Itk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Itk
Entrez Gene ID	363577
Full Name	IL2-inducible T-cell kinase
General protein information	Preferred Names IL2-inducible T-cell kinase Names tyrosine-protein kinase ITK/TSK
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q21

mRNA and Protein(s)

mRNA	Protein	Name
XM_017597420.1	XP_017452909.1	tyrosine-protein kinase ITK/TSK isoform X1
NM_001108825.1	NP_001102295.1	tyrosine-protein kinase ITK/TSK

Pathways from BioSystems

Homologies

Homo sapiens (human)	ITK	NP_005537.3
Pan troglodytes (chimpanzee)	ITK	XP_001136073.1
Bos taurus (cattle)	ITK	NP_001098858.1
Canis lupus familiaris (dog)	ITK	XP_546277.3
Mus musculus (house mouse)	Itk	NP_001268894.1
	ITK	XP_001113468.1
Danio rerio (zebrafish)	itk	NP_571179.1
Rattus norvegicus (Norway rat)	Itk	NP_001102295.1
Gallus gallus (chicken)	ITK	XP_414568.3

Gene Ontology
Bibliography

Related articles in PubMed

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Liang Y, Cucchetti M, Roncagalli R, Yokosuka T, Malzac A, Bertosio E, Imbert J, Nijman IJ, Suchanek M, Saito T, W?lfing C, Malissen B, Malissen M
Nature immunology14(8)858-66(2013 Aug)

The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival.
Felices M, Berg LJ
Journal of immunology (Baltimore, Md. : 1950)180(5)3007-18(2008 Mar)

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH
Science (New York, N.Y.)307(5708)430-3(2005 Jan)

Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.
Perez-Villar JJ, Whitney GS, Sitnick MT, Dunn RJ, Venkatesan S, O'Day K, Schieven GL, Lin TA, Kanner SB
Biochemistry41(34)10732-40(2002 Aug)

Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.
Schaeffer EM, Debnath J, Yap G, McVicar D, Liao XC, Littman DR, Sher A, Varmus HE, Lenardo MJ, Schwartzberg PL
Science (New York, N.Y.)284(5414)638-41(1999 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Itk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08440	NM_001108825.1 Latest version!	Rattus norvegicus IL2-inducible T-cell kinase (Itk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa57412	XM_017597420.1 Latest version!	Rattus norvegicus IL2-inducible T-cell kinase (Itk), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Itk ( NM_001108825.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102295.1 Rattus norvegicus IL2-inducible T-cell kinase (Itk), mRNA.

Price & Availability↑

CloneID	ORa08440
Clone ID Related Accession (Same CDS sequence)	NM_001108825.1
Accession Version	NM_001108825.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1881bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase ITK/TSK
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473948.1. On or before Oct 4, 2007 this sequence version replaced XM_343880.3, XM_001068937.1, XM_001068881.1. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2689594, SAMEA2689599 [ECO:0000350] ##Evidence-Data-END##

ATGAACAACT TCATCCTCCT GGAAGAACAG CTGATCAAGA AGTCCCAACA GAAGAGAAGG 
ACTTCTCCCT CGAATTTTAA AGTCCGTTTC TTCGTCTTAA CGAAAGCCAG CCTGGCATAC 
TTCGAGGACC GCCACGGGAA GAAGCGCACG TTGAAGGGCT CCATCGAACT CTCCAGAATC 
AAGTGCGTGG AGATTGTCAA GAGTGACATT AGCATCCCGT GCCACTATAA ATACCCTTTT 
CAGACTCTTA CGTCCTTCCA GGTCATGCAC GACAACTACC TCCTGTACGT GTTTGCTCCA 
GACTGCGAGA GCCGTCAGCG CTGGGTGCTC ACCCTTAAAG AAGAAACGAG GAATAACAAC 
AGCCTAGTAT CCAAGTATCA CCCTAATTTC TGGATGGATG GGCGGTGGAG GTGCTGTTCC 
CAGCTAGAGA AGCTTGCCGT AGGCTGTGCT CCCTACGACC CAACGAAGAA TGCTTCAAAG 
AAGCCTCTTC CTCCTACTCC TGAAGACAAC AGGCGGTCAT TTCAGGAACC TGAAGAAACC 
CTGGTCATTG CCTTGTACGA CTACCAAACC AACGATCCTC AGGAGCTCGC GCTGCGGCGT 
GATGAAGAGT ACTACCTGCT GGACAGCTCC GAGATCCACT GGTGGCGGGT TCAAGACAAG 
AATGGGCATG AAGGATATGC ACCCAGCAGT TACCTGGTGG AAAAGTCTCC AAATAGCCTT 
GAAACCTACG AGTGGTACAA TAAAAGCATC AGCCGAGACA AAGCTGAAAA ACTTCTTTTG 
GACACAGGTA AAGAAGGAGC ATTCATGGTC CGAGATTCCA GGACACCCGG GACATACACA 
GTCTCTGTCT TCACCAAGGC CATCATAAGT GAGAACAACC CCTGTATAAA ACATTATCAC 
ATCAAAGAAA CAAATGACAG CCCCAAGCGG TACTATGTGG CTGAGAAGTA TGTGTTTGAC 
TCCATCCCTC TCCTCATCCA GTATCACCAA TACAATGGAG GAGGTTTGGT CACTCGACTC 
CGGTATCCAG TTTGCTCCTG GAGGCAGAAA GCCCCTGTCA CAGCAGGGCT AAGATATGGG 
AAGTGGGTGA TCCAGCCCTC GGAGCTAACT TTCGTGCAGG AGATTGGCAG CGGGCAGTTT 
GGACTGGTGC ATCTCGGCTA CTGGCTCAAC AAGGACAAGG TGGCCATCAA GACCATTCAG 
GAAGGGGCGA TGTCAGAAGA AGACTTTATC GAGGAGGCAG AAGTCATGAT GAAACTCTCT 
CACCCCAAGC TGGTGCAGCT CTATGGGGTG TGCTTGGAGC AAGCCCCCAT CTGCCTGGTG 
TTTGAGTTCA TGGAGCACGG CTGCCTATCG GATTACCTTC GAAGTCAGCG GGGTCTCTTT 
GCTGCAGAGA CCCTGCTGGG CATGTGCCTG GACGTGTGTG AGGGCATGGC CTACCTAGAA 
AAAGCGTGTG TCATCCACAG AGACCTGGCC GCCAGGAACT GTTTGGTGGG AGAAAACCAG 
GTCATCAAGG TGTCCGACTT CGGCATGACA AGGTTTGTCC TTGATGATCA ATATACCAGC 
TCCACGGGCA CCAAATTCCC AGTGAAGTGG GCATCCCCAG AAGTGTTCTC CTTCAGCCGC 
TACAGCAGCA AGTCAGATGT GTGGTCATTT GGTGTACTGA TGTGGGAAGT CTTCAGCGAA 
GGCAAAATCC CATATGAAAA CCGAAGCAAT TCAGAGGTCG TGGAAGACAT CAGCACTGGC 
TTTCGGTTAT ACAAGCCCCG CCTGGCCTCC CCTCATGTCT ACCAGGTCAT GAATCACTGC 
TGGAAAGAGA AACCGGAAGA CCGGCCACCC TTCTCCCGGC TGTTAAGCCA ACTGGCTGAA 
ATCGCAGAAT GTGGACTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102295.1
CDS	91..1971
Translation	MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQTLTSFQVMHDNYLLYVFAPDCESRQRWVLTLKEETRNNNSLVSKYHPNFWMDGRWRCCSQLEKLAVGCAPYDPTKNASKKPLPPTPEDNRRSFQEPEETLVIALYDYQTNDPQELALRRDEEYYLLDSSEIHWWRVQDKNGHEGYAPSSYLVEKSPNSLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTPGTYTVSVFTKAIISENNPCIKHYHIKETNDSPKRYYVAEKYVFDSIPLLIQYHQYNGGGLVTRLRYPVCSWRQKAPVTAGLRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASPHVYQVMNHCWKEKPEDRPPFSRLLSQLAEIAECGL

