Ncoa4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ncoa4
Entrez Gene ID	619385
Full Name	nuclear receptor coactivator 4
General protein information	Preferred Names nuclear receptor coactivator 4 Names nuclear receptor coactivator 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p16

mRNA and Protein(s)

mRNA	Protein	Name
NM_001034007.1	NP_001029179.1	nuclear receptor coactivator 4
NM_001034008.1	NP_001029180.1	nuclear receptor coactivator 4
XM_006252660.3	XP_006252722.1	nuclear receptor coactivator 4 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	NCOA4	NP_001138732.1
Pan troglodytes (chimpanzee)	NCOA4	XP_003312606.1
Bos taurus (cattle)	NCOA4	NP_001069336.1
Mus musculus (house mouse)	Ncoa4	NP_001029160.1
Canis lupus familiaris (dog)	NCOA4	XP_005637547.1
Danio rerio (zebrafish)	ncoa4	NP_957423.1
Xenopus tropicalis (tropical clawed frog)	ncoa4	XP_004919877.1
	NCOA4	XP_001106334.2
Rattus norvegicus (Norway rat)	Ncoa4	NP_001029179.1
Gallus gallus (chicken)	NCOA4	NP_001006495.1

Gene Ontology
Bibliography

Related articles in PubMed

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.
Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y
Trends in biochemical sciences41(3)274-86(2016 Mar)

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.
Lane DJ, Merlot AM, Huang ML, Bae DH, Jansson PJ, Sahni S, Kalinowski DS, Richardson DR
Biochimica et biophysica acta1853(5)1130-44(2015 May)

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, Cantwell J, Luu C, Cornella-Taracido I, Harrington E, Fekkes P, Lei H, Fang Q, Digan ME, Burdick D, Powers AF, Helliwell SB, D'Aquin S, Bastien J, Wang H, Wiederschain D, Kuerth J, Bergman P, Schwalb D, Thomas J, Ugwonali S, Harbinski F, Tallarico J, Wilson CJ, Myer VE, Porter JA, Bussiere DE, Finan PM, Labow MA, Mao X, Hamann LG, Manning BD, Valdez RA, Nicholson T, Schirle M, Knapp MS, Keaney EP, Murphy LO
Nature cell biology16(11)1069-79(2014 Nov)

Direct regulation of androgen receptor-associated protein 70 by thyroid hormone and its receptors.
Tai PJ, Huang YH, Shih CH, Chen RN, Chen CD, Chen WJ, Wang CS, Lin KH
Endocrinology148(7)3485-95(2007 Jul)

Evaluation of steroid receptors, coregulators, and molecules associated with uterine receptivity in secretory endometria from untreated women with polycystic ovary syndrome.
Quezada S, Avellaira C, Johnson MC, Gabler F, Fuentes A, Vega M
Fertility and sterility85(4)1017-26(2006 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ncoa4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ncoa4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa08819	NM_001034007.1 Latest version!	Rattus norvegicus nuclear receptor coactivator 4 (Ncoa4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa08819	NM_001034008.1 Latest version!	Rattus norvegicus nuclear receptor coactivator 4 (Ncoa4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa37076	XM_006252660.3 Latest version!	Rattus norvegicus nuclear receptor coactivator 4 (Ncoa4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ncoa4 ( NM_001034007.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001029179.1 Rattus norvegicus nuclear receptor coactivator 4 (Ncoa4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa08819
Clone ID Related Accession (Same CDS sequence)	NM_001034007.1 , NM_001034008.1
Accession Version	NM_001034007.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1869bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	nuclear receptor coactivator 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB806310.1, CV119475.1, BC061839.1, AI031008.1, CV795771.1 and AI112421.1. Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same isoform. ##Evidence-Data-START## CDS exon combination :: BC160817.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATACAT CCCTGGAGCA GAGTGGCTGC TGCAGTAGTA GAGAGACACT TCTGAGGTGC 
AGTGATGCAA GGAGGGAGCT GGAGCTTGCG ATTGGTGGAG TCCTCCGGGC CGAGCAGCAA 
ATGAAAGATA ATCTACGAGA GGTGAAAGCT CAGATTCACA GCTGCATTAG TCGCCACCTG 
GAATGCCTTC GAAGCCGAGA GGTGTGGCTC AACGAGCAGG TGGATCTCAT CTATCAGCTG 
AAGGAGGAGA CGCTGCAGCA GCAGGCTCAG CAGCTGTACT GGCTAATGGG CCAATTCAAT 
TGTCTTATTC ATCAACTGGA GATTACCCAG AACAAGGATC TTGCCAATCA AGTCGCGCTG 
TGCTTGGAGA GACTGGGCAG TTTGACCCTT AAGCCTGAGG ATTCTACTGT CCTGCTCTTT 
GAAGCAGATG CATCTGCCCT GCGTCAGACC ATCACCACGT TTGGGTCCCT CAAGACCATT 
CAAATTCCTG AGCACCTGAT GGCTCATCCT AGTTCTTCAA GTGTCAGGCC TTTCCTGGAG 
AAAAGAGGTT ATACCCAGGT GCCAGAGCAG AAGTCAGCAT CCAGCGGCAC AGCTGTTTCT 
CTCAGTGAAT GGCTTCTTGT AAGCAAACCT GCCATTGGTC CTCAGGCTCC ATACGTACCC 
AGTACCAACC CACAGGACTG GCTCACCCCA AAACAGACCT TGGAGAACAG TCAGACTTCT 
GCCAGAATCT GCAGCGATGC CTGGGGCAAT CTGAAGGGCT TAGAAAACTG GCTCCTTAAC 
AGTCATCAAC AAGAAATTCC TGGAAAACCA AGTTCCTCAA AATGTAATAG CCATTGTAGC 
ACCAGTTCTT TCTCTACTGA AGATGAAAAG GTTGAAGATG TAGAGGTCCT CGATCAAGAC 
GAGCTGGACC TGTCTGATTG GTTGGTGACT CCTCAGGAAC CCCGTGATCT GGAGAAGCCT 
GTGAATGGCC GCTCTGACAC CAGTGACAAG TTTAAGCTCT TGTTCCAGGT GTTCAGAGAG 
CCCTACAATG TGAATGATTG GCTTGTCAAG CCTGACTCCT GTACCAACTG TCAGGGTAAC 
CAGCCCAGAG GTGTGGAGAT TGAGAACCTG GGCAATCTGA AATGCCTGAA TGACCACTTG 
GAGGCTAAAA AGTCATTGCC AGTCCCCGGC GTAATCACCG AGGGCTGGCT TGTCCAGAAC 
CATCAGGACA CATGTAAAGT AGAGGAAGTC TGCAAAGCCA ACGAGCCCTG CACCAGCTTT 
GCAGAGTGTG TGTGTGATGA CAGCTGTGAG AAGGAAGCGA TGCATAAATG GCTTCTGAAG 
AAAGAAGGGA AGGACAAGAA TGGAATGCCT ATGGGACCCA AATCTGAGTC TGAGAAACAC 
AGAGAGTCCC TGTCTCTGTG GCTTTGCCCT TCTAGAAATG AGCTAACAGA ACACGCTAAG 
ACACCCAAGA CTACGGCTCC TGCTAGAATT GCTGACTCCT TCCACATCAT AAGGAATAGC 
TCCTTGTCAG AGTGGCTTAT TGGGCCTACA TGCAAAGGAG GAGGCCCCAA GGAAGTGCCC 
AATATGGAGG AGAGAGCTAG CAAAGAAATG CTTAAAAGCC CCATGGCCAC TTACTGGCGT 
CCTTTTAACA CTGCTGACTG GGTCTTACCA GGAAAGAAAG TGGGAAACCT TAGTCAGTTC 
TCCTCGGGAG AAGATAAGTG GCTACTTCGA AAGAAGGCAC AGGAAGTATT TCTTAATTCA 
CCCCTACAAG AAGAACGTAA CTTTCGCTCA GATTGTTACG GCCTCCCGGC AGTTTGTGAT 
CTCTTTGCCT GTATGCAGCT TAAAGTTGAT AAGGACAAAT GGCTGTACAG AGCCCCTCTT 
CAGATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001029179.1
CDS	58..1926
Translation	MNTSLEQSGCCSSRETLLRCSDARRELELAIGGVLRAEQQMKDNLREVKAQIHSCISRHLECLRSREVWLNEQVDLIYQLKEETLQQQAQQLYWLMGQFNCLIHQLEITQNKDLANQVALCLERLGSLTLKPEDSTVLLFEADASALRQTITTFGSLKTIQIPEHLMAHPSSSSVRPFLEKRGYTQVPEQKSASSGTAVSLSEWLLVSKPAIGPQAPYVPSTNPQDWLTPKQTLENSQTSARICSDAWGNLKGLENWLLNSHQQEIPGKPSSSKCNSHCSTSSFSTEDEKVEDVEVLDQDELDLSDWLVTPQEPRDLEKPVNGRSDTSDKFKLLFQVFREPYNVNDWLVKPDSCTNCQGNQPRGVEIENLGNLKCLNDHLEAKKSLPVPGVITEGWLVQNHQDTCKVEEVCKANEPCTSFAECVCDDSCEKEAMHKWLLKKEGKDKNGMPMGPKSESEKHRESLSLWLCPSRNELTEHAKTPKTTAPARIADSFHIIRNSSLSEWLIGPTCKGGGPKEVPNMEERASKEMLKSPMATYWRPFNTADWVLPGKKVGNLSQFSSGEDKWLLRKKAQEVFLNSPLQEERNFRSDCYGLPAVCDLFACMQLKVDKDKWLYRAPLQM

