Itgal cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Itgal
Entrez Gene ID	308995
Full Name	integrin subunit alpha L
Synonyms	LFA-1
General protein information	Preferred Names integrin subunit alpha L Names integrin alpha-L integrin, alpha L lymphocyte function-associated antigen-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q37
Summary	human homolog encodes the integrin alpha L chain which combines with beta 2 chain to form LFA-1 [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001033998.2	NP_001029170.1	integrin alpha-L precursor
XM_006230269.3	XP_006230331.1	integrin alpha-L isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Itgal	NP_001240801.1
Danio rerio (zebrafish)	zmp:0000001082	XP_005171121.1
Homo sapiens (human)	ITGAL	NP_002200.2
Pan troglodytes (chimpanzee)	ITGAL	NP_001029341.1
Canis lupus familiaris (dog)	ITGAL	XP_547024.2
Bos taurus (cattle)	ITGAL	NP_937864.2
Rattus norvegicus (Norway rat)	Itgal	NP_001029170.1

Gene Ontology
Bibliography

Related articles in PubMed

Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines.
Roberts LL, Robinson CM
Immunology141(1)39-51(2014 Jan)

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Liang Y, Cucchetti M, Roncagalli R, Yokosuka T, Malzac A, Bertosio E, Imbert J, Nijman IJ, Suchanek M, Saito T, W?lfing C, Malissen B, Malissen M
Nature immunology14(8)858-66(2013 Aug)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

Forced swimming test decreases chemotactic responsiveness and expression of CD11a in rat monocytes.
Brice?o F, Arcaya JL, Carrizo E, Rinc?n J, Mosquera J
Neuroimmunomodulation17(6)369-78(2010)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Downregulated expression of CD11a in an experimental model of depression could be an important mechanisms to induce impaired immune responses in experimental and clinical depression.
Title: Forced swimming test decreases chemotactic responsiveness and expression of CD11a in rat monocytes.

The following Itgal gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itgal cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13687	NM_001033998.2 Latest version!	Rattus norvegicus integrin subunit alpha L (Itgal), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$853.30 $1219.00
ORa23435	XM_006230269.3 Latest version!	Rattus norvegicus integrin subunit alpha L (Itgal), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Itgal ( NM_001033998.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001029170.1 Rattus norvegicus integrin subunit alpha L (Itgal), mRNA.

Price & Availability↑

CloneID	ORa13687
Clone ID Related Accession (Same CDS sequence)	NM_001033998.2
Accession Version	NM_001033998.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	integrin alpha-L precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC101849.1, CV076006.1, DV727670.1 and CR471677.1. On May 3, 2007 this sequence version replaced NM_001033998.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC101849.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689598 [ECO:0000348] ##Evidence-Data-END##

ATGAGTTTCC GGATCCCTGG CCCCAGACTT CTGCTATTGG GGCTCCAGCT GTTTGTGAAT 
GCCTGGAGCT ACAACCTGGA CACGCGGCAT GCGCAGAGCT TCTTGACACA AGCTGGAAGA 
CATTTTGGGT ACCAGGTCTT GCAGTTTGGA GATGGGGTTG TCGTGGGAGC TCCAGGAGAG 
GGGAACAGCA CAGGAAACCT CTATCACTGT CACCCAAGCA GCGGCTCCTG CCAGCCAGTC 
CACCTAGGTT CTAACCATAC CTCCAAATAC TTGGGAATGA CCATGGTGAC AGATGCTGCC 
AAGGGAAGCC TTTTGGCCTG TGATCCTGGA CTGTCTCGGA CCTGTGATCA GAACCCCTAC 
CTCAGTGGGC TGTGCTACTT ATTTTCCCAG AGCCTGGGGA AACCTATATT ACAAAATCGT 
CCTGCTTATC AGGAATGTAT GAAGGGCAAT GTCGACCTAG TGTTTCTGTT CGATGGCTCA 
CAGAGCTTGG ATAAAAAGGA CTTTGAAAAA ATCGTGGACT TCATGAAGGA TGTGATGAGG 
AAACTCAGCA ACACTTCCTA CCAGTTTGCT GCTGTTCAGT TTTCCACAGA GTGCAAAACA 
GAATTTACTT TCTTGGACTA CATCAAGCTA AACAAGAATC CTGATGTTCT GCTAGGCAAC 
GTGACGCCCA TGTTCTTGCT GACCAATACC TTCCGTGCCA TCAACTACGT GGTGACACAC 
GTGTTCAAAG AAGAGTCTGG TGCCAGGCCA GATGCTACCA AGGTGCTTGT CATCATTACA 
GACGGGGAAG CAAGTGACAA TGGCAACATC GATGCAGCCC AAGACATAAC CCGCTATATC 
ATCGGGATTG GCAAGCATTT TTCAACCACA CAAAAGCAGG AGAAACTCCA CATATTTGCC 
TCAAAACCTG TAGAGGAATT TGTCAAGATT CTGGACACAT TTGAGAAGCT GAAGGATCTG 
TTTACTGATC TGCAGAGGAA GATTTATGCC ATTGAGGGCA CAAGCAAACA GGACCTGGCA 
TCCTTTAATA TGGAACTCTC CTCCAGCGGG ATCAGCGCAG ACCTCAGCAA GGGCCATGCG 
GTTGTTGGAG CCGTTGGGGC TAAGGATTGG GCTGGGGGCT TTCTGGACCT GCATGAAGAC 
CTGGAGGGTG CCACATTTGT TGGGCAGGAA CCGCTGACCT CAGATGAGAG AGGAGGTTAT 
CTGGGTTACA CTGTGGCCTG GCTGACCTCC CGGAGCTCTA GACCACTGCT GGCAGCAGGA 
GCTCCGCGGT ACCAGCATGT GGGACAAGTG CTGCTTTTCC AAGCCCCAGA AGCTGGAGGA 
CATTGGAACC AGACTCAGAA GATAGAAGGG ACTCAGATCG GATCTTACTT TGGTGGGGAG 
CTATGTAGCG TTGACCTGCA CCAAGATGGC GAGACAGATC TGCTGCTGAT TGGAGCGCCC 
CTCTTCTACG GGGAGCAGAG AGGAGGCCGA GTGTCCGTTT ACCAGAGAAG ACGGTCACTG 
TTCGAAATGG TCTCAGAGCT GCAGGGTGAC CCAGGCTACC CGCTTGGTCG GTTTGGAGCT 
GCCATAAGTG CCCTGACAGA CATCAATGGG GATGGGCTGA CTGATGTGGC CGTGGGAGCC 
CCTCTGGAGG AGCAGGGGGC TGTGTATATC TTCAATGGGA AGCCTGGTGG GTTCAGTTCC 
CAGTCAAGTC AGCGTATACC AGGAACCCAG GTGTCCCCGG GAGTCCGGTG GTTTGGACGC 
TCCATCCATG GGGTGAAGGA CCTTGGAGGG GACAGGCTGG CAGATGTGGT TGTAGGAGCT 
GAGGGCCAGG TGATTGTGCT GAGCTCGAGG CCGGTGGTGG ATATTGTCAC TGAGCTGTCC 
TTCTCCCCAG ACGAAATCCC AGTGCATGAG GTGGAGTGCT CCTACTCAGC CAGTCAGGAG 
CAGAAGGAAG GCGTCAAGCT CAAGGTGTGC TTCCAGATCC GCCCCCTTAC GTCTCAGTTT 
CAAGGTCGCC TGCTTGCCAA CCTCAGCTAC ACCCTGCAGC TGGACGGCCA TCGGACGAGG 
AGCCGAGGTC TGTTCCCAGG AGGAAGCCGT GAGCTCGGCG GAAACACATT TGTCACCCCA 
GATAGGTCCT GCATGGACTT CCACTTCCAC TTCCCAATCT GCATTCAAGA CCTCATCTCC 
CCTATCAATG TCTCTCTGAA TTTCTCTCTT TTGGAGGAAG AAGGATCACC AAGGGACCAA 
AAGGGGGGCA GGGACATGCA GCCCATCCTG AGACCTTCGA TCCATGCAGT CACTAAGGAG 
ATCCCCTTTG AGAAGAACTG TGGTGAGGAT AAGAAGTGTG AGGCAGACCT GGCCCTGTCA 
CCTCCTGCCA GATCCGGAGT CCTGCGTCTG ATGTCCTCTG CCAGCCTTGC TGTGGAGTGG 
ACACTGAGGA ACTTGGGAGA AGACGCTTAC TGGGTGCGAC TGGACCTGGA CTTCCCCCGG 
GGCCTCTCCT TCCGAAAAGT GGAGATGCTT CAGCCACACA GCCAAATACC TGTGAGCTGC 
GAGGAGCTCA CCGAGGAGTC GAGTCTCCTG ACTAAGACCC TGAAATGCAA TGTGAGCTCT 
CCCATCTTCA AAGCAGGCAA ACAGATGACC CTCCAGGTGA TGTTTAACAC GCTACTCAAC 
AGTTCCTGGG GAGATTTTGT CGAGCTGAAC GGCACTGTGC ACTGTGAGAA CGAGAACTCA 
AGCCTCGGGA AGGACAACTC AGCCACCACC CGCATTCCTG TCCTGTACCC TGTCAACATC 
CTTACTGAGG ACCAGGAGAA CTCCACACTC TATATCAGTT TCACCCCTAA AGGTCCCAAG 
ACTCAACAAG TCCAGCATAT CTACAAGGTG AGGATTCAGC CTTCTGCCTA TGACCACAAC 
ATGCCCGCAC TGGAGGCCTT GGTTGAGGTG CCGCAGCCTC ACAGCGAGGG CCCCATCGCA 
CACACATGGA CTGTGCATAC GGATCCCCTT GTCACTTGCC ACTGTGAGGA CCTGAAGAAG 
CCAACCAGGG AAGCTGAGCC CTGTCTGCCT GGAGTCCAGT TCCGCTGCCC AATTGTCTTC 
AGGCAAGAGA CCTTCATCCG AGTGGCCGGG ACTGTGGAAC TCTCAGAGAA AATCAAGGCC 
TCCTCCACAC TCAGCCTCTG CAGCTCGCTC TCAGTCTCCT TCAACAGCAG CAAGCATTTC 
CATTTGTATG GTAGCAAGGC CTCCAAGGCC CAGGTCCTCA TGAAGGTTGA CATGATCTAT 
GAGAAGGAGA TGCTTCACCT GTACGTGCTC AGCGGCATTG GGGGGCTATT GCTACTGTCC 
CTGATTTTCC TAGCGCTCTA CAAGGTTGGT TTCTTCAAAC GGAAGCTGAA GGAGAAGATG 
GAGGCGGATG GAGGTGTTCC AAATGGAAGC CCTGGCGAAG ACGCTGACCC TCTGGCAGTA 
CCTGGGGAAG AGACCAAAGA TATGGGCTGT CTAGAGCCCC TCCGTGAGAG TGACAAGGAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001029170.1
CDS	78..3560
Translation	MSFRIPGPRLLLLGLQLFVNAWSYNLDTRHAQSFLTQAGRHFGYQVLQFGDGVVVGAPGEGNSTGNLYHCHPSSGSCQPVHLGSNHTSKYLGMTMVTDAAKGSLLACDPGLSRTCDQNPYLSGLCYLFSQSLGKPILQNRPAYQECMKGNVDLVFLFDGSQSLDKKDFEKIVDFMKDVMRKLSNTSYQFAAVQFSTECKTEFTFLDYIKLNKNPDVLLGNVTPMFLLTNTFRAINYVVTHVFKEESGARPDATKVLVIITDGEASDNGNIDAAQDITRYIIGIGKHFSTTQKQEKLHIFASKPVEEFVKILDTFEKLKDLFTDLQRKIYAIEGTSKQDLASFNMELSSSGISADLSKGHAVVGAVGAKDWAGGFLDLHEDLEGATFVGQEPLTSDERGGYLGYTVAWLTSRSSRPLLAAGAPRYQHVGQVLLFQAPEAGGHWNQTQKIEGTQIGSYFGGELCSVDLHQDGETDLLLIGAPLFYGEQRGGRVSVYQRRRSLFEMVSELQGDPGYPLGRFGAAISALTDINGDGLTDVAVGAPLEEQGAVYIFNGKPGGFSSQSSQRIPGTQVSPGVRWFGRSIHGVKDLGGDRLADVVVGAEGQVIVLSSRPVVDIVTELSFSPDEIPVHEVECSYSASQEQKEGVKLKVCFQIRPLTSQFQGRLLANLSYTLQLDGHRTRSRGLFPGGSRELGGNTFVTPDRSCMDFHFHFPICIQDLISPINVSLNFSLLEEEGSPRDQKGGRDMQPILRPSIHAVTKEIPFEKNCGEDKKCEADLALSPPARSGVLRLMSSASLAVEWTLRNLGEDAYWVRLDLDFPRGLSFRKVEMLQPHSQIPVSCEELTEESSLLTKTLKCNVSSPIFKAGKQMTLQVMFNTLLNSSWGDFVELNGTVHCENENSSLGKDNSATTRIPVLYPVNILTEDQENSTLYISFTPKGPKTQQVQHIYKVRIQPSAYDHNMPALEALVEVPQPHSEGPIAHTWTVHTDPLVTCHCEDLKKPTREAEPCLPGVQFRCPIVFRQETFIRVAGTVELSEKIKASSTLSLCSSLSVSFNSSKHFHLYGSKASKAQVLMKVDMIYEKEMLHLYVLSGIGGLLLLSLIFLALYKVGFFKRKLKEKMEADGGVPNGSPGEDADPLAVPGEETKDMGCLEPLRESDKD

