Fzd8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fzd8
Entrez Gene ID	364754
Full Name	frizzled class receptor 8
General protein information	Preferred Names frizzled class receptor 8 Names frizzled-8 frizzled family receptor 8 fz-8
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17q12.1

mRNA and Protein(s)

mRNA	Protein	Name
XM_006254142.3	XP_006254204.1	frizzled-8 isoform X1
NM_001044251.2	NP_001037716.1	frizzled-8 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	FZD8	NP_114072.1
Mus musculus (house mouse)	Fzd8	NP_032084.2
Rattus norvegicus (Norway rat)	Fzd8	NP_001037716.1
Rattus norvegicus (Norway rat)	LOC100909849	XP_003751769.1
Xenopus tropicalis (tropical clawed frog)	fzd8	NP_001090860.2
Canis lupus familiaris (dog)	FZD8	XP_005617125.1
Caenorhabditis elegans (roundworm)	cfz-2	NP_503965.2
Pan troglodytes (chimpanzee)	FZD8	XP_001142144.2
Danio rerio (zebrafish)	fzd8a	NP_570993.2
	FZD8	XP_001096837.1
Bos taurus (cattle)	FZD8	XP_005214377.1

Gene Ontology
Bibliography

Related articles in PubMed

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.
Voloshanenko O, Gmach P, Winter J, Kranz D, Boutros M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(11)4832-4844(2017 Nov)

miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts.
Miao CG, Shi WJ, Xiong YY, Yu H, Zhang XL, Qin MS, Du CL, Song TW, Li J
Immunology letters164(1)1-10(2015 Mar)

Structural basis of Wnt recognition by Frizzled.
Janda CY, Waghray D, Levin AM, Thomas C, Garcia KC
Science (New York, N.Y.)337(6090)59-64(2012 Jul)

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
Hao HX, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, Lei H, Mickanin C, Liu D, Ruffner H, Mao X, Ma Q, Zamponi R, Bouwmeester T, Finan PM, Kirschner MW, Porter JA, Serluca FC, Cong F
Nature485(7397)195-200(2012 Apr)

Frizzled-8 as a putative therapeutic target in human lung cancer.
Wang HQ, Xu ML, Ma J, Zhang Y, Xie CH
Biochemical and biophysical research communications417(1)62-6(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts
Title: miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts.

The following Fzd8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fzd8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13725	NM_001044251.2 Latest version!	Rattus norvegicus frizzled class receptor 8 (Fzd8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
ORa13725	XM_006254142.3 Latest version!	Rattus norvegicus frizzled class receptor 8 (Fzd8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fzd8 ( NM_001044251.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001037716.1 Rattus norvegicus frizzled class receptor 8 (Fzd8), mRNA.

Price & Availability↑

CloneID	ORa13725
Clone ID Related Accession (Same CDS sequence)	XM_006254142.3 , NM_001044251.2
Accession Version	NM_001044251.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2055bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	frizzled-8 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC100088.1. On Aug 31, 2012 this sequence version replaced NM_001044251.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC100088.1 [ECO:0000332] ##Evidence-Data-END##

