Xylt2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Xylt2
Entrez Gene ID	64134
Full Name	xylosyltransferase 2
Synonyms	xylt-II
General protein information	Preferred Names xylosyltransferase 2 Names xylosyltransferase 2 peptide O-xylosyltransferase 2 xylosyltransferase II
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q26
Summary	isoform of the xylosyltransferase enzyme that catalyzes the transfer of xylose to proteoglycan core protein in glycosaminoglycan biosynthesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022296.2	NP_071632.2	xylosyltransferase 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Xylt2	NP_665827.2
Pan troglodytes (chimpanzee)	XYLT2	NP_001009086.1
Bos taurus (cattle)	XYLT2	NP_001008667.1
Xenopus tropicalis (tropical clawed frog)	xylt2	NP_001006733.1
Rattus norvegicus (Norway rat)	Xylt2	NP_071632.2
Gallus gallus (chicken)	XYLT2	NP_001001785.1
	XYLT2	XP_001093519.1
Homo sapiens (human)	XYLT2	NP_071450.2
Canis lupus familiaris (dog)	XYLT2	NP_001008714.1
Danio rerio (zebrafish)	zgc:194562	NP_001124250.1

Gene Ontology
Bibliography

Related articles in PubMed

Homozygosity for frameshift mutations in XYLT2 result in a spondylo-ocular syndrome with bone fragility, cataracts, and hearing defects.
Munns CF, Fahiminiya S, Poudel N, Munteanu MC, Majewski J, Sillence DO, Metcalf JP, Biggin A, Glorieux F, Fassier F, Rauch F, Hinsdale ME
American journal of human genetics96(6)971-8(2015 Jun)

Xylosyltransferase II is the predominant isoenzyme which is responsible for the steady-state level of xylosyltransferase activity in human serum.
Kuhn J, G?tting C, Beahm BJ, Bertozzi CR, Faust I, Kuzaj P, Knabbe C, Hendig D
Biochemical and biophysical research communications459(3)469-74(2015 Apr)

Heterologous expression and biochemical characterization of soluble human xylosyltransferase II.
Casanova JC, Kuhn J, Kleesiek K, G?tting C
Biochemical and biophysical research communications365(4)678-84(2008 Jan)

Polycystic disease caused by deficiency in xylosyltransferase 2, an initiating enzyme of glycosaminoglycan biosynthesis.
Condac E, Silasi-Mansat R, Kosanke S, Schoeb T, Towner R, Lupu F, Cummings RD, Hinsdale ME
Proceedings of the National Academy of Sciences of the United States of America104(22)9416-21(2007 May)

Human xylosyltransferase II is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulfate and heparan sulfate proteoglycans.
P?nighaus C, Ambrosius M, Casanova JC, Prante C, Kuhn J, Esko JD, Kleesiek K, G?tting C
The Journal of biological chemistry282(8)5201-6(2007 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Xylt2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Xylt2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05655	NM_022296.2 Latest version!	Rattus norvegicus xylosyltransferase 2 (Xylt2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$510.30 $729.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Xylt2 ( NM_022296.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071632.2 Rattus norvegicus xylosyltransferase 2 (Xylt2), mRNA.

Price & Availability↑

CloneID	ORa05655
Clone ID Related Accession (Same CDS sequence)	NM_022296.2
Accession Version	NM_022296.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2595bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	xylosyltransferase 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC105767.1. On Oct 16, 2005 this sequence version replaced NM_022296.1. ##Evidence-Data-START## Transcript exon combination :: BC105767.1, AJ295749.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGTGGCGA GCGCGCGGGT GCAGAAGCTG GTGCGGCGCT ACAAGCTGGC GATCGCCACC 
GCGCTGGCCA TCCTGCTGCT GCAGGGCCTG GTGGTGTGGA GCTTCAGCGG CCTGGAGGAG 
GACGAGCCGG GCGAGAAAGG AAGGCAGAGA AAGCCACGGC CGCTAGACCC TGGAGAGGGT 
TCCAAGGACA CGGACAGCTC TGCAGGGCGT AGGGGCAGTG CTGGGAGAAG GCACGGACGG 
TGGCGGGGCC GCGCCGAGAG CCCAGGTGTG CCTGTGGCCA AGGTGGTGCG GGCAGTAACC 
AGTCGGCAGA GAGCCAGCCG ACGGGTGCCC CCTGCCCCAC CTCCAGAGGC ACCAGGCCGC 
CAGAACCTGA GTGGAGCAGC AGCCGGGGAA GCACTGATAG GTGCCGCCGG CTTCCCACAA 
CATGGAGACA CAGGGAGTGT GGAGGGTGCC CCTCAGCCCA CGGATAACAG CTTCACTCCG 
AAGTGTGAGA TTGTGGGCAA GGATGCACTG TCAGCACTGG CCCGGGCCAG CACCAAGCAT 
TGTCAACAAG AGATTGCTAA TGTAGTGTGC CTGCACCAAG CTGGGAACCT AATGCCCAAG 
TCTGTGCCCC GGCACTGCCA GCTGGCTGGC AAGGTGAGCC CTGGCATCCA GTGGGAAGAG 
GTCCGGGCCC AGCAGCCTGT GAGTGGCCCT CTGGTACGCA TCGCCTACAT GCTGGTGGTT 
CACGGCCGTG CTGTGCGCCA GCTGAAGCGT CTTCTGAAGG CCGTCTACCA CGAGGAGCAC 
TTCTTTTATA TTCATGTGGA CAAGCGTTCC AACTACCTGT ACCGGGAGGT GGTAGAGCTG 
GCCCAGCACT ACGACAATGT ACGGGTAACA CCTTGGCGCA TGGTCACCAT CTGGGGTGGG 
GCTAGCCTTC TGAGGATGTA CCTGCGGAGC ATGAAGGACC TTCTGGAGAT TCCTGGCTGG 
ACCTGGGACT TCTTCATCAA CCTGAGCGCT ACTGACTATC CAACCAGGAC GAATGAGGAG 
CTGGTAGCGT TCTTATCCAA GAACCGGGAC AAGAATTTCC TCAAGTCACA CGGGCGAGAC 
AATTCCAGGT TCATCAAGAA GCAAGGCCTG GACCGGCTTT TCCATGAGTG TGATTCCCAC 
ATGTGGCGCC TGGGTGAACG GCAGATCCCG GCAGGCATCG TGGTGGATGG TGGCTCTGAC 
TGGTTCGTGC TGACACGCAG CTTTGTGGAA TATGTGGTGT ATACAGAGGA TCCTCTGGTG 
GCCCAGCTTC GCCAGTTCTA TACATACACA TTGCTTCCAG CCGAGTCCTT CTTCCACACA 
GTGCTGGAGA ACAGCCCAGC CTGTGAGAGC CTAGTGGACA ACAACCTGCG GGTTACCAAC 
TGGAACCGGA AGCTGGGCTG CAAGTGCCAG TACAAGCACA TCGTGGACTG GTGTGGCTGC 
TCCCCCAACG ACTTCAAGCC ACAGGACTTC CTGCGGCTTC AGCAAGTCTC CAGACCCACC 
