Lrp6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lrp6
Entrez Gene ID	312781
Full Name	LDL receptor related protein 6
General protein information	Preferred Names LDL receptor related protein 6 Names low-density lipoprotein receptor-related protein 6
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q43

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107892.1	NP_001101362.1	low-density lipoprotein receptor-related protein 6
XM_017592658.1	XP_017448147.1	low-density lipoprotein receptor-related protein 6 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LRP6	XP_534886.2
	LOC695843	XP_002808022.1
Pan troglodytes (chimpanzee)	LRP6	XP_001152103.1
Bos taurus (cattle)	LRP6	XP_002687829.2
Mus musculus (house mouse)	Lrp6	NP_032540.2
Gallus gallus (chicken)	LRP6	XP_417286.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011770	XP_320740.4
Homo sapiens (human)	LRP6	NP_002327.2
Rattus norvegicus (Norway rat)	Lrp6	NP_001101362.1
Danio rerio (zebrafish)	lrp6	NP_001128156.1
Drosophila melanogaster (fruit fly)	arr	NP_524737.2
Xenopus tropicalis (tropical clawed frog)	lrp6	XP_002942697.2

Gene Ontology
Bibliography

Related articles in PubMed

LRP6 acts as a scaffold protein in cardiac gap junction assembly.
Li J, Li C, Liang D, Lv F, Yuan T, The E, Ma X, Wu Y, Zhen L, Xie D, Wang S, Liu Y, Huang J, Shi J, Liu Y, Shi D, Xu L, Lin L, Peng L, Cui J, Zhu W, Chen YH
Nature communications711775(2016 Jun)

REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-?-catenin signaling.
Song Z, Zhu T, Zhou X, Barrow P, Yang W, Cui Y, Yang L, Zhao D
Oncotarget7(11)12035-52(2016 Mar)

Reduced LRP6 expression and increase in the interaction of GSK3? with p53 contribute to podocyte apoptosis in diabetes mellitus and are prevented by green tea.
Peixoto EB, Papadimitriou A, Teixeira DA, Montemurro C, Duarte DA, Silva KC, Joazeiro PP, Lopes de Faria JM, Lopes de Faria JB
The Journal of nutritional biochemistry26(4)416-30(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Authors demonstrate for the first time novel neuroprotective function of REST in prion diseases and hypothesise that the LRP6-Wnt-beta-catenin/REST signaling plays critical and collaborative roles in neuroprotection.
Title: REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-?-catenin signaling.

GSK3beta is activated and p-LRP6 is down-regulated in kidneys of diabetic rats. These abnormalities were prevented by treatment with green tea.
Title: Reduced LRP6 expression and increase in the interaction of GSK3? with p53 contribute to podocyte apoptosis in diabetes mellitus and are prevented by green tea.

study demonstrates that LRP5/6 mediates pulmonary vascular remodeling and PH in hyperoxia-induced neonatal lung injury
Title: Inhibition of LRP5/6-mediated Wnt/?-catenin signaling by Mesd attenuates hyperoxia-induced pulmonary hypertension in neonatal rats.

Traumatic brain injury caused a rapid, but transient, increase in LRP6 phosphorylation that is followed by a modest decrease in ss-Catenin phosphorylation. Phospho-GSK-3beta immunoreactivity was found to increase three days post injury.
Title: Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome.

SERPINA3K is a high-affinity, endogenous antagonist of LRP6
Title: Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family.

The following Lrp6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lrp6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41815	NM_001107892.1 Latest version!	Rattus norvegicus LDL receptor related protein 6 (Lrp6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$643.30 $919.00
ORa27843	XM_017592658.1 Latest version!	Rattus norvegicus LDL receptor related protein 6 (Lrp6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$811.30 $1159.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lrp6 ( NM_001107892.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101362.1 Rattus norvegicus LDL receptor related protein 6 (Lrp6), mRNA.