ATGGAGTGGG GTTACCTGTT GGAAGTGACC TCGCTACTAG CCGCCTTGGC GGTGCTACAG 
CGCTCGAGCG GCGCTGCCGC GGCTTCGGCC AAGGAGCTGG CGTGCCAAGA GATCACAGTG 
CCGCTGTGCA AGGGCATCGG TTACAACTAC ACCTACATGC CCAACCAGTT CAACCACGAC 
ACGCAAGATG AGGCGGGCCT AGAGGTACAC CAGTTCTGGC CGCTGGTGGA GATCCAGTGC 
TCCCCGGACC TCAAGTTCTT TCTGTGTAGC ATGTACACGC CCATCTGCCT GGAGGACTAC 
AAGAAACCTC TGCCGCCTTG CCGCTCTGTG TGTGAACGCG CCAAGGCCGG CTGCGCGCCG 
CTCATGCGCC AGTACGGCTT TGCCTGGCCT GACCGAATGC GCTGCGATCG GCTGCCGGAG 
CAGGGCAACC CCGACACTCT GTGCATGGAC TACAACCGCA CCGACCTCAC CACGGCCGCG 
CCCAGCCCAC CGCGCCGCCT GCCGCCGCCG CAGCCTGGCG AGCAGCCGCC CTCCGGCAGC 
GGCCACAGCC GCCCGCCAGG GGCCAGGCCC CCACATCGTG GCGGCAGCAG TAGGGGCAGC 
GGGGACACGG CGGCTGCGCC CCCCTCTCGC GGCGGGAAGG CGAGGCCCCC TGGTGGCGGC 
GCCGCTCCCT GCGAGCCCGG GTGCCAGTGC CGCGCGCCCA TGGTGAGTGT GTCCAGCGAA 
CGCCACCCGC TCTACAACCG CGTCAAGACC GGCCAGATCG CCAACTGTGC GCTGCCCTGC 
CACAACCCCT TCTTTAGCCA GGATGAGCGC GCCTTCACTG TCTTCTGGAT CGGCTTGTGG 
TCGGTGCTCT GCTTCGTCTC CACCTTCGCC ACTGTCTCTA CCTTCCTCAT CGATATGGAG 
CGCTTTAAGT ACCCGGAACG GCCCATTATA TTCCTCTCTG CCTGCTACCT CTTCGTGTCT 
GTCGGGTACC TGGTGCGCCT GGTGGCTGGA CACGAGAAAG TGGCCTGCAG CGGCGGCGCG 
CCGGGTGCAG GAGGAGCTGG GGGTGCTGGC GGCGCGGCGA CCGCTGGCGC GGGGGCGGCG 
GGAGCGGGGG CGAGCAGCCC GGGCGCGCGC GGCGAGTACG AGGAGCTGGG TGCAGTGGAG 
CAGCACGTGC GCTATGAGAC CACTGGCCCC GCGCTGTGCA CGGTAGTCTT CCTCCTTGTC 
TACTTTTTTG GCATGGCTAG CTCCATCTGG TGGGTAATCC TGTCTCTCAC GTGGTTCTTG 
GCGGCTGGTA TGAAATGGGG CAACGAGGCC ATAGCAGGCT ACTCGCAATA CTTCCACCTT 
GCCGCGTGGC TCGTGCCCAG CGTCAAGTCC ATAGCGGTGC TGGCGCTCAG CTCCGTGGAC 
GGCGACCCGG TGGCGGGCAT CTGCTACGTG GGCAACCAGA GCCTTGACAA CCTACGCGGC 
TTTGTACTGG CGCCACTGGT CATCTACCTC TTCATTGGGA CTATGTTTCT GTTAGCTGGC 
TTCGTGTCGC TGTTCCGAAT CCGCTCAGTC ATCAAGCAAC AAGGAGGCCC AACCAAGACT 
CACAAGCTAG AAAAGCTCAT GATCCGCTTG GGCCTCTTCA CCGTGCTCTA CACGGTGCCC 
GCCGCCGTCG TTGTCGCCTG CCTTTTCTAT GAGCAGCACA ACCGACCGCG CTGGGAGGCC 
ACGCACAACT GCCCATGCCT TCGCGACCTG CAGCCAGACC AGGCTCGCAG GCCCGACTAC 
GCGGTCTTCA TGCTCAAGTA CTTCATGTGC CTAGTGGTGG GCATCACATC AGGCGTGTGG 
GTCTGGTCCG GCAAGACTCT GGAGTCCTGG CGTGCGTTGT GTACTCGCTG CTGCTGGGCC 
AGCAAGGGCG CTGCAGTTGG CGCGGGCGCC GGAGGCAGCG GCCCTGGGGG CGGTGGCCCC 
GGGCCCGGTG GGGGTGGGGG GCACGGCGGA GGTGGGGGAT CCCTCTACAG CGACGTCAGC 
ACCGGCCTGA CGTGGCGGTC TGGCACGGCC AGCTCTGTAT CTTACCCTAA GCAAATGCCA 
TTGTCCCAAG TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001037716.1
CDS	241..2295
Translation	MEWGYLLEVTSLLAALAVLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPQPGEQPPSGSGHSRPPGARPPHRGGSSRGSGDTAAAPPSRGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAATAGAGAAGAGASSPGARGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRALCTRCCWASKGAAVGAGAGGSGPGGGGPGPGGGGGHGGGGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV

Target ORF information:

RefSeq Version	NM_001044251.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus frizzled class receptor 8 (Fzd8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001044251.2

