Adam3a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adam3a
Entrez Gene ID	57021
Full Name	ADAM metallopeptidase domain 3A
Synonyms	Adam3,tMDCI
General protein information	Preferred Names ADAM metallopeptidase domain 3A Names ADAM metallopeptidase domain 3A ADAM metallopeptidase domain 3 ADAM metallopeptidase domain 3A (cyritestin 1) ADAM metallopeptidase domain 3A (pseudogene) a disintegrin and metallopeptidase domain 3 (cyritestin) a disintegrin and metalloprotease domain 3 (cyritestin) cyritestin tMDC I
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q12.4
Summary	germ-cell specific metalloprotease-disintegrin that may play a role in cell-cell and cell-matrix interactions during spermatogenesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_020302.2	NP_064698.1	ADAM metallopeptidase domain 3A precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC607729	XP_005629893.1
Rattus norvegicus (Norway rat)	Adam3a	NP_064698.1
Bos taurus (cattle)	ADAM3A	NP_001091635.1
	LOC707094	XP_002805363.1
Canis lupus familiaris (dog)	LOC475575	XP_532794.4
Mus musculus (house mouse)	Adam3	NP_033749.2

Gene Ontology
Bibliography

Related articles in PubMed

Identification of multiple DNA copy number alterations including frequent 8p11.22 amplification in conjunctival squamous cell carcinoma.
Asnaghi L, Alkatan H, Mahale A, Othman M, Alwadani S, Al-Hussain H, Jastaneiah S, Yu W, Maktabi A, Edward DP, Eberhart CG
Investigative ophthalmology & visual science55(12)8604-13(2014 Dec)

GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice.
Fujihara Y, Okabe M, Ikawa M
Biology of reproduction90(3)60(2014 Mar)

Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa.
Yamaguchi R, Fujihara Y, Ikawa M, Okabe M
Molecular biology of the cell23(14)2671-9(2012 Jul)

Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility [corrected].
Tokuhiro K, Ikawa M, Benham AM, Okabe M
Proceedings of the National Academy of Sciences of the United States of America109(10)3850-5(2012 Mar)

Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm.
Marcello MR, Jia W, Leary JA, Moore KL, Evans JP
The Journal of biological chemistry286(15)13060-70(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Adam3a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adam3a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04775	NM_020302.2 Latest version!	Rattus norvegicus ADAM metallopeptidase domain 3A (Adam3a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adam3a ( NM_020302.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_064698.1 Rattus norvegicus ADAM metallopeptidase domain 3A (Adam3a), mRNA.

Price & Availability↑

CloneID	ORa04775
Clone ID Related Accession (Same CDS sequence)	NM_020302.2
Accession Version	NM_020302.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2223bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	ADAM metallopeptidase domain 3A precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Y07903.1. On Dec 24, 2015 this sequence version replaced NM_020302.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y07903.1, BC078839.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689604, SAMN02642708 [ECO:0000348] ##Evidence-Data-END##

ATGCTGCCGT TATTCCTGGT CCTCTCATGC CTAGGCCAAT TGATCGCCGT AGGCAAGGAC 
ATAGAAACAC CACTTATACA GATCACAGTG CCAGAGAAAA TCGAGACCAA CATCAAGGAT 
GCCAAGGAAT CAGAAACACA AGTCACTTAT GTGATCAGAA TTGAGGGCAA AGCATACACA 
CTCCAACTTG AAAAACAGTC ATTTTTACAT CCACATTTTG TGACAAATTT GCATAACAAG 
TTGGGAACAT TGCAACCATA TTTTTCTTTA GTAAAGAGTC ACTGCTTTTA TCAAGGACAT 
GCTGTCGAGA TTCCAGCATC GACCGTGACA CTCAGCACTT GCTCAGGTCT CAGGGGCTTG 
CTGCAGTTGG AGAACGTGAC TTACGGAATT GAACCCTTAG AGTCTTCAAC TACACTCGAA 
CACATACTTT ATGAAATACA GAATCATAAA ATTGATTATT CTCCCTTAAA AGAAAACTAC 
ACGAATTCCC AGGATGAAAG TGGGTCCTAC CGAATTCTCG TGAAACCATT GAAAAGTTCA 
AACTCGAAAC TAAGGAAGAG AATTCTGACG GTAAAGATCA TCATGGATAA AGGCATGTTT 
GACCACGTGG GCTCTGAGGT GGGAGTCGCG ACTCAGAAAG TTGTTCAGAT GTTTGGTCTC 
ATTAACACTA TGTTTTCCCA GCTGAAGATG ACTGTGATGT TAAACTCTCT GGAGATCTGG 
TCAGAAGAAA ACAAGATAGA AACAAATGGG GATGCTGATG AAGTCCTGCA AAGGTTTCTG 
CTGTGGACAC ACAAGGAAAT GCCTCAAACA ACCAAGGAAA TAACCTACTT ACTCCTGTAT 
AAGGACCATC CTGATTATGT GGGAGCGACA TATCATGGGA TGGCCTGCAA CCCAAAGTTC 
ACAGCAGGAA TCGCTCTGCA CCCAAAGACG TTAGGTGTGG AGGGCTTTGC CATTGTTCTG 
TCACAGTTGC TGGGAATTAA CCTGGGGCTG ACATACGATG ACATCTACAA TTGCTTCTGT 
CGAGGAAGCA CATGCATAAT GAATCCTTCA GCAATACATT CCGAAGGCAT AAAGGTTTTT 
AGCAGTTGCA GCATGGATGA ATTCAGGCAG CTGGCTTCAC AGCCTGACCT AGATTGCCTT 
CTGAAGACAC AGGAGACAGA AGTTGTTGCC CTGCCCCAGG CTGCAAAAGT TTGTGGTAAC 
TACATCCTGG AGCCCCCAGA GCAGTGTGAC TGTGGCCCAG CAGAGAGATG TTCTCATAAA 
AAGTGCTGTA AGTCTGAGGA TTGTACCCTG CTTAGTGATG CAGAGTGTGG TTCTGGGGCG 
TGCTGTGATA AAAGAACATG CAAGATAGCT GAAAGAGGAC GCCTATGTAG GAAAAGTACG 
GACCAGTGCG ACTTCCCAGA ATTCTGCAAT GGGACGTCTG AATTCTGTGT AGCTGATATA 
AAAGCTGCGG ACCTGGAACC TTGCAACAAT GAAACCGCCT ATTGCTTCAA AGGGGTTTGC 
