Galr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Galr1
Entrez Gene ID	50577
Full Name	galanin receptor 1
Synonyms	Galnr1
General protein information	Preferred Names galanin receptor 1 Names galanin receptor type 1 GAL1-R GALR-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18q12.3
Summary	G-protein coupled receptor that binds the neuropeptide galanin; inhibits cAMP formation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012958.3	NP_037090.2	galanin receptor type 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GALR1	XP_523975.2
	GALR1	XP_001086740.1
Bos taurus (cattle)	GALR1	NP_001179170.1
Mus musculus (house mouse)	Galr1	NP_032108.1
Gallus gallus (chicken)	GALR1	NP_001121534.1
Danio rerio (zebrafish)	galr1	XP_696215.1
Caenorhabditis elegans (roundworm)	CELE_Y54E2A.1	NP_497057.2
Xenopus tropicalis (tropical clawed frog)	galr1	NP_001107355.1
Homo sapiens (human)	GALR1	NP_001471.2
Canis lupus familiaris (dog)	GALR1	XP_541048.2
Rattus norvegicus (Norway rat)	Galr1	NP_037090.2

Gene Ontology
Bibliography

Related articles in PubMed

Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats.
Li SY, Huo ML, Wu XY, Huang YQ, Wang L, Zhang X, Jiang YM, Zhang ML, Wang LL, Yu LC
Scientific reports7(1)15317(2017 Nov)

Spinal neuropeptide expression and neuropathic behavior in the acute and chronic phases after spinal cord injury: Effects of progesterone administration.
Coronel MF, Villar MJ, Brumovsky PR, Gonz?lez SL
Peptides88189-195(2017 Feb)

Depression-like behavior in rat: Involvement of galanin receptor subtype 1 in the ventral periaqueductal gray.
Wang P, Li H, Barde S, Zhang MD, Sun J, Wang T, Zhang P, Luo H, Wang Y, Yang Y, Wang C, Svenningsson P, Theodorsson E, H?kfelt TG, Xu ZQ
Proceedings of the National Academy of Sciences of the United States of America113(32)E4726-35(2016 08)

Central Administration of Galanin Receptor 1 Agonist Boosted Insulin Sensitivity in Adipose Cells of Diabetic Rats.
Zhang Z, Fang P, He B, Guo L, Runesson J, Langel ?, Shi M, Zhu Y, Bo P
Journal of diabetes research20169095648(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the central effect of GALR1 agonist M617 on insulin resistance in skeletal muscle and its underlying mechanisms.
Title: Central injection of GALR1 agonist M617 attenuates diabetic rat skeletal muscle insulin resistance through the Akt/AS160/GLUT4 pathway.

PG early treatment prevented Y1R upregulation and resulted in lower NPY, Y2R and GalR1 mRNA levels. In the chronic phase, injured rats showed well-established mechanical and cold allodynia and significant increases in galanin, NPY, GalR1 and Y1R mRNAs, while maintaining reduced GalR2 expression. Animals receiving PG treatment showed basal expression levels of galanin, NPY, GalR1 and Y1R, and reduced Y2R mRNA levels
Title: Spinal neuropeptide expression and neuropathic behavior in the acute and chronic phases after spinal cord injury: Effects of progesterone administration.

Suggest that excitation of central galanin receptor 1 facilitates insulin sensitivity via activation of the Akt/AS160 signaling pathway in the fat cells of type 2 diabetic rats.
Title: Central Administration of Galanin Receptor 1 Agonist Boosted Insulin Sensitivity in Adipose Cells of Diabetic Rats.

The sensitivity of GluA4 AMPA receptors to human galectin-1 could be enhanced by supplementation of culture media with uridine and N-acetylglucosamine (GlcNAc), precursors for hexosamine pathway that supplies UDP-GlcNAc for synthesis of oligosaccharides.
Title: Modulation of ionotropic glutamate receptor function by vertebrate galectins.

Transient occlusion of the middle cerebral artery altered GalR1 gene expression in rat brain supportting the notion that GalR1 may play a role in the response of the central nervous system to injury.
Title: Changes in galanin and GalR1 gene expression in discrete brain regions after transient occlusion of the middle cerebral artery in female rats.

The following Galr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Galr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01466	NM_012958.3 Latest version!	Rattus norvegicus galanin receptor 1 (Galr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Galr1 ( NM_012958.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037090.2 Rattus norvegicus galanin receptor 1 (Galr1), mRNA.

Price & Availability↑

CloneID	ORa01466
Clone ID Related Accession (Same CDS sequence)	NM_012958.3
Accession Version	NM_012958.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Rattus norvegicus(Norway rat)
Product	galanin receptor type 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U30290.2 and AC132699.4. On Jan 7, 2017 this sequence version replaced NM_012958.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052297, SAMN02642606 [ECO:0000348] ##Evidence-Data-END##

ATGGAACTGG CTCCGGTGAA CCTCAGTGAA GGGAATGGGA GCGACCCTGA ACCTCCAGCG 
GAACCCAGGC CGCTCTTCGG CATCGGCGTG GAGAACTTCA TCACGCTGGT GGTGTTTGGC 
CTTATTTTCG CGATGGGCGT GCTGGGCAAC AGCCTGGTGA TCACCGTGCT GGCGCGCAGC 
AAACCGGGCA AGCCGCGCAG CACCACCAAC CTGTTCATCC TCAACCTGAG CATCGCAGAC 
CTGGCCTACC TGCTCTTCTG CATCCCTTTC CAGGCCACCG TGTACGCACT GCCCACCTGG 
GTGCTGGGCG CCTTCATCTG CAAGTTTATA CACTACTTCT TCACCGTGTC CATGCTCGTG 
AGCATCTTCA CCCTGGCCGC GATGTCTGTG GATCGCTATG TGGCCATTGT GCATTCACGG 
CGCTCCTCCT CCCTCAGGGT GTCCCGCAAC GCGCTGCTGG GCGTGGGCTT CATCTGGGCG 
CTGTCCATCG CTATGGCCTC GCCGGTGGCC TACTACCAGC GCCTTTTTCA TCGGGACAGC 
AACCAAACCT TCTGCTGGGA GCACTGGCCC AACCAACTCC ACAAGAAGGC TTACGTGGTG 
TGCACTTTCG TCTTTGGTTA CCTTCTGCCC TTACTGCTCA TCTGCTTTTG CTATGCCAAG 
GTTCTCAATC ATCTGCATAA AAAGTTGAAG AACATGTCAA AAAAGTCAGA GGCATCCAAG 
AAAAAGACTG CACAGACTGT CCTGGTGGTC GTTGTGGTAT TTGGCATATC ATGGCTGCCC 
CATCATGTCA TCCACCTCTG GGCTGAGTTC GGAGCATTCC CGCTGACCCC AGCTTCCTTC 
TTCTTCAGAA TCACTGCCCA CTGCCTGGCA TACAGCAACT CCTCGGTGAA CCCCATCATC 
TACGCCTTTC TCTCAGAAAA CTTCCGGAAG GCGTACAAGC AAGTGTTCAA GTGCCGTGTT 
TGCAATGAGT CGCCGCACGG CGATGCTAAA GAAAAGAACC GAATAGATAC CCCGCCCTCC 
ACCAACTGCA CCCACGTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037090.2
CDS	226..1266
Translation	MELAPVNLSEGNGSDPEPPAEPRPLFGIGVENFITLVVFGLIFAMGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGFIWALSIAMASPVAYYQRLFHRDSNQTFCWEHWPNQLHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHVIHLWAEFGAFPLTPASFFFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCRVCNESPHGDAKEKNRIDTPPSTNCTHV

Target ORF information:

RefSeq Version	NM_012958.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus galanin receptor 1 (Galr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012958.3

ORF Insert Sequence:

ATGGAACTGG CTCCGGTGAA CCTCAGTGAA GGGAATGGGA GCGACCCTGA ACCTCCAGCG 
GAACCCAGGC CGCTCTTCGG CATCGGCGTG GAGAACTTCA TCACGCTGGT GGTGTTTGGC 
CTTATTTTCG CGATGGGCGT GCTGGGCAAC AGCCTGGTGA TCACCGTGCT GGCGCGCAGC 
AAACCGGGCA AGCCGCGCAG CACCACCAAC CTGTTCATCC TCAACCTGAG CATCGCAGAC 
CTGGCCTACC TGCTCTTCTG CATCCCTTTC CAGGCCACCG TGTACGCACT GCCCACCTGG 
GTGCTGGGCG CCTTCATCTG CAAGTTTATA CACTACTTCT TCACCGTGTC CATGCTCGTG 
AGCATCTTCA CCCTGGCCGC GATGTCTGTG GATCGCTATG TGGCCATTGT GCATTCACGG 
CGCTCCTCCT CCCTCAGGGT GTCCCGCAAC GCGCTGCTGG GCGTGGGCTT CATCTGGGCG 
CTGTCCATCG CTATGGCCTC GCCGGTGGCC TACTACCAGC GCCTTTTTCA TCGGGACAGC 
AACCAAACCT TCTGCTGGGA GCACTGGCCC AACCAACTCC ACAAGAAGGC TTACGTGGTG 
TGCACTTTCG TCTTTGGTTA CCTTCTGCCC TTACTGCTCA TCTGCTTTTG CTATGCCAAG 
GTTCTCAATC ATCTGCATAA AAAGTTGAAG AACATGTCAA AAAAGTCAGA GGCATCCAAG 
AAAAAGACTG CACAGACTGT CCTGGTGGTC GTTGTGGTAT TTGGCATATC ATGGCTGCCC 
CATCATGTCA TCCACCTCTG GGCTGAGTTC GGAGCATTCC CGCTGACCCC AGCTTCCTTC 
TTCTTCAGAA TCACTGCCCA CTGCCTGGCA TACAGCAACT CCTCGGTGAA CCCCATCATC 
TACGCCTTTC TCTCAGAAAA CTTCCGGAAG GCGTACAAGC AAGTGTTCAA GTGCCGTGTT 
TGCAATGAGT CGCCGCACGG CGATGCTAAA GAAAAGAACC GAATAGATAC CCCGCCCTCC 
ACCAACTGCA CCCACGTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats.
Scientific reports7(1)15317(2017 Nov)
Li SY,Huo ML,Wu XY,Huang YQ,Wang L,Zhang X,Jiang YM,Zhang ML,Wang LL,Yu LC

Spinal neuropeptide expression and neuropathic behavior in the acute and chronic phases after spinal cord injury: Effects of progesterone administration.
Peptides88189-195(2017 Feb)
Coronel MF,Villar MJ,Brumovsky PR,Gonz?lez SL

Depression-like behavior in rat: Involvement of galanin receptor subtype 1 in the ventral periaqueductal gray.
Proceedings of the National Academy of Sciences of the United States of America113(32)E4726-35(2016 08)
Wang P,Li H,Barde S,Zhang MD,Sun J,Wang T,Zhang P,Luo H,Wang Y,Yang Y,Wang C,Svenningsson P,Theodorsson E,H?kfelt TG,Xu ZQ

Central Administration of Galanin Receptor 1 Agonist Boosted Insulin Sensitivity in Adipose Cells of Diabetic Rats.
Journal of diabetes research20169095648(2016)
Zhang Z,Fang P,He B,Guo L,Runesson J,Langel ?,Shi M,Zhu Y,Bo P

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Galr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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