ORF Insert Sequence:

ATGGAGTGGG GTTACCTGTT GGAAGTGACC TCGCTACTAG CCGCCTTGGC GGTGCTACAG 
CGCTCGAGCG GCGCTGCCGC GGCTTCGGCC AAGGAGCTGG CGTGCCAAGA GATCACAGTG 
CCGCTGTGCA AGGGCATCGG TTACAACTAC ACCTACATGC CCAACCAGTT CAACCACGAC 
ACGCAAGATG AGGCGGGCCT AGAGGTACAC CAGTTCTGGC CGCTGGTGGA GATCCAGTGC 
TCCCCGGACC TCAAGTTCTT TCTGTGTAGC ATGTACACGC CCATCTGCCT GGAGGACTAC 
AAGAAACCTC TGCCGCCTTG CCGCTCTGTG TGTGAACGCG CCAAGGCCGG CTGCGCGCCG 
CTCATGCGCC AGTACGGCTT TGCCTGGCCT GACCGAATGC GCTGCGATCG GCTGCCGGAG 
CAGGGCAACC CCGACACTCT GTGCATGGAC TACAACCGCA CCGACCTCAC CACGGCCGCG 
CCCAGCCCAC CGCGCCGCCT GCCGCCGCCG CAGCCTGGCG AGCAGCCGCC CTCCGGCAGC 
GGCCACAGCC GCCCGCCAGG GGCCAGGCCC CCACATCGTG GCGGCAGCAG TAGGGGCAGC 
GGGGACACGG CGGCTGCGCC CCCCTCTCGC GGCGGGAAGG CGAGGCCCCC TGGTGGCGGC 
GCCGCTCCCT GCGAGCCCGG GTGCCAGTGC CGCGCGCCCA TGGTGAGTGT GTCCAGCGAA 
CGCCACCCGC TCTACAACCG CGTCAAGACC GGCCAGATCG CCAACTGTGC GCTGCCCTGC 
CACAACCCCT TCTTTAGCCA GGATGAGCGC GCCTTCACTG TCTTCTGGAT CGGCTTGTGG 
TCGGTGCTCT GCTTCGTCTC CACCTTCGCC ACTGTCTCTA CCTTCCTCAT CGATATGGAG 
CGCTTTAAGT ACCCGGAACG GCCCATTATA TTCCTCTCTG CCTGCTACCT CTTCGTGTCT 
GTCGGGTACC TGGTGCGCCT GGTGGCTGGA CACGAGAAAG TGGCCTGCAG CGGCGGCGCG 
CCGGGTGCAG GAGGAGCTGG GGGTGCTGGC GGCGCGGCGA CCGCTGGCGC GGGGGCGGCG 
GGAGCGGGGG CGAGCAGCCC GGGCGCGCGC GGCGAGTACG AGGAGCTGGG TGCAGTGGAG 
CAGCACGTGC GCTATGAGAC CACTGGCCCC GCGCTGTGCA CGGTAGTCTT CCTCCTTGTC 
TACTTTTTTG GCATGGCTAG CTCCATCTGG TGGGTAATCC TGTCTCTCAC GTGGTTCTTG 
GCGGCTGGTA TGAAATGGGG CAACGAGGCC ATAGCAGGCT ACTCGCAATA CTTCCACCTT 
GCCGCGTGGC TCGTGCCCAG CGTCAAGTCC ATAGCGGTGC TGGCGCTCAG CTCCGTGGAC 
GGCGACCCGG TGGCGGGCAT CTGCTACGTG GGCAACCAGA GCCTTGACAA CCTACGCGGC 
TTTGTACTGG CGCCACTGGT CATCTACCTC TTCATTGGGA CTATGTTTCT GTTAGCTGGC 
TTCGTGTCGC TGTTCCGAAT CCGCTCAGTC ATCAAGCAAC AAGGAGGCCC AACCAAGACT 
CACAAGCTAG AAAAGCTCAT GATCCGCTTG GGCCTCTTCA CCGTGCTCTA CACGGTGCCC 
GCCGCCGTCG TTGTCGCCTG CCTTTTCTAT GAGCAGCACA ACCGACCGCG CTGGGAGGCC 
ACGCACAACT GCCCATGCCT TCGCGACCTG CAGCCAGACC AGGCTCGCAG GCCCGACTAC 
GCGGTCTTCA TGCTCAAGTA CTTCATGTGC CTAGTGGTGG GCATCACATC AGGCGTGTGG 
GTCTGGTCCG GCAAGACTCT GGAGTCCTGG CGTGCGTTGT GTACTCGCTG CTGCTGGGCC 
AGCAAGGGCG CTGCAGTTGG CGCGGGCGCC GGAGGCAGCG GCCCTGGGGG CGGTGGCCCC 
GGGCCCGGTG GGGGTGGGGG GCACGGCGGA GGTGGGGGAT CCCTCTACAG CGACGTCAGC 
ACCGGCCTGA CGTGGCGGTC TGGCACGGCC AGCTCTGTAT CTTACCCTAA GCAAATGCCA 
TTGTCCCAAG TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fzd8 ( XM_006254142.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254204.1 Rattus norvegicus frizzled class receptor 8 (Fzd8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa13725
Clone ID Related Accession (Same CDS sequence)	XM_006254142.3 , NM_001044251.2
Accession Version	XM_006254142.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2055bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	frizzled-8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005116.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006254142.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTGGG GTTACCTGTT GGAAGTGACC TCGCTACTAG CCGCCTTGGC GGTGCTACAG 
CGCTCGAGCG GCGCTGCCGC GGCTTCGGCC AAGGAGCTGG CGTGCCAAGA GATCACAGTG 
CCGCTGTGCA AGGGCATCGG TTACAACTAC ACCTACATGC CCAACCAGTT CAACCACGAC 
ACGCAAGATG AGGCGGGCCT AGAGGTACAC CAGTTCTGGC CGCTGGTGGA GATCCAGTGC 
TCCCCGGACC TCAAGTTCTT TCTGTGTAGC ATGTACACGC CCATCTGCCT GGAGGACTAC 
AAGAAACCTC TGCCGCCTTG CCGCTCTGTG TGTGAACGCG CCAAGGCCGG CTGCGCGCCG 
CTCATGCGCC AGTACGGCTT TGCCTGGCCT GACCGAATGC GCTGCGATCG GCTGCCGGAG 
CAGGGCAACC CCGACACTCT GTGCATGGAC TACAACCGCA CCGACCTCAC CACGGCCGCG 
CCCAGCCCAC CGCGCCGCCT GCCGCCGCCG CAGCCTGGCG AGCAGCCGCC CTCCGGCAGC 
GGCCACAGCC GCCCGCCAGG GGCCAGGCCC CCACATCGTG GCGGCAGCAG TAGGGGCAGC 
GGGGACACGG CGGCTGCGCC CCCCTCTCGC GGCGGGAAGG CGAGGCCCCC TGGTGGCGGC 
GCCGCTCCCT GCGAGCCCGG GTGCCAGTGC CGCGCGCCCA TGGTGAGTGT GTCCAGCGAA 