Price & Availability↑

CloneID	ORa41815
Clone ID Related Accession (Same CDS sequence)	NM_001107892.1
Accession Version	NM_001107892.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Rattus norvegicus(Norway rat)
Product	low-density lipoprotein receptor-related protein 6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473964.2. On or before Oct 4, 2007 this sequence version replaced XM_001071349.1, XM_232466.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGTACTGGA CAGACTGGGG AGAAGTGCCA AAGATAGAAC GTGCTGGAAT GGATGGTTCA 
AGTCGCTTTG TTATAATAAA CACTGAGATT TACTGGCCAA ATGGACTGAC TCTGGATTAT 
GAGGAGCGGA AGCTTTATTG GGCAGATGCA AAACTTAATT TCATCCATAA ATCAAACCTG 
GACGGAACAA ATCGACAGGC AGTGGTTAAA GGTTCCCTTC CACATCCTTT TGCCTTGACG 
TTATTTGAGG ACACATTGTA CTGGACTGAC TGGAATACAC ACTCTATTTT GGCTTGCAAC 
AAGTATACTG GCGAGGGTCT GCGTGAAATT CATTCTAACA TCTTCTCTCC CATGGATATA 
CATGCTTTCA GCCAACAGAG GCAGCCAAAT GCTACAAATC CATGTGGAAT TGATAATGGT 
GGTTGTTCCC ATTTGTGTTT GATGTCTCCA GTCAAGCCTT TTTATCAGTG TGCTTGTCCA 
ACTGGGGTCA AGCTTCTGGA GAGTGGAAAA ACCTGCAAAG ATGGTGCCAC TGAACTATTG 
CTGTTAGCCC GACGGACAGA CTTGAGGCGC ATCTCTTTGG ATACACCAGA TTTCACCGAC 
ATTGTCCTAC AGTTAGAAGA CATCCGACAT GCCATTGCCA TAGACTACGA CCCCGTGGAA 
GGCTACGTCT ACTGGACGGA CGATGAAGTA CGGGCCATCC GTCGCTCCTT CATTGATGGA 
TCTGGCAGTC AGTTTGTGGT CACGGCCCAG ATTGCCCATC CTGATGGTAT TGCTGTTGAC 
TGGGTGGCAA GAAACCTGTA CTGGACAGAC ACTGGCACTG ATCGGATAGA AGTGACAAGG 
CTCAATGGGA CCATGAGGAA GATCCTGATT TCAGAGGACT TAGAGGAGCC CCGGGCTATT 
GTGTTAGATC CCATGGCTGG GTACATGTAC TGGACGGACT GGGGAGAAAT CCCAAAAATC 
GAGCGAGCTG CTCTGGACGG ATCTGACCGA GTAGTTCTTG TTAACACTTC CCTTGGTTGG 
CCAAATGGCT TAGCCCTGGA TTATGATGAA GGCACAATAT ACTGGGGAGA TGCCAAAACA 
GACAAAATTG AGGTTATGAA TACTGATGGC ACTGGGAGGC GAGTGCTGGT GGAAGACAAG 
ATCCCTCACA TATTTGGGTT TACCTTGCTG GGCGACTATG TTTACTGGAC TGACTGGCAG 
AGGCGGAGCA TCGAGAGAGT GCACAAGCGG AGTGCAGAGA GGGAGGTCAT AATAGACCAG 
CTGCCAGACC TCATGGGACT GAAGGCCACA AGCGTTCACA GAGTCATTGG TTCTAACCCC 
TGTGCTGAGG AGAATGGAGG ATGTAGCCAT CTTTGCCTCT ACAGGCCTCA GGGACTTCGA 
TGTGCCTGTC CCATTGGCTT TGAGCTCATT AGTGACATGA AGACATGCAT TGTTCCTGAG 
GCTTTCCTTC TGTTCTCACG GAGAGCAGAT ATAAGACGCA TCTCTTTGGA AACAAACAAC 
AACAATGTGG CCATTCCTCT CACGGGTGTC AAAGAAGCTT CTGCTTTGGA TTTTGATGTC 
ACAGACAACA GAATTTACTG GACCGATATA TCCCTGAAGA CTATTAGCAG AGCTTTTATG 
AATGGCAGTG CACTGGAACA TGTGGTAGAG TTCGGCTTAG ATTACCCAGA AGGCATGGCA 
GTGGACTGGC TTGGGAAGAA CTTATACTGG GCAGACACAG GAACAAATCG CATTGAGGTG 
TCAAAGTTGG ATGGACAGCA CCGACAGGTT TTGGTATGGA AAGACCTTGA CAGTCCCCGA 
GCTCTGGCAT TGGATCCTGC TGAAGGATTT ATGTATTGGA CTGAGTGGGG AGGGAAGCCT 
AAGATTGACA GAGCGGCTAT GGATGGAAGT GAACGCACTA CATTAGTTCC AAATGTGGGT 
CGAGCAAATG GCCTTACCAT CGACTATGCT AAGAGGCGGC TTTACTGGAC AGACCTGGAC 
ACTAACTTAA TAGAATCTTC AAATATGCTC GGACTCAACC GTGAAGTTAT AGCAGATGAC 
TTGCCTCATC CTTTTGGCTT AACTCAGTAC CAAGATTACA TCTACTGGAC AGACTGGAGC 
CGACGCAGCA TTGAACGTGC CAACAAAACC AGTGGCCAAA ACCGCACCAT CATCCAGGGC 
CATTTGGATT ATGTGATGGA CATCCTAGTC TTTCACTCTT CCCGGCAGGC AGGGTGGAAT 
GAATGTGCCT CCAGCAACGG GCACTGCTCC CACCTTTGCT TGGCTGTGCC TGTTGGAGGT 
TTTGTGTGTG GATGCCCTGC CCACTACTCC CTGAATGCTG ACAACAGGAC CTGTAGTGCT 
CCTACCACCT TCCTGCTCTT CAGTCAGAAG AGCGCCATCA ACCGCATGGT GATTGATGAA 
CAACAGAGTC CTGACATCAT CCTTCCTATC CACAGCCTTC GGAACGTCCG GGCCATTGAT 
TATGACCCTT TGGACAAGCA GCTCTACTGG ATTGACTCTC GACAAAACAT GATACGAAAG 
GCACAAGAAG ATGGTGGCCA GGGTTTTACT GTAGTTGTAA GCTCGGTTCC AAATCAGAAC 
CTTGAAATAC AGCCCTATGA TCTCAGCATT GATATTTATA GCCGTTACAT CTATTGGACC 
TGTGAAGCTA CCAATGTCAT TGATGTGACG AGATTAGATG GTCGATCAGT TGGAGTGGTC 
CTAAAAGGCG AGCAAGACAG ACCTCGAGCC ATTGTGGTAA ACCCTGAGAA AGGGTATATG 
TATTTTACCA ATCTTCAGGA AAGATCTCCC AAAATTGAAC GGGCTGCCTT GGATGGAACA 
GAACGGGAGG TTCTCTTTTT CAGTGGCCTG AGTAAGCCCG TCGCTTTGGC TCTCGACAGC 
AAGCTGAGCA GGCTCTTCTG GGCTGACTCC GACCTCCGGC GAATTGAGAG CAGCGACCTC 
TCAGGTGCCA ACAGGATCGT GCTAGAGGAC TCTAATATAT TGCAGCCTGT GGGTCTGACC 
GTGTTTGAGA ACTGGCTCTA CTGGATTGAT AAGCAGCAAC AGATGATTGA AAAAATTGAC 
ATGACTGGTC GCGAAGGCAG AACCAAGGTC CAGGCTCGGA TTGCTCAGCT CAGTGACATC 
CATGCAGTGA AGGAGCTGAA CCTTCAGGAA TACAGACAGC ACCCGTGTGC CCAGGATAAT 
GGTGGCTGTT CACATATTTG CCTTGTAAAA GGAGATGGTA CCACAAGATG CTCCTGTCCC 
ATGCATTTAG TTCTGCTTCA GGATGAGCTG TCCTGTGGAG AGCCTCCAAC ATGTTCTCCT 
CAGCAGTTTA CGTGTTTCAC TGGGGACATT GACTGCATCC CTGTGGCCTG GCGGTGTGAT 
GGGTTTACTG AATGTGAAGA CCACAGTGAT GAGCTCAACT GTCCTGTGTG CTCGGAGTCT 
CAGTTCCAGT GTGCCAGCGG GCAGTGCATT GACGGCGCCC TTCGATGCAA TGGTGACGCG 
AACTGCCAGG ATAAATCGGA TGAGAAGAAC TGTGAAGTGC TTTGTCTAAT TGATCAGTTC 
CGCTGTGCCA ATGGTCAGTG CGTTGGAAAA CACAAGAAAT GCGACCACAA TGTGGACTGC 
AGTGACAGAT CTGATGAACT GGACTGCTAT TTTGAACCCA CCACCATCCT ACAGGCCGTA 
CAGCTACCGG CACTTTGCAC CGCCCACTAC ACCCTGCAGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101362.1
CDS	399..4103
Translation	MYWTDWGEVPKIERAGMDGSSRFVIINTEIYWPNGLTLDYEERKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDTLYWTDWNTHSILACNKYTGEGLREIHSNIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLESGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYVYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMAGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATSVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQGFTVVVSSVPNQNLEIQPYDLSIDIYSRYIYWTCEATNVIDVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPVALALDSKLSRLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGDIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDCYFEPTTILQAVQLPALCTAHYTLQH

Target ORF information:

RefSeq Version	NM_001107892.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus LDL receptor related protein 6 (Lrp6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107892.1

ORF Insert Sequence:

ATGTACTGGA CAGACTGGGG AGAAGTGCCA AAGATAGAAC GTGCTGGAAT GGATGGTTCA 
AGTCGCTTTG TTATAATAAA CACTGAGATT TACTGGCCAA ATGGACTGAC TCTGGATTAT 
GAGGAGCGGA AGCTTTATTG GGCAGATGCA AAACTTAATT TCATCCATAA ATCAAACCTG 
GACGGAACAA ATCGACAGGC AGTGGTTAAA GGTTCCCTTC CACATCCTTT TGCCTTGACG 
TTATTTGAGG ACACATTGTA CTGGACTGAC TGGAATACAC ACTCTATTTT GGCTTGCAAC 
AAGTATACTG GCGAGGGTCT GCGTGAAATT CATTCTAACA TCTTCTCTCC CATGGATATA 
CATGCTTTCA GCCAACAGAG GCAGCCAAAT GCTACAAATC CATGTGGAAT TGATAATGGT 
GGTTGTTCCC ATTTGTGTTT GATGTCTCCA GTCAAGCCTT TTTATCAGTG TGCTTGTCCA 
ACTGGGGTCA AGCTTCTGGA GAGTGGAAAA ACCTGCAAAG ATGGTGCCAC TGAACTATTG 
CTGTTAGCCC GACGGACAGA CTTGAGGCGC ATCTCTTTGG ATACACCAGA TTTCACCGAC 
ATTGTCCTAC AGTTAGAAGA CATCCGACAT GCCATTGCCA TAGACTACGA CCCCGTGGAA 
GGCTACGTCT ACTGGACGGA CGATGAAGTA CGGGCCATCC GTCGCTCCTT CATTGATGGA 
TCTGGCAGTC AGTTTGTGGT CACGGCCCAG ATTGCCCATC CTGATGGTAT TGCTGTTGAC 
TGGGTGGCAA GAAACCTGTA CTGGACAGAC ACTGGCACTG ATCGGATAGA AGTGACAAGG 
CTCAATGGGA CCATGAGGAA GATCCTGATT TCAGAGGACT TAGAGGAGCC CCGGGCTATT 
GTGTTAGATC CCATGGCTGG GTACATGTAC TGGACGGACT GGGGAGAAAT CCCAAAAATC 
GAGCGAGCTG CTCTGGACGG ATCTGACCGA GTAGTTCTTG TTAACACTTC CCTTGGTTGG 
CCAAATGGCT TAGCCCTGGA TTATGATGAA GGCACAATAT ACTGGGGAGA TGCCAAAACA 
GACAAAATTG AGGTTATGAA TACTGATGGC ACTGGGAGGC GAGTGCTGGT GGAAGACAAG 
ATCCCTCACA TATTTGGGTT TACCTTGCTG GGCGACTATG TTTACTGGAC TGACTGGCAG 
AGGCGGAGCA TCGAGAGAGT GCACAAGCGG AGTGCAGAGA GGGAGGTCAT AATAGACCAG 
CTGCCAGACC TCATGGGACT GAAGGCCACA AGCGTTCACA GAGTCATTGG TTCTAACCCC 
TGTGCTGAGG AGAATGGAGG ATGTAGCCAT CTTTGCCTCT ACAGGCCTCA GGGACTTCGA 
TGTGCCTGTC CCATTGGCTT TGAGCTCATT AGTGACATGA AGACATGCAT TGTTCCTGAG 
GCTTTCCTTC TGTTCTCACG GAGAGCAGAT ATAAGACGCA TCTCTTTGGA AACAAACAAC 
AACAATGTGG CCATTCCTCT CACGGGTGTC AAAGAAGCTT CTGCTTTGGA TTTTGATGTC 
ACAGACAACA GAATTTACTG GACCGATATA TCCCTGAAGA CTATTAGCAG AGCTTTTATG 
AATGGCAGTG CACTGGAACA TGTGGTAGAG TTCGGCTTAG ATTACCCAGA AGGCATGGCA 
GTGGACTGGC TTGGGAAGAA CTTATACTGG GCAGACACAG GAACAAATCG CATTGAGGTG 
TCAAAGTTGG ATGGACAGCA CCGACAGGTT TTGGTATGGA AAGACCTTGA CAGTCCCCGA 
GCTCTGGCAT TGGATCCTGC TGAAGGATTT ATGTATTGGA CTGAGTGGGG AGGGAAGCCT 
AAGATTGACA GAGCGGCTAT GGATGGAAGT GAACGCACTA CATTAGTTCC AAATGTGGGT 
CGAGCAAATG GCCTTACCAT CGACTATGCT AAGAGGCGGC TTTACTGGAC AGACCTGGAC 
ACTAACTTAA TAGAATCTTC AAATATGCTC GGACTCAACC GTGAAGTTAT AGCAGATGAC 
TTGCCTCATC CTTTTGGCTT AACTCAGTAC CAAGATTACA TCTACTGGAC AGACTGGAGC 
CGACGCAGCA TTGAACGTGC CAACAAAACC AGTGGCCAAA ACCGCACCAT CATCCAGGGC 
CATTTGGATT ATGTGATGGA CATCCTAGTC TTTCACTCTT CCCGGCAGGC AGGGTGGAAT 
GAATGTGCCT CCAGCAACGG GCACTGCTCC CACCTTTGCT TGGCTGTGCC TGTTGGAGGT 
TTTGTGTGTG GATGCCCTGC CCACTACTCC CTGAATGCTG ACAACAGGAC CTGTAGTGCT 
CCTACCACCT TCCTGCTCTT CAGTCAGAAG AGCGCCATCA ACCGCATGGT GATTGATGAA 
CAACAGAGTC CTGACATCAT CCTTCCTATC CACAGCCTTC GGAACGTCCG GGCCATTGAT 
TATGACCCTT TGGACAAGCA GCTCTACTGG ATTGACTCTC GACAAAACAT GATACGAAAG 
GCACAAGAAG ATGGTGGCCA GGGTTTTACT GTAGTTGTAA GCTCGGTTCC AAATCAGAAC 
CTTGAAATAC AGCCCTATGA TCTCAGCATT GATATTTATA GCCGTTACAT CTATTGGACC 
TGTGAAGCTA CCAATGTCAT TGATGTGACG AGATTAGATG GTCGATCAGT TGGAGTGGTC 
CTAAAAGGCG AGCAAGACAG ACCTCGAGCC ATTGTGGTAA ACCCTGAGAA AGGGTATATG 
TATTTTACCA ATCTTCAGGA AAGATCTCCC AAAATTGAAC GGGCTGCCTT GGATGGAACA 
GAACGGGAGG TTCTCTTTTT CAGTGGCCTG AGTAAGCCCG TCGCTTTGGC TCTCGACAGC 
AAGCTGAGCA GGCTCTTCTG GGCTGACTCC GACCTCCGGC GAATTGAGAG CAGCGACCTC 
TCAGGTGCCA ACAGGATCGT GCTAGAGGAC TCTAATATAT TGCAGCCTGT GGGTCTGACC 
GTGTTTGAGA ACTGGCTCTA CTGGATTGAT AAGCAGCAAC AGATGATTGA AAAAATTGAC 
ATGACTGGTC GCGAAGGCAG AACCAAGGTC CAGGCTCGGA TTGCTCAGCT CAGTGACATC 
CATGCAGTGA AGGAGCTGAA CCTTCAGGAA TACAGACAGC ACCCGTGTGC CCAGGATAAT 
GGTGGCTGTT CACATATTTG CCTTGTAAAA GGAGATGGTA CCACAAGATG CTCCTGTCCC 
ATGCATTTAG TTCTGCTTCA GGATGAGCTG TCCTGTGGAG AGCCTCCAAC ATGTTCTCCT 
CAGCAGTTTA CGTGTTTCAC TGGGGACATT GACTGCATCC CTGTGGCCTG GCGGTGTGAT 
GGGTTTACTG AATGTGAAGA CCACAGTGAT GAGCTCAACT GTCCTGTGTG CTCGGAGTCT 
CAGTTCCAGT GTGCCAGCGG GCAGTGCATT GACGGCGCCC TTCGATGCAA TGGTGACGCG 
AACTGCCAGG ATAAATCGGA TGAGAAGAAC TGTGAAGTGC TTTGTCTAAT TGATCAGTTC 
CGCTGTGCCA ATGGTCAGTG CGTTGGAAAA CACAAGAAAT GCGACCACAA TGTGGACTGC 
AGTGACAGAT CTGATGAACT GGACTGCTAT TTTGAACCCA CCACCATCCT ACAGGCCGTA 
CAGCTACCGG CACTTTGCAC CGCCCACTAC ACCCTGCAGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lrp6 ( XM_017592658.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017448147.1 Rattus norvegicus LDL receptor related protein 6 (Lrp6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa27843
Clone ID Related Accession (Same CDS sequence)	XM_017592658.1
Accession Version	XM_017592658.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4842bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	low-density lipoprotein receptor-related protein 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGGCCG TGCTGAGGAG CCTCCTGGCC TGCAGCTTCT GCGTGCTGCT GAGAGCGGCC 
CCTTTGTTGC TTTATGCAAA CAGACGGGAC TTGAGATTGG TTGATGCTAC AAATGGCAAA 
GAGAATGCGA CGATTGTAGT TGGAGGCTTG GAGGATGCAG CTGCGGTGGA CTTTGTGTTT 
GGTCATGGCT TGATATACTG GAGTGACGTC AGCGAAGAAG CCATTAAACG AACAGAATTT 
AACAAAACTG AGAGTGTACA GAATGTCGTT GTTTCTGGAT TATTGTCCCC GGATGGGCTG 
GCATGTGATT GGCTTGGAGA AAAATTGTAC TGGACAGATT CTGAAACTAA TCGTATTGAA 
GTTTCTAATT TAGATGGATC TTTACGAAAA GTTTTATTTT GGCAAGAGTT GGATCAACCC 
AGAGCTATTG CCTTAGATCC ATCAAGTGGG TTCATGTACT GGACAGACTG GGGAGAAGTG 
CCAAAGATAG AACGTGCTGG AATGGATGGT TCAAGTCGCT TTGTTATAAT AAACACTGAG 
ATTTACTGGC CAAATGGACT GACTCTGGAT TATGAGGAGC GGAAGCTTTA TTGGGCAGAT 
GCAAAACTTA ATTTCATCCA TAAATCAAAC CTGGACGGAA CAAATCGACA GGCAGTGGTT 
AAAGGTTCCC TTCCACATCC TTTTGCCTTG ACGTTATTTG AGGACACATT GTACTGGACT 
GACTGGAATA CACACTCTAT TTTGGCTTGC AACAAGTATA CTGGCGAGGG TCTGCGTGAA 
ATTCATTCTA ACATCTTCTC TCCCATGGAT ATACATGCTT TCAGCCAACA GAGGCAGCCA 
AATGCTACAA ATCCATGTGG AATTGATAAT GGTGGTTGTT CCCATTTGTG TTTGATGTCT 
CCAGTCAAGC CTTTTTATCA GTGTGCTTGT CCAACTGGGG TCAAGCTTCT GGAGAGTGGA 
AAAACCTGCA AAGATGGTGC CACTGAACTA TTGCTGTTAG CCCGACGGAC AGACTTGAGG 
CGCATCTCTT TGGATACACC AGATTTCACC GACATTGTCC TACAGTTAGA AGACATCCGA 
CATGCCATTG CCATAGACTA CGACCCCGTG GAAGGCTACG TCTACTGGAC GGACGATGAA 
GTACGGGCCA TCCGTCGCTC CTTCATTGAT GGATCTGGCA GTCAGTTTGT GGTCACGGCC 
CAGATTGCCC ATCCTGATGG TATTGCTGTT GACTGGGTGG CAAGAAACCT GTACTGGACA 
GACACTGGCA CTGATCGGAT AGAAGTGACA AGGCTCAATG GGACCATGAG GAAGATCCTG 
ATTTCAGAGG ACTTAGAGGA GCCCCGGGCT ATTGTGTTAG ATCCCATGGC TGGGTACATG 
TACTGGACGG ACTGGGGAGA AATCCCAAAA ATCGAGCGAG CTGCTCTGGA CGGATCTGAC 
CGAGTAGTTC TTGTTAACAC TTCCCTTGGT TGGCCAAATG GCTTAGCCCT GGATTATGAT 
GAAGGCACAA TATACTGGGG AGATGCCAAA ACAGACAAAA TTGAGGTTAT GAATACTGAT 
GGCACTGGGA GGCGAGTGCT GGTGGAAGAC AAGATCCCTC ACATATTTGG GTTTACCTTG 
CTGGGCGACT ATGTTTACTG GACTGACTGG CAGAGGCGGA GCATCGAGAG AGTGCACAAG 
CGGAGTGCAG AGAGGGAGGT CATAATAGAC CAGCTGCCAG ACCTCATGGG ACTGAAGGCC 
ACAAGCGTTC ACAGAGTCAT TGGTTCTAAC CCCTGTGCTG AGGAGAATGG AGGATGTAGC 
CATCTTTGCC TCTACAGGCC TCAGGGACTT CGATGTGCCT GTCCCATTGG CTTTGAGCTC 
ATTAGTGACA TGAAGACATG CATTGTTCCT GAGGCTTTCC TTCTGTTCTC ACGGAGAGCA 
GATATAAGAC GCATCTCTTT GGAAACAAAC AACAACAATG TGGCCATTCC TCTCACGGGT 
GTCAAAGAAG CTTCTGCTTT GGATTTTGAT GTCACAGACA ACAGAATTTA CTGGACCGAT 
ATATCCCTGA AGACTATTAG CAGAGCTTTT ATGAATGGCA GTGCACTGGA ACATGTGGTA 
GAGTTCGGCT TAGATTACCC AGAAGGCATG GCAGTGGACT GGCTTGGGAA GAACTTATAC 
TGGGCAGACA CAGGAACAAA TCGCATTGAG GTGTCAAAGT TGGATGGACA GCACCGACAG 
GTTTTGGTAT GGAAAGACCT TGACAGTCCC CGAGCTCTGG CATTGGATCC TGCTGAAGGA 
TTTATGTATT GGACTGAGTG GGGAGGGAAG CCTAAGATTG ACAGAGCGGC TATGGATGGA 
AGTGAACGCA CTACATTAGT TCCAAATGTG GGTCGAGCAA ATGGCCTTAC CATCGACTAT 
GCTAAGAGGC GGCTTTACTG GACAGACCTG GACACTAACT TAATAGAATC TTCAAATATG 
CTCGGACTCA ACCGTGAAGT TATAGCAGAT GACTTGCCTC ATCCTTTTGG CTTAACTCAG 
TACCAAGATT ACATCTACTG GACAGACTGG AGCCGACGCA GCATTGAACG TGCCAACAAA 
ACCAGTGGCC AAAACCGCAC CATCATCCAG GGCCATTTGG ATTATGTGAT GGACATCCTA 
GTCTTTCACT CTTCCCGGCA GGCAGGGTGG AATGAATGTG CCTCCAGCAA CGGGCACTGC 
TCCCACCTTT GCTTGGCTGT GCCTGTTGGA GGTTTTGTGT GTGGATGCCC TGCCCACTAC 
TCCCTGAATG CTGACAACAG GACCTGTAGT GCTCCTACCA CCTTCCTGCT CTTCAGTCAG 
AAGAGCGCCA TCAACCGCAT GGTGATTGAT GAACAACAGA GTCCTGACAT CATCCTTCCT 
ATCCACAGCC TTCGGAACGT CCGGGCCATT GATTATGACC CTTTGGACAA GCAGCTCTAC 
TGGATTGACT CTCGACAAAA CATGATACGA AAGGCACAAG AAGATGGTGG CCAGGGTTTT 
ACTGTAGTTG TAAGCTCGGT TCCAAATCAG AACCTTGAAA TACAGCCCTA TGATCTCAGC 
ATTGATATTT ATAGCCGTTA CATCTATTGG ACCTGTGAAG CTACCAATGT CATTGATGTG 
ACGAGATTAG ATGGTCGATC AGTTGGAGTG GTCCTAAAAG GCGAGCAAGA CAGACCTCGA 
GCCATTGTGG TAAACCCTGA GAAAGGGTAT ATGTATTTTA CCAATCTTCA GGAAAGATCT 
CCCAAAATTG AACGGGCTGC CTTGGATGGA ACAGAACGGG AGGTTCTCTT TTTCAGTGGC 
CTGAGTAAGC CCGTCGCTTT GGCTCTCGAC AGCAAGCTGA GCAGGCTCTT CTGGGCTGAC 
TCCGACCTCC GGCGAATTGA GAGCAGCGAC CTCTCAGGTG CCAACAGGAT CGTGCTAGAG 
GACTCTAATA TATTGCAGCC TGTGGGTCTG ACCGTGTTTG AGAACTGGCT CTACTGGATT 
GATAAGCAGC AACAGATGAT TGAAAAAATT GACATGACTG GTCGCGAAGG CAGAACCAAG 
GTCCAGGCTC GGATTGCTCA GCTCAGTGAC ATCCATGCAG TGAAGGAGCT GAACCTTCAG 
GAATACAGAC AGCACCCGTG TGCCCAGGAT AATGGTGGCT GTTCACATAT TTGCCTTGTA 
AAAGGAGATG GTACCACAAG ATGCTCCTGT CCCATGCATT TAGTTCTGCT TCAGGATGAG 
CTGTCCTGTG GAGAGCCTCC AACATGTTCT CCTCAGCAGT TTACGTGTTT CACTGGGGAC 
ATTGACTGCA TCCCTGTGGC CTGGCGGTGT GATGGGTTTA CTGAATGTGA AGACCACAGT 
GATGAGCTCA ACTGTCCTGT GTGCTCGGAG TCTCAGTTCC AGTGTGCCAG CGGGCAGTGC 
ATTGACGGCG CCCTTCGATG CAATGGTGAC GCGAACTGCC AGGATAAATC GGATGAGAAG 
AACTGTGAAG TGCTTTGTCT AATTGATCAG TTCCGCTGTG CCAATGGTCA GTGCGTTGGA 
AAACACAAGA AATGCGACCA CAATGTGGAC TGCAGTGACA GATCTGATGA ACTGGACTGC 
TATCCAACTG AGGAGCCAGC ACCACAGGCC ACCAACACAG TTGGTTCCGT TATCGGAGTA 
ATTGTCACCA TTTTTGTGTC TGGAACCATA TACTTTATCT GCCAAAGGAT GCTGTGTCCT 
CGTATGAAGG GGGATGGGGA AACCATGACT AATGACTACG TGGTTCACGG CCCAGCTTCT 
GTGCCCCTTG GTTATGTTCC TCACCCAAGC TCTCTGTCTG GATCTCTTCC AGGGATGTCT 
CGAGGCAAAT CAATGATCAG TTCTCTCAGT ATCATGGGGG GGAGCAGTGG GCCCCCCTAC 
GATCGAGCAC ACGTCACGGG AGCGTCCTCA AGCAGCTCTT CCAGTACCAA AGGCACTTAC 
TTCCCTGCAA TTTTGAACCC ACCACCATCG CCTGCCACAG AGCGATCCCA TTATACCATG 
GAGTTTGGCT ATTCTTCCAA CAGTCCTTCC ACACATAGGT CCTACAGCTA CAGGCCGTAC 
AGCTACCGGC ACTTTGCACC GCCCACTACA CCCTGCAGCA CTGATGTCTG TGACAGTGAC 
TATGCTCCTA GCCGGAGAAT GACCTCAGTG GCAACAGCCA AGGGCTACAC CAGTGACTTG 
AACTATGACT CAGAACCTGT GCCCCCACCA CCCACACCCC GAAGCCAGTA CTTGTCGGCA 
GAGGAGAACT ATGAAAGCTG CCCCCCTTCT CCATACACTG AGAGGAGTTA CTCCCATCAC 
CTCTACCCAC CACCACCTTC CCCCTGCACG GACTCCTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017448147.1
CDS	253..5094
Translation	MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFGHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFVIINTEIYWPNGLTLDYEERKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDTLYWTDWNTHSILACNKYTGEGLREIHSNIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLESGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYVYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMAGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATSVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQGFTVVVSSVPNQNLEIQPYDLSIDIYSRYIYWTCEATNVIDVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPVALALDSKLSRLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGDIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTIYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS

Target ORF information:

RefSeq Version	XM_017592658.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus LDL receptor related protein 6 (Lrp6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017592658.1

ORF Insert Sequence:

ATGGGGGCCG TGCTGAGGAG CCTCCTGGCC TGCAGCTTCT GCGTGCTGCT GAGAGCGGCC 
CCTTTGTTGC TTTATGCAAA CAGACGGGAC TTGAGATTGG TTGATGCTAC AAATGGCAAA 
GAGAATGCGA CGATTGTAGT TGGAGGCTTG GAGGATGCAG CTGCGGTGGA CTTTGTGTTT 
GGTCATGGCT TGATATACTG GAGTGACGTC AGCGAAGAAG CCATTAAACG AACAGAATTT 
AACAAAACTG AGAGTGTACA GAATGTCGTT GTTTCTGGAT TATTGTCCCC GGATGGGCTG 
GCATGTGATT GGCTTGGAGA AAAATTGTAC TGGACAGATT CTGAAACTAA TCGTATTGAA 
GTTTCTAATT TAGATGGATC TTTACGAAAA GTTTTATTTT GGCAAGAGTT GGATCAACCC 
AGAGCTATTG CCTTAGATCC ATCAAGTGGG TTCATGTACT GGACAGACTG GGGAGAAGTG 
CCAAAGATAG AACGTGCTGG AATGGATGGT TCAAGTCGCT TTGTTATAAT AAACACTGAG 
ATTTACTGGC CAAATGGACT GACTCTGGAT TATGAGGAGC GGAAGCTTTA TTGGGCAGAT 
GCAAAACTTA ATTTCATCCA TAAATCAAAC CTGGACGGAA CAAATCGACA GGCAGTGGTT 
AAAGGTTCCC TTCCACATCC TTTTGCCTTG ACGTTATTTG AGGACACATT GTACTGGACT 
GACTGGAATA CACACTCTAT TTTGGCTTGC AACAAGTATA CTGGCGAGGG TCTGCGTGAA 
ATTCATTCTA ACATCTTCTC TCCCATGGAT ATACATGCTT TCAGCCAACA GAGGCAGCCA 
AATGCTACAA ATCCATGTGG AATTGATAAT GGTGGTTGTT CCCATTTGTG TTTGATGTCT 
CCAGTCAAGC CTTTTTATCA GTGTGCTTGT CCAACTGGGG TCAAGCTTCT GGAGAGTGGA 
AAAACCTGCA AAGATGGTGC CACTGAACTA TTGCTGTTAG CCCGACGGAC AGACTTGAGG 
CGCATCTCTT TGGATACACC AGATTTCACC GACATTGTCC TACAGTTAGA AGACATCCGA 
CATGCCATTG CCATAGACTA CGACCCCGTG GAAGGCTACG TCTACTGGAC GGACGATGAA 
GTACGGGCCA TCCGTCGCTC CTTCATTGAT GGATCTGGCA GTCAGTTTGT GGTCACGGCC 
CAGATTGCCC ATCCTGATGG TATTGCTGTT GACTGGGTGG CAAGAAACCT GTACTGGACA 
GACACTGGCA CTGATCGGAT AGAAGTGACA AGGCTCAATG GGACCATGAG GAAGATCCTG 
ATTTCAGAGG ACTTAGAGGA GCCCCGGGCT ATTGTGTTAG ATCCCATGGC TGGGTACATG 
TACTGGACGG ACTGGGGAGA AATCCCAAAA ATCGAGCGAG CTGCTCTGGA CGGATCTGAC 
CGAGTAGTTC TTGTTAACAC TTCCCTTGGT TGGCCAAATG GCTTAGCCCT GGATTATGAT 
GAAGGCACAA TATACTGGGG AGATGCCAAA ACAGACAAAA TTGAGGTTAT GAATACTGAT 
GGCACTGGGA GGCGAGTGCT GGTGGAAGAC AAGATCCCTC ACATATTTGG GTTTACCTTG 
CTGGGCGACT ATGTTTACTG GACTGACTGG CAGAGGCGGA GCATCGAGAG AGTGCACAAG 
CGGAGTGCAG AGAGGGAGGT CATAATAGAC CAGCTGCCAG ACCTCATGGG ACTGAAGGCC 
ACAAGCGTTC ACAGAGTCAT TGGTTCTAAC CCCTGTGCTG AGGAGAATGG AGGATGTAGC 
CATCTTTGCC TCTACAGGCC TCAGGGACTT CGATGTGCCT GTCCCATTGG CTTTGAGCTC 
ATTAGTGACA TGAAGACATG CATTGTTCCT GAGGCTTTCC TTCTGTTCTC ACGGAGAGCA 
GATATAAGAC GCATCTCTTT GGAAACAAAC AACAACAATG TGGCCATTCC TCTCACGGGT 
GTCAAAGAAG CTTCTGCTTT GGATTTTGAT GTCACAGACA ACAGAATTTA CTGGACCGAT 
ATATCCCTGA AGACTATTAG CAGAGCTTTT ATGAATGGCA GTGCACTGGA ACATGTGGTA 
GAGTTCGGCT TAGATTACCC AGAAGGCATG GCAGTGGACT GGCTTGGGAA GAACTTATAC 
TGGGCAGACA CAGGAACAAA TCGCATTGAG GTGTCAAAGT TGGATGGACA GCACCGACAG 
GTTTTGGTAT GGAAAGACCT TGACAGTCCC CGAGCTCTGG CATTGGATCC TGCTGAAGGA 
TTTATGTATT GGACTGAGTG GGGAGGGAAG CCTAAGATTG ACAGAGCGGC TATGGATGGA 
AGTGAACGCA CTACATTAGT TCCAAATGTG GGTCGAGCAA ATGGCCTTAC CATCGACTAT 
GCTAAGAGGC GGCTTTACTG GACAGACCTG GACACTAACT TAATAGAATC TTCAAATATG 
CTCGGACTCA ACCGTGAAGT TATAGCAGAT GACTTGCCTC ATCCTTTTGG CTTAACTCAG 
TACCAAGATT ACATCTACTG GACAGACTGG AGCCGACGCA GCATTGAACG TGCCAACAAA 
ACCAGTGGCC AAAACCGCAC CATCATCCAG GGCCATTTGG ATTATGTGAT GGACATCCTA 
GTCTTTCACT CTTCCCGGCA GGCAGGGTGG AATGAATGTG CCTCCAGCAA CGGGCACTGC 
TCCCACCTTT GCTTGGCTGT GCCTGTTGGA GGTTTTGTGT GTGGATGCCC TGCCCACTAC 
TCCCTGAATG CTGACAACAG GACCTGTAGT GCTCCTACCA CCTTCCTGCT CTTCAGTCAG 
AAGAGCGCCA TCAACCGCAT GGTGATTGAT GAACAACAGA GTCCTGACAT CATCCTTCCT 
ATCCACAGCC TTCGGAACGT CCGGGCCATT GATTATGACC CTTTGGACAA GCAGCTCTAC 
TGGATTGACT CTCGACAAAA CATGATACGA AAGGCACAAG AAGATGGTGG CCAGGGTTTT 
ACTGTAGTTG TAAGCTCGGT TCCAAATCAG AACCTTGAAA TACAGCCCTA TGATCTCAGC 
ATTGATATTT ATAGCCGTTA CATCTATTGG ACCTGTGAAG CTACCAATGT CATTGATGTG 
ACGAGATTAG ATGGTCGATC AGTTGGAGTG GTCCTAAAAG GCGAGCAAGA CAGACCTCGA 
GCCATTGTGG TAAACCCTGA GAAAGGGTAT ATGTATTTTA CCAATCTTCA GGAAAGATCT 
CCCAAAATTG AACGGGCTGC CTTGGATGGA ACAGAACGGG AGGTTCTCTT TTTCAGTGGC 
CTGAGTAAGC CCGTCGCTTT GGCTCTCGAC AGCAAGCTGA GCAGGCTCTT CTGGGCTGAC 
TCCGACCTCC GGCGAATTGA GAGCAGCGAC CTCTCAGGTG CCAACAGGAT CGTGCTAGAG 
GACTCTAATA TATTGCAGCC TGTGGGTCTG ACCGTGTTTG AGAACTGGCT CTACTGGATT 
GATAAGCAGC AACAGATGAT TGAAAAAATT GACATGACTG GTCGCGAAGG CAGAACCAAG 
GTCCAGGCTC GGATTGCTCA GCTCAGTGAC ATCCATGCAG TGAAGGAGCT GAACCTTCAG 
GAATACAGAC AGCACCCGTG TGCCCAGGAT AATGGTGGCT GTTCACATAT TTGCCTTGTA 
AAAGGAGATG GTACCACAAG ATGCTCCTGT CCCATGCATT TAGTTCTGCT TCAGGATGAG 
CTGTCCTGTG GAGAGCCTCC AACATGTTCT CCTCAGCAGT TTACGTGTTT CACTGGGGAC 
ATTGACTGCA TCCCTGTGGC CTGGCGGTGT GATGGGTTTA CTGAATGTGA AGACCACAGT 
GATGAGCTCA ACTGTCCTGT GTGCTCGGAG TCTCAGTTCC AGTGTGCCAG CGGGCAGTGC 
ATTGACGGCG CCCTTCGATG CAATGGTGAC GCGAACTGCC AGGATAAATC GGATGAGAAG 
AACTGTGAAG TGCTTTGTCT AATTGATCAG TTCCGCTGTG CCAATGGTCA GTGCGTTGGA 
AAACACAAGA AATGCGACCA CAATGTGGAC TGCAGTGACA GATCTGATGA ACTGGACTGC 
TATCCAACTG AGGAGCCAGC ACCACAGGCC ACCAACACAG TTGGTTCCGT TATCGGAGTA 
ATTGTCACCA TTTTTGTGTC TGGAACCATA TACTTTATCT GCCAAAGGAT GCTGTGTCCT 
CGTATGAAGG GGGATGGGGA AACCATGACT AATGACTACG TGGTTCACGG CCCAGCTTCT 
GTGCCCCTTG GTTATGTTCC TCACCCAAGC TCTCTGTCTG GATCTCTTCC AGGGATGTCT 
CGAGGCAAAT CAATGATCAG TTCTCTCAGT ATCATGGGGG GGAGCAGTGG GCCCCCCTAC 
GATCGAGCAC ACGTCACGGG AGCGTCCTCA AGCAGCTCTT CCAGTACCAA AGGCACTTAC 
TTCCCTGCAA TTTTGAACCC ACCACCATCG CCTGCCACAG AGCGATCCCA TTATACCATG 
GAGTTTGGCT ATTCTTCCAA CAGTCCTTCC ACACATAGGT CCTACAGCTA CAGGCCGTAC 
AGCTACCGGC ACTTTGCACC GCCCACTACA CCCTGCAGCA CTGATGTCTG TGACAGTGAC 
TATGCTCCTA GCCGGAGAAT GACCTCAGTG GCAACAGCCA AGGGCTACAC CAGTGACTTG 
AACTATGACT CAGAACCTGT GCCCCCACCA CCCACACCCC GAAGCCAGTA CTTGTCGGCA 
GAGGAGAACT ATGAAAGCTG CCCCCCTTCT CCATACACTG AGAGGAGTTA CTCCCATCAC 
CTCTACCCAC CACCACCTTC CCCCTGCACG GACTCCTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LRP6 acts as a scaffold protein in cardiac gap junction assembly.
Nature communications711775(2016 Jun)
Li J,Li C,Liang D,Lv F,Yuan T,The E,Ma X,Wu Y,Zhen L,Xie D,Wang S,Liu Y,Huang J,Shi J,Liu Y,Shi D,Xu L,Lin L,Peng L,Cui J,Zhu W,Chen YH

REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-?-catenin signaling.
Oncotarget7(11)12035-52(2016 Mar)
Song Z,Zhu T,Zhou X,Barrow P,Yang W,Cui Y,Yang L,Zhao D

Reduced LRP6 expression and increase in the interaction of GSK3? with p53 contribute to podocyte apoptosis in diabetes mellitus and are prevented by green tea.
The Journal of nutritional biochemistry26(4)416-30(2015 Apr)
Peixoto EB,Papadimitriou A,Teixeira DA,Montemurro C,Duarte DA,Silva KC,Joazeiro PP,Lopes de Faria JM,Lopes de Faria JB

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Lrp6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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