Target ORF information:

RefSeq Version	NM_001034007.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nuclear receptor coactivator 4 (Ncoa4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001034007.1

ORF Insert Sequence:

ATGAATACAT CCCTGGAGCA GAGTGGCTGC TGCAGTAGTA GAGAGACACT TCTGAGGTGC 
AGTGATGCAA GGAGGGAGCT GGAGCTTGCG ATTGGTGGAG TCCTCCGGGC CGAGCAGCAA 
ATGAAAGATA ATCTACGAGA GGTGAAAGCT CAGATTCACA GCTGCATTAG TCGCCACCTG 
GAATGCCTTC GAAGCCGAGA GGTGTGGCTC AACGAGCAGG TGGATCTCAT CTATCAGCTG 
AAGGAGGAGA CGCTGCAGCA GCAGGCTCAG CAGCTGTACT GGCTAATGGG CCAATTCAAT 
TGTCTTATTC ATCAACTGGA GATTACCCAG AACAAGGATC TTGCCAATCA AGTCGCGCTG 
TGCTTGGAGA GACTGGGCAG TTTGACCCTT AAGCCTGAGG ATTCTACTGT CCTGCTCTTT 
GAAGCAGATG CATCTGCCCT GCGTCAGACC ATCACCACGT TTGGGTCCCT CAAGACCATT 
CAAATTCCTG AGCACCTGAT GGCTCATCCT AGTTCTTCAA GTGTCAGGCC TTTCCTGGAG 
AAAAGAGGTT ATACCCAGGT GCCAGAGCAG AAGTCAGCAT CCAGCGGCAC AGCTGTTTCT 
CTCAGTGAAT GGCTTCTTGT AAGCAAACCT GCCATTGGTC CTCAGGCTCC ATACGTACCC 
AGTACCAACC CACAGGACTG GCTCACCCCA AAACAGACCT TGGAGAACAG TCAGACTTCT 
GCCAGAATCT GCAGCGATGC CTGGGGCAAT CTGAAGGGCT TAGAAAACTG GCTCCTTAAC 
AGTCATCAAC AAGAAATTCC TGGAAAACCA AGTTCCTCAA AATGTAATAG CCATTGTAGC 
ACCAGTTCTT TCTCTACTGA AGATGAAAAG GTTGAAGATG TAGAGGTCCT CGATCAAGAC 
GAGCTGGACC TGTCTGATTG GTTGGTGACT CCTCAGGAAC CCCGTGATCT GGAGAAGCCT 
GTGAATGGCC GCTCTGACAC CAGTGACAAG TTTAAGCTCT TGTTCCAGGT GTTCAGAGAG 
CCCTACAATG TGAATGATTG GCTTGTCAAG CCTGACTCCT GTACCAACTG TCAGGGTAAC 
CAGCCCAGAG GTGTGGAGAT TGAGAACCTG GGCAATCTGA AATGCCTGAA TGACCACTTG 
GAGGCTAAAA AGTCATTGCC AGTCCCCGGC GTAATCACCG AGGGCTGGCT TGTCCAGAAC 
CATCAGGACA CATGTAAAGT AGAGGAAGTC TGCAAAGCCA ACGAGCCCTG CACCAGCTTT 
GCAGAGTGTG TGTGTGATGA CAGCTGTGAG AAGGAAGCGA TGCATAAATG GCTTCTGAAG 
AAAGAAGGGA AGGACAAGAA TGGAATGCCT ATGGGACCCA AATCTGAGTC TGAGAAACAC 
AGAGAGTCCC TGTCTCTGTG GCTTTGCCCT TCTAGAAATG AGCTAACAGA ACACGCTAAG 
ACACCCAAGA CTACGGCTCC TGCTAGAATT GCTGACTCCT TCCACATCAT AAGGAATAGC 
TCCTTGTCAG AGTGGCTTAT TGGGCCTACA TGCAAAGGAG GAGGCCCCAA GGAAGTGCCC 
AATATGGAGG AGAGAGCTAG CAAAGAAATG CTTAAAAGCC CCATGGCCAC TTACTGGCGT 
CCTTTTAACA CTGCTGACTG GGTCTTACCA GGAAAGAAAG TGGGAAACCT TAGTCAGTTC 
TCCTCGGGAG AAGATAAGTG GCTACTTCGA AAGAAGGCAC AGGAAGTATT TCTTAATTCA 
CCCCTACAAG AAGAACGTAA CTTTCGCTCA GATTGTTACG GCCTCCCGGC AGTTTGTGAT 
CTCTTTGCCT GTATGCAGCT TAAAGTTGAT AAGGACAAAT GGCTGTACAG AGCCCCTCTT 
CAGATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ncoa4 ( NM_001034008.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001029180.1 Rattus norvegicus nuclear receptor coactivator 4 (Ncoa4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa08819
Clone ID Related Accession (Same CDS sequence)	NM_001034007.1 , NM_001034008.1
Accession Version	NM_001034008.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1869bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	nuclear receptor coactivator 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB758330.1, CV119475.1, BC061839.1, AI031008.1, CV795771.1 and AI112421.1. Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 encode the same isoform. ##Evidence-Data-START## Transcript exon combination :: BC160817.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAATACAT CCCTGGAGCA GAGTGGCTGC TGCAGTAGTA GAGAGACACT TCTGAGGTGC 