CGCCACCCGC TCTACAACCG CGTCAAGACC GGCCAGATCG CCAACTGTGC GCTGCCCTGC 
CACAACCCCT TCTTTAGCCA GGATGAGCGC GCCTTCACTG TCTTCTGGAT CGGCTTGTGG 
TCGGTGCTCT GCTTCGTCTC CACCTTCGCC ACTGTCTCTA CCTTCCTCAT CGATATGGAG 
CGCTTTAAGT ACCCGGAACG GCCCATTATA TTCCTCTCTG CCTGCTACCT CTTCGTGTCT 
GTCGGGTACC TGGTGCGCCT GGTGGCTGGA CACGAGAAAG TGGCCTGCAG CGGCGGCGCG 
CCGGGTGCAG GAGGAGCTGG GGGTGCTGGC GGCGCGGCGA CCGCTGGCGC GGGGGCGGCG 
GGAGCGGGGG CGAGCAGCCC GGGCGCGCGC GGCGAGTACG AGGAGCTGGG TGCAGTGGAG 
CAGCACGTGC GCTATGAGAC CACTGGCCCC GCGCTGTGCA CGGTAGTCTT CCTCCTTGTC 
TACTTTTTTG GCATGGCTAG CTCCATCTGG TGGGTAATCC TGTCTCTCAC GTGGTTCTTG 
GCGGCTGGTA TGAAATGGGG CAACGAGGCC ATAGCAGGCT ACTCGCAATA CTTCCACCTT 
GCCGCGTGGC TCGTGCCCAG CGTCAAGTCC ATAGCGGTGC TGGCGCTCAG CTCCGTGGAC 
GGCGACCCGG TGGCGGGCAT CTGCTACGTG GGCAACCAGA GCCTTGACAA CCTACGCGGC 
TTTGTACTGG CGCCACTGGT CATCTACCTC TTCATTGGGA CTATGTTTCT GTTAGCTGGC 
TTCGTGTCGC TGTTCCGAAT CCGCTCAGTC ATCAAGCAAC AAGGAGGCCC AACCAAGACT 
CACAAGCTAG AAAAGCTCAT GATCCGCTTG GGCCTCTTCA CCGTGCTCTA CACGGTGCCC 
GCCGCCGTCG TTGTCGCCTG CCTTTTCTAT GAGCAGCACA ACCGACCGCG CTGGGAGGCC 
ACGCACAACT GCCCATGCCT TCGCGACCTG CAGCCAGACC AGGCTCGCAG GCCCGACTAC 
GCGGTCTTCA TGCTCAAGTA CTTCATGTGC CTAGTGGTGG GCATCACATC AGGCGTGTGG 
GTCTGGTCCG GCAAGACTCT GGAGTCCTGG CGTGCGTTGT GTACTCGCTG CTGCTGGGCC 
AGCAAGGGCG CTGCAGTTGG CGCGGGCGCC GGAGGCAGCG GCCCTGGGGG CGGTGGCCCC 
GGGCCCGGTG GGGGTGGGGG GCACGGCGGA GGTGGGGGAT CCCTCTACAG CGACGTCAGC 
ACCGGCCTGA CGTGGCGGTC TGGCACGGCC AGCTCTGTAT CTTACCCTAA GCAAATGCCA 
TTGTCCCAAG TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254204.1
CDS	1664..3718
Translation	MEWGYLLEVTSLLAALAVLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPQPGEQPPSGSGHSRPPGARPPHRGGSSRGSGDTAAAPPSRGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAATAGAGAAGAGASSPGARGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRALCTRCCWASKGAAVGAGAGGSGPGGGGPGPGGGGGHGGGGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV

Target ORF information:

RefSeq Version	XM_006254142.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus frizzled class receptor 8 (Fzd8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254142.3

ORF Insert Sequence:

ATGGAGTGGG GTTACCTGTT GGAAGTGACC TCGCTACTAG CCGCCTTGGC GGTGCTACAG 
CGCTCGAGCG GCGCTGCCGC GGCTTCGGCC AAGGAGCTGG CGTGCCAAGA GATCACAGTG 
CCGCTGTGCA AGGGCATCGG TTACAACTAC ACCTACATGC CCAACCAGTT CAACCACGAC 
ACGCAAGATG AGGCGGGCCT AGAGGTACAC CAGTTCTGGC CGCTGGTGGA GATCCAGTGC 
TCCCCGGACC TCAAGTTCTT TCTGTGTAGC ATGTACACGC CCATCTGCCT GGAGGACTAC 
AAGAAACCTC TGCCGCCTTG CCGCTCTGTG TGTGAACGCG CCAAGGCCGG CTGCGCGCCG 
CTCATGCGCC AGTACGGCTT TGCCTGGCCT GACCGAATGC GCTGCGATCG GCTGCCGGAG 
CAGGGCAACC CCGACACTCT GTGCATGGAC TACAACCGCA CCGACCTCAC CACGGCCGCG 
CCCAGCCCAC CGCGCCGCCT GCCGCCGCCG CAGCCTGGCG AGCAGCCGCC CTCCGGCAGC 
GGCCACAGCC GCCCGCCAGG GGCCAGGCCC CCACATCGTG GCGGCAGCAG TAGGGGCAGC 
GGGGACACGG CGGCTGCGCC CCCCTCTCGC GGCGGGAAGG CGAGGCCCCC TGGTGGCGGC 
GCCGCTCCCT GCGAGCCCGG GTGCCAGTGC CGCGCGCCCA TGGTGAGTGT GTCCAGCGAA 
CGCCACCCGC TCTACAACCG CGTCAAGACC GGCCAGATCG CCAACTGTGC GCTGCCCTGC 
CACAACCCCT TCTTTAGCCA GGATGAGCGC GCCTTCACTG TCTTCTGGAT CGGCTTGTGG 
TCGGTGCTCT GCTTCGTCTC CACCTTCGCC ACTGTCTCTA CCTTCCTCAT CGATATGGAG 
CGCTTTAAGT ACCCGGAACG GCCCATTATA TTCCTCTCTG CCTGCTACCT CTTCGTGTCT 
GTCGGGTACC TGGTGCGCCT GGTGGCTGGA CACGAGAAAG TGGCCTGCAG CGGCGGCGCG 
CCGGGTGCAG GAGGAGCTGG GGGTGCTGGC GGCGCGGCGA CCGCTGGCGC GGGGGCGGCG 
GGAGCGGGGG CGAGCAGCCC GGGCGCGCGC GGCGAGTACG AGGAGCTGGG TGCAGTGGAG 
CAGCACGTGC GCTATGAGAC CACTGGCCCC GCGCTGTGCA CGGTAGTCTT CCTCCTTGTC 
TACTTTTTTG GCATGGCTAG CTCCATCTGG TGGGTAATCC TGTCTCTCAC GTGGTTCTTG 
GCGGCTGGTA TGAAATGGGG CAACGAGGCC ATAGCAGGCT ACTCGCAATA CTTCCACCTT 
GCCGCGTGGC TCGTGCCCAG CGTCAAGTCC ATAGCGGTGC TGGCGCTCAG CTCCGTGGAC 
GGCGACCCGG TGGCGGGCAT CTGCTACGTG GGCAACCAGA GCCTTGACAA CCTACGCGGC 
TTTGTACTGG CGCCACTGGT CATCTACCTC TTCATTGGGA CTATGTTTCT GTTAGCTGGC 
TTCGTGTCGC TGTTCCGAAT CCGCTCAGTC ATCAAGCAAC AAGGAGGCCC AACCAAGACT 
CACAAGCTAG AAAAGCTCAT GATCCGCTTG GGCCTCTTCA CCGTGCTCTA CACGGTGCCC 
GCCGCCGTCG TTGTCGCCTG CCTTTTCTAT GAGCAGCACA ACCGACCGCG CTGGGAGGCC 
ACGCACAACT GCCCATGCCT TCGCGACCTG CAGCCAGACC AGGCTCGCAG GCCCGACTAC 
GCGGTCTTCA TGCTCAAGTA CTTCATGTGC CTAGTGGTGG GCATCACATC AGGCGTGTGG 
GTCTGGTCCG GCAAGACTCT GGAGTCCTGG CGTGCGTTGT GTACTCGCTG CTGCTGGGCC 
AGCAAGGGCG CTGCAGTTGG CGCGGGCGCC GGAGGCAGCG GCCCTGGGGG CGGTGGCCCC 
GGGCCCGGTG GGGGTGGGGG GCACGGCGGA GGTGGGGGAT CCCTCTACAG CGACGTCAGC 
ACCGGCCTGA CGTGGCGGTC TGGCACGGCC AGCTCTGTAT CTTACCCTAA GCAAATGCCA 
TTGTCCCAAG TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(11)4832-4844(2017 Nov)
Voloshanenko O,Gmach P,Winter J,Kranz D,Boutros M

miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts.
Immunology letters164(1)1-10(2015 Mar)
Miao CG,Shi WJ,Xiong YY,Yu H,Zhang XL,Qin MS,Du CL,Song TW,Li J

Structural basis of Wnt recognition by Frizzled.
Science (New York, N.Y.)337(6090)59-64(2012 Jul)
Janda CY,Waghray D,Levin AM,Thomas C,Garcia KC

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
Nature485(7397)195-200(2012 Apr)
Hao HX,Xie Y,Zhang Y,Charlat O,Oster E,Avello M,Lei H,Mickanin C,Liu D,Ruffner H,Mao X,Ma Q,Zamponi R,Bouwmeester T,Finan PM,Kirschner MW,Porter JA,Serluca FC,Cong F

Frizzled-8 as a putative therapeutic target in human lung cancer.
Biochemical and biophysical research communications417(1)62-6(2012 Jan)
Wang HQ,Xu ML,Ma J,Zhang Y,Xie CH

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Fzd8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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