Copb2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Copb2
Entrez Gene ID	60384
Full Name	coatomer protein complex subunit beta 2
Synonyms	Rack2,p102
General protein information	Preferred Names coatomer protein complex subunit beta 2 Names coatomer subunit beta' beta prime COP beta'-COP beta'-coat protein coatomer protein complex, subunit beta 2 (beta prime)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q31
Summary	acts as a receptor for activated protein kinase C epsilon; may play a role in vesicle mediated transport [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021765.1	NP_068533.1	coatomer subunit beta'

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	COPB2	XP_005634562.1
Gallus gallus (chicken)	COPB2	XP_422637.2
Bos taurus (cattle)	COPB2	NP_776706.2
Mus musculus (house mouse)	Copb2	NP_056642.1
Rattus norvegicus (Norway rat)	Copb2	NP_068533.1
Saccharomyces cerevisiae (baker's yeast)	SEC27	NP_011378.1
Eremothecium gossypii	AGOS_AFL118W	NP_985432.1
Schizosaccharomyces pombe (fission yeast)	sec27	XP_001713153.1
Magnaporthe oryzae (rice blast fungus)	MGG_10504	XP_003710112.1
Neurospora crassa	NCU07319	XP_962477.1
Arabidopsis thaliana (thale cress)	AT3G15980	NP_001189907.1
Oryza sativa (rice)	Os06g0143900	NP_001056779.1
Danio rerio (zebrafish)	copb2	NP_001001940.1
Drosophila melanogaster (fruit fly)	beta'Cop	NP_524836.2
Xenopus tropicalis (tropical clawed frog)	copb2	NP_001027518.1
Homo sapiens (human)	COPB2	NP_004757.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004798	XP_318012.4
Arabidopsis thaliana (thale cress)	AT1G52360	NP_175645.1
Arabidopsis thaliana (thale cress)	AT1G79990	NP_001154478.1
Pan troglodytes (chimpanzee)	COPB2	XP_003310064.1
Caenorhabditis elegans (roundworm)	CELE_F38E11.5	NP_501671.1
Kluyveromyces lactis	KLLA0B01958g	XP_451618.1

Gene Ontology
Bibliography

Related articles in PubMed

CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells.
Slater LH, Hett EC, Clatworthy AE, Mark KG, Hung DT
Proceedings of the National Academy of Sciences of the United States of America110(24)9932-7(2013 Jun)

A new role for the muscle repair protein dysferlin in endothelial cell adhesion and angiogenesis.
Sharma A, Yu C, Leung C, Trane A, Lau M, Utokaparch S, Shaheen F, Sheibani N, Bernatchez P
Arteriosclerosis, thrombosis, and vascular biology30(11)2196-204(2010 Nov)

Association with {beta}-COP regulates the trafficking of the newly synthesized Na,K-ATPase.
Morton MJ, Farr GA, Hull M, Capendeguy O, Horisberger JD, Caplan MJ
The Journal of biological chemistry285(44)33737-46(2010 Oct)

The COPI system: molecular mechanisms and function.
Beck R, Rawet M, Ravet M, Wieland FT, Cassel D
FEBS letters583(17)2701-9(2009 Sep)

Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic.
Burman JL, Bourbonniere L, Philie J, Stroh T, Dejgaard SY, Presley JF, McPherson PS
The Journal of biological chemistry283(33)22774-86(2008 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

trafficking of the newly synthesized Na,K-ATPase is regulated by association with beta-COP
Title: Association with {beta}-COP regulates the trafficking of the newly synthesized Na,K-ATPase.

Golgi organization depends on mutually interacting domains in betaCOP and p115, suggesting that vesicle tethering at the Golgi involves p115 binding to the COPI coat
Title: Coat-tether interaction in Golgi organization.

Afadin DIL domain-interacting protein co-localizes with beta'-COP at the Golgi complex in Madin Darby canine kidney and normal rat kidney cells
Title: Afadin- and alpha-actinin-binding protein ADIP directly binds beta'-COP, a subunit of the coatomer complex.