AGTGATGCAA GGAGGGAGCT GGAGCTTGCG ATTGGTGGAG TCCTCCGGGC CGAGCAGCAA 
ATGAAAGATA ATCTACGAGA GGTGAAAGCT CAGATTCACA GCTGCATTAG TCGCCACCTG 
GAATGCCTTC GAAGCCGAGA GGTGTGGCTC AACGAGCAGG TGGATCTCAT CTATCAGCTG 
AAGGAGGAGA CGCTGCAGCA GCAGGCTCAG CAGCTGTACT GGCTAATGGG CCAATTCAAT 
TGTCTTATTC ATCAACTGGA GATTACCCAG AACAAGGATC TTGCCAATCA AGTCGCGCTG 
TGCTTGGAGA GACTGGGCAG TTTGACCCTT AAGCCTGAGG ATTCTACTGT CCTGCTCTTT 
GAAGCAGATG CATCTGCCCT GCGTCAGACC ATCACCACGT TTGGGTCCCT CAAGACCATT 
CAAATTCCTG AGCACCTGAT GGCTCATCCT AGTTCTTCAA GTGTCAGGCC TTTCCTGGAG 
AAAAGAGGTT ATACCCAGGT GCCAGAGCAG AAGTCAGCAT CCAGCGGCAC AGCTGTTTCT 
CTCAGTGAAT GGCTTCTTGT AAGCAAACCT GCCATTGGTC CTCAGGCTCC ATACGTACCC 
AGTACCAACC CACAGGACTG GCTCACCCCA AAACAGACCT TGGAGAACAG TCAGACTTCT 
GCCAGAATCT GCAGCGATGC CTGGGGCAAT CTGAAGGGCT TAGAAAACTG GCTCCTTAAC 
AGTCATCAAC AAGAAATTCC TGGAAAACCA AGTTCCTCAA AATGTAATAG CCATTGTAGC 
ACCAGTTCTT TCTCTACTGA AGATGAAAAG GTTGAAGATG TAGAGGTCCT CGATCAAGAC 
GAGCTGGACC TGTCTGATTG GTTGGTGACT CCTCAGGAAC CCCGTGATCT GGAGAAGCCT 
GTGAATGGCC GCTCTGACAC CAGTGACAAG TTTAAGCTCT TGTTCCAGGT GTTCAGAGAG 
CCCTACAATG TGAATGATTG GCTTGTCAAG CCTGACTCCT GTACCAACTG TCAGGGTAAC 
CAGCCCAGAG GTGTGGAGAT TGAGAACCTG GGCAATCTGA AATGCCTGAA TGACCACTTG 
GAGGCTAAAA AGTCATTGCC AGTCCCCGGC GTAATCACCG AGGGCTGGCT TGTCCAGAAC 
CATCAGGACA CATGTAAAGT AGAGGAAGTC TGCAAAGCCA ACGAGCCCTG CACCAGCTTT 
GCAGAGTGTG TGTGTGATGA CAGCTGTGAG AAGGAAGCGA TGCATAAATG GCTTCTGAAG 
AAAGAAGGGA AGGACAAGAA TGGAATGCCT ATGGGACCCA AATCTGAGTC TGAGAAACAC 
AGAGAGTCCC TGTCTCTGTG GCTTTGCCCT TCTAGAAATG AGCTAACAGA ACACGCTAAG 
ACACCCAAGA CTACGGCTCC TGCTAGAATT GCTGACTCCT TCCACATCAT AAGGAATAGC 
TCCTTGTCAG AGTGGCTTAT TGGGCCTACA TGCAAAGGAG GAGGCCCCAA GGAAGTGCCC 
AATATGGAGG AGAGAGCTAG CAAAGAAATG CTTAAAAGCC CCATGGCCAC TTACTGGCGT 
CCTTTTAACA CTGCTGACTG GGTCTTACCA GGAAAGAAAG TGGGAAACCT TAGTCAGTTC 
TCCTCGGGAG AAGATAAGTG GCTACTTCGA AAGAAGGCAC AGGAAGTATT TCTTAATTCA 
CCCCTACAAG AAGAACGTAA CTTTCGCTCA GATTGTTACG GCCTCCCGGC AGTTTGTGAT 
CTCTTTGCCT GTATGCAGCT TAAAGTTGAT AAGGACAAAT GGCTGTACAG AGCCCCTCTT 
CAGATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001029180.1
CDS	104..1972
Translation	MNTSLEQSGCCSSRETLLRCSDARRELELAIGGVLRAEQQMKDNLREVKAQIHSCISRHLECLRSREVWLNEQVDLIYQLKEETLQQQAQQLYWLMGQFNCLIHQLEITQNKDLANQVALCLERLGSLTLKPEDSTVLLFEADASALRQTITTFGSLKTIQIPEHLMAHPSSSSVRPFLEKRGYTQVPEQKSASSGTAVSLSEWLLVSKPAIGPQAPYVPSTNPQDWLTPKQTLENSQTSARICSDAWGNLKGLENWLLNSHQQEIPGKPSSSKCNSHCSTSSFSTEDEKVEDVEVLDQDELDLSDWLVTPQEPRDLEKPVNGRSDTSDKFKLLFQVFREPYNVNDWLVKPDSCTNCQGNQPRGVEIENLGNLKCLNDHLEAKKSLPVPGVITEGWLVQNHQDTCKVEEVCKANEPCTSFAECVCDDSCEKEAMHKWLLKKEGKDKNGMPMGPKSESEKHRESLSLWLCPSRNELTEHAKTPKTTAPARIADSFHIIRNSSLSEWLIGPTCKGGGPKEVPNMEERASKEMLKSPMATYWRPFNTADWVLPGKKVGNLSQFSSGEDKWLLRKKAQEVFLNSPLQEERNFRSDCYGLPAVCDLFACMQLKVDKDKWLYRAPLQM