Target ORF information:

RefSeq Version	NM_001033998.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus integrin subunit alpha L (Itgal), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033998.2

ORF Insert Sequence:

ATGAGTTTCC GGATCCCTGG CCCCAGACTT CTGCTATTGG GGCTCCAGCT GTTTGTGAAT 
GCCTGGAGCT ACAACCTGGA CACGCGGCAT GCGCAGAGCT TCTTGACACA AGCTGGAAGA 
CATTTTGGGT ACCAGGTCTT GCAGTTTGGA GATGGGGTTG TCGTGGGAGC TCCAGGAGAG 
GGGAACAGCA CAGGAAACCT CTATCACTGT CACCCAAGCA GCGGCTCCTG CCAGCCAGTC 
CACCTAGGTT CTAACCATAC CTCCAAATAC TTGGGAATGA CCATGGTGAC AGATGCTGCC 
AAGGGAAGCC TTTTGGCCTG TGATCCTGGA CTGTCTCGGA CCTGTGATCA GAACCCCTAC 
CTCAGTGGGC TGTGCTACTT ATTTTCCCAG AGCCTGGGGA AACCTATATT ACAAAATCGT 
CCTGCTTATC AGGAATGTAT GAAGGGCAAT GTCGACCTAG TGTTTCTGTT CGATGGCTCA 
CAGAGCTTGG ATAAAAAGGA CTTTGAAAAA ATCGTGGACT TCATGAAGGA TGTGATGAGG 
AAACTCAGCA ACACTTCCTA CCAGTTTGCT GCTGTTCAGT TTTCCACAGA GTGCAAAACA 
GAATTTACTT TCTTGGACTA CATCAAGCTA AACAAGAATC CTGATGTTCT GCTAGGCAAC 
GTGACGCCCA TGTTCTTGCT GACCAATACC TTCCGTGCCA TCAACTACGT GGTGACACAC 
GTGTTCAAAG AAGAGTCTGG TGCCAGGCCA GATGCTACCA AGGTGCTTGT CATCATTACA 
GACGGGGAAG CAAGTGACAA TGGCAACATC GATGCAGCCC AAGACATAAC CCGCTATATC 
ATCGGGATTG GCAAGCATTT TTCAACCACA CAAAAGCAGG AGAAACTCCA CATATTTGCC 
TCAAAACCTG TAGAGGAATT TGTCAAGATT CTGGACACAT TTGAGAAGCT GAAGGATCTG 
TTTACTGATC TGCAGAGGAA GATTTATGCC ATTGAGGGCA CAAGCAAACA GGACCTGGCA 
TCCTTTAATA TGGAACTCTC CTCCAGCGGG ATCAGCGCAG ACCTCAGCAA GGGCCATGCG 
GTTGTTGGAG CCGTTGGGGC TAAGGATTGG GCTGGGGGCT TTCTGGACCT GCATGAAGAC 
CTGGAGGGTG CCACATTTGT TGGGCAGGAA CCGCTGACCT CAGATGAGAG AGGAGGTTAT 
CTGGGTTACA CTGTGGCCTG GCTGACCTCC CGGAGCTCTA GACCACTGCT GGCAGCAGGA 
GCTCCGCGGT ACCAGCATGT GGGACAAGTG CTGCTTTTCC AAGCCCCAGA AGCTGGAGGA 
CATTGGAACC AGACTCAGAA GATAGAAGGG ACTCAGATCG GATCTTACTT TGGTGGGGAG 
CTATGTAGCG TTGACCTGCA CCAAGATGGC GAGACAGATC TGCTGCTGAT TGGAGCGCCC 
CTCTTCTACG GGGAGCAGAG AGGAGGCCGA GTGTCCGTTT ACCAGAGAAG ACGGTCACTG 
TTCGAAATGG TCTCAGAGCT GCAGGGTGAC CCAGGCTACC CGCTTGGTCG GTTTGGAGCT 
GCCATAAGTG CCCTGACAGA CATCAATGGG GATGGGCTGA CTGATGTGGC CGTGGGAGCC 
CCTCTGGAGG AGCAGGGGGC TGTGTATATC TTCAATGGGA AGCCTGGTGG GTTCAGTTCC 
CAGTCAAGTC AGCGTATACC AGGAACCCAG GTGTCCCCGG GAGTCCGGTG GTTTGGACGC 
TCCATCCATG GGGTGAAGGA CCTTGGAGGG GACAGGCTGG CAGATGTGGT TGTAGGAGCT 
GAGGGCCAGG TGATTGTGCT GAGCTCGAGG CCGGTGGTGG ATATTGTCAC TGAGCTGTCC 
TTCTCCCCAG ACGAAATCCC AGTGCATGAG GTGGAGTGCT CCTACTCAGC CAGTCAGGAG 
CAGAAGGAAG GCGTCAAGCT CAAGGTGTGC TTCCAGATCC GCCCCCTTAC GTCTCAGTTT 
CAAGGTCGCC TGCTTGCCAA CCTCAGCTAC ACCCTGCAGC TGGACGGCCA TCGGACGAGG 
AGCCGAGGTC TGTTCCCAGG AGGAAGCCGT GAGCTCGGCG GAAACACATT TGTCACCCCA 
GATAGGTCCT GCATGGACTT CCACTTCCAC TTCCCAATCT GCATTCAAGA CCTCATCTCC 
CCTATCAATG TCTCTCTGAA TTTCTCTCTT TTGGAGGAAG AAGGATCACC AAGGGACCAA 
AAGGGGGGCA GGGACATