Vkorc1l1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Vkorc1l1
Entrez Gene ID	399684
Full Name	vitamin K epoxide reductase complex, subunit 1-like 1
General protein information	Preferred Names vitamin K epoxide reductase complex, subunit 1-like 1 Names vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1-like protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q12-q13

mRNA and Protein(s)

mRNA	Protein	Name
XM_017598418.1	XP_017453907.1	vitamin K epoxide reductase complex subunit 1-like protein 1 isoform X1
NM_203338.1	NP_976083.1	vitamin K epoxide reductase complex subunit 1-like protein 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Vkorc1l1	NP_081397.1
Homo sapiens (human)	VKORC1L1	NP_775788.2
Pan troglodytes (chimpanzee)	VKORC1L1	XP_527770.2
	VKORC1L1	XP_001088069.1
Bos taurus (cattle)	VKORC1L1	XP_002698121.1
Rattus norvegicus (Norway rat)	Vkorc1l1	NP_976083.1
Xenopus tropicalis (tropical clawed frog)	vkorc1l1	NP_001016769.2
Canis lupus familiaris (dog)	VKORC1L1	XP_848485.1
Gallus gallus (chicken)	VKORC1L1	NP_001001328.1
Danio rerio (zebrafish)	vkorc1l1	NP_001018524.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000543	XP_310541.3

Gene Ontology
Bibliography

Related articles in PubMed

Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration.
Tie JK, Jin DY, Stafford DW
The Journal of biological chemistry289(13)9396-407(2014 Mar)

VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
Hammed A, Matagrin B, Spohn G, Prouillac C, Benoit E, Lattard V
The Journal of biological chemistry288(40)28733-42(2013 Oct)

Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function.
Westhofen P, Watzka M, Marinova M, Hass M, Kirfel G, M?ller J, Bevans CG, M?ller CR, Oldenburg J
The Journal of biological chemistry286(17)15085-94(2011 Apr)

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
Rost S, Fregin A, Ivaskevicius V, Conzelmann E, H?rtnagel K, Pelz HJ, Lappegard K, Seifried E, Scharrer I, Tuddenham EG, M?ller CR, Strom TM, Oldenburg J
Nature427(6974)537-41(2004 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The involvement of VKORC1L1 in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists.
Title: VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.

molecular cloning
Title: Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.

The following Vkorc1l1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vkorc1l1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13535	NM_203338.1 Latest version!	Rattus norvegicus vitamin K epoxide reductase complex, subunit 1-like 1 (Vkorc1l1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa52809	XM_017598418.1 Latest version!	Rattus norvegicus vitamin K epoxide reductase complex, subunit 1-like 1 (Vkorc1l1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Vkorc1l1 ( NM_203338.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_976083.1 Rattus norvegicus vitamin K epoxide reductase complex, subunit 1-like 1 (Vkorc1l1), mRNA.

Price & Availability↑

CloneID	ORa13535
Clone ID Related Accession (Same CDS sequence)	NM_203338.1
Accession Version	NM_203338.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-14
Organism	Rattus norvegicus(Norway rat)
Product	vitamin K epoxide reductase complex subunit 1-like protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY423048.1. ##Evidence-Data-START## Transcript exon combination :: AY423048.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGGT GGGAACGGGT GGCCCGGTAT 
GCAGTGTGCG CCGCCGGGAT CCTGCTCTCC ATCTACGCCT ACCACGTGGA GCGGGAGAAG 
GAGAGGGACC CGGAGCACCG GGCCCTCTGC GACCTGGGGC CCTGGGTGAA GTGCTCCGCC 
GCCCTGGCCT CCAGATGGGG TCGAGGATTT GGTCTTTTGG GTTCCATTTT TGGAAAAGAT 
GGTGTATTAA ACCAGCCAAA CAGTGTCTTT GGACTTATAT TTTATATACT ACAGTTATTA 
CTTGGCATGA CAGCCAGCGC AGTTGCAGCT CTGGTCCTCA TGACCTCCTC CATCGTGTCC 
GTGGTGGGGT CTTTGTACCT GGCCTACATT CTGTACTTTG TGCTGAAGGA GTTTTGCATC 
ATCTGCGTCA CCACATATGT GCTGAACTTC CTTCTCCTCA TCATCAACTA CAAACGACTG 
GTTTACTTGA ATGAGGCCTG GAAGCGACAA CTGCAGCCTA AGGAAGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_976083.1
CDS	51..581
Translation	MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRWGRGFGLLGSIFGKDGVLNQPNSVFGLIFYILQLLLGMTASAVAALVLMTSSIVSVVGSLYLAYILYFVLKEFCIICVTTYVLNFLLLIINYKRLVYLNEAWKRQLQPKED

Target ORF information:

RefSeq Version	NM_203338.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus vitamin K epoxide reductase complex, subunit 1-like 1 (Vkorc1l1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_203338.1

ORF Insert Sequence:

ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGGT GGGAACGGGT GGCCCGGTAT 
GCAGTGTGCG CCGCCGGGAT CCTGCTCTCC ATCTACGCCT ACCACGTGGA GCGGGAGAAG 
GAGAGGGACC CGGAGCACCG GGCCCTCTGC GACCTGGGGC CCTGGGTGAA GTGCTCCGCC 
GCCCTGGCCT CCAGATGGGG TCGAGGATTT GGTCTTTTGG GTTCCATTTT TGGAAAAGAT 
GGTGTATTAA ACCAGCCAAA CAGTGTCTTT GGACTTATAT TTTATATACT ACAGTTATTA 
CTTGGCATGA CAGCCAGCGC AGTTGCAGCT CTGGTCCTCA TGACCTCCTC CATCGTGTCC 
GTGGTGGGGT CTTTGTACCT GGCCTACATT CTGTACTTTG TGCTGAAGGA GTTTTGCATC 
ATCTGCGTCA CCACATATGT GCTGAACTTC CTTCTCCTCA TCATCAACTA CAAACGACTG 
GTTTACTTGA ATGAGGCCTG GAAGCGACAA CTGCAGCCTA AGGAAGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Vkorc1l1 ( XM_017598418.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017453907.1 Rattus norvegicus vitamin K epoxide reductase complex, subunit 1-like 1 (Vkorc1l1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa52809
Clone ID Related Accession (Same CDS sequence)	XM_017598418.1
Accession Version	XM_017598418.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	vitamin K epoxide reductase complex subunit 1-like protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGGT GGGAACGGGT GGCCCGGTAT 
GCAGTGTGCG CCGCCGGGAT CCTGCTCTCC ATCTACGCCT ACCACGTGGA GCGGGAGAAG 
GAGAGGGACC CGGAGCACCG GGCCCTCTGC GACCTGGGGC CCTGGGTGAA GTGCTCCGCC 
GCCCTGGCCT CCAGGCATGA CAGCCAGCGC AGTTGCAGCT CTGGTCCTCA TGACCTCCTC 
CATCGTGTCC GTGGTGGGGT CTTTGTACCT GGCCTACATT CTGTACTTTG TGCTGAAGGA 
GTTTTGCATC ATCTGCGTCA CCACATATGT GCTGAACTTC CTTCTCCTCA TCATCAACTA 
CAAACGACTG GTTTACTTGA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017453907.1
CDS	44..427
Translation	MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRHDSQRSCSSGPHDLLHRVRGGVFVPGLHSVLCAEGVLHHLRHHICAELPSPHHQLQTTGLLE

Target ORF information:

RefSeq Version	XM_017598418.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus vitamin K epoxide reductase complex, subunit 1-like 1 (Vkorc1l1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017598418.1

ORF Insert Sequence:

ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGGT GGGAACGGGT GGCCCGGTAT 
GCAGTGTGCG CCGCCGGGAT CCTGCTCTCC ATCTACGCCT ACCACGTGGA GCGGGAGAAG 
GAGAGGGACC CGGAGCACCG GGCCCTCTGC GACCTGGGGC CCTGGGTGAA GTGCTCCGCC 
GCCCTGGCCT CCAGGCATGA CAGCCAGCGC AGTTGCAGCT CTGGTCCTCA TGACCTCCTC 
CATCGTGTCC GTGGTGGGGT CTTTGTACCT GGCCTACATT CTGTACTTTG TGCTGAAGGA 
GTTTTGCATC ATCTGCGTCA CCACATATGT GCTGAACTTC CTTCTCCTCA TCATCAACTA 
CAAACGACTG GTTTACTTGA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration.
The Journal of biological chemistry289(13)9396-407(2014 Mar)
Tie JK,Jin DY,Stafford DW

VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
The Journal of biological chemistry288(40)28733-42(2013 Oct)
Hammed A,Matagrin B,Spohn G,Prouillac C,Benoit E,Lattard V

Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function.
The Journal of biological chemistry286(17)15085-94(2011 Apr)
Westhofen P,Watzka M,Marinova M,Hass M,Kirfel G,M?ller J,Bevans CG,M?ller CR,Oldenburg J

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
Nature427(6974)537-41(2004 Feb)
Rost S,Fregin A,Ivaskevicius V,Conzelmann E,H?rtnagel K,Pelz HJ,Lappegard K,Seifried E,Scharrer I,Tuddenham EG,M?ller CR,Strom TM,Oldenburg J

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Vkorc1l1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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