Aox1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Aox1
Entrez Gene ID	54349
Full Name	aldehyde oxidase 1
General protein information	Preferred Names aldehyde oxidase 1 Names aldehyde oxidase 1 aldehyde oxidase (female form) azaheterocycle hydroxylase 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q31

mRNA and Protein(s)

mRNA	Protein	Name
NM_019363.3	NP_062236.2	aldehyde oxidase 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	AOX1	NP_788841.1
Mus musculus (house mouse)	Aox1	NP_033806.2
Rattus norvegicus (Norway rat)	Aox1	NP_062236.2
Xenopus tropicalis (tropical clawed frog)	LOC100495429	XP_002937768.2
Homo sapiens (human)	AOX1	NP_001150.3
	AOX1	XP_001089327.2
Gallus gallus (chicken)	AOX1	NP_001033781.1

Gene Ontology
Bibliography

Related articles in PubMed

Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms.
Foti A, Hartmann T, Coelho C, Santos-Silva T, Rom?o MJ, Leimk?hler S
Drug metabolism and disposition: the biological fate of chemicals44(8)1277-85(2016 Aug)

Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase.
Coelho C, Foti A, Hartmann T, Santos-Silva T, Leimk?hler S, Rom?o MJ
Nature chemical biology11(10)779-83(2015 Oct)

Nitrite reductase activity of rat and human xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: evaluation of their contribution to NO formation in vivo.
Maia LB, Pereira V, Mira L, Moura JJ
Biochemistry54(3)685-710(2015 Jan)

Aldehyde oxidase 1 (AOX1) in human liver cytosols: quantitative characterization of AOX1 expression level and activity relationship.
Fu C, Di L, Han X, Soderstrom C, Snyder M, Troutman MD, Obach RS, Zhang H
Drug metabolism and disposition: the biological fate of chemicals41(10)1797-804(2013 Oct)

Aldehyde oxidase importance in vivo in xenobiotic metabolism: imidacloprid nitroreduction in mice.
Swenson TL, Casida JE
Toxicological sciences : an official journal of the Society of Toxicology133(1)22-8(2013 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results supported the possibility that XO/XD and AO can contribute to nitric oxide generation.
Title: Nitrite reductase activity of rat and human xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: evaluation of their contribution to NO formation in vivo.

It was shown that show that Nrf2 binds to and strongly activates the rat AOX1 gene.
Title: Aldehyde oxidase 1 gene is regulated by Nrf2 pathway.

Data show that aldehyde oxidase (AO) and xanthine oxidase (XO) activities increased significantly after induction of diabetes.
Title: Aldehyde and xanthine oxidase activities in tissues of streptozotocin-induced diabetic rats: effects of vitamin E and selenium supplementation.

Study of aldehyde oxidase-catalyzed metabolic pathway of phenanthridine using MCR-ALS method.
Title: Study of aldehyde oxidase-catalyzed metabolic pathway of phenanthridine using MCR-ALS method.

AO-catalyzed nitrite reduction can be an important source of NO generation, and its NO production will be further increased by therapeutic administration of nitrite
Title: Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite.

The following Aox1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aox1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04558	NM_019363.3 Latest version!	Rattus norvegicus aldehyde oxidase 1 (Aox1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$727.30 $1039.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Aox1 ( NM_019363.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062236.2 Rattus norvegicus aldehyde oxidase 1 (Aox1), mRNA.

Price & Availability↑

CloneID	ORa04558
Clone ID Related Accession (Same CDS sequence)	NM_019363.3
Accession Version	NM_019363.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	aldehyde oxidase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF110478.1. On Aug 30, 2012 this sequence version replaced NM_019363.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF110478.1, AF110477.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGATCCCC CGCAGCTGCT CTTCTACGTG AATGGCCAGA AGGTGGTAGA AAACAATGTT 
GATCCTGAGA TGATGCTTTT ACCGTACCTG AGGAAGAACC TCCGACTCAC GGGAACTAAG 
TATGGCTGTG GAGGCGGCGG CTGCGGTGCC TGCACAGTGA TGATCTCACG GTACAACCCC 
AGCACCAAGA GCATCAGGCA TCATCCTGTC AATGCCTGTC TGACCCCCAT CTGCTCTCTG 
TACGGTACAG CAGTCACCAC AGTAGAGGGC ATAGGCAACA CCAGGACCAG ACTTCATCCT 
GTTCAGGAGA GGATCGCCAA GTGTCACAGC ACCCAGTGTG GGTTCTGTAC CCCTGCGAGG 
GTGATGTCCA TGTATGCTCT GCTCAGGAAC CACCCAGAGC CCTCTCTAGA TCAGTTAACT 
GATGCCCTTG GGGGGAATCT GTGCCGCTGT ACCGGATACA GGCCCATAAT TGACGCTTGC 
AAGACTTTCT GTAGAGCTTC TGGTTGCTGT GAAAGTAAAG AAAATGGGGT GTGCTGTTTG 
GATCAAGGAA TAAATGGATC GGCAGAATTT CAGGAAGGAG ATGAGACAAG TCCAGAACTG 
TTCTCGGAAA AGGAATTTCA GCCACTGGAC CCAACCCAAG AGCTGATATT TCCTCCAGAG 
CTAATGAGAA TAGCCGAGAA ACAGCCACCA AAGACCAGAG TGTTCTACAG TAATAGAATG 
ACATGGATCT CCCCGGTGAC CCTGGAGGAA CTTGTGGAAG CTAAGTTCAA GTATCCTGGG 
GCCCCCATTG TCATGGGGTA CACCTCTGTG GGGCCTGAAG TAAAGTTTAA AGGTGTCTTC 
CACCCCATCA TAATTTCTCC TGACAGAATT GAAGAGCTGA GTATCATAAA CCAGACTGGG 
GATGGGCTGA CCCTGGGTGC TGGCCTCAGC CTGGACCAGG TGAAGGACAT TCTCACTGAC 
GTGGTCCAGA AGCTTCCAGA AGAGACGACA CAGACATACC GTGCGCTCCT GAAGCACCTG 
AGAACTCTGG CTGGCTCTCA GATCAGGAAT ATGGCTTCTT TAGGGGGCCA CATCGTGAGC 
AGACATCTGG ACTCGGATCT GAATCCCCTT CTGGCTGTGG GTAATTGTAC CCTCAACTTA 
CTATCCAAAG ATGGAAAACG GCAGATCCCT TTAAGTGAGC AGTTTCTCCG CAAGTGTCCT 
GACTCGGATC TTAAGCCTCA GGAAGTCTTG GTCTCAGTGA ACATCCCCTG TTCCAGGAAG 
TGGGAGTTTG TGTCAGCCTT CCGACAAGCC CAGAGACAGC AGAATGCACT AGCGATTGTC 
AACTCTGGAA TGAGAGTCCT TTTTAGAGAA GGAGGTGGCG TCATTAAAGA GTTATCCATT 
TTGTATGGAG GTGTCGGTCC AACCACCATC GGTGCCAAGA ACTCCTGTCA GAAACTCATT 
GGAAGGCCCT GGAATGAAGA GATGCTGGAC ACAGCATGCA GGCTGGTTTT GGATGAAGTC 