TTCTTTGCCC GGAAGTTTGA GTCGACTGTG AACCAGGAAG TCCTGGAAAT TTTGGACTTC 
CACCTGTATG GCAGCTACCC ACCCGGCACC CCAGCCCTCA AGGCCTACTG GGAGAACATC 
TACGACATGG CCGATGGCCC TAGTGGACTC AGCGATGTCC TACTCACTGC TTACACAGCC 
TTTGCCCGTA TCAGTCTGCG TCATGCTGCC ACTGTTTCCC CACTGGCCAC TGCAGTCTGC 
AGGTTTGAGC CCAGGGGGTT GCCGTCCAGC GTGCACCTGT ATTTCTATGA CGACCATTTC 
CAGGGCTACC TGGTGACGCA GGCAGTGCAG CCCTCAGCCC AGGGGCCAGC AGAGACACTT 
GAGATGTGGC TGATGCCCCA GAGGTTGCTG AAGCTGTTGG GGCACAGTGA CCAGGCCAGC 
CGGCTCCAGA GTCTGGAGGT TGGCACTGAG TGGGACCCCA AAGAACGTCT CTTCCGGAAC 
TTTGGGGGCC TGTTGGGACC ACTGGATGAA CCTGTGGCCA TGCAGCGCTG GGCCCGGGGC 
CCCAACCTCA CAGCCACTGT GGTCTGGATT GACCCCACCT ATGTTGTGGC CACATCCTAT 
GACATCACGG TAGATGCGGA CACTGAAGTC ACGCAGTACA AGCCCCCACT GAGCCTGCCA 
CTGCGGCCAG GAGCCTGGAC TGTTCGATTG CTTCAGTTCT GGGAGCCCCT GGGTGAGACC 
CGCTTCCTCG TGCTGCCATT GACCTTCAAC CGCAAACTAC CTCTCAGGAA AGATGATGCC 
AGCTGGCTGC ATGCGGGACC ACCCCACAAC GAATACATGG AACAGAGTTT CCAGGGACTA 
AGTGGCATCC TGAATCTGCC TCAGCCAGAG GCCGTGGAGG AGGCTGCCCG GCGGCACACA 
GAGCTCACAG GTCCTGCACT TGAGGCCTGG ACAGATGGGG AACTGAGCAG TTTCTGGTCT 
GTTGCAGGAT TGTGTGCCAT AGGGCCTTCT TCTTGTCCCT CCCTGGAGCT CTGCAGACTG 
ACCAGCTGGA GCTCTCTGTC TCCTGACCCC AAGTCAGAGC TGGGGCCTGT CAAAGCTGAC 
GGACGACTCA GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071632.2
CDS	5..2599
Translation	MVASARVQKLVRRYKLAIATALAILLLQGLVVWSFSGLEEDEPGEKGRQRKPRPLDPGEGSKDTDSSAGRRGSAGRRHGRWRGRAESPGVPVAKVVRAVTSRQRASRRVPPAPPPEAPGRQNLSGAAAGEALIGAAGFPQHGDTGSVEGAPQPTDNSFTPKCEIVGKDALSALARASTKHCQQEIANVVCLHQAGNLMPKSVPRHCQLAGKVSPGIQWEEVRAQQPVSGPLVRIAYMLVVHGRAVRQLKRLLKAVYHEEHFFYIHVDKRSNYLYREVVELAQHYDNVRVTPWRMVTIWGGASLLRMYLRSMKDLLEIPGWTWDFFINLSATDYPTRTNEELVAFLSKNRDKNFLKSHGRDNSRFIKKQGLDRLFHECDSHMWRLGERQIPAGIVVDGGSDWFVLTRSFVEYVVYTEDPLVAQLRQFYTYTLLPAESFFHTVLENSPACESLVDNNLRVTNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFLRLQQVSRPTFFARKFESTVNQEVLEILDFHLYGSYPPGTPALKAYWENIYDMADGPSGLSDVLLTAYTAFARISLRHAATVSPLATAVCRFEPRGLPSSVHLYFYDDHFQGYLVTQAVQPSAQGPAETLEMWLMPQRLLKLLGHSDQASRLQSLEVGTEWDPKERLFRNFGGLLGPLDEPVAMQRWARGPNLTATVVWIDPTYVVATSYDITVDADTEVTQYKPPLSLPLRPGAWTVRLLQFWEPLGETRFLVLPLTFNRKLPLRKDDASWLHAGPPHNEYMEQSFQGLSGILNLPQPEAVEEAARRHTELTGPALEAWTDGELSSFWSVAGLCAIGPSSCPSLELCRLTSWSSLSPDPKSELGPVKADGRLR