CAAGACCGCG ACAGGCAGTG CACAGACTTA TTTGGAAAAT ATGCTAAGGG TCCTAATTAT 
GTGTGTGCAC AAGAAGTGAA TCTGCAGAAT GACAAATTTG GAAACTGTCA TGGGCGCTGT 
AATTATAGTG CTCTATTTTG TGGAAAAGCA GTTTGTTACT GGAGCTTTGC AGAACTCGTG 
AAAACAGACG TATTTGATGT TCAATATACT TACTTGGGAG GCCAAGTGTG TGTGTCCGCA 
CATTTAAGAG TAAGGAATGA TGAGACCAAG GATGACACAT ATGTCCGTGA TGGCACTATT 
TGTGGTAATG GCCAGGTGTG TTACCGAGGG GAGTGCTTGC GTGTGCACGT CCTGAGGGGG 
GATAGGGAGT GTGAGGCCGA TGACAAATGC CAAGGACATG GGATTTGCAA CAATCAAAAC 
AACTGTCAAT GTGAAGCTGG TTTCGCTCCT CCAGAATGTG ACATGACCCC TTCATCTCCA 
GGAGGGAGCA TGGACGATGG ATTTTGGCTG CCCTTAGATA AAAGCACACC GTTGGTTATC 
AAGCGGCCTG GCACTCAATA TAAAAAGGGA CTTTTGATCA GTTTCTATGT CTTCCTGCCT 
TTTCTCATTG TGACAGCCAT TATGGTTGTT AAGCAGAATA TCTCAAAGAT GTTCGGGCAA 
GGAGAGGAAG AGTTTAGTGA AGGATCCATA TCAGAAGAAA TTAACGACAG CAAGCAGTCA 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064698.1
CDS	111..2333
Translation	MLPLFLVLSCLGQLIAVGKDIETPLIQITVPEKIETNIKDAKESETQVTYVIRIEGKAYTLQLEKQSFLHPHFVTNLHNKLGTLQPYFSLVKSHCFYQGHAVEIPASTVTLSTCSGLRGLLQLENVTYGIEPLESSTTLEHILYEIQNHKIDYSPLKENYTNSQDESGSYRILVKPLKSSNSKLRKRILTVKIIMDKGMFDHVGSEVGVATQKVVQMFGLINTMFSQLKMTVMLNSLEIWSEENKIETNGDADEVLQRFLLWTHKEMPQTTKEITYLLLYKDHPDYVGATYHGMACNPKFTAGIALHPKTLGVEGFAIVLSQLLGINLGLTYDDIYNCFCRGSTCIMNPSAIHSEGIKVFSSCSMDEFRQLASQPDLDCLLKTQETEVVALPQAAKVCGNYILEPPEQCDCGPAERCSHKKCCKSEDCTLLSDAECGSGACCDKRTCKIAERGRLCRKSTDQCDFPEFCNGTSEFCVADIKAADLEPCNNETAYCFKGVCQDRDRQCTDLFGKYAKGPNYVCAQEVNLQNDKFGNCHGRCNYSALFCGKAVCYWSFAELVKTDVFDVQYTYLGGQVCVSAHLRVRNDETKDDTYVRDGTICGNGQVCYRGECLRVHVLRGDRECEADDKCQGHGICNNQNNCQCEAGFAPPECDMTPSSPGGSMDDGFWLPLDKSTPLVIKRPGTQYKKGLLISFYVFLPFLIVTAIMVVKQNISKMFGQGEEEFSEGSISEEINDSKQS

Target ORF information:

RefSeq Version	NM_020302.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ADAM metallopeptidase domain 3A (Adam3a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020302.2

ORF Insert Sequence:

ATGCTGCCGT TATTCCTGGT CCTCTCATGC CTAGGCCAAT TGATCGCCGT AGGCAAGGAC 
ATAGAAACAC CACTTATACA GATCACAGTG CCAGAGAAAA TCGAGACCAA CATCAAGGAT 
GCCAAGGAAT CAGAAACACA AGTCACTTAT GTGATCAGAA TTGAGGGCAA AGCATACACA 
CTCCAACTTG AAAAACAGTC ATTTTTACAT CCACATTTTG TGACAAATTT GCATAACAAG 
TTGGGAACAT TGCAACCATA TTTTTCTTTA GTAAAGAGTC ACTGCTTTTA TCAAGGACAT 
GCTGTCGAGA TTCCAGCATC GACCGTGACA CTCAGCACTT GCTCAGGTCT CAGGGGCTTG 
CTGCAGTTGG AGAACGTGAC TTACGGAATT GAACCCTTAG AGTCTTCAAC TACACTCGAA 
CACATACTTT ATGAAATACA GAATCATAAA ATTGATTATT CTCCCTTAAA AGAAAACTAC 
ACGAATTCCC AGGATGAAAG TGGGTCCTAC CGAATTCTCG TGAAACCATT GAAAAGTTCA 
AACTCGAAAC TAAGGAAGAG AATTCTGACG GTAAAGATCA TCATGGATAA AGGCATGTTT 
GACCACGTGG GCTCTGAGGT GGGAGTCGCG ACTCAGAAAG TTGTTCAGAT GTTTGGTCTC 
ATTAACACTA TGTTTTCCCA GCTGAAGATG ACTGTGATGT TAAACTCTCT GGAGATCTGG 
TCAGAAGAAA ACAAGATAGA AACAAATGGG GATGCTGATG AAGTCCTGCA AAGGTTTCTG 
CTGTGGACAC ACAAGGAAAT GCCTCAAACA ACCAAGGAAA TAACCTACTT ACTCCTGTAT 
AAGGACCATC CTGATTATGT GGGAGCGACA TATCATGGGA TGGCCTGCAA CCCAAAGTTC 
ACAGCAGGAA TCGCTCTGCA CCCAAAGACG TTAGGTGTGG AGGGCTTTGC CATTGTTCTG 
TCACAGTTGC TGGGAATTAA CCTGGGGCTG ACATACGATG ACATCTACAA TTGCTTCTGT 
CGAGGAAGCA CATGCATAAT GAATCCTTCA GCAATACATT CCGAAGGCAT AAAGGTTTTT 
AGCAGTTGCA GCATGGATGA ATTCAGGCAG CTGGCTTCAC AGCCTGACCT AGATTGCCTT 
CTGAAGACAC AGGAGACAGA AGTTGTTGCC CTGCCCCAGG CTGCAAAAGT TTGTGGTAAC 
TACATCCTGG AGCCCCCAGA GCAGTGTGAC TGTGGCCCAG CAGAGAGATG TTCTCATAAA 
AAGTGCTGTA AGTCTGAGGA TTGTACCCTG CTTAGTGATG CAGAGTGTGG TTCTGGGGCG 
TGCTGTGATA AAAGAACATG CAAGATAGCT GAAAGAGGAC GCCTATGTAG GAAAAGTACG 
GACCAGTGCG ACTTCCCAGA ATTCTGCAAT GGGACGTCTG AATTCTGTGT AGCTGATATA 
AAAGCTGCGG ACCTGGAACC TTGCAACAAT GAAACCGCCT ATTGCTTCAA AGGGGTTTGC 
CAAGACCGCG ACAGGCAGTG CACAGACTTA TTTGGAAAAT ATGCTAAGGG TCCTAATTAT 
GTGTGTGCAC AAGAAGTGAA TCTGCAGAAT GACAAATTTG GAAACTGTCA TGGGCGCTGT 
AATTATAGTG CTCTATTTTG TGGAAAAGCA GTTTGTTACT GGAGCTTTGC AGAACTCGTG 
AAAACAGACG TATTTGATGT TCAATATACT TACTTGGGAG GCCAAGTGTG TGTGTCCGCA 
CATTTAAGAG TAAGGAATGA TGAGACCAAG GATGACACAT ATGTCCGTGA TGGCACTATT 
TGTGGTAATG GCCAGGTGTG TTACCGAGGG GAGTGCTTGC GTGTGCACGT CCTGAGGGGG 
GATAGGGAGT GTGAGGCCGA TGACAAATGC CAAGGACATG GGATTTGCAA CAATCAAAAC 
AACTGTCAAT GTGAAGCTGG TTTCGCTCCT CCAGAATGTG ACATGACCCC TTCATCTCCA 
GGAGGGAGCA TGGACGATGG ATTTTGGCTG CCCTTAGATA AAAGCACACC GTTGGTTATC 
AAGCGGCCTG GCACTCAATA TAAAAAGGGA CTTTTGATCA GTTTCTATGT CTTCCTGCCT 
TTTCTCATTG TGACAGCCAT TATGGTTGTT AAGCAGAATA TCTCAAAGAT GTTCGGGCAA 
GGAGAGGAAG AGTTTAGTGA AGGATCCATA TCAGAAGAAA TTAACGACAG CAAGCAGTCA 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of multiple DNA copy number alterations including frequent 8p11.22 amplification in conjunctival squamous cell carcinoma.
Investigative ophthalmology & visual science55(12)8604-13(2014 Dec)
Asnaghi L,Alkatan H,Mahale A,Othman M,Alwadani S,Al-Hussain H,Jastaneiah S,Yu W,Maktabi A,Edward DP,Eberhart CG

GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice.
Biology of reproduction90(3)60(2014 Mar)
Fujihara Y,Okabe M,Ikawa M

Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa.
Molecular biology of the cell23(14)2671-9(2012 Jul)
Yamaguchi R,Fujihara Y,Ikawa M,Okabe M

Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility [corrected].
Proceedings of the National Academy of Sciences of the United States of America109(10)3850-5(2012 Mar)
Tokuhiro K,Ikawa M,Benham AM,Okabe M

Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm.
The Journal of biological chemistry286(15)13060-70(2011 Apr)
Marcello MR,Jia W,Leary JA,Moore KL,Evans JP

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Adam3a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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