ACCCTTGCAG GTTCAGCTCC TGGTGGGAAG GTGGAGTTCA AGAGGACCCT CATCATCAGC 
TTCCTTTTCA AGTTCTACCT GGAGGTGCTG CAGGGTCTGA AGAGGGAGGA CCCAGGTCAC 
TATCCTAGCT TGACAAACAA TTATGAGAGT GCTTTAGAAG ATCTCCATTC AAAACATCAC 
TGGAGAACAT TAACCCACCA GAACGTGGAT TCGATGCAGC TTCCTCAGGA CCCAATTGGC 
CGTCCCATCA TGCACCTTTC TGGTATTAAG CACGCTACCG GCGAGGCCAT CTACTGTGAC 
GACATGCCTG CAGTAGACCG GGAGCTTTTC CTGACTTTTG TAACAAGTTC AAGAGCACAC 
GCTAAGATTG TGTCCATTGA TCTGTCAGAA GCTCTCAGCC TGCCAGGCGT GGTGGACATC 
ATTACTGCGG ATCATCTTCA GGACACAACC ACCTTCGGCA CAGAGACGCT TCTGGCCACA 
GATAAGGTCC ACTGCGTGGG CCAACTTGTC TGTGCCGTGA TTGCGGATTC TGAGACACGG 
GCAAAGCAAG CGGCGAAGCA CGTGAAGGTG GTCTACCGAG ACTTGGAGCC TCTGATCCTA 
ACTATTGAGG AAGCTATACA ACACAAGTCC TTCTTCGAGT CAGAACGGAA GCTGGAGTGT 
GGAAATGTTG ATGAAGCGTT TAAAATTGCT GATCAAATTC TTGAAGGTGA GATACACATA 
GGCGGCCAGG AACATTTTTA TATGGAAACC CAAAGCATGC TTGTTGTCCC CAAAGGAGAG 
GACGGAGAGA TTGACATCTA TGTGTCCACA CAGTTCCCCA AGCATATACA GGATATAGTT 
GCTGCAACCT TGAAGCTTTC AGTCAACAAG GTCATGTGTC ATGTAAGGCG TGTTGGTGGG 
GCGTTCGGAG GGAAGGTAGG CAAGACCAGC ATCATGGCGG CCATCACTGC ATTCGCTGCC 
AGCAAACACG GTCGCGCGGT CCGCTGCACT CTGGAACGAG GGGAAGACAT GTTGATAACT 
GGGGGCCGCC ATCCTTACCT TGGAAAGTAT AAAGTTGGAT TCATGAGGGA CGGCAGAATC 
GTGGCCCTGG ATGTGGAGCA CTATTGCAAT GGAGGGAGCT CCCTGGATGA GTCCTTATGG 
GTGATAGAAA TGGGGCTTCT GAAGATGGAC AACGCTTACA AGTTTCCCAA TCTACGCTGC 
CGGGGCTGGG CCTGCAGAAC CAACCTCCCG TCCCACACTG CTCTGCGTGG GTTTGGCTTT 
CCTCAGGCAG GGCTGGTCAC CGAAGCCTGT GTCACAGAAG TGGCAATCAG ATGTGGCCTG 
TCTCCTGAGC AGGTTCGAAC CATAAATATG TACAAGCAAA TTGATAATAC CCATTACAAG 
CAAGAATTCA GCGCCAAGAC CCTCTTTGAG TGCTGGAGAG AATGCATGGC CAAGTGTTCC 
TACTCTGAGA GGAAAACGGC TGTAGGAAAA TTCAATGCAG AGAATTCCTG GAAGAAGAGG 
GGAATGGCCG TGATTCCATT GAAGTTTCCT GTGGGTGTTG GCTCAGTAGC CATGGGACAG 
GCGGCTGCCC TGGTCCATAT TTATCTTGAT GGCTCTGCAC TGGTCTCTCA CGGTGGGATT 
GAGATGGGGC AGGGTGTCCA CACTAAAATG ATCCAGGTGG TCAGCCGGGA ATTAAAGATG 
CCAATGTCGA GTGTCCACCT GCGTGGGACA AGCACAGAAA CCGTCCCCAA CACCAATGCA 
TCTGGAGGCT CTGTGGTGGC AGATCTCAAT GGATTGGCAG TAAAGGATGC TTGCCAGACC 
CTTCTAAAAC GCCTTGAGCC CATCATCAGC AAGAACCCCC AGGGAACTTG GAAGGATTGG 
GCCCAGACTG CTTTTGACCA GAGCGTCAGT CTCTCGGCTG TTGGATATTT CAGGGGCTAC 