Target ORF information:

RefSeq Version	NM_001108825.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus IL2-inducible T-cell kinase (Itk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108825.1

ORF Insert Sequence:

ATGAACAACT TCATCCTCCT GGAAGAACAG CTGATCAAGA AGTCCCAACA GAAGAGAAGG 
ACTTCTCCCT CGAATTTTAA AGTCCGTTTC TTCGTCTTAA CGAAAGCCAG CCTGGCATAC 
TTCGAGGACC GCCACGGGAA GAAGCGCACG TTGAAGGGCT CCATCGAACT CTCCAGAATC 
AAGTGCGTGG AGATTGTCAA GAGTGACATT AGCATCCCGT GCCACTATAA ATACCCTTTT 
CAGACTCTTA CGTCCTTCCA GGTCATGCAC GACAACTACC TCCTGTACGT GTTTGCTCCA 
GACTGCGAGA GCCGTCAGCG CTGGGTGCTC ACCCTTAAAG AAGAAACGAG GAATAACAAC 
AGCCTAGTAT CCAAGTATCA CCCTAATTTC TGGATGGATG GGCGGTGGAG GTGCTGTTCC 
CAGCTAGAGA AGCTTGCCGT AGGCTGTGCT CCCTACGACC CAACGAAGAA TGCTTCAAAG 
AAGCCTCTTC CTCCTACTCC TGAAGACAAC AGGCGGTCAT TTCAGGAACC TGAAGAAACC 
CTGGTCATTG CCTTGTACGA CTACCAAACC AACGATCCTC AGGAGCTCGC GCTGCGGCGT 
GATGAAGAGT ACTACCTGCT GGACAGCTCC GAGATCCACT GGTGGCGGGT TCAAGACAAG 
AATGGGCATG AAGGATATGC ACCCAGCAGT TACCTGGTGG AAAAGTCTCC AAATAGCCTT 
GAAACCTACG AGTGGTACAA TAAAAGCATC AGCCGAGACA AAGCTGAAAA ACTTCTTTTG 
GACACAGGTA AAGAAGGAGC ATTCATGGTC CGAGATTCCA GGACACCCGG GACATACACA 
GTCTCTGTCT TCACCAAGGC CATCATAAGT GAGAACAACC CCTGTATAAA ACATTATCAC 
ATCAAAGAAA CAAATGACAG CCCCAAGCGG TACTATGTGG CTGAGAAGTA TGTGTTTGAC 
TCCATCCCTC TCCTCATCCA GTATCACCAA TACAATGGAG GAGGTTTGGT CACTCGACTC 
CGGTATCCAG TTTGCTCCTG GAGGCAGAAA GCCCCTGTCA CAGCAGGGCT AAGATATGGG 
AAGTGGGTGA TCCAGCCCTC GGAGCTAACT TTCGTGCAGG AGATTGGCAG CGGGCAGTTT 
GGACTGGTGC ATCTCGGCTA CTGGCTCAAC AAGGACAAGG TGGCCATCAA GACCATTCAG 
GAAGGGGCGA TGTCAGAAGA AGACTTTATC GAGGAGGCAG AAGTCATGAT GAAACTCTCT 
CACCCCAAGC TGGTGCAGCT CTATGGGGTG TGCTTGGAGC AAGCCCCCAT CTGCCTGGTG 
TTTGAGTTCA TGGAGCACGG CTGCCTATCG GATTACCTTC GAAGTCAGCG GGGTCTCTTT 
GCTGCAGAGA CCCTGCTGGG CATGTGCCTG GACGTGTGTG AGGGCATGGC CTACCTAGAA 
AAAGCGTGTG TCATCCACAG AGACCTGGCC GCCAGGAACT GTTTGGTGGG AGAAAACCAG 
GTCATCAAGG TGTCCGACTT CGGCATGACA AGGTTTGTCC TTGATGATCA ATATACCAGC 
TCCACGGGCA CCAAATTCCC AGTGAAGTGG GCATCCCCAG AAGTGTTCTC CTTCAGCCGC 
TACAGCAGCA AGTCAGATGT GTGGTCATTT GGTGTACTGA TGTGGGAAGT CTTCAGCGAA 
GGCAAAATCC CATATGAAAA CCGAAGCAAT TCAGAGGTCG TGGAAGACAT CAGCACTGGC 
TTTCGGTTAT ACAAGCCCCG CCTGGCCTCC CCTCATGTCT ACCAGGTCAT GAATCACTGC 
TGGAAAGAGA AACCGGAAGA CCGGCCACCC TTCTCCCGGC TGTTAAGCCA ACTGGCTGAA 
ATCGCAGAAT GTGGACTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Itk ( XM_017597420.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017452909.1 Rattus norvegicus IL2-inducible T-cell kinase (Itk), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa57412
Clone ID Related Accession (Same CDS sequence)	XM_017597420.1
Accession Version	XM_017597420.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1863bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase ITK/TSK isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACAACT TCATCCTCCT GGAAGAACAG CTGATCAAGA AGTCCCAACA GAAGAGAAGG 
ACTTCTCCCT CGAATTTTAA AGTCCGTTTC TTCGTCTTAA CGAAAGCCAG CCTGGCATAC 
TTCGAGGACC GCCACGGGAA GAAGCGCACG TTGAAGGGCT CCATCGAACT CTCCAGAATC 
AAGTGCGTGG AGATTGTCAA GAGTGACATT AGCATCCCGT GCCACTATAA ATACCCTTTT 
CAGGTCATGC ACGACAACTA CCTCCTGTAC GTGTTTGCTC CAGACTGCGA GAGCCGTCAG 
CGCTGGGTGC TCACCCTTAA AGAAGAAACG AGGAATAACA ACAGCCTAGT ATCCAAGTAT 
CACCCTAATT TCTGGATGGA TGGGCGGTGG AGGTGCTGTT CCCAGCTAGA GAAGCTTGCC 
GTAGGCTGTG CTCCCTACGA CCCAACGAAG AATGCTTCAA AGAAGCCTCT TCCTCCTACT 
CCTGAAGACA ACAGGCGGTC ATTTCAGGAA CCTGAAGAAA CCCTGGTCAT TGCCTTGTAC 
GACTACCAAA CCAACGATCC TCAGGAGCTC GCGCTGCGGC GTGATGAAGA GTACTACCTG 
CTGGACAGCT CCGAGATCCA CTGGTGGCGG GTTCAAGACA AGAATGGGCA TGAAGGATAT 
GCACCCAGCA GTTACCTGGT GGAAAAGTCT CCAAATAGCC TTGAAACCTA CGAGTGGTAC 