Target ORF information:

RefSeq Version	NM_022296.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus xylosyltransferase 2 (Xylt2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022296.2

ORF Insert Sequence:

ATGGTGGCGA GCGCGCGGGT GCAGAAGCTG GTGCGGCGCT ACAAGCTGGC GATCGCCACC 
GCGCTGGCCA TCCTGCTGCT GCAGGGCCTG GTGGTGTGGA GCTTCAGCGG CCTGGAGGAG 
GACGAGCCGG GCGAGAAAGG AAGGCAGAGA AAGCCACGGC CGCTAGACCC TGGAGAGGGT 
TCCAAGGACA CGGACAGCTC TGCAGGGCGT AGGGGCAGTG CTGGGAGAAG GCACGGACGG 
TGGCGGGGCC GCGCCGAGAG CCCAGGTGTG CCTGTGGCCA AGGTGGTGCG GGCAGTAACC 
AGTCGGCAGA GAGCCAGCCG ACGGGTGCCC CCTGCCCCAC CTCCAGAGGC ACCAGGCCGC 
CAGAACCTGA GTGGAGCAGC AGCCGGGGAA GCACTGATAG GTGCCGCCGG CTTCCCACAA 
CATGGAGACA CAGGGAGTGT GGAGGGTGCC CCTCAGCCCA CGGATAACAG CTTCACTCCG 
AAGTGTGAGA TTGTGGGCAA GGATGCACTG TCAGCACTGG CCCGGGCCAG CACCAAGCAT 
TGTCAACAAG AGATTGCTAA TGTAGTGTGC CTGCACCAAG CTGGGAACCT AATGCCCAAG 
TCTGTGCCCC GGCACTGCCA GCTGGCTGGC AAGGTGAGCC CTGGCATCCA GTGGGAAGAG 
GTCCGGGCCC AGCAGCCTGT GAGTGGCCCT CTGGTACGCA TCGCCTACAT GCTGGTGGTT 
CACGGCCGTG CTGTGCGCCA GCTGAAGCGT CTTCTGAAGG CCGTCTACCA CGAGGAGCAC 
TTCTTTTATA TTCATGTGGA CAAGCGTTCC AACTACCTGT ACCGGGAGGT GGTAGAGCTG 
GCCCAGCACT ACGACAATGT ACGGGTAACA CCTTGGCGCA TGGTCACCAT CTGGGGTGGG 
GCTAGCCTTC TGAGGATGTA CCTGCGGAGC ATGAAGGACC TTCTGGAGAT TCCTGGCTGG 
ACCTGGGACT TCTTCATCAA CCTGAGCGCT ACTGACTATC CAACCAGGAC GAATGAGGAG 
CTGGTAGCGT TCTTATCCAA GAACCGGGAC AAGAATTTCC TCAAGTCACA CGGGCGAGAC 
AATTCCAGGT TCATCAAGAA GCAAGGCCTG GACCGGCTTT TCCATGAGTG TGATTCCCAC 
ATGTGGCGCC TGGGTGAACG GCAGATCCCG GCAGGCATCG TGGTGGATGG TGGCTCTGAC 
TGGTTCGTGC TGACACGCAG CTTTGTGGAA TATGTGGTGT ATACAGAGGA TCCTCTGGTG 
GCCCAGCTTC GCCAGTTCTA TACATACACA TTGCTTCCAG CCGAGTCCTT CTTCCACACA 
GTGCTGGAGA ACAGCCCAGC CTGTGAGAGC CTAGTGGACA ACAACCTGCG GGTTACCAAC 
TGGAACCGGA AGCTGGGCTG CAAGTGCCAG TACAAGCACA TCGTGGACTG GTGTGGCTGC 
TCCCCCAACG ACTTCAAGCC ACAGGACTTC CTGCGGCTTC AGCAAGTCTC CAGACCCACC 
TTCTTTGCCC GGAAGTTTGA GTCGACTGTG AACCAGGAAG TCCTGGAAAT TTTGGACTTC 
CACCTGTATG GCAGCTACCC ACCCGGCACC CCAGCCCTCA AGGCCTACTG GGAGAACATC 
TACGACATGG CCGATGGCCC TAGTGGACTC AGCGATGTCC TACTCACTGC TTACACAGCC 
TTTGCCCGTA TCAGTCTGCG TCATGCTGCC ACTGTTTCCC CACTGGCCAC TGCAGTCTGC 
AGGTTTGAGC CCAGGGGGTT GCCGTCCAGC GTGCACCTGT ATTTCTATGA CGACCATTTC 
CAGGGCTACC TGGTGACGCA GGCAGTGCAG CCCTCAGCCC AGGGGCCAGC AGAGACACTT 
GAGATGTGGC TGATGCCCCA GAGGTTGCTG AAGCTGTTGG GGCACAGTGA CCAGGCCAGC 
CGGCTCCAGA GTCTGGAGGT TGGCACTGAG TGGGACCCCA AAGAACGTCT CTTCCGGAAC 
TTTGGGGGCC TGTTGGGACC ACTGGATGAA CCTGTGGCCA TGCAGCGCTG GGCCCGGGGC 
CCCAACCTCA CAGCCACTGT GGTCTGGATT GACCCCACCT ATGTTGTGGC CACATCCTAT 
GACATCACGG TAGATGCGGA CACTGAAGTC ACGCAGTACA AGCCCCCACT GAGCCTGCCA 
CTGCGGCCAG GAGCCTGGAC TGTTCGATTG CTTCAGTTCT GGGAGCCCCT GGGTGAGACC 
CGCTTCCTCG TGCTGCCATT GACCTTCAAC CGCAAACTAC CTCTCAGGAA AGATGATGCC 
AGCTGGCTGC ATGCGGGACC ACCCCACAAC GAATACATGG AACAGAGTTT CCAGGGACTA 
AGTGGCATCC TGAATCTGCC TCAGCCAGAG GCCGTGGAGG AGGCTGCCCG GCGGCACACA 
GAGCTCACAG GTCCTGCACT TGAGGCCTGG ACAGATGGGG AACTGAGCAG TTTCTGGTCT 
GTTGCAGGAT TGTGTGCCAT AGGGCCTTCT TCTTGTCCCT CCCTGGAGCT CTGCAGACTG 
ACCAGCTGGA GCTCTCTGTC TCCTGACCCC AAGTCAGAGC TGGGGCCTGT CAAAGCTGAC 
GGACGACTCA GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Homozygosity for frameshift mutations in XYLT2 result in a spondylo-ocular syndrome with bone fragility, cataracts, and hearing defects.
American journal of human genetics96(6)971-8(2015 Jun)
Munns CF,Fahiminiya S,Poudel N,Munteanu MC,Majewski J,Sillence DO,Metcalf JP,Biggin A,Glorieux F,Fassier F,Rauch F,Hinsdale ME

Xylosyltransferase II is the predominant isoenzyme which is responsible for the steady-state level of xylosyltransferase activity in human serum.
Biochemical and biophysical research communications459(3)469-74(2015 Apr)
Kuhn J,G?tting C,Beahm BJ,Bertozzi CR,Faust I,Kuzaj P,Knabbe C,Hendig D

Heterologous expression and biochemical characterization of soluble human xylosyltransferase II.
Biochemical and biophysical research communications365(4)678-84(2008 Jan)
Casanova JC,Kuhn J,Kleesiek K,G?tting C

Polycystic disease caused by deficiency in xylosyltransferase 2, an initiating enzyme of glycosaminoglycan biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America104(22)9416-21(2007 May)
Condac E,Silasi-Mansat R,Kosanke S,Schoeb T,Towner R,Lupu F,Cummings RD,Hinsdale ME

Human xylosyltransferase II is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulfate and heparan sulfate proteoglycans.
The Journal of biological chemistry282(8)5201-6(2007 Feb)
P?nighaus C,Ambrosius M,Casanova JC,Prante C,Kuhn J,Esko JD,Kleesiek K,G?tting C

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Xylt2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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