GAGTCGAATA TAAACTGGGA GAAAGGGGAA GGCCATCCCT TCGAATACTT TGTGTATGGA 
GCTGCCTGCT CAGAGGTTGA AATAGACTGC CTGACCGGGG ACCATAAGAA TATCAGAACA 
GACATCGTGA TGGATGTTGG CCACAGCATA AACCCAGCCC TTGACATAGG CCAGGTTGAA 
GGTGCATTTA TTCAAGGAAT GGGACTTTAC ACGATAGAGG AGCTGAGCTA CTCTCCTCAG 
GGCATTCTGT ACAGTCGTGG TCCAAACCAG TACAAGATCC CTGCCATCTG CGACATCCCC 
ACCGAGATGC ACATTTCTTT TTTGCCCCCA TCCGAACACT CAAACACCCT GTATTCATCT 
AAGGGTCTGG GAGAGTCTGG GGTGTTCCTG GGCTGTTCGG TATTTCTTGC CATCCATGAC 
GCAGTGAGGG CAGCGCGGCA GGAGAGAGGC ATCTCTGGAC CATGGAAGCT CACTAGTCCT 
CTGACTCCAG AGAAAATCAG AATGGCTTGT GAAGATAAGT TCAGAAAAAT GATTCCAAGA 
GATGAACCTG GATCCTATGT TCCCTGGAAC ATACCTGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062236.2
CDS	49..4050
Translation	MDPPQLLFYVNGQKVVENNVDPEMMLLPYLRKNLRLTGTKYGCGGGGCGACTVMISRYNPSTKSIRHHPVNACLTPICSLYGTAVTTVEGIGNTRTRLHPVQERIAKCHSTQCGFCTPARVMSMYALLRNHPEPSLDQLTDALGGNLCRCTGYRPIIDACKTFCRASGCCESKENGVCCLDQGINGSAEFQEGDETSPELFSEKEFQPLDPTQELIFPPELMRIAEKQPPKTRVFYSNRMTWISPVTLEELVEAKFKYPGAPIVMGYTSVGPEVKFKGVFHPIIISPDRIEELSIINQTGDGLTLGAGLSLDQVKDILTDVVQKLPEETTQTYRALLKHLRTLAGSQIRNMASLGGHIVSRHLDSDLNPLLAVGNCTLNLLSKDGKRQIPLSEQFLRKCPDSDLKPQEVLVSVNIPCSRKWEFVSAFRQAQRQQNALAIVNSGMRVLFREGGGVIKELSILYGGVGPTTIGAKNSCQKLIGRPWNEEMLDTACRLVLDEVTLAGSAPGGKVEFKRTLIISFLFKFYLEVLQGLKREDPGHYPSLTNNYESALEDLHSKHHWRTLTHQNVDSMQLPQDPIGRPIMHLSGIKHATGEAIYCDDMPAVDRELFLTFVTSSRAHAKIVSIDLSEALSLPGVVDIITADHLQDTTTFGTETLLATDKVHCVGQLVCAVIADSETRAKQAAKHVKVVYRDLEPLILTIEEAIQHKSFFESERKLECGNVDEAFKIADQILEGEIHIGGQEHFYMETQSMLVVPKGEDGEIDIYVSTQFPKHIQDIVAATLKLSVNKVMCHVRRVGGAFGGKVGKTSIMAAITAFAASKHGRAVRCTLERGEDMLITGGRHPYLGKYKVGFMRDGRIVALDVEHYCNGGSSLDESLWVIEMGLLKMDNAYKFPNLRCRGWACRTNLPSHTALRGFGFPQAGLVTEACVTEVAIRCGLSPEQVRTINMYKQIDNTHYKQEFSAKTLFECWRECMAKCSYSERKTAVGKFNAENSWKKRGMAVIPLKFPVGVGSVAMGQAAALVHIYLDGSALVSHGGIEMGQGVHTKMIQVVSRELKMPMSSVHLRGTSTETVPNTNASGGSVVADLNGLAVKDACQTLLKRLEPIISKNPQGTWKDWAQTAFDQSVSLSAVGYFRGYESNINWEKGEGHPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGHSINPALDIGQVEGAFIQGMGLYTIEELSYSPQGILYSRGPNQYKIPAICDIPTEMHISFLPPSEHSNTLYSSKGLGESGVFLGCSVFLAIHDAVRAARQERGISGPWKLTSPLTPEKIRMACEDKFRKMIPRDEPGSYVPWNIPV

Target ORF information:

RefSeq Version	NM_019363.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aldehyde oxidase 1 (Aox1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019363.3

ORF Insert Sequence:

ATGGATCCCC CGCAGCTGCT CTTCTACGTG AATGGCCAGA AGGTGGTAGA AAACAATGTT 
GATCCTGAGA TGATGCTTTT ACCGTACCTG AGGAAGAACC TCCGACTCAC GGGAACTAAG 
TATGGCTGTG GAGGCGGCGG CTGCGGTGCC TGCACAGTGA TGATCTCACG GTACAACCCC 
AGCACCAAGA GCATCAGGCA TCATCCTGTC AATGCCTGTC TGACCCCCAT CTGCTCTCTG 
TACGGTACAG CAGTCACCAC AGTAGAGGGC ATAGGCAACA CCAGGACCAG ACTTCATCCT 
GTTCAGGAGA GGATCGCCAA GTGTCACAGC ACCCAGTGTG GGTTCTGTAC CCCTGCGAGG 
GTGATGTCCA TGTATGCTCT GCTCAGGAAC CACCCAGAGC CCTCTCTAGA TCAGTTAACT 
GATGCCCTTG GGGGGAATCT GTGCCGCTGT ACCGGATACA GGCCCATAAT TGACGCTTGC 
AAGACTTTCT GTAGAGCTTC TGGTTGCTGT GAAAGTAAAG AAAATGGGGT GTGCTGTTTG 
GATCAAGGAA TAAATGGATC GGCAGAATTT CAGGAAGGAG ATGAGACAAG TCCAGAACTG 
TTCTCGGAAA AGGAATTTCA GCCACTGGAC CCAACCCAAG AGCTGATATT TCCTCCAGAG 
CTAATGAGAA TAGCCGAGAA ACAGCCACCA AAGACCAGAG TGTTCTACAG TAATAGAATG 
ACATGGATCT CCCCGGTGAC CCTGGAGGAA CTTGTGGAAG CTAAGTTCAA GTATCCTGGG 
GCCCCCATTG TCATGGGGTA CACCTCTGTG GGGCCTGAAG TAAAGTTTAA AGGTGTCTTC 
CACCCCATCA TAATTTCTCC TGACAGAATT GAAGAGCTGA GTATCATAAA CCAGACTGGG 
GATGGGCTGA CCCTGGGTGC TGGCCTCAGC CTGGACCAGG TGAAGGACAT TCTCACTGAC 
GTGGTCCAGA AGCTTCCAGA AGAGACGACA CAGACATACC GTGCGCTCCT GAAGCACCTG 
AGAACTCTGG CTGGCTCTCA GATCAGGAAT ATGGCTTCTT TAGGGGGCCA CATCGTGAGC 
AGACATCTGG ACTCGGATCT GAATCCCCTT CTGGCTGTGG GTAATTGTAC CCTCAACTTA 
CTATCCAAAG ATGGAAAACG GCAGATCCCT TTAAGTGAGC AGTTTCTCCG CAAGTGTCCT 
GACTCGGATC TTAAGCCTCA GGAAGTCTTG GTCTCAGTGA ACATCCCCTG TTCCAGGAAG 
TGGGAGTTTG TGTCAGCCTT CCGACAAGCC CAGAGACAGC AGAATGCACT AGCGATTGTC 
AACTCTGGAA TGAGAGTCCT TTTTAGAGAA GGAGGTGGCG TCATTAAAGA GTTATCCATT 
TTGTATGGAG GTGTCGGTCC AACCACCATC GGTGCCAAGA ACTCCTGTCA GAAACTCATT 
GGAAGGCCCT GGAATGAAGA GATGCTGGAC ACAGCATGCA GGCTGGTTTT GGATGAAGTC 
ACCCTTGCAG GTTCAGCTCC TGGTGGGAAG GTGGAGTTCA AGAGGACCCT CATCATCAGC 
