Tmeff2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tmeff2
Entrez Gene ID	363228
Full Name	transmembrane protein with EGF-like and two follistatin-like domains 2
General protein information	Preferred Names transmembrane protein with EGF-like and two follistatin-like domains 2 Names tomoregulin-2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q22

mRNA and Protein(s)

mRNA	Protein	Name
XM_017596515.1	XP_017452004.1	tomoregulin-2 isoform X1
NM_001108795.1	NP_001102265.1	tomoregulin-2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Tmeff2	NP_001102265.1
Xenopus tropicalis (tropical clawed frog)	tmeff2	NP_001090692.1

Gene Ontology
Bibliography

Related articles in PubMed

The TMEFF2 tumor suppressor modulates integrin expression, RhoA activation and migration of prostate cancer cells.
Chen X, Corbin JM, Tipton GJ, Yang LV, Asch AS, Ruiz-Echevarr?a MJ
Biochimica et biophysica acta1843(6)1216-24(2014 Jun)

Refined mapping of blood pressure quantitative trait loci using congenic strains developed from two genetically hypertensive rat models.
Kumarasamy S, Gopalakrishnan K, Toland EJ, Yerga-Woolwine S, Farms P, Morgan EE, Joe B
Hypertension research : official journal of the Japanese Society of Hypertension34(12)1263-70(2011 Dec)

Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo.
Chen Q, Watson JT, Marengo SR, Decker KS, Coleman I, Nelson PS, Sikes RA
Cancer letters244(2)274-88(2006 Dec)

Preclinical validation of anti-TMEFF2-auristatin E-conjugated antibodies in the treatment of prostate cancer.
Afar DE, Bhaskar V, Ibsen E, Breinberg D, Henshall SM, Kench JG, Drobnjak M, Powers R, Wong M, Evangelista F, O'Hara C, Powers D, DuBridge RB, Caras I, Winter R, Anderson T, Solvason N, Stricker PD, Cordon-Cardo C, Scher HI, Grygiel JJ, Sutherland RL, Murray R, Ramakrishnan V, Law DA
Molecular cancer therapeutics3(8)921-32(2004 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Tmeff2 can be prioritized as a candidate gene for hypertension and associated cardiac hypertrophy in both rats and in humans
Title: Refined mapping of blood pressure quantitative trait loci using congenic strains developed from two genetically hypertensive rat models.

The following Tmeff2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tmeff2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13489	NM_001108795.1 Latest version!	Rattus norvegicus transmembrane protein with EGF-like and two follistatin-like domains 2 (Tmeff2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa62806	XM_017596515.1 Latest version!	Rattus norvegicus transmembrane protein with EGF-like and two follistatin-like domains 2 (Tmeff2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tmeff2 ( NM_001108795.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102265.1 Rattus norvegicus transmembrane protein with EGF-like and two follistatin-like domains 2 (Tmeff2), mRNA.

Price & Availability↑

CloneID	ORa13489
Clone ID Related Accession (Same CDS sequence)	NM_001108795.1
Accession Version	NM_001108795.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	tomoregulin-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473965.2. On or before Oct 4, 2007 this sequence version replaced XM_343566.3, XM_001064388.1. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGTGCTGT GGGAGTCCCC GCGGCAGTGC AGCAGCTGGA CACTTTGCGA GGGCTTCTGC 
TGGCTGCTGC TGCTGCCGGT GACGCTGCTT ATCATAGCCC GCCCGGTGAA ACTCGCTGCT 
TTCCCTACCT CCTTAAGTGA CTGCCAAACG CCCACCGGCT GGAACTGCTC CGGTTACGAT 
GACAGAGAAA ATGATCTCTT CCTGTGTGAT ACCAACACCT GTAAATTTGA CGGGGAATGT 
CTAAGGATTG GAGACACTGT GACTTGCGTC TGTCAGTTCA AGTGTAACAG TGACTACGTG 
CCTGTGTGTG GCTCCAATGG AGAGAGCTAC CAGAATGAAT GCTACCTGAG GCAAGCTGCC 
TGCAAGCAAC AGAGTGAGAT ACTTGTGGTC TCAGAAGGAT CCTGTGCTAC AGATGCAGGA 
TCGGGATCTG GAGACGGAGT CCATGAAGGC TCTGGAGAGA CCAGTCAGAA GGAGACATCT 
ACCTGTGACA TTTGCCAGTT TGGTGCGGAA TGCGATGAAG ATGCTGAGGA TGTCTGGTGT 
GTGTGCAACA TTGACTGTTC TCAAACCAAC TTTAATCCCC TCTGTGCTTC TGATGGGAAA 
TCTTATGATA ATGCATGTCA AATCAAAGAA GCGTCATGTC AGAAACAGGA GAAAATTGAA 
GTCATGTCTC TGGGTCGATG TCAAGATAAC ACAACTACAA CCACTAAATC TGAAGATGGG 
CATTATGCAA GAACAGATTA TGCAGATGTG ATGCTGGTTA TACTGGTCAA CACTGTGAAA 
AGAAGGACTA CAGTGTTCTC TACGTTGTTC CTGGTCCTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102265.1
CDS	431..1252
Translation	MVLWESPRQCSSWTLCEGFCWLLLLPVTLLIIARPVKLAAFPTSLSDCQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNSDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYADVMLVILVNTVKRRTTVFSTLFLVL

Target ORF information:

RefSeq Version	NM_001108795.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transmembrane protein with EGF-like and two follistatin-like domains 2 (Tmeff2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108795.1

ORF Insert Sequence:

ATGGTGCTGT GGGAGTCCCC GCGGCAGTGC AGCAGCTGGA CACTTTGCGA GGGCTTCTGC 
TGGCTGCTGC TGCTGCCGGT GACGCTGCTT ATCATAGCCC GCCCGGTGAA ACTCGCTGCT 
TTCCCTACCT CCTTAAGTGA CTGCCAAACG CCCACCGGCT GGAACTGCTC CGGTTACGAT 
GACAGAGAAA ATGATCTCTT CCTGTGTGAT ACCAACACCT GTAAATTTGA CGGGGAATGT 
CTAAGGATTG GAGACACTGT GACTTGCGTC TGTCAGTTCA AGTGTAACAG TGACTACGTG 
CCTGTGTGTG GCTCCAATGG AGAGAGCTAC CAGAATGAAT GCTACCTGAG GCAAGCTGCC 
TGCAAGCAAC AGAGTGAGAT ACTTGTGGTC TCAGAAGGAT CCTGTGCTAC AGATGCAGGA 
TCGGGATCTG GAGACGGAGT CCATGAAGGC TCTGGAGAGA CCAGTCAGAA GGAGACATCT 
ACCTGTGACA TTTGCCAGTT TGGTGCGGAA TGCGATGAAG ATGCTGAGGA TGTCTGGTGT 
GTGTGCAACA TTGACTGTTC TCAAACCAAC TTTAATCCCC TCTGTGCTTC TGATGGGAAA 
TCTTATGATA ATGCATGTCA AATCAAAGAA GCGTCATGTC AGAAACAGGA GAAAATTGAA 
GTCATGTCTC TGGGTCGATG TCAAGATAAC ACAACTACAA CCACTAAATC TGAAGATGGG 
CATTATGCAA GAACAGATTA TGCAGATGTG ATGCTGGTTA TACTGGTCAA CACTGTGAAA 
AGAAGGACTA CAGTGTTCTC TACGTTGTTC CTGGTCCTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tmeff2 ( XM_017596515.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017452004.1 Rattus norvegicus transmembrane protein with EGF-like and two follistatin-like domains 2 (Tmeff2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa62806
Clone ID Related Accession (Same CDS sequence)	XM_017596515.1
Accession Version	XM_017596515.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1125bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	tomoregulin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGCTGT GGGAGTCCCC GCGGCAGTGC AGCAGCTGGA CACTTTGCGA GGGCTTCTGC 
TGGCTGCTGC TGCTGCCGGT GACGCTGCTT ATCATAGCCC GCCCGGTGAA ACTCGCTGCT 
TTCCCTACCT CCTTAAGTGA CTGCCAAACG CCCACCGGCT GGAACTGCTC CGGTTACGAT 
GACAGAGAAA ATGATCTCTT CCTGTGTGAT ACCAACACCT GTAAATTTGA CGGGGAATGT 
CTAAGGATTG GAGACACTGT GACTTGCGTC TGTCAGTTCA AGTGTAACAG TGACTACGTG 
CCTGTGTGTG GCTCCAATGG AGAGAGCTAC CAGAATGAAT GCTACCTGAG GCAAGCTGCC 
TGCAAGCAAC AGAGTGAGAT ACTTGTGGTC TCAGAAGGAT CCTGTGCTAC AGATGCAGGA 
TCGGGATCTG GAGACGGAGT CCATGAAGGC TCTGGAGAGA CCAGTCAGAA GGAGACATCT 
ACCTGTGACA TTTGCCAGTT TGGTGCGGAA TGCGATGAAG ATGCTGAGGA TGTCTGGTGT 
GTGTGCAACA TTGACTGTTC TCAAACCAAC TTTAATCCCC TCTGTGCTTC TGATGGGAAA 
TCTTATGATA ATGCATGTCA AATCAAAGAA GCGTCATGTC AGAAACAGGA GAAAATTGAA 
GTCATGTCTC TGGGTCGATG TCAAGATAAC ACAACTACAA CCACTAAATC TGAAGATGGG 
CATTATGCAA GAACAGATTA TGCAGAGAAT GCTAACAAAT TAGAAGAAAG TGCCAGAGAA 
CACCACATAC CTTGTCCAGA ACACTACAAC GGTTTCTGCA TGCATGGCAA GTGTGAACAC 
TCCATCAATA TGCAGGAGCC ATCTTGCAGA TGTGATGCTG GTTATACTGG TCAACACTGT 
GAAAAGAAGG ACTACAGTGT TCTCTACGTT GTTCCTGGTC CTGTAAGATT CCAGTACGTC 
TTGATTGCAG CTGTGATTGG AACAATTCAG ATTGCTGTCA TCTGTGTGGT GGTCCTCTGT 
ATCACAAGGA AATGTCCCAG AAGCAACAGA ATTCACAGAC AGAAGCAAAA TACAGGGCAC 
TACAGTTCAG ACAACACAAC AAGAGCATCC ACACGGTTAA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017452004.1
CDS	428..1552
Translation	MVLWESPRQCSSWTLCEGFCWLLLLPVTLLIIARPVKLAAFPTSLSDCQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNSDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRKCPRSNRIHRQKQNTGHYSSDNTTRASTRLI

Target ORF information:

RefSeq Version	XM_017596515.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transmembrane protein with EGF-like and two follistatin-like domains 2 (Tmeff2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017596515.1

ORF Insert Sequence:

ATGGTGCTGT GGGAGTCCCC GCGGCAGTGC AGCAGCTGGA CACTTTGCGA GGGCTTCTGC 
TGGCTGCTGC TGCTGCCGGT GACGCTGCTT ATCATAGCCC GCCCGGTGAA ACTCGCTGCT 
TTCCCTACCT CCTTAAGTGA CTGCCAAACG CCCACCGGCT GGAACTGCTC CGGTTACGAT 
GACAGAGAAA ATGATCTCTT CCTGTGTGAT ACCAACACCT GTAAATTTGA CGGGGAATGT 
CTAAGGATTG GAGACACTGT GACTTGCGTC TGTCAGTTCA AGTGTAACAG TGACTACGTG 
CCTGTGTGTG GCTCCAATGG AGAGAGCTAC CAGAATGAAT GCTACCTGAG GCAAGCTGCC 
TGCAAGCAAC AGAGTGAGAT ACTTGTGGTC TCAGAAGGAT CCTGTGCTAC AGATGCAGGA 
TCGGGATCTG GAGACGGAGT CCATGAAGGC TCTGGAGAGA CCAGTCAGAA GGAGACATCT 
ACCTGTGACA TTTGCCAGTT TGGTGCGGAA TGCGATGAAG ATGCTGAGGA TGTCTGGTGT 
GTGTGCAACA TTGACTGTTC TCAAACCAAC TTTAATCCCC TCTGTGCTTC TGATGGGAAA 
TCTTATGATA ATGCATGTCA AATCAAAGAA GCGTCATGTC AGAAACAGGA GAAAATTGAA 
GTCATGTCTC TGGGTCGATG TCAAGATAAC ACAACTACAA CCACTAAATC TGAAGATGGG 
CATTATGCAA GAACAGATTA TGCAGAGAAT GCTAACAAAT TAGAAGAAAG TGCCAGAGAA 
CACCACATAC CTTGTCCAGA ACACTACAAC GGTTTCTGCA TGCATGGCAA GTGTGAACAC 
TCCATCAATA TGCAGGAGCC ATCTTGCAGA TGTGATGCTG GTTATACTGG TCAACACTGT 
GAAAAGAAGG ACTACAGTGT TCTCTACGTT GTTCCTGGTC CTGTAAGATT CCAGTACGTC 
TTGATTGCAG CTGTGATTGG AACAATTCAG ATTGCTGTCA TCTGTGTGGT GGTCCTCTGT 
ATCACAAGGA AATGTCCCAG AAGCAACAGA ATTCACAGAC AGAAGCAAAA TACAGGGCAC 
TACAGTTCAG ACAACACAAC AAGAGCATCC ACACGGTTAA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The TMEFF2 tumor suppressor modulates integrin expression, RhoA activation and migration of prostate cancer cells.
Biochimica et biophysica acta1843(6)1216-24(2014 Jun)
Chen X,Corbin JM,Tipton GJ,Yang LV,Asch AS,Ruiz-Echevarr?a MJ

Refined mapping of blood pressure quantitative trait loci using congenic strains developed from two genetically hypertensive rat models.
Hypertension research : official journal of the Japanese Society of Hypertension34(12)1263-70(2011 Dec)
Kumarasamy S,Gopalakrishnan K,Toland EJ,Yerga-Woolwine S,Farms P,Morgan EE,Joe B

Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo.
Cancer letters244(2)274-88(2006 Dec)
Chen Q,Watson JT,Marengo SR,Decker KS,Coleman I,Nelson PS,Sikes RA

Preclinical validation of anti-TMEFF2-auristatin E-conjugated antibodies in the treatment of prostate cancer.
Molecular cancer therapeutics3(8)921-32(2004 Aug)
Afar DE,Bhaskar V,Ibsen E,Breinberg D,Henshall SM,Kench JG,Drobnjak M,Powers R,Wong M,Evangelista F,O'Hara C,Powers D,DuBridge RB,Caras I,Winter R,Anderson T,Solvason N,Stricker PD,Cordon-Cardo C,Scher HI,Grygiel JJ,Sutherland RL,Murray R,Ramakrishnan V,Law DA

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Tmeff2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報