Il22ra2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Il22ra2
Entrez Gene ID	444986
Full Name	interleukin 22 receptor subunit alpha 2
Synonyms	Crf2-s1
General protein information	Preferred Names interleukin 22 receptor subunit alpha 2 Names interleukin-22 receptor subunit alpha-2 IL-22 receptor subunit alpha-2 IL-22BP IL-22R-alpha-2 IL-22RA2 IL22BP cytokine receptor family II soluble 1 cytokine receptor family type 2, soluble 1 interleukin 22 receptor, alpha 2 interleukin-22-binding protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1p12

mRNA and Protein(s)

mRNA	Protein	Name
XM_017589530.1	XP_017445019.1	interleukin-22 receptor subunit alpha-2 isoform X2
XM_017589531.1	XP_017445020.1	interleukin-22 receptor subunit alpha-2 isoform X2
XM_017589528.1	XP_017445017.1	interleukin-22 receptor subunit alpha-2 isoform X1
NM_001003404.1	NP_001003404.1	interleukin-22 receptor subunit alpha-2 precursor
XM_017589529.1	XP_017445018.1	interleukin-22 receptor subunit alpha-2 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	IL22RA2	XP_003638820.1
	LOC711059	XP_001099782.2
Rattus norvegicus (Norway rat)	Il22ra2	NP_001003404.1
Pan troglodytes (chimpanzee)	IL22RA2	XP_001171428.1
Mus musculus (house mouse)	Il22ra2	NP_839989.2
Gallus gallus (chicken)	IL22RA2	XP_004935760.1
Danio rerio (zebrafish)	crfb9	NP_001038744.1
Homo sapiens (human)	IL22RA2	NP_443194.1
Bos taurus (cattle)	IL22RA2	XP_002690307.2

Gene Ontology
Bibliography

Related articles in PubMed

Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation.
Martin JC, Wolk K, B?riou G, Abidi A, Witte-H?ndel E, Louvet C, Kokolakis G, Drujont L, Dumoutier L, Renauld JC, Sabat R, Josien R
Journal of immunology (Baltimore, Md. : 1950)198(9)3671-3678(2017 May)

IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis.
Martin JC, B?riou G, Heslan M, Bossard C, Jarry A, Abidi A, Hulin P, M?noret S, Thinard R, Anegon I, Jacqueline C, Lardeux B, Halary F, Renauld JC, Bourreille A, Josien R
Mucosal immunology9(2)539-49(2016 Mar)

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.
Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W Jr, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA
Nature491(7423)259-63(2012 Nov)

IL-22RA2 associates with multiple sclerosis and macrophage effector mechanisms in experimental neuroinflammation.
Beyeen AD, Adzemovic MZ, Ockinger J, Stridh P, Becanovic K, Laaksonen H, Lassmann H, Harris RA, Hillert J, Alfredsson L, Celius EG, Harbo HF, Kockum I, Jagodic M, Olsson T
Journal of immunology (Baltimore, Md. : 1950)185(11)6883-90(2010 Dec)

Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart.
Weiss B, Wolk K, Gr?nberg BH, Volk HD, Sterry W, Asadullah K, Sabat R
Genes and immunity5(5)330-6(2004 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study shows that rats with genetic IL-22BP deficiency (Il22ra2-/-) display exacerbated psoriasis that is associated with enhanced expression of IL-22-inducible antimicrobial peptides
Title: Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation.

IL-22BP is produced by eosinophils in the gut and blocks IL-22 protective actions in colitis.
Title: IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis.

Through a combined approach including genetic and immunological investigation in an animal model and large-scale association studies of patients with multiple sclerosis (MS), IL-22RA2 is established as an MS risk gene.
Title: IL-22RA2 associates with multiple sclerosis and macrophage effector mechanisms in experimental neuroinflammation.

The following Il22ra2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il22ra2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa09860	NM_001003404.1 Latest version!	Rattus norvegicus interleukin 22 receptor subunit alpha 2 (Il22ra2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa09860	XM_017589529.1 Latest version!	Rattus norvegicus interleukin 22 receptor subunit alpha 2 (Il22ra2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa09860	XM_017589528.1 Latest version!	Rattus norvegicus interleukin 22 receptor subunit alpha 2 (Il22ra2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa56769	XM_017589530.1 Latest version!	Rattus norvegicus interleukin 22 receptor subunit alpha 2 (Il22ra2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
ORa56769	XM_017589531.1 Latest version!	Rattus norvegicus interleukin 22 receptor subunit alpha 2 (Il22ra2), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Il22ra2 ( NM_001003404.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001003404.1 Rattus norvegicus interleukin 22 receptor subunit alpha 2 (Il22ra2), mRNA.

Price & Availability↑

CloneID	ORa09860
Clone ID Related Accession (Same CDS sequence)	XM_017589528.1 , NM_001003404.1 , XM_017589529.1
Accession Version	NM_001003404.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-22 receptor subunit alpha-2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ555485.1. On Apr 19, 2005 this sequence version replaced XM_579098.1. Sequence Note: This sequence has been modified as follows: removed 22 bp suspected to be vector contamination from the 5' end. ##Evidence-Data-START## Transcript exon combination :: AJ555485.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689603, SAMEA2689605 [ECO:0000348] ##Evidence-Data-END##

ATGCCTAAGC ACTGCTTTCT AGGCCTCCTC ATCATGCTCT TGACCACTGC CACAGAAACG 
CAGCCAGCCC ATGTGTCTCT GAAGCCTCAG AAGGTCCAAT TTCAGTCCAG AAATTTCCAC 
AACATTTTGC ACTGGCAACC AGGGAACTCC CTCACCAGCA ACGGCAGCGT CTACTTTGTG 
CAGTACAAGA CGTATGGACA GGGACAATGG AAAGATAAAA ATGACTGCTG GGGGACCACA 
GCGCTCTTTT GTGACCTGAC CAAAGAAACC TTAGACCCAT ACGAGCCATA CTATGGGAGG 
GTGATGATGG CCTGGGCTGG AAGCTACTCT GAATGGACCA GGACACCCCG CTTCACTCCA 
TGGTGGGAAA CAAAATTAGA TCCTCCGGTC GTGACTATAA CCCGAGTTAA TGCATCTTTG 
AGGGTTCGTC TCCGCCCCCC AGAGTTGCCA CATAGAAACC AAACTGGAAA AAATACGTCC 
ATGGAAAATT ACTACAACTT AGTATACCGA GTTTCCATAA TCAACAATTC ACTGGAGAAG 
GAACAAAAAG CCTACGAAGG AACTCAGAGA GCTGTTGAAA TTCAAGGTCT GACACCTCAT 
TGCAGTTACT GCGTAGTGGC TGAAATGTAC CAGCCCATGT TCGACAGAAG AAGCCCAAGA 
AGCAAGGAGA GATGTGTGCA GATTCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003404.1
CDS	33..722
Translation	MPKHCFLGLLIMLLTTATETQPAHVSLKPQKVQFQSRNFHNILHWQPGNSLTSNGSVYFVQYKTYGQGQWKDKNDCWGTTALFCDLTKETLDPYEPYYGRVMMAWAGSYSEWTRTPRFTPWWETKLDPPVVTITRVNASLRVRLRPPELPHRNQTGKNTSMENYYNLVYRVSIINNSLEKEQKAYEGTQRAVEIQGLTPHCSYCVVAEMYQPMFDRRSPRSKERCVQIP

Target ORF information:

RefSeq Version	NM_001003404.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 22 receptor subunit alpha 2 (Il22ra2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003404.1

ORF Insert Sequence:

ATGCCTAAGC ACTGCTTTCT AGGCCTCCTC ATCATGCTCT TGACCACTGC CACAGAAACG 
CAGCCAGCCC ATGTGTCTCT GAAGCCTCAG AAGGTCCAAT TTCAGTCCAG AAATTTCCAC 
AACATTTTGC ACTGGCAACC AGGGAACTCC CTCACCAGCA ACGGCAGCGT CTACTTTGTG 
CAGTACAAGA CGTATGGACA GGGACAATGG AAAGATAAAA ATGACTGCTG GGGGACCACA 
GCGCTCTTTT GTGACCTGAC CAAAGAAACC TTAGACCCAT ACGAGCCATA CTATGGGAGG 
GTGATGATGG CCTGGGCTGG AAGCTACTCT GAATGGACCA GGACACCCCG CTTCACTCCA 
TGGTGGGAAA CAAAATTAGA TCCTCCGGTC GTGACTATAA CCCGAGTTAA TGCATCTTTG 
AGGGTTCGTC TCCGCCCCCC AGAGTTGCCA CATAGAAACC AAACTGGAAA AAATACGTCC 
ATGGAAAATT ACTACAACTT AGTATACCGA GTTTCCATAA TCAACAATTC ACTGGAGAAG 
GAACAAAAAG CCTACGAAGG AACTCAGAGA GCTGTTGAAA TTCAAGGTCT GACACCTCAT 
TGCAGTTACT GCGTAGTGGC TGAAATGTAC CAGCCCATGT TCGACAGAAG AAGCCCAAGA 
AGCAAGGAGA GATGTGTGCA GATTCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il22ra2 ( XM_017589528.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017445017.1 Rattus norvegicus interleukin 22 receptor subunit alpha 2 (Il22ra2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa09860
Clone ID Related Accession (Same CDS sequence)	XM_017589528.1 , NM_001003404.1 , XM_017589529.1
Accession Version	XM_017589528.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-22 receptor subunit alpha-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTAAGC ACTGCTTTCT AGGCCTCCTC ATCATGCTCT TGACCACTGC CACAGAAACG 
CAGCCAGCCC ATGTGTCTCT GAAGCCTCAG AAGGTCCAAT TTCAGTCCAG AAATTTCCAC 
AACATTTTGC ACTGGCAACC AGGGAACTCC CTCACCAGCA ACGGCAGCGT CTACTTTGTG 
CAGTACAAGA CGTATGGACA GGGACAATGG AAAGATAAAA ATGACTGCTG GGGGACCACA 
GCGCTCTTTT GTGACCTGAC CAAAGAAACC TTAGACCCAT ACGAGCCATA CTATGGGAGG 
GTGATGATGG CCTGGGCTGG AAGCTACTCT GAATGGACCA GGACACCCCG CTTCACTCCA 
TGGTGGGAAA CAAAATTAGA TCCTCCGGTC GTGACTATAA CCCGAGTTAA TGCATCTTTG 
AGGGTTCGTC TCCGCCCCCC AGAGTTGCCA CATAGAAACC AAACTGGAAA AAATACGTCC 
ATGGAAAATT ACTACAACTT AGTATACCGA GTTTCCATAA TCAACAATTC ACTGGAGAAG 
GAACAAAAAG CCTACGAAGG AACTCAGAGA GCTGTTGAAA TTCAAGGTCT GACACCTCAT 
TGCAGTTACT GCGTAGTGGC TGAAATGTAC CAGCCCATGT TCGACAGAAG AAGCCCAAGA 
AGCAAGGAGA GATGTGTGCA GATTCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017445017.1
CDS	432..1121
Translation	MPKHCFLGLLIMLLTTATETQPAHVSLKPQKVQFQSRNFHNILHWQPGNSLTSNGSVYFVQYKTYGQGQWKDKNDCWGTTALFCDLTKETLDPYEPYYGRVMMAWAGSYSEWTRTPRFTPWWETKLDPPVVTITRVNASLRVRLRPPELPHRNQTGKNTSMENYYNLVYRVSIINNSLEKEQKAYEGTQRAVEIQGLTPHCSYCVVAEMYQPMFDRRSPRSKERCVQIP

Target ORF information:

RefSeq Version	XM_017589528.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 22 receptor subunit alpha 2 (Il22ra2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589528.1

ORF Insert Sequence:

ATGCCTAAGC ACTGCTTTCT AGGCCTCCTC ATCATGCTCT TGACCACTGC CACAGAAACG 
CAGCCAGCCC ATGTGTCTCT GAAGCCTCAG AAGGTCCAAT TTCAGTCCAG AAATTTCCAC 
AACATTTTGC ACTGGCAACC AGGGAACTCC CTCACCAGCA ACGGCAGCGT CTACTTTGTG 
CAGTACAAGA CGTATGGACA GGGACAATGG AAAGATAAAA ATGACTGCTG GGGGACCACA 
GCGCTCTTTT GTGACCTGAC CAAAGAAACC TTAGACCCAT ACGAGCCATA CTATGGGAGG 
GTGATGATGG CCTGGGCTGG AAGCTACTCT GAATGGACCA GGACACCCCG CTTCACTCCA 
TGGTGGGAAA CAAAATTAGA TCCTCCGGTC GTGACTATAA CCCGAGTTAA TGCATCTTTG 
AGGGTTCGTC TCCGCCCCCC AGAGTTGCCA CATAGAAACC AAACTGGAAA AAATACGTCC 
ATGGAAAATT ACTACAACTT AGTATACCGA GTTTCCATAA TCAACAATTC ACTGGAGAAG 
GAACAAAAAG CCTACGAAGG AACTCAGAGA GCTGTTGAAA TTCAAGGTCT GACACCTCAT 
TGCAGTTACT GCGTAGTGGC TGAAATGTAC CAGCCCATGT TCGACAGAAG AAGCCCAAGA 
AGCAAGGAGA GATGTGTGCA GATTCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il22ra2 ( XM_017589529.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017445018.1 Rattus norvegicus interleukin 22 receptor subunit alpha 2 (Il22ra2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa09860
Clone ID Related Accession (Same CDS sequence)	XM_017589528.1 , NM_001003404.1 , XM_017589529.1
Accession Version	XM_017589529.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-22 receptor subunit alpha-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTAAGC ACTGCTTTCT AGGCCTCCTC ATCATGCTCT TGACCACTGC CACAGAAACG 
CAGCCAGCCC ATGTGTCTCT GAAGCCTCAG AAGGTCCAAT TTCAGTCCAG AAATTTCCAC 
AACATTTTGC ACTGGCAACC AGGGAACTCC CTCACCAGCA ACGGCAGCGT CTACTTTGTG 
CAGTACAAGA CGTATGGACA GGGACAATGG AAAGATAAAA ATGACTGCTG GGGGACCACA 
GCGCTCTTTT GTGACCTGAC CAAAGAAACC TTAGACCCAT ACGAGCCATA CTATGGGAGG 
GTGATGATGG CCTGGGCTGG AAGCTACTCT GAATGGACCA GGACACCCCG CTTCACTCCA 
TGGTGGGAAA CAAAATTAGA TCCTCCGGTC GTGACTATAA CCCGAGTTAA TGCATCTTTG 
AGGGTTCGTC TCCGCCCCCC AGAGTTGCCA CATAGAAACC AAACTGGAAA AAATACGTCC 
ATGGAAAATT ACTACAACTT AGTATACCGA GTTTCCATAA TCAACAATTC ACTGGAGAAG 
GAACAAAAAG CCTACGAAGG AACTCAGAGA GCTGTTGAAA TTCAAGGTCT GACACCTCAT 
TGCAGTTACT GCGTAGTGGC TGAAATGTAC CAGCCCATGT TCGACAGAAG AAGCCCAAGA 
AGCAAGGAGA GATGTGTGCA GATTCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017445018.1
CDS	1251..1940
Translation	MPKHCFLGLLIMLLTTATETQPAHVSLKPQKVQFQSRNFHNILHWQPGNSLTSNGSVYFVQYKTYGQGQWKDKNDCWGTTALFCDLTKETLDPYEPYYGRVMMAWAGSYSEWTRTPRFTPWWETKLDPPVVTITRVNASLRVRLRPPELPHRNQTGKNTSMENYYNLVYRVSIINNSLEKEQKAYEGTQRAVEIQGLTPHCSYCVVAEMYQPMFDRRSPRSKERCVQIP

Target ORF information:

RefSeq Version	XM_017589529.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 22 receptor subunit alpha 2 (Il22ra2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589529.1

ORF Insert Sequence:

ATGCCTAAGC ACTGCTTTCT AGGCCTCCTC ATCATGCTCT TGACCACTGC CACAGAAACG 
CAGCCAGCCC ATGTGTCTCT GAAGCCTCAG AAGGTCCAAT TTCAGTCCAG AAATTTCCAC 
AACATTTTGC ACTGGCAACC AGGGAACTCC CTCACCAGCA ACGGCAGCGT CTACTTTGTG 
CAGTACAAGA CGTATGGACA GGGACAATGG AAAGATAAAA ATGACTGCTG GGGGACCACA 
GCGCTCTTTT GTGACCTGAC CAAAGAAACC TTAGACCCAT ACGAGCCATA CTATGGGAGG 
GTGATGATGG CCTGGGCTGG AAGCTACTCT GAATGGACCA GGACACCCCG CTTCACTCCA 
TGGTGGGAAA CAAAATTAGA TCCTCCGGTC GTGACTATAA CCCGAGTTAA TGCATCTTTG 
AGGGTTCGTC TCCGCCCCCC AGAGTTGCCA CATAGAAACC AAACTGGAAA AAATACGTCC 
ATGGAAAATT ACTACAACTT AGTATACCGA GTTTCCATAA TCAACAATTC ACTGGAGAAG 
GAACAAAAAG CCTACGAAGG AACTCAGAGA GCTGTTGAAA TTCAAGGTCT GACACCTCAT 
TGCAGTTACT GCGTAGTGGC TGAAATGTAC CAGCCCATGT TCGACAGAAG AAGCCCAAGA 
AGCAAGGAGA GATGTGTGCA GATTCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il22ra2 ( XM_017589530.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017445019.1 Rattus norvegicus interleukin 22 receptor subunit alpha 2 (Il22ra2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa56769
Clone ID Related Accession (Same CDS sequence)	XM_017589530.1 , XM_017589531.1
Accession Version	XM_017589530.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-22 receptor subunit alpha-2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTAAGC ACTGCTTTCT AGGCCTCCTC ATCATGCTCT TGACCACTGC CACAGAAACG 
CAGCCAGCCC ATGTGTCTCT GAAGCCTCAG AAGGTCCAAT TTCAGTCCAG AAATTTCCAC 
AACATTTTGC ACTGGCAACC AGGGAACTCC CTCACCAGCA ACGGCAGCGT CTACTTTGTG 
CAGTACAAGA CGTATGGACA GGGACAATGG AAAGATAAAA ATGACTGCTG GGGGACCACA 
GCGCTCTTTT GTGACCTGAC CAAAGAAACC TTAGACCCAT ACGAGCCATA CTATGGGAGG 
GTGATGATGG CCTGGGCTGG AAGCTACTCT GAATGGACCA GGACACCCCG CTTCACTCCA 
TGGTGGGAAA CAAAATTAGA TCCTCCGGTC GTGACTATAA CCCGAGTTAA TGCATCTTTG 
AGGGTTCGTC TCCGCCCCCC AGAGTTGCCA CATAGAAACC AAACTGGAAA AAATACGTCC 
ATGGAAAATT ACTACAACTT AGTATACCGA GTTTCCATAA TCAACAATTC ACTGGAGAAG 
ATCTTTCCCT GTCTTTTATT CGTCCATCTT CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017445019.1
CDS	432..1007
Translation	MPKHCFLGLLIMLLTTATETQPAHVSLKPQKVQFQSRNFHNILHWQPGNSLTSNGSVYFVQYKTYGQGQWKDKNDCWGTTALFCDLTKETLDPYEPYYGRVMMAWAGSYSEWTRTPRFTPWWETKLDPPVVTITRVNASLRVRLRPPELPHRNQTGKNTSMENYYNLVYRVSIINNSLEKIFPCLLFVHLH

Target ORF information:

RefSeq Version	XM_017589530.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 22 receptor subunit alpha 2 (Il22ra2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589530.1

ORF Insert Sequence:

ATGCCTAAGC ACTGCTTTCT AGGCCTCCTC ATCATGCTCT TGACCACTGC CACAGAAACG 
CAGCCAGCCC ATGTGTCTCT GAAGCCTCAG AAGGTCCAAT TTCAGTCCAG AAATTTCCAC 
AACATTTTGC ACTGGCAACC AGGGAACTCC CTCACCAGCA ACGGCAGCGT CTACTTTGTG 
CAGTACAAGA CGTATGGACA GGGACAATGG AAAGATAAAA ATGACTGCTG GGGGACCACA 
GCGCTCTTTT GTGACCTGAC CAAAGAAACC TTAGACCCAT ACGAGCCATA CTATGGGAGG 
GTGATGATGG CCTGGGCTGG AAGCTACTCT GAATGGACCA GGACACCCCG CTTCACTCCA 
TGGTGGGAAA CAAAATTAGA TCCTCCGGTC GTGACTATAA CCCGAGTTAA TGCATCTTTG 
AGGGTTCGTC TCCGCCCCCC AGAGTTGCCA CATAGAAACC AAACTGGAAA AAATACGTCC 
ATGGAAAATT ACTACAACTT AGTATACCGA GTTTCCATAA TCAACAATTC ACTGGAGAAG 
ATCTTTCCCT GTCTTTTATT CGTCCATCTT CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il22ra2 ( XM_017589531.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017445020.1 Rattus norvegicus interleukin 22 receptor subunit alpha 2 (Il22ra2), transcript variant X4, mRNA.

Price & Availability↑

CloneID	ORa56769
Clone ID Related Accession (Same CDS sequence)	XM_017589530.1 , XM_017589531.1
Accession Version	XM_017589531.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-22 receptor subunit alpha-2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTAAGC ACTGCTTTCT AGGCCTCCTC ATCATGCTCT TGACCACTGC CACAGAAACG 
CAGCCAGCCC ATGTGTCTCT GAAGCCTCAG AAGGTCCAAT TTCAGTCCAG AAATTTCCAC 
AACATTTTGC ACTGGCAACC AGGGAACTCC CTCACCAGCA ACGGCAGCGT CTACTTTGTG 
CAGTACAAGA CGTATGGACA GGGACAATGG AAAGATAAAA ATGACTGCTG GGGGACCACA 
GCGCTCTTTT GTGACCTGAC CAAAGAAACC TTAGACCCAT ACGAGCCATA CTATGGGAGG 
GTGATGATGG CCTGGGCTGG AAGCTACTCT GAATGGACCA GGACACCCCG CTTCACTCCA 
TGGTGGGAAA CAAAATTAGA TCCTCCGGTC GTGACTATAA CCCGAGTTAA TGCATCTTTG 
AGGGTTCGTC TCCGCCCCCC AGAGTTGCCA CATAGAAACC AAACTGGAAA AAATACGTCC 
ATGGAAAATT ACTACAACTT AGTATACCGA GTTTCCATAA TCAACAATTC ACTGGAGAAG 
ATCTTTCCCT GTCTTTTATT CGTCCATCTT CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017445020.1
CDS	432..1007
Translation	MPKHCFLGLLIMLLTTATETQPAHVSLKPQKVQFQSRNFHNILHWQPGNSLTSNGSVYFVQYKTYGQGQWKDKNDCWGTTALFCDLTKETLDPYEPYYGRVMMAWAGSYSEWTRTPRFTPWWETKLDPPVVTITRVNASLRVRLRPPELPHRNQTGKNTSMENYYNLVYRVSIINNSLEKIFPCLLFVHLH