TTCCTTTTCA AGTTCTACCT GGAGGTGCTG CAGGGTCTGA AGAGGGAGGA CCCAGGTCAC 
TATCCTAGCT TGACAAACAA TTATGAGAGT GCTTTAGAAG ATCTCCATTC AAAACATCAC 
TGGAGAACAT TAACCCACCA GAACGTGGAT TCGATGCAGC TTCCTCAGGA CCCAATTGGC 
CGTCCCATCA TGCACCTTTC TGGTATTAAG CACGCTACCG GCGAGGCCAT CTACTGTGAC 
GACATGCCTG CAGTAGACCG GGAGCTTTTC CTGACTTTTG TAACAAGTTC AAGAGCACAC 
GCTAAGATTG TGTCCATTGA TCTGTCAGAA GCTCTCAGCC TGCCAGGCGT GGTGGACATC 
ATTACTGCGG ATCATCTTCA GGACACAACC ACCTTCGGCA CAGAGACGCT TCTGGCCACA 
GATAAGGTCC ACTGCGTGGG CCAACTTGTC TGTGCCGTGA TTGCGGATTC TGAGACACGG 
GCAAAGCAAG CGGCGAAGCA CGTGAAGGTG GTCTACCGAG ACTTGGAGCC TCTGATCCTA 
ACTATTGAGG AAGCTATACA ACACAAGTCC TTCTTCGAGT CAGAACGGAA GCTGGAGTGT 
GGAAATGTTG ATGAAGCGTT TAAAATTGCT GATCAAATTC TTGAAGGTGA GATACACATA 
GGCGGCCAGG AACATTTTTA TATGGAAACC CAAAGCATGC TTGTTGTCCC CAAAGGAGAG 
GACGGAGAGA TTGACATCTA TGTGTCCACA CAGTTCCCCA AGCATATACA GGATATAGTT 
GCTGCAACCT TGAAGCTTTC AGTCAACAAG GTCATGTGTC ATGTAAGGCG TGTTGGTGGG 
GCGTTCGGAG GGAAGGTAGG CAAGACCAGC ATCATGGCGG CCATCACTGC ATTCGCTGCC 
AGCAAACACG GTCGCGCGGT CCGCTGCACT CTGGAACGAG GGGAAGACAT GTTGATAACT 
GGGGGCCGCC ATCCTTACCT TGGAAAGTAT AAAGTTGGAT TCATGAGGGA CGGCAGAATC 
GTGGCCCTGG ATGTGGAGCA CTATTGCAAT GGAGGGAGCT CCCTGGATGA GTCCTTATGG 
GTGATAGAAA TGGGGCTTCT GAAGATGGAC AACGCTTACA AGTTTCCCAA TCTACGCTGC 
CGGGGCTGGG CCTGCAGAAC CAACCTCCCG TCCCACACTG CTCTGCGTGG GTTTGGCTTT 
CCTCAGGCAG GGCTGGTCAC CGAAGCCTGT GTCACAGAAG TGGCAATCAG ATGTGGCCTG 
TCTCCTGAGC AGGTTCGAAC CATAAATATG TACAAGCAAA TTGATAATAC CCATTACAAG 
CAAGAATTCA GCGCCAAGAC CCTCTTTGAG TGCTGGAGAG AATGCATGGC CAAGTGTTCC 
TACTCTGAGA GGAAAACGGC TGTAGGAAAA TTCAATGCAG AGAATTCCTG GAAGAAGAGG 
GGAATGGCCG TGATTCCATT GAAGTTTCCT GTGGGTGTTG GCTCAGTAGC CATGGGACAG 
GCGGCTGCCC TGGTCCATAT TTATCTTGAT GGCTCTGCAC TGGTCTCTCA CGGTGGGATT 
GAGATGGGGC AGGGTGTCCA CACTAAAATG ATCCAGGTGG TCAGCCGGGA ATTAAAGATG 
CCAATGTCGA GTGTCCACCT GCGTGGGACA AGCACAGAAA CCGTCCCCAA CACCAATGCA 
TCTGGAGGCT CTGTGGTGGC AGATCTCAAT GGATTGGCAG TAAAGGATGC TTGCCAGACC 
CTTCTAAAAC GCCTTGAGCC CATCATCAGC AAGAACCCCC AGGGAACTTG GAAGGATTGG 
