Cd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Liang Y, Cucchetti M, Roncagalli R, Yokosuka T, Malzac A, Bertosio E, Imbert J, Nijman IJ, Suchanek M, Saito T, W?lfing C, Malissen B, Malissen M
Nature immunology14(8)858-66(2013 Aug)

The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells.
Motomura Y, Kitamura H, Hijikata A, Matsunaga Y, Matsumoto K, Inoue H, Atarashi K, Hori S, Watarai H, Zhu J, Taniguchi M, Kubo M
Nature immunology12(5)450-9(2011 May)

Human intestinal intraepithelial lymphocytes and epithelial cells coinduce interleukin-8 production through the CD2-CD58 interaction.
Ebert EC, Panja A, Praveen R
American journal of physiology. Gastrointestinal and liver physiology296(3)G671-7(2009 Mar)

In vivo proliferation of rat lamina propria T lymphocytes: general hyporesponsiveness but increased importance of the CD2 and CD28 pathways.
Hoffmann JC, Peters K, Pawlowski NN, Grollich K, Henschke S, Herrmann B, Zeitz M, Westermann J
Immunological investigations38(6)466-82(2009)

Protein interactions between CD2 and Lck are required for the lipid raft distribution of CD2.
Nunes RJ, Castro MA, Gon?alves CM, Bamberger M, Pereira CF, Bismuth G, Carmo AM
Journal of immunology (Baltimore, Md. : 1950)180(2)988-97(2008 Jan)

CD2/CD28 costimulation is the strongest T cell stimulus in vivo in rat lamina propria.
Title: In vivo proliferation of rat lamina propria T lymphocytes: general hyporesponsiveness but increased importance of the CD2 and CD28 pathways.

CD48 is a CD2 and CD244 (2B4)-binding protein
Title: Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48.

Data show that designed cyclic peptides with beta-turn structure have the ability to modulate the CD2-CD58 interaction, which is critical for an immune response.
Title: Design, structure and biological activity of beta-turn peptides of CD2 protein for inhibition of T-cell adhesion.

The fact that both the extracellular and the cytoplasmic domains of CD2 interact with CD5 suggests a specific and tight association between the two molecules, possibly relevant for the fine-tuning of signal transduction in T lymphocytes.
Title: CD2 physically associates with CD5 in rat T lymphocytes with the involvement of both extracellular and intracellular domains.

Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. Review.
Title: Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation.