC ACATCGAGCT 
TATGCAGAGA AAAGGATGCT CACCGAGGTT TGA