AATAAAAGCA TCAGCCGAGA CAAAGCTGAA AAACTTCTTT TGGACACAGG TAAAGAAGGA 
GCATTCATGG TCCGAGATTC CAGGACACCC GGGACATACA CAGTCTCTGT CTTCACCAAG 
GCCATCATAA GTGAGAACAA CCCCTGTATA AAACATTATC ACATCAAAGA AACAAATGAC 
AGCCCCAAGC GGTACTATGT GGCTGAGAAG TATGTGTTTG ACTCCATCCC TCTCCTCATC 
CAGTATCACC AATACAATGG AGGAGGTTTG GTCACTCGAC TCCGGTATCC AGTTTGCTCC 
TGGAGGCAGA AAGCCCCTGT CACAGCAGGG CTAAGATATG GGAAGTGGGT GATCCAGCCC 
TCGGAGCTAA CTTTCGTGCA GGAGATTGGC AGCGGGCAGT TTGGACTGGT GCATCTCGGC 
TACTGGCTCA ACAAGGACAA GGTGGCCATC AAGACCATTC AGGAAGGGGC GATGTCAGAA 
GAAGACTTTA TCGAGGAGGC AGAAGTCATG ATGAAACTCT CTCACCCCAA GCTGGTGCAG 
CTCTATGGGG TGTGCTTGGA GCAAGCCCCC ATCTGCCTGG TGTTTGAGTT CATGGAGCAC 
GGCTGCCTAT CGGATTACCT TCGAAGTCAG CGGGGTCTCT TTGCTGCAGA GACCCTGCTG 
GGCATGTGCC TGGACGTGTG TGAGGGCATG GCCTACCTAG AAAAAGCGTG TGTCATCCAC 
AGAGACCTGG CCGCCAGGAA CTGTTTGGTG GGAGAAAACC AGGTCATCAA GGTGTCCGAC 
TTCGGCATGA CAAGGTTTGT CCTTGATGAT CAATATACCA GCTCCACGGG CACCAAATTC 
CCAGTGAAGT GGGCATCCCC AGAAGTGTTC TCCTTCAGCC GCTACAGCAG CAAGTCAGAT 
GTGTGGTCAT TTGGTGTACT GATGTGGGAA GTCTTCAGCG AAGGCAAAAT CCCATATGAA 
AACCGAAGCA ATTCAGAGGT CGTGGAAGAC ATCAGCACTG GCTTTCGGTT ATACAAGCCC 
CGCCTGGCCT CCCCTCATGT CTACCAGGTC ATGAATCACT GCTGGAAAGA GAAACCGGAA 
GACCGGCCAC CCTTCTCCCG GCTGTTAAGC CAACTGGCTG AAATCGCAGA ATGTGGACTT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017452909.1
CDS	147..2009
Translation	MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVMHDNYLLYVFAPDCESRQRWVLTLKEETRNNNSLVSKYHPNFWMDGRWRCCSQLEKLAVGCAPYDPTKNASKKPLPPTPEDNRRSFQEPEETLVIALYDYQTNDPQELALRRDEEYYLLDSSEIHWWRVQDKNGHEGYAPSSYLVEKSPNSLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTPGTYTVSVFTKAIISENNPCIKHYHIKETNDSPKRYYVAEKYVFDSIPLLIQYHQYNGGGLVTRLRYPVCSWRQKAPVTAGLRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASPHVYQVMNHCWKEKPEDRPPFSRLLSQLAEIAECGL

Target ORF information:

RefSeq Version	XM_017597420.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus IL2-inducible T-cell kinase (Itk), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597420.1

ORF Insert Sequence:

ATGAACAACT TCATCCTCCT GGAAGAACAG CTGATCAAGA AGTCCCAACA GAAGAGAAGG 
ACTTCTCCCT CGAATTTTAA AGTCCGTTTC TTCGTCTTAA CGAAAGCCAG CCTGGCATAC 
TTCGAGGACC GCCACGGGAA GAAGCGCACG TTGAAGGGCT CCATCGAACT CTCCAGAATC 
AAGTGCGTGG AGATTGTCAA GAGTGACATT AGCATCCCGT GCCACTATAA ATACCCTTTT 
CAGGTCATGC ACGACAACTA CCTCCTGTAC GTGTTTGCTC CAGACTGCGA GAGCCGTCAG 
CGCTGGGTGC TCACCCTTAA AGAAGAAACG AGGAATAACA ACAGCCTAGT ATCCAAGTAT 
CACCCTAATT TCTGGATGGA TGGGCGGTGG AGGTGCTGTT CCCAGCTAGA GAAGCTTGCC 
GTAGGCTGTG CTCCCTACGA CCCAACGAAG AATGCTTCAA AGAAGCCTCT TCCTCCTACT 
CCTGAAGACA ACAGGCGGTC ATTTCAGGAA CCTGAAGAAA CCCTGGTCAT TGCCTTGTAC 
GACTACCAAA CCAACGATCC TCAGGAGCTC GCGCTGCGGC GTGATGAAGA GTACTACCTG 
CTGGACAGCT CCGAGATCCA CTGGTGGCGG GTTCAAGACA AGAATGGGCA TGAAGGATAT 
GCACCCAGCA GTTACCTGGT GGAAAAGTCT CCAAATAGCC TTGAAACCTA CGAGTGGTAC 
AATAAAAGCA TCAGCCGAGA CAAAGCTGAA AAACTTCTTT TGGACACAGG TAAAGAAGGA 
GCATTCATGG TCCGAGATTC CAGGACACCC GGGACATACA CAGTCTCTGT CTTCACCAAG 
GCCATCATAA GTGAGAACAA CCCCTGTATA AAACATTATC ACATCAAAGA AACAAATGAC 
AGCCCCAAGC GGTACTATGT GGCTGAGAAG TATGTGTTTG ACTCCATCCC TCTCCTCATC 
CAGTATCACC AATACAATGG AGGAGGTTTG GTCACTCGAC TCCGGTATCC AGTTTGCTCC 
TGGAGGCAGA AAGCCCCTGT CACAGCAGGG CTAAGATATG GGAAGTGGGT GATCCAGCCC 
TCGGAGCTAA CTTTCGTGCA GGAGATTGGC AGCGGGCAGT TTGGACTGGT GCATCTCGGC 
TACTGGCTCA ACAAGGACAA GGTGGCCATC AAGACCATTC AGGAAGGGGC GATGTCAGAA 
GAAGACTTTA TCGAGGAGGC AGAAGTCATG ATGAAACTCT CTCACCCCAA GCTGGTGCAG 
CTCTATGGGG TGTGCTTGGA GCAAGCCCCC ATCTGCCTGG TGTTTGAGTT CATGGAGCAC 
GGCTGCCTAT CGGATTACCT TCGAAGTCAG CGGGGTCTCT TTGCTGCAGA GACCCTGCTG 
GGCATGTGCC TGGACGTGTG TGAGGGCATG GCCTACCTAG AAAAAGCGTG TGTCATCCAC 
AGAGACCTGG CCGCCAGGAA CTGTTTGGTG GGAGAAAACC AGGTCATCAA GGTGTCCGAC 
TTCGGCATGA CAAGGTTTGT CCTTGATGAT CAATATACCA GCTCCACGGG CACCAAATTC 
CCAGTGAAGT GGGCATCCCC AGAAGTGTTC TCCTTCAGCC GCTACAGCAG CAAGTCAGAT 
GTGTGGTCAT TTGGTGTACT GATGTGGGAA GTCTTCAGCG AAGGCAAAAT CCCATATGAA 
AACCGAAGCA ATTCAGAGGT CGTGGAAGAC ATCAGCACTG GCTTTCGGTT ATACAAGCCC 
CGCCTGGCCT CCCCTCATGT CTACCAGGTC ATGAATCACT GCTGGAAAGA GAAACCGGAA 
GACCGGCCAC CCTTCTCCCG GCTGTTAAGC CAACTGGCTG AAATCGCAGA ATGTGGACTT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Nature immunology14(8)858-66(2013 Aug)
Liang Y,Cucchetti M,Roncagalli R,Yokosuka T,Malzac A,Bertosio E,Imbert J,Nijman IJ,Suchanek M,Saito T,W?lfing C,Malissen B,Malissen M

The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival.
Journal of immunology (Baltimore, Md. : 1950)180(5)3007-18(2008 Mar)
Felices M,Berg LJ

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
Science (New York, N.Y.)307(5708)430-3(2005 Jan)
Hwang ES,Szabo SJ,Schwartzberg PL,Glimcher LH

Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.
Biochemistry41(34)10732-40(2002 Aug)
Perez-Villar JJ,Whitney GS,Sitnick MT,Dunn RJ,Venkatesan S,O'Day K,Schieven GL,Lin TA,Kanner SB

Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.
Science (New York, N.Y.)284(5414)638-41(1999 Apr)
Schaeffer EM,Debnath J,Yap G,McVicar D,Liao XC,Littman DR,Sher A,Varmus HE,Lenardo MJ,Schwartzberg PL

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Itk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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