Target ORF information:

RefSeq Version	NM_001034008.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nuclear receptor coactivator 4 (Ncoa4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001034008.1

ORF Insert Sequence:

ATGAATACAT CCCTGGAGCA GAGTGGCTGC TGCAGTAGTA GAGAGACACT TCTGAGGTGC 
AGTGATGCAA GGAGGGAGCT GGAGCTTGCG ATTGGTGGAG TCCTCCGGGC CGAGCAGCAA 
ATGAAAGATA ATCTACGAGA GGTGAAAGCT CAGATTCACA GCTGCATTAG TCGCCACCTG 
GAATGCCTTC GAAGCCGAGA GGTGTGGCTC AACGAGCAGG TGGATCTCAT CTATCAGCTG 
AAGGAGGAGA CGCTGCAGCA GCAGGCTCAG CAGCTGTACT GGCTAATGGG CCAATTCAAT 
TGTCTTATTC ATCAACTGGA GATTACCCAG AACAAGGATC TTGCCAATCA AGTCGCGCTG 
TGCTTGGAGA GACTGGGCAG TTTGACCCTT AAGCCTGAGG ATTCTACTGT CCTGCTCTTT 
GAAGCAGATG CATCTGCCCT GCGTCAGACC ATCACCACGT TTGGGTCCCT CAAGACCATT 
CAAATTCCTG AGCACCTGAT GGCTCATCCT AGTTCTTCAA GTGTCAGGCC TTTCCTGGAG 
AAAAGAGGTT ATACCCAGGT GCCAGAGCAG AAGTCAGCAT CCAGCGGCAC AGCTGTTTCT 
CTCAGTGAAT GGCTTCTTGT AAGCAAACCT GCCATTGGTC CTCAGGCTCC ATACGTACCC 
AGTACCAACC CACAGGACTG GCTCACCCCA AAACAGACCT TGGAGAACAG TCAGACTTCT 
GCCAGAATCT GCAGCGATGC CTGGGGCAAT CTGAAGGGCT TAGAAAACTG GCTCCTTAAC 
AGTCATCAAC AAGAAATTCC TGGAAAACCA AGTTCCTCAA AATGTAATAG CCATTGTAGC 
ACCAGTTCTT TCTCTACTGA AGATGAAAAG GTTGAAGATG TAGAGGTCCT CGATCAAGAC 
GAGCTGGACC TGTCTGATTG GTTGGTGACT CCTCAGGAAC CCCGTGATCT GGAGAAGCCT 
GTGAATGGCC GCTCTGACAC CAGTGACAAG TTTAAGCTCT TGTTCCAGGT GTTCAGAGAG 
CCCTACAATG TGAATGATTG GCTTGTCAAG CCTGACTCCT GTACCAACTG TCAGGGTAAC 
CAGCCCAGAG GTGTGGAGAT TGAGAACCTG GGCAATCTGA AATGCCTGAA TGACCACTTG 
GAGGCTAAAA AGTCATTGCC AGTCCCCGGC GTAATCACCG AGGGCTGGCT TGTCCAGAAC 
CATCAGGACA CATGTAAAGT AGAGGAAGTC TGCAAAGCCA ACGAGCCCTG CACCAGCTTT 
GCAGAGTGTG TGTGTGATGA CAGCTGTGAG AAGGAAGCGA TGCATAAATG GCTTCTGAAG 
AAAGAAGGGA AGGACAAGAA TGGAATGCCT ATGGGACCCA AATCTGAGTC TGAGAAACAC 
AGAGAGTCCC TGTCTCTGTG GCTTTGCCCT TCTAGAAATG AGCTAACAGA ACACGCTAAG 
ACACCCAAGA CTACGGCTCC TGCTAGAATT GCTGACTCCT TCCACATCAT AAGGAATAGC 
TCCTTGTCAG AGTGGCTTAT TGGGCCTACA TGCAAAGGAG GAGGCCCCAA GGAAGTGCCC 
AATATGGAGG AGAGAGCTAG CAAAGAAATG CTTAAAAGCC CCATGGCCAC TTACTGGCGT 
CCTTTTAACA CTGCTGACTG GGTCTTACCA GGAAAGAAAG TGGGAAACCT TAGTCAGTTC 
TCCTCGGGAG AAGATAAGTG GCTACTTCGA AAGAAGGCAC AGGAAGTATT TCTTAATTCA 
CCCCTACAAG AAGAACGTAA CTTTCGCTCA GATTGTTACG GCCTCCCGGC AGTTTGTGAT 
CTCTTTGCCT GTATGCAGCT TAAAGTTGAT AAGGACAAAT GGCTGTACAG AGCCCCTCTT 
CAGATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ncoa4 ( XM_006252660.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006252722.1 Rattus norvegicus nuclear receptor coactivator 4 (Ncoa4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa37076
Clone ID Related Accession (Same CDS sequence)	XM_006252660.3
Accession Version	XM_006252660.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1893bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	nuclear receptor coactivator 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005115.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006252660.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCAAG GAACAGTGAG CAGAATGAAT ACATCCCTGG AGCAGAGTGG CTGCTGCAGT 
AGTAGAGAGA CACTTCTGAG GTGCAGTGAT GCAAGGAGGG AGCTGGAGCT TGCGATTGGT 
GGAGTCCTCC GGGCCGAGCA GCAAATGAAA GATAATCTAC GAGAGGTGAA AGCTCAGATT 
CACAGCTGCA TTAGTCGCCA CCTGGAATGC CTTCGAAGCC GAGAGGTGTG GCTCAACGAG 
CAGGTGGATC TCATCTATCA GCTGAAGGAG GAGACGCTGC AGCAGCAGGC TCAGCAGCTG 
TACTGGCTAA TGGGCCAATT CAATTGTCTT ATTCATCAAC TGGAGATTAC CCAGAACAAG 
GATCTTGCCA ATCAAGTCGC GCTGTGCTTG GAGAGACTGG GCAGTTTGAC CCTTAAGCCT 
GAGGATTCTA CTGTCCTGCT CTTTGAAGCA GATGCATCTG CCCTGCGTCA GACCATCACC 
ACGTTTGGGT CCCTCAAGAC CATTCAAATT CCTGAGCACC TGATGGCTCA TCCTAGTTCT 
TCAAGTGTCA GGCCTTTCCT GGAGAAAAGA GGTTATACCC AGGTGCCAGA GCAGAAGTCA 
GCATCCAGCG GCACAGCTGT TTCTCTCAGT GAATGGCTTC TTGTAAGCAA ACCTGCCATT 
GGTCCTCAGG CTCCATACGT ACCCAGTACC AACCCACAGG ACTGGCTCAC CCCAAAACAG 
ACCTTGGAGA ACAGTCAGAC TTCTGCCAGA ATCTGCAGCG ATGCCTGGGG CAATCTGAAG 
GGCTTAGAAA ACTGGCTCCT TAACAGTCAT CAACAAGAAA TTCCTGGAAA ACCAAGTTCC 
TCAAAATGTA ATAGCCATTG TAGCACCAGT TCTTTCTCTA CTGAAGATGA AAAGGTTGAA 
GATGTAGAGG TCCTCGATCA AGACGAGCTG GACCTGTCTG ATTGGTTGGT GACTCCTCAG 
GAACCCCGTG ATCTGGAGAA GCCTGTGAAT GGCCGCTCTG ACACCAGTGA CAAGTTTAAG 
CTCTTGTTCC AGGTGTTCAG AGAGCCCTAC AATGTGAATG ATTGGCTTGT CAAGCCTGAC 
TCCTGTACCA ACTGTCAGGG TAACCAGCCC AGAGGTGTGG AGATTGAGAA CCTGGGCAAT 
CTGAAATGCC TGAATGACCA CTTGGAGGCT AAAAAGTCAT TGCCAGTCCC CGGCGTAATC 
ACCGAGGGCT GGCTTGTCCA GAACCATCAG GACACATGTA AAGTAGAGGA AGTCTGCAAA 
GCCAACGAGC CCTGCACCAG CTTTGCAGAG TGTGTGTGTG ATGACAGCTG TGAGAAGGAA 
GCGATGCATA AATGGCTTCT GAAGAAAGAA GGGAAGGACA AGAATGGAAT GCCTATGGGA 
CCCAAATCTG AGTCTGAGAA ACACAGAGAG TCCCTGTCTC TGTGGCTTTG CCCTTCTAGA 
AATGAGCTAA CAGAACACGC TAAGACACCC AAGACTACGG CTCCTGCTAG AATTGCTGAC 
TCCTTCCACA TCATAAGGAA TAGCTCCTTG TCAGAGTGGC TTATTGGGCC TACATGCAAA 
GGAGGAGGCC CCAAGGAAGT GCCCAATATG GAGGAGAGAG CTAGCAAAGA AATGCTTAAA 
AGCCCCATGG CCACTTACTG GCGTCCTTTT AACACTGCTG ACTGGGTCTT ACCAGGAAAG 
AAAGTGGGAA ACCTTAGTCA GTTCTCCTCG GGAGAAGATA AGTGGCTACT TCGAAAGAAG 
GCACAGGAAG TATTTCTTAA TTCACCCCTA CAAGAAGAAC GTAACTTTCG CTCAGATTGT 
TACGGCCTCC CGGCAGTTTG TGATCTCTTT GCCTGTATGC AGCTTAAAGT TGATAAGGAC 
AAATGGCTGT ACAGAGCCCC TCTTCAGATG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006252722.1
CDS	382..2274
Translation	MAQGTVSRMNTSLEQSGCCSSRETLLRCSDARRELELAIGGVLRAEQQMKDNLREVKAQIHSCISRHLECLRSREVWLNEQVDLIYQLKEETLQQQAQQLYWLMGQFNCLIHQLEITQNKDLANQVALCLERLGSLTLKPEDSTVLLFEADASALRQTITTFGSLKTIQIPEHLMAHPSSSSVRPFLEKRGYTQVPEQKSASSGTAVSLSEWLLVSKPAIGPQAPYVPSTNPQDWLTPKQTLENSQTSARICSDAWGNLKGLENWLLNSHQQEIPGKPSSSKCNSHCSTSSFSTEDEKVEDVEVLDQDELDLSDWLVTPQEPRDLEKPVNGRSDTSDKFKLLFQVFREPYNVNDWLVKPDSCTNCQGNQPRGVEIENLGNLKCLNDHLEAKKSLPVPGVITEGWLVQNHQDTCKVEEVCKANEPCTSFAECVCDDSCEKEAMHKWLLKKEGKDKNGMPMGPKSESEKHRESLSLWLCPSRNELTEHAKTPKTTAPARIADSFHIIRNSSLSEWLIGPTCKGGGPKEVPNMEERASKEMLKSPMATYWRPFNTADWVLPGKKVGNLSQFSSGEDKWLLRKKAQEVFLNSPLQEERNFRSDCYGLPAVCDLFACMQLKVDKDKWLYRAPLQM

