Pth2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pth2
Entrez Gene ID	499149
Full Name	parathyroid hormone 2
Synonyms	RGD1559447,Tifp39,Tip39
General protein information	Preferred Names parathyroid hormone 2 Names tuberoinfundibular peptide of 39 residues tuberoinfundibular peptide of 39 amino acids tuberoinfundibular peptide of 39 residues (TIP39) preprohormone
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q22

mRNA and Protein(s)

mRNA	Protein	Name
NM_001109144.1	NP_001102614.1	tuberoinfundibular peptide of 39 residues precursor
XM_006229118.3	XP_006229180.1	tuberoinfundibular peptide of 39 residues isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PTH2	XP_003638907.1
Bos taurus (cattle)	PTH2	NP_001193210.1
Homo sapiens (human)	PTH2	NP_848544.1
Rattus norvegicus (Norway rat)	Pth2	NP_001102614.1
	PTH2	XP_001114966.1
Mus musculus (house mouse)	Pth2	NP_444486.1

Gene Ontology
Bibliography

Related articles in PubMed

Tuberoinfundibular peptide of 39 residues is activated during lactation and participates in the suckling-induced prolactin release in rat.
Cserven?k M, Bodn?r I, Usdin TB, Palkovits M, Nagy GM, Dobolyi A
Endocrinology151(12)5830-40(2010 Dec)

Acoustic stress activates tuberoinfundibular peptide of 39 residues neurons in the rat brain.
Palkovits M, Helfferich F, Dobolyi A, Usdin TB
Brain structure & function214(1)15-23(2009 Dec)

Tuberoinfundibular peptide of 39 residues in the embryonic and early postnatal rat brain.
Brenner D, Bag? AG, Gallatz K, Palkovits M, Usdin TB, Dobolyi A
Journal of chemical neuroanatomy36(1)59-68(2008 Sep)

Forebrain projections of tuberoinfundibular peptide of 39 residues (TIP39)-containing subparafascicular neurons.
Wang J, Palkovits M, Usdin TB, Dobolyi A
Neuroscience138(4)1245-63(2006)

Tuberoinfundibular peptide of 39 residues: a new mediator of cardiac function via nitric oxide production in the rat heart.
Ross G, Engel P, Abdallah Y, Kummer W, Schluter KD
Endocrinology146(5)2221-8(2005 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TIP39 neurons in the PIL may regulate suckling-induced prolactin release in rat dams.
Title: Tuberoinfundibular peptide of 39 residues is activated during lactation and participates in the suckling-induced prolactin release in rat.

TIP39 neurons are sensitive to loud noise and they may participate in the central organization of responses to acoustic stress; non-TIP39-expressing neurons may play a prevalent role in the activity of the "acoustic thalamus"
Title: Acoustic stress activates tuberoinfundibular peptide of 39 residues neurons in the rat brain.

The complex pattern of TIP39 expression during early brain development suggests the involvement of TIP39 in transient functions during ontogeny.
Title: Tuberoinfundibular peptide of 39 residues in the embryonic and early postnatal rat brain.

Our data provide an anatomical basis for the potential involvement of rostral subparafascicular neurons in limbic and autonomic regulation, with TIP39 cells being major subparafascicular output neurons projecting to forebrain regions.
Title: Forebrain projections of tuberoinfundibular peptide of 39 residues (TIP39)-containing subparafascicular neurons.

results suggest that an inhibition of endogenous nitric oxide production unmasks a profound negative inotropic effect of tuberoinfundibular peptide (TIP39) that is mediated by an activation of the parathyroid hormone receptor 2 receptor
Title: Tuberoinfundibular peptide of 39 residues: a new mediator of cardiac function via nitric oxide production in the rat heart.

The following Pth2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pth2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09116	NM_001109144.1 Latest version!	Rattus norvegicus parathyroid hormone 2 (Pth2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa22765	XM_006229118.3 Latest version!	Rattus norvegicus parathyroid hormone 2 (Pth2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pth2 ( NM_001109144.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102614.1 Rattus norvegicus parathyroid hormone 2 (Pth2), mRNA.

Price & Availability↑

CloneID	ORa09116
Clone ID Related Accession (Same CDS sequence)	NM_001109144.1
Accession Version	NM_001109144.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	tuberoinfundibular peptide of 39 residues precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473979.2. On or before Oct 4, 2007 this sequence version replaced XM_574444.1, XM_001079083.1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGTGACAT TGAGATTCTG TTCCCTGTGT CCACAGGTGA TGGAGACCTG CCAGATGTCC 
AGGAGCCCTC GAGAGCGGCT GCTGCTGCTT TTGCTGCTTC TACTGCTTGT GCCCTGGGGC 
ACTGGCCCTG CCTCAGGTGT TGCTCTGCCC CTCGCTGGTG TGTTCAGCCT GCGAGCCCCG 
GGCCGTGGCT GGGCGGACTT GGGTACCCCC CTGTCTCGGC GCAGCCTGGC GCTAGCTGAC 
GACGCGGCTT TTCGGGAGCG CGCGCGCCTG CTGGCCGCCC TGGAGCGCCG CCGCTGGCTG 
GACTCTTACA TGCAGAAGCT GTTGCTACTG GACGCGCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102614.1
CDS	74..415
Translation	MVTLRFCSLCPQVMETCQMSRSPRERLLLLLLLLLLVPWGTGPASGVALPLAGVFSLRAPGRGWADLGTPLSRRSLALADDAAFRERARLLAALERRRWLDSYMQKLLLLDAP