Target ORF information:

RefSeq Version	XM_017589531.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 22 receptor subunit alpha 2 (Il22ra2), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589531.1

ORF Insert Sequence:

ATGCCTAAGC ACTGCTTTCT AGGCCTCCTC ATCATGCTCT TGACCACTGC CACAGAAACG 
CAGCCAGCCC ATGTGTCTCT GAAGCCTCAG AAGGTCCAAT TTCAGTCCAG AAATTTCCAC 
AACATTTTGC ACTGGCAACC AGGGAACTCC CTCACCAGCA ACGGCAGCGT CTACTTTGTG 
CAGTACAAGA CGTATGGACA GGGACAATGG AAAGATAAAA ATGACTGCTG GGGGACCACA 
GCGCTCTTTT GTGACCTGAC CAAAGAAACC TTAGACCCAT ACGAGCCATA CTATGGGAGG 
GTGATGATGG CCTGGGCTGG AAGCTACTCT GAATGGACCA GGACACCCCG CTTCACTCCA 
TGGTGGGAAA CAAAATTAGA TCCTCCGGTC GTGACTATAA CCCGAGTTAA TGCATCTTTG 
AGGGTTCGTC TCCGCCCCCC AGAGTTGCCA CATAGAAACC AAACTGGAAA AAATACGTCC 
ATGGAAAATT ACTACAACTT AGTATACCGA GTTTCCATAA TCAACAATTC ACTGGAGAAG 
ATCTTTCCCT GTCTTTTATT CGTCCATCTT CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation.
Journal of immunology (Baltimore, Md. : 1950)198(9)3671-3678(2017 May)
Martin JC,Wolk K,B?riou G,Abidi A,Witte-H?ndel E,Louvet C,Kokolakis G,Drujont L,Dumoutier L,Renauld JC,Sabat R,Josien R

IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis.
Mucosal immunology9(2)539-49(2016 Mar)
Martin JC,B?riou G,Heslan M,Bossard C,Jarry A,Abidi A,Hulin P,M?noret S,Thinard R,Anegon I,Jacqueline C,Lardeux B,Halary F,Renauld JC,Bourreille A,Josien R

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.
Nature491(7423)259-63(2012 Nov)
Huber S,Gagliani N,Zenewicz LA,Huber FJ,Bosurgi L,Hu B,Hedl M,Zhang W,O'Connor W Jr,Murphy AJ,Valenzuela DM,Yancopoulos GD,Booth CJ,Cho JH,Ouyang W,Abraham C,Flavell RA

IL-22RA2 associates with multiple sclerosis and macrophage effector mechanisms in experimental neuroinflammation.
Journal of immunology (Baltimore, Md. : 1950)185(11)6883-90(2010 Dec)
Beyeen AD,Adzemovic MZ,Ockinger J,Stridh P,Becanovic K,Laaksonen H,Lassmann H,Harris RA,Hillert J,Alfredsson L,Celius EG,Harbo HF,Kockum I,Jagodic M,Olsson T

Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart.
Genes and immunity5(5)330-6(2004 Aug)
Weiss B,Wolk K,Gr?nberg BH,Volk HD,Sterry W,Asadullah K,Sabat R

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Il22ra2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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