Target ORF information:

RefSeq Version	XM_006252660.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nuclear receptor coactivator 4 (Ncoa4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006252660.3

ORF Insert Sequence:

ATGGCTCAAG GAACAGTGAG CAGAATGAAT ACATCCCTGG AGCAGAGTGG CTGCTGCAGT 
AGTAGAGAGA CACTTCTGAG GTGCAGTGAT GCAAGGAGGG AGCTGGAGCT TGCGATTGGT 
GGAGTCCTCC GGGCCGAGCA GCAAATGAAA GATAATCTAC GAGAGGTGAA AGCTCAGATT 
CACAGCTGCA TTAGTCGCCA CCTGGAATGC CTTCGAAGCC GAGAGGTGTG GCTCAACGAG 
CAGGTGGATC TCATCTATCA GCTGAAGGAG GAGACGCTGC AGCAGCAGGC TCAGCAGCTG 
TACTGGCTAA TGGGCCAATT CAATTGTCTT ATTCATCAAC TGGAGATTAC CCAGAACAAG 
GATCTTGCCA ATCAAGTCGC GCTGTGCTTG GAGAGACTGG GCAGTTTGAC CCTTAAGCCT 
GAGGATTCTA CTGTCCTGCT CTTTGAAGCA GATGCATCTG CCCTGCGTCA GACCATCACC 
ACGTTTGGGT CCCTCAAGAC CATTCAAATT CCTGAGCACC TGATGGCTCA TCCTAGTTCT 
TCAAGTGTCA GGCCTTTCCT GGAGAAAAGA GGTTATACCC AGGTGCCAGA GCAGAAGTCA 
GCATCCAGCG GCACAGCTGT TTCTCTCAGT GAATGGCTTC TTGTAAGCAA ACCTGCCATT 
GGTCCTCAGG CTCCATACGT ACCCAGTACC AACCCACAGG ACTGGCTCAC CCCAAAACAG 
ACCTTGGAGA ACAGTCAGAC TTCTGCCAGA ATCTGCAGCG ATGCCTGGGG CAATCTGAAG 
GGCTTAGAAA ACTGGCTCCT TAACAGTCAT CAACAAGAAA TTCCTGGAAA ACCAAGTTCC 
TCAAAATGTA ATAGCCATTG TAGCACCAGT TCTTTCTCTA CTGAAGATGA AAAGGTTGAA 
GATGTAGAGG TCCTCGATCA AGACGAGCTG GACCTGTCTG ATTGGTTGGT GACTCCTCAG 
GAACCCCGTG ATCTGGAGAA GCCTGTGAAT GGCCGCTCTG ACACCAGTGA CAAGTTTAAG 
CTCTTGTTCC AGGTGTTCAG AGAGCCCTAC AATGTGAATG ATTGGCTTGT CAAGCCTGAC 
TCCTGTACCA ACTGTCAGGG TAACCAGCCC AGAGGTGTGG AGATTGAGAA CCTGGGCAAT 
CTGAAATGCC TGAATGACCA CTTGGAGGCT AAAAAGTCAT TGCCAGTCCC CGGCGTAATC 
ACCGAGGGCT GGCTTGTCCA GAACCATCAG GACACATGTA AAGTAGAGGA AGTCTGCAAA 
GCCAACGAGC CCTGCACCAG CTTTGCAGAG TGTGTGTGTG ATGACAGCTG TGAGAAGGAA 
GCGATGCATA AATGGCTTCT GAAGAAAGAA GGGAAGGACA AGAATGGAAT GCCTATGGGA 
CCCAAATCTG AGTCTGAGAA ACACAGAGAG TCCCTGTCTC TGTGGCTTTG CCCTTCTAGA 
AATGAGCTAA CAGAACACGC TAAGACACCC AAGACTACGG CTCCTGCTAG AATTGCTGAC 
TCCTTCCACA TCATAAGGAA TAGCTCCTTG TCAGAGTGGC TTATTGGGCC TACATGCAAA 
GGAGGAGGCC CCAAGGAAGT GCCCAATATG GAGGAGAGAG CTAGCAAAGA AATGCTTAAA 
AGCCCCATGG CCACTTACTG GCGTCCTTTT AACACTGCTG ACTGGGTCTT ACCAGGAAAG 
AAAGTGGGAA ACCTTAGTCA GTTCTCCTCG GGAGAAGATA AGTGGCTACT TCGAAAGAAG 
GCACAGGAAG TATTTCTTAA TTCACCCCTA CAAGAAGAAC GTAACTTTCG CTCAGATTGT 
TACGGCCTCC CGGCAGTTTG TGATCTCTTT GCCTGTATGC AGCTTAAAGT TGATAAGGAC 
AAATGGCTGT ACAGAGCCCC TCTTCAGATG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.
Trends in biochemical sciences41(3)274-86(2016 Mar)
Bogdan AR,Miyazawa M,Hashimoto K,Tsuji Y

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.
Biochimica et biophysica acta1853(5)1130-44(2015 May)
Lane DJ,Merlot AM,Huang ML,Bae DH,Jansson PJ,Sahni S,Kalinowski DS,Richardson DR

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Nature cell biology16(11)1069-79(2014 Nov)
Dowdle WE,Nyfeler B,Nagel J,Elling RA,Liu S,Triantafellow E,Menon S,Wang Z,Honda A,Pardee G,Cantwell J,Luu C,Cornella-Taracido I,Harrington E,Fekkes P,Lei H,Fang Q,Digan ME,Burdick D,Powers AF,Helliwell SB,D'Aquin S,Bastien J,Wang H,Wiederschain D,Kuerth J,Bergman P,Schwalb D,Thomas J,Ugwonali S,Harbinski F,Tallarico J,Wilson CJ,Myer VE,Porter JA,Bussiere DE,Finan PM,Labow MA,Mao X,Hamann LG,Manning BD,Valdez RA,Nicholson T,Schirle M,Knapp MS,Keaney EP,Murphy LO

Direct regulation of androgen receptor-associated protein 70 by thyroid hormone and its receptors.
Endocrinology148(7)3485-95(2007 Jul)
Tai PJ,Huang YH,Shih CH,Chen RN,Chen CD,Chen WJ,Wang CS,Lin KH

Evaluation of steroid receptors, coregulators, and molecules associated with uterine receptivity in secretory endometria from untreated women with polycystic ovary syndrome.
Fertility and sterility85(4)1017-26(2006 Apr)
Quezada S,Avellaira C,Johnson MC,Gabler F,Fuentes A,Vega M

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Ncoa4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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