Target ORF information:

RefSeq Version	NM_001109144.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus parathyroid hormone 2 (Pth2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001109144.1

ORF Insert Sequence:

ATGGTGACAT TGAGATTCTG TTCCCTGTGT CCACAGGTGA TGGAGACCTG CCAGATGTCC 
AGGAGCCCTC GAGAGCGGCT GCTGCTGCTT TTGCTGCTTC TACTGCTTGT GCCCTGGGGC 
ACTGGCCCTG CCTCAGGTGT TGCTCTGCCC CTCGCTGGTG TGTTCAGCCT GCGAGCCCCG 
GGCCGTGGCT GGGCGGACTT GGGTACCCCC CTGTCTCGGC GCAGCCTGGC GCTAGCTGAC 
GACGCGGCTT TTCGGGAGCG CGCGCGCCTG CTGGCCGCCC TGGAGCGCCG CCGCTGGCTG 
GACTCTTACA TGCAGAAGCT GTTGCTACTG GACGCGCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pth2 ( XM_006229118.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006229180.1 Rattus norvegicus parathyroid hormone 2 (Pth2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa22765
Clone ID Related Accession (Same CDS sequence)	XM_006229118.3
Accession Version	XM_006229118.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	tuberoinfundibular peptide of 39 residues isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006229118.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGACCT GCCAGATGTC CAGGAGCCCT CGAGAGCGGC TGCTGCTGCT TTTGCTGCTT 
CTACTGCTTG TGCCCTGGGG CACTGGCCCT GCCTCAGGTG TTGCTCTGCC CCTCGCTGGT 
GTGTTCAGCC TGCGAGCCCC GGGCCGTGGC TGGGCGGACT TGGGTACCCC CCTGTCTCGG 
CGCAGCCTGG CGCTAGCTGA CGACGCGGCT TTTCGGGAGC GCGCGCGCCT GCTGGCCGCC 
CTGGAGCGCC GCCGCTGGCT GGACTCTTAC ATGCAGAAGC TGTTGCTACT GGACGCGCCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006229180.1
CDS	85..387
Translation	METCQMSRSPRERLLLLLLLLLLVPWGTGPASGVALPLAGVFSLRAPGRGWADLGTPLSRRSLALADDAAFRERARLLAALERRRWLDSYMQKLLLLDAP

Target ORF information:

RefSeq Version	XM_006229118.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus parathyroid hormone 2 (Pth2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006229118.3

ORF Insert Sequence:

ATGGAGACCT GCCAGATGTC CAGGAGCCCT CGAGAGCGGC TGCTGCTGCT TTTGCTGCTT 
CTACTGCTTG TGCCCTGGGG CACTGGCCCT GCCTCAGGTG TTGCTCTGCC CCTCGCTGGT 
GTGTTCAGCC TGCGAGCCCC GGGCCGTGGC TGGGCGGACT TGGGTACCCC CCTGTCTCGG 
CGCAGCCTGG CGCTAGCTGA CGACGCGGCT TTTCGGGAGC GCGCGCGCCT GCTGGCCGCC 
CTGGAGCGCC GCCGCTGGCT GGACTCTTAC ATGCAGAAGC TGTTGCTACT GGACGCGCCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tuberoinfundibular peptide of 39 residues is activated during lactation and participates in the suckling-induced prolactin release in rat.
Endocrinology151(12)5830-40(2010 Dec)
Cserven?k M,Bodn?r I,Usdin TB,Palkovits M,Nagy GM,Dobolyi A

Acoustic stress activates tuberoinfundibular peptide of 39 residues neurons in the rat brain.
Brain structure & function214(1)15-23(2009 Dec)
Palkovits M,Helfferich F,Dobolyi A,Usdin TB

Tuberoinfundibular peptide of 39 residues in the embryonic and early postnatal rat brain.
Journal of chemical neuroanatomy36(1)59-68(2008 Sep)
Brenner D,Bag? AG,Gallatz K,Palkovits M,Usdin TB,Dobolyi A

Forebrain projections of tuberoinfundibular peptide of 39 residues (TIP39)-containing subparafascicular neurons.
Neuroscience138(4)1245-63(2006)
Wang J,Palkovits M,Usdin TB,Dobolyi A

Tuberoinfundibular peptide of 39 residues: a new mediator of cardiac function via nitric oxide production in the rat heart.
Endocrinology146(5)2221-8(2005 May)
Ross G,Engel P,Abdallah Y,Kummer W,Schluter KD

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Pth2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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