The following Copb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Copb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05203	NM_021765.1 Latest version!	Rattus norvegicus COPI coat complex subunit beta 2 (Copb2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$531.30 $759.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Copb2 ( NM_021765.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_068533.1 Rattus norvegicus COPI coat complex subunit beta 2 (Copb2), mRNA.

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CloneID	ORa05203
Clone ID Related Accession (Same CDS sequence)	NM_021765.1
Accession Version	NM_021765.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2718bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Rattus norvegicus(Norway rat)
Product	coatomer subunit beta'
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF002705.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF002705.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCCTCTTC GACTTGACAT CAAGAGAAAG CTAACTGCTA TGTCTGATCG GGTTAAGAGT 
GTGGATTTGC ATCCGACTGA GCCATGGATG CTGGCTAGTC TTTACAATGG CAGTGTGTGT 
GTTTGGAATC ATGAAACTCA GACGCTGGTG AAGACCTTTG AAGTGTGTGA TCTCCCTGTT 
CGAGCTGCGA AGTTTGTCGC AAGGAAGAAC TGGGTGGTGA CAGGAGCAGA TGATATGCAG 
ATTAGAGTGT TCAATTATAA CACCCTGGAG AGGGTGCACA TGTTTGAAGC ACACTCGGAT 
TACATCCGTT GCATTGCTGT TCATCCCACC CAGCCGTTCA TTCTCACAAG CAGTGATGAC 
ATGCTTATTA AGCTCTGGGA CTGGGACAAA AAATGGTCTT GTTCACAAGT GTTTGAAGGA 
CACACGCATT ATGTTATGCA GATTGTGATA AACCCCAAAG ATAACAATCA GTTTGCCAGT 
GCATCTCTCG ACAGGACCAT CAAGGTGTGG CAGCTGGGCT CTTCATCACC AAACTTTACG 
CTGGAGGGAC ATGAAAAAGG CGTGAATTGC ATTGATTACT ACAGTGGTGG TGATAAGCCA 
TACCTCATTT CAGGTGCAGA TGACCGGCTC GTTAAAATAT GGGATTATCA GAATAAAACT 
TGTGTGCAGA CCCCGGAGGG ACATGCCCAG AATGTGTCAT GCGCAACGTT CCATCCTGAG 
CTGCCCATCA TCATCACAGG GTCGGAAGAC GGAACGGTGC GAATTTGGCA CTCCAGCACC 
TACCGGCTGG AGAGCACACT GAATTACGGA ATGGAGCGAG TGTGGTGTGT GGCCAGTCTG 
AGAGGCTCCA ACAATGTCGC TCTGGGCTAC GATGAAGGGA GCATCATTGT TAAGCTTGGT 
CGGGAGGAAC CTGCCATGTC CATGGATGCC AATGGAAAGA TAATCTGGGC CAAGCATTCA 
GAGGTCCAGC AGGCCAACCT GAAAGCAATG GGTGACACCG AAATTAAAGA TGGAGAAAGA 
CTGCCACTAG CAGTAAAGGA TATGGGCAGC TGTGAAATAT ATCCACAGAC CATTCAGCAC 
AATCCTAATG GGAGGTTTGT CGTGGTGTGT GGTGATGGAG AATATATCAT CTACACAGCA 
ATGGCCTTGA GAAACAAGAG CTTTGGATCT GCCCAGGAGT TTGCATGGGC CCACGATTCT 
TCAGAGTATG CAATAAGAGA AAGCAACAGT GTTGTAAAGA TATTTAAGAA CTTTAAGGAA 
AAGAAATCAT TTAAACCTGA TTTTGGAGCT GAAAGTATCT ATGGGGGCTT CTTGCTGGGA 
GTCAGGTCTG TAAATGGCTT AGCATTCTAT GACTGGGAGA ATACCGAACT CATCCGCAGA 
ATTGAAATTC AGCCCAAGCA CATCTTCTGG TCTGACTCTG GAGAGCTGGT CTGTATTGCC 
ACCGAGGAGT CATTTTTTAT TCTTAAATAT CTGTCAGAAA AAGTCTTGGC TGCACAGGAA 
ACCCACGAGG GAGTTACTGA GGATGGCATT GAGGACGCCT TTGAGGTTCT TGGTGAAATT 
CAGGAAATTG TGAAAACTGG GCTGTGGGTA GGTGACTGCT TCATCTACAC AAGTTCTGTG 
AACAGATTAA ACTATTATGT GGGAGGCGAG ATTGTCACCA TTGCCCACTT GGACAGGACA 
ATGTACCTTC TGGGCTATAT TCCAAAAGAC AATAGGCTTT ATCTGGGAGA TAAAGAATTG 
AACATAGTTA GCTACTCCCT GTTAGTTTCA GTCCTGGAAT ACCAGACTGC TGTCATGCGG 
AGGGATTTCA GCATGGCTGA TAAGGTGCTC CCTACTATCC CAAAAGAACA GAGGACCAGA 
GTTGCACACT TTTTGGAAAA GCAGGGCTTC AAGCAGCAAG CACTCACAGT ATCCACAGAT 
CCTGAACATC GTTTTGAGCT TGCTCTTCAA CTTGGGGAGC TGAAAATTGC TTACCAGTTA 
GCAGTGGAGG CAGAGTCGGA GCAGAAGTGG AAACAACTTG CCGAACTTGC CATTAGTAAA 
TGTCAGTTCA GCCTAGCCCA GGAGTGTTTG CACCATGCCC AGGACTACGG TGGTCTGCTG 
CTCTTGGCCA CTGCCTCTGG AAACGCTAGT ATGGTGAACA AGCTGGCAGA AGGTGCGGAG 
AGAGATGGCA AAAATAACGT GGCATTCATG AGCTATTTTT TACAGGGCAA GCTTGATGCT 
TGCCTAGAGC TCTTGATCAG AACAGGAAGA CTCCCAGAAG CCGCCTTCCT GGCCCGAACT 
TACTTACCCA GCCAGGTCTC AAGGGTAGTG AAGTTGTGGA GGGAGAATCT CTCAAAAGTC 
AACCAGAAAG CAGCAGAATC CCTCGCTGAC CCCACAGAGT ATGAAAACCT TTTCCCTGGA 
TTAAAAGAAG CCTTTGTTGT TGAAGAATGG GTGAAGGAGA CACATGCGGA TCTGTGGCCA 
GCCAAGCAGT ACCCTCTTGT CACGCCAAAT GAAGAGAGAA ATGTTATGGA AGAGGCAAAA 
CGGTTTCAGC CCTCAAGAGC CACAGCTCAG CAGGAACCTG ATGGGAAACC AGCTTCTAGC 
CCAGTTATCA TGGCCTCCCA AACCACTCAC AAAGAAGAAA AGAGTTTCCA GGAACTAGAA 
GATGATTTAG ATACCATGGA ATTAGAGGAT ATTGATACAA CAGACATCAA TCTGGATGAA 
GATATTCTGG ATGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068533.1
CDS	89..2806
Translation	MPLRLDIKRKLTAMSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTPEGHAQNVSCATFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDTEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQEFAWAHDSSEYAIRESNSVVKIFKNFKEKKSFKPDFGAESIYGGFLLGVRSVNGLAFYDWENTELIRRIEIQPKHIFWSDSGELVCIATEESFFILKYLSEKVLAAQETHEGVTEDGIEDAFEVLGEIQEIVKTGLWVGDCFIYTSSVNRLNYYVGGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIVSYSLLVSVLEYQTAVMRRDFSMADKVLPTIPKEQRTRVAHFLEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQLAVEAESEQKWKQLAELAISKCQFSLAQECLHHAQDYGGLLLLATASGNASMVNKLAEGAERDGKNNVAFMSYFLQGKLDACLELLIRTGRLPEAAFLARTYLPSQVSRVVKLWRENLSKVNQKAAESLADPTEYENLFPGLKEAFVVEEWVKETHADLWPAKQYPLVTPNEERNVMEEAKRFQPSRATAQQEPDGKPASSPVIMASQTTHKEEKSFQELEDDLDTMELEDIDTTDINLDEDILDD

Target ORF information:

RefSeq Version	NM_021765.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus COPI coat complex subunit beta 2 (Copb2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021765.1

ORF Insert Sequence:

ATGCCTCTTC GACTTGACAT CAAGAGAAAG CTAACTGCTA TGTCTGATCG GGTTAAGAGT 
GTGGATTTGC ATCCGACTGA GCCATGGATG CTGGCTAGTC TTTACAATGG CAGTGTGTGT 
GTTTGGAATC ATGAAACTCA GACGCTGGTG AAGACCTTTG AAGTGTGTGA TCTCCCTGTT 
CGAGCTGCGA AGTTTGTCGC AAGGAAGAAC TGGGTGGTGA CAGGAGCAGA TGATATGCAG 
ATTAGAGTGT TCAATTATAA CACCCTGGAG AGGGTGCACA TGTTTGAAGC ACACTCGGAT 
TACATCCGTT GCATTGCTGT TCATCCCACC CAGCCGTTCA TTCTCACAAG CAGTGATGAC 
ATGCTTATTA AGCTCTGGGA CTGGGACAAA AAATGGTCTT GTTCACAAGT GTTTGAAGGA 
CACACGCATT ATGTTATGCA GATTGTGATA AACCCCAAAG ATAACAATCA GTTTGCCAGT 
GCATCTCTCG ACAGGACCAT CAAGGTGTGG CAGCTGGGCT CTTCATCACC AAACTTTACG 
CTGGAGGGAC ATGAAAAAGG CGTGAATTGC ATTGATTACT ACAGTGGTGG TGATAAGCCA 
TACCTCATTT CAGGTGCAGA TGACCGGCTC GTTAAAATAT GGGATTATCA GAATAAAACT 
TGTGTGCAGA CCCCGGAGGG ACATGCCCAG AATGTGTCAT GCGCAACGTT CCATCCTGAG 
CTGCCCATCA TCATCACAGG GTCGGAAGAC GGAACGGTGC GAATTTGGCA CTCCAGCACC 
TACCGGCTGG AGAGCACACT GAATTACGGA ATGGAGCGAG TGTGGTGTGT GGCCAGTCTG 
AGAGGCTCCA ACAATGTCGC TCTGGGCTAC GATGAAGGGA GCATCATTGT TAAGCTTGGT 
CGGGAGGAAC CTGCCATGTC CATGGATGCC AATGGAAAGA TAATCTGGGC CAAGCATTCA 
GAGGTCCAGC AGGCCAACCT GAAAGCAATG GGTGACACCG AAATTAAAGA TGGAGAAAGA 
CTGCCACTAG CAGTAAAGGA TATGGGCAGC TGTGAAATAT ATCCACAGAC CATTCAGCAC 
AATCCTAATG GGAGGTTTGT CGTGGTGTGT GGTGATGGAG AATATATCAT CTACACAGCA 
ATGGCCTTGA GAAACAAGAG CTTTGGATCT GCCCAGGAGT TTGCATGGGC CCACGATTCT 
TCAGAGTATG CAATAAGAGA AAGCAACAGT GTTGTAAAGA TATTTAAGAA CTTTAAGGAA 
AAGAAATCAT TTAAACCTGA TTTTGGAGCT GAAAGTATCT ATGGGGGCTT CTTGCTGGGA 
GTCAGGTCTG TAAATGGCTT AGCATTCTAT GACTGGGAGA ATACCGAACT CATCCGCAGA 
ATTGAAATTC AGCCCAAGCA CATCTTCTGG TCTGACTCTG GAGAGCTGGT CTGTATTGCC 
ACCGAGGAGT CATTTTTTAT TCTTAAATAT CTGTCAGAAA AAGTCTTGGC TGCACAGGAA 
ACCCACGAGG GAGTTACTGA GGATGGCATT GAGGACGCCT TTGAGGTTCT TGGTGAAATT 
CAGGAAATTG TGAAAACTGG GCTGTGGGTA GGTGACTGCT TCATCTACAC AAGTTCTGTG 
AACAGATTAA ACTATTATGT GGGAGGCGAG ATTGTCACCA TTGCCCACTT GGACAGGACA 
ATGTACCTTC TGGGCTATAT TCCAAAAGAC AATAGGCTTT ATCTGGGAGA TAAAGAATTG 
AACATAGTTA GCTACTCCCT GTTAGTTTCA GTCCTGGAAT ACCAGACTGC TGTCATGCGG 
AGGGATTTCA GCATGGCTGA TAAGGTGCTC CCTACTATCC CAAAAGAACA GAGGACCAGA 
GTTGCACACT TTTTGGAAAA GCAGGGCTTC AAGCAGCAAG CACTCACAGT ATCCACAGAT 
CCTGAACATC GTTTTGAGCT TGCTCTTCAA CTTGGGGAGC TGAAAATTGC TTACCAGTTA 
GCAGTGGAGG CAGAGTCGGA GCAGAAGTGG AAACAACTTG CCGAACTTGC CATTAGTAAA 
TGTCAGTTCA GCCTAGCCCA GGAGTGTTTG CACCATGCCC AGGACTACGG TGGTCTGCTG 
CTCTTGGCCA CTGCCTCTGG AAACGCTAGT ATGGTGAACA AGCTGGCAGA AGGTGCGGAG 
AGAGATGGCA AAAATAACGT GGCATTCATG AGCTATTTTT TACAGGGCAA GCTTGATGCT 
TGCCTAGAGC TCTTGATCAG AACAGGAAGA CTCCCAGAAG CCGCCTTCCT GGCCCGAACT 
TACTTACCCA GCCAGGTCTC AAGGGTAGTG AAGTTGTGGA GGGAGAATCT CTCAAAAGTC 
AACCAGAAAG CAGCAGAATC CCTCGCTGAC CCCACAGAGT ATGAAAACCT TTTCCCTGGA 
TTAAAAGAAG CCTTTGTTGT TGAAGAATGG GTGAAGGAGA CACATGCGGA TCTGTGGCCA 
GCCAAGCAGT ACCCTCTTGT CACGCCAAAT GAAGAGAGAA ATGTTATGGA AGAGGCAAAA 
CGGTTTCAGC CCTCAAGAGC CACAGCTCAG CAGGAACCTG ATGGGAAACC AGCTTCTAGC 
CCAGTTATCA TGGCCTCCCA AACCACTCAC AAAGAAGAAA AGAGTTTCCA GGAACTAGAA 
GATGATTTAG ATACCATGGA ATTAGAGGAT ATTGATACAA CAGACATCAA TCTGGATGAA 
GATATTCTGG ATGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells.
Proceedings of the National Academy of Sciences of the United States of America110(24)9932-7(2013 Jun)
Slater LH,Hett EC,Clatworthy AE,Mark KG,Hung DT

A new role for the muscle repair protein dysferlin in endothelial cell adhesion and angiogenesis.
Arteriosclerosis, thrombosis, and vascular biology30(11)2196-204(2010 Nov)
Sharma A,Yu C,Leung C,Trane A,Lau M,Utokaparch S,Shaheen F,Sheibani N,Bernatchez P

Association with {beta}-COP regulates the trafficking of the newly synthesized Na,K-ATPase.
The Journal of biological chemistry285(44)33737-46(2010 Oct)
Morton MJ,Farr GA,Hull M,Capendeguy O,Horisberger JD,Caplan MJ

The COPI system: molecular mechanisms and function.
FEBS letters583(17)2701-9(2009 Sep)
Beck R,Rawet M,Ravet M,Wieland FT,Cassel D

Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic.
The Journal of biological chemistry283(33)22774-86(2008 Aug)
Burman JL,Bourbonniere L,Philie J,Stroh T,Dejgaard SY,Presley JF,McPherson PS

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Copb2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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