GCCCAGACTG CTTTTGACCA GAGCGTCAGT CTCTCGGCTG TTGGATATTT CAGGGGCTAC 
GAGTCGAATA TAAACTGGGA GAAAGGGGAA GGCCATCCCT TCGAATACTT TGTGTATGGA 
GCTGCCTGCT CAGAGGTTGA AATAGACTGC CTGACCGGGG ACCATAAGAA TATCAGAACA 
GACATCGTGA TGGATGTTGG CCACAGCATA AACCCAGCCC TTGACATAGG CCAGGTTGAA 
GGTGCATTTA TTCAAGGAAT GGGACTTTAC ACGATAGAGG AGCTGAGCTA CTCTCCTCAG 
GGCATTCTGT ACAGTCGTGG TCCAAACCAG TACAAGATCC CTGCCATCTG CGACATCCCC 
ACCGAGATGC ACATTTCTTT TTTGCCCCCA TCCGAACACT CAAACACCCT GTATTCATCT 
AAGGGTCTGG GAGAGTCTGG GGTGTTCCTG GGCTGTTCGG TATTTCTTGC CATCCATGAC 
GCAGTGAGGG CAGCGCGGCA GGAGAGAGGC ATCTCTGGAC CATGGAAGCT CACTAGTCCT 
CTGACTCCAG AGAAAATCAG AATGGCTTGT GAAGATAAGT TCAGAAAAAT GATTCCAAGA 
GATGAACCTG GATCCTATGT TCCCTGGAAC ATACCTGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms.
Drug metabolism and disposition: the biological fate of chemicals44(8)1277-85(2016 Aug)
Foti A,Hartmann T,Coelho C,Santos-Silva T,Rom?o MJ,Leimk?hler S

Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase.
Nature chemical biology11(10)779-83(2015 Oct)
Coelho C,Foti A,Hartmann T,Santos-Silva T,Leimk?hler S,Rom?o MJ

Nitrite reductase activity of rat and human xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: evaluation of their contribution to NO formation in vivo.
Biochemistry54(3)685-710(2015 Jan)
Maia LB,Pereira V,Mira L,Moura JJ

Aldehyde oxidase 1 (AOX1) in human liver cytosols: quantitative characterization of AOX1 expression level and activity relationship.
Drug metabolism and disposition: the biological fate of chemicals41(10)1797-804(2013 Oct)
Fu C,Di L,Han X,Soderstrom C,Snyder M,Troutman MD,Obach RS,Zhang H

Aldehyde oxidase importance in vivo in xenobiotic metabolism: imidacloprid nitroreduction in mice.
Toxicological sciences : an official journal of the Society of Toxicology133(1)22-8(2013 May)
Swenson TL,Casida JE

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Aox1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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