Nr2c2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nr2c2
Entrez Gene ID	50659
Full Name	nuclear receptor subfamily 2, group C, member 2
Synonyms	Tr4
General protein information	Preferred Names nuclear receptor subfamily 2, group C, member 2 Names nuclear receptor subfamily 2 group C member 2 TR4 orphan receptor TR4-NS orphan receptor orphan nuclear receptor TR4 orphan receptor TR4 testicular receptor 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q34
Summary	member of the nuclear receptor subfamily 2; involved in stress response pathway; potentially involved in neuronal differentiation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017323.1	NP_059019.1	nuclear receptor subfamily 2 group C member 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NR2C2	XP_005632175.1
Danio rerio (zebrafish)	nr2c2	NP_001116766.1
Xenopus tropicalis (tropical clawed frog)	nr2c2	XP_002938282.2
	NR2C2	XP_002798750.1
Rattus norvegicus (Norway rat)	Nr2c2	NP_059019.1
Mus musculus (house mouse)	Nr2c2	NP_035760.1
Homo sapiens (human)	NR2C2	NP_003289.2
Bos taurus (cattle)	NR2C2	NP_001178990.1
Pan troglodytes (chimpanzee)	NR2C2	XP_001158643.1
Gallus gallus (chicken)	NR2C2	XP_004944782.1

Gene Ontology
Bibliography

Related articles in PubMed

TGF-?-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway.
Tran P, Ho SM, Kim BG, Vuong TA, Leem YE, Bae GU, Kang JS
The Journal of biological chemistry287(15)11602-15(2012 Apr)

Overexpression of Jazf1 induces cardiac malformation through the upregulation of pro-apoptotic genes in mice.
Bae KB, Kim MO, Yu DH, Shin MJ, Kim HJ, Yuh HS, Ji YR, Kim JY, Kim JM, Hyun BH, Lee HC, Chang WK, Park SB, Kim DH, Lee HS, Choo YS, Lee S, Ryoo ZY
Transgenic research20(5)1019-31(2011 Oct)

Altered cerebellar development in nuclear receptor TAK1/ TR4 null mice is associated with deficits in GLAST(+) glia, alterations in social behavior, motor learning, startle reactivity, and microglia.
Kim YS, Harry GJ, Kang HS, Goulding D, Wine RN, Kissling GE, Liao G, Jetten AM
Cerebellum (London, England)9(3)310-23(2010 Sep)

Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells.
Shyr CR, Kang HY, Tsai MY, Liu NC, Ku PY, Huang KE, Chang C
Endocrinology150(5)2454-62(2009 May)

The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription.
Tanabe O, Shen Y, Liu Q, Campbell AD, Kuroha T, Yamamoto M, Engel JD
Genes & development21(21)2832-44(2007 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Both in vitro and in vivo data demonstrate the identification of a new pathway, TR4---> phosphoenolpyruvate carboxykinase--->gluconeogenesis--->blood glucose.
Title: Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis.

expression of TR4 in rat testis is stage dependent and androgen inductive, and TR4 may have an important role in spermatogenesis
Title: Stage dependent and androgen inductive expression of orphan receptor TR4 in rat testis.

Together, our data demonstrate that TR4 can enhance apoE gene expression via binding to TR4RE-DR0 in apoE 5' promoter and this TR4 binding is essential for synergistic interaction with another transcription factor, Sp1.
Title: Induction of apolipoprotein E expression by TR4 orphan nuclear receptor via 5' proximal promoter region.

Together, these findings provide the first in vivo evidence that an orphan nuclear receptor, such as TR4, may play major roles in the RA-mediated apoptosis or differentiation in P19 cells.
Title: Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan nuclear receptor.

The following Nr2c2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nr2c2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03647	NM_017323.1 Latest version!	Rattus norvegicus nuclear receptor subfamily 2, group C, member 2 (Nr2c2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nr2c2 ( NM_017323.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_059019.1 Rattus norvegicus nuclear receptor subfamily 2, group C, member 2 (Nr2c2), mRNA.

Price & Availability↑

CloneID	ORa03647
Clone ID Related Accession (Same CDS sequence)	NM_017323.1
Accession Version	NM_017323.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1791bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	nuclear receptor subfamily 2 group C member 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L27513.1. On Dec 17, 2003 this sequence version replaced XM_346712.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L27513.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACCAGCC CCTCCCCGCG CATCCAGATA ATTTCCACCG ACTCTGCGGT ACGCTCACCT 
CAGCGCATTC AGATTGTAAC AGACCAGCAG ACAGGACAAA AGCTCCAGAT AGTCACCGCA 
GTGGACGCCT CTGGATCCTC TAAACAGCAG TTCATCCTAA CCAGCCCAGA TGGAGCTGGA 
ACTGGGAAGG TGATCCTGGC TTCTCCAGAG ACATCCAGTG CCAAGCAGCT CATATTCACC 
ACCTCAGACA ACCTTGTCCC TGGCAGGATC CAGATCGTCA CGGATTCTGC TTCTGTGGAG 
CGATTGCTGG GGAAGGCAGA CGTCCAGCGG CCCCAGGTGG TGGAGTACTG TGTGGTCTGT 
GGTGACAAAG CCTCTGGCCG ACACTATGGG GCTGTCAGTT GTGAAGGTTG CAAAGGTTTC 
TTCAAAAGGA GTGTGAGGAA GAATCTGACC TATAGCTGTC GTAGCAGCCA AGACTGCATC 
ATCAACAAGC ACCACCGCAA CCGCTGCCAG TTCTGCCGGC TGAAGAAGTG CCTGGAGATG 
GGCATGAAGA TGGAGTCTGT ACAGAGTGAA CGGAAGCCCT TTGATGTGCA ACGGGAGAAA 
CCAAGCAATT GTGCTGCTTC CACTGAGAAG ATCTATATCC GGAAAGACCT GAGAAGTCCT 
CTGATAGCCA CTCCCACATT TGTGGCAGAC AAAGATGGAT CAAGACAGAC TGGTCTTCTT 
GATCCAGGGA TGCTTGTGAA CATCCAACAG CCTTTGATAC GTGAGGATGG TACAGTTCTT 
TTGGCCACGG ATTCCAAGGC TGAAACAAGC CAAGGAGCTC TAGGTACACT GGCAAATGTA 
GTGACCTCTC TGGCCAACCT GAGTGAATCT TTGAACAATG GTGATGCTTC AGAAATGCAG 
CCAGAGGACC AGTCTGCAAG TGAAATTACA CGGGCATTTG ACACCCTAGC GAAAGCACTT 
AATACCACAG ATAGTGCTTC ACCTCCAAGC CTGGCAGATG GGATAGATGC TAGTGGAGGA 
GGGAGTATCC ATGTCATCAG CAGAGATCAG TCAACACCCA TCATTGAAGT CGAAGGCCCT 
CTCCTTTCAG ACACACATGT CACATTTAAG CTTACAATGC CTAGTCCTAT GCCAGAGTAC 
CTCAATGTAC ATTACATCTG CGAGTCTGCA TCCCGCCTGC TTTTCCTCTC CATGCACTGG 
GCAAGGTCAA TCCCAGCCTT CCAGGCACTT GGACAGGACT GCAATACCAG CCTGGTACGG 
GCCTGCTGGA ATGAGCTCTT CACTCTTGGC CTGGCCCAGT GTGCCCAGGT CATGAGTCTC 
TCCACCATCC TGGCAGCCAT TGTCAACCAC TTACAGAACA GCATCCAGGA AGATAAGCTT 
TCTGGTGACC GGATAAAGCA AGTCATGGAG CACATCTGGA AGCTGCAGGA GTTCTGTAAC 
AGCATGGCAA AACTGGATAT AGACGGTCAT GAGTACGCAT ACCTTAAAGC TATAGTTCTC 
TTTAGTCCCG ATCATCCAGG TTTGACAGGC ACAAGCCAGA TTGAGAAATT TCAGGAGAAG 
GCACAGATGG AATTACAAGA CTATGTGCAG AAAACCTACT CAGAAGACAC ATACAGATTG 
GCCAGGATTC TTGTCCGCCT GCCAGCACTC AGGCTTATGA GCTCCAATAT AACAGAAGAA 
CTTTTTTTTA CTGGTCTCAT TGGCAATGTT TCAATAGACA GCATAATTCC CTACATCCTA 
AAGATGGAGA CAGCAGAATA TAATGGCCAG ATCACCGGAG CCAGTCTATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059019.1
CDS	171..1961
Translation	MTSPSPRIQIISTDSAVRSPQRIQIVTDQQTGQKLQIVTAVDASGSSKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKADVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSSQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGSRQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDASEMQPEDQSASEITRAFDTLAKALNTTDSASPPSLADGIDASGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGHEYAYLKAIVLFSPDHPGLTGTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL

Target ORF information:

RefSeq Version	NM_017323.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nuclear receptor subfamily 2, group C, member 2 (Nr2c2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017323.1

ORF Insert Sequence:

ATGACCAGCC CCTCCCCGCG CATCCAGATA ATTTCCACCG ACTCTGCGGT ACGCTCACCT 
CAGCGCATTC AGATTGTAAC AGACCAGCAG ACAGGACAAA AGCTCCAGAT AGTCACCGCA 
GTGGACGCCT CTGGATCCTC TAAACAGCAG TTCATCCTAA CCAGCCCAGA TGGAGCTGGA 
ACTGGGAAGG TGATCCTGGC TTCTCCAGAG ACATCCAGTG CCAAGCAGCT CATATTCACC 
ACCTCAGACA ACCTTGTCCC TGGCAGGATC CAGATCGTCA CGGATTCTGC TTCTGTGGAG 
CGATTGCTGG GGAAGGCAGA CGTCCAGCGG CCCCAGGTGG TGGAGTACTG TGTGGTCTGT 
GGTGACAAAG CCTCTGGCCG ACACTATGGG GCTGTCAGTT GTGAAGGTTG CAAAGGTTTC 
TTCAAAAGGA GTGTGAGGAA GAATCTGACC TATAGCTGTC GTAGCAGCCA AGACTGCATC 
ATCAACAAGC ACCACCGCAA CCGCTGCCAG TTCTGCCGGC TGAAGAAGTG CCTGGAGATG 
GGCATGAAGA TGGAGTCTGT ACAGAGTGAA CGGAAGCCCT TTGATGTGCA ACGGGAGAAA 
CCAAGCAATT GTGCTGCTTC CACTGAGAAG ATCTATATCC GGAAAGACCT GAGAAGTCCT 
CTGATAGCCA CTCCCACATT TGTGGCAGAC AAAGATGGAT CAAGACAGAC TGGTCTTCTT 
GATCCAGGGA TGCTTGTGAA CATCCAACAG CCTTTGATAC GTGAGGATGG TACAGTTCTT 
TTGGCCACGG ATTCCAAGGC TGAAACAAGC CAAGGAGCTC TAGGTACACT GGCAAATGTA 
GTGACCTCTC TGGCCAACCT GAGTGAATCT TTGAACAATG GTGATGCTTC AGAAATGCAG 
CCAGAGGACC AGTCTGCAAG TGAAATTACA CGGGCATTTG ACACCCTAGC GAAAGCACTT 
AATACCACAG ATAGTGCTTC ACCTCCAAGC CTGGCAGATG GGATAGATGC TAGTGGAGGA 
GGGAGTATCC ATGTCATCAG CAGAGATCAG TCAACACCCA TCATTGAAGT CGAAGGCCCT 
CTCCTTTCAG ACACACATGT CACATTTAAG CTTACAATGC CTAGTCCTAT GCCAGAGTAC 
CTCAATGTAC ATTACATCTG CGAGTCTGCA TCCCGCCTGC TTTTCCTCTC CATGCACTGG 
GCAAGGTCAA TCCCAGCCTT CCAGGCACTT GGACAGGACT GCAATACCAG CCTGGTACGG 
GCCTGCTGGA ATGAGCTCTT CACTCTTGGC CTGGCCCAGT GTGCCCAGGT CATGAGTCTC 
TCCACCATCC TGGCAGCCAT TGTCAACCAC TTACAGAACA GCATCCAGGA AGATAAGCTT 
TCTGGTGACC GGATAAAGCA AGTCATGGAG CACATCTGGA AGCTGCAGGA GTTCTGTAAC 
AGCATGGCAA AACTGGATAT AGACGGTCAT GAGTACGCAT ACCTTAAAGC TATAGTTCTC 
TTTAGTCCCG ATCATCCAGG TTTGACAGGC ACAAGCCAGA TTGAGAAATT TCAGGAGAAG 
GCACAGATGG AATTACAAGA CTATGTGCAG AAAACCTACT CAGAAGACAC ATACAGATTG 
GCCAGGATTC TTGTCCGCCT GCCAGCACTC AGGCTTATGA GCTCCAATAT AACAGAAGAA 
CTTTTTTTTA CTGGTCTCAT TGGCAATGTT TCAATAGACA GCATAATTCC CTACATCCTA 
AAGATGGAGA CAGCAGAATA TAATGGCCAG ATCACCGGAG CCAGTCTATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TGF-?-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway.
The Journal of biological chemistry287(15)11602-15(2012 Apr)
Tran P,Ho SM,Kim BG,Vuong TA,Leem YE,Bae GU,Kang JS

Overexpression of Jazf1 induces cardiac malformation through the upregulation of pro-apoptotic genes in mice.
Transgenic research20(5)1019-31(2011 Oct)
Bae KB,Kim MO,Yu DH,Shin MJ,Kim HJ,Yuh HS,Ji YR,Kim JY,Kim JM,Hyun BH,Lee HC,Chang WK,Park SB,Kim DH,Lee HS,Choo YS,Lee S,Ryoo ZY

Altered cerebellar development in nuclear receptor TAK1/ TR4 null mice is associated with deficits in GLAST(+) glia, alterations in social behavior, motor learning, startle reactivity, and microglia.
Cerebellum (London, England)9(3)310-23(2010 Sep)
Kim YS,Harry GJ,Kang HS,Goulding D,Wine RN,Kissling GE,Liao G,Jetten AM

Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells.
Endocrinology150(5)2454-62(2009 May)
Shyr CR,Kang HY,Tsai MY,Liu NC,Ku PY,Huang KE,Chang C

The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription.
Genes & development21(21)2832-44(2007 Nov)
Tanabe O,Shen Y,Liu Q,Campbell AD,Kuroha T,Yamamoto M,Engel JD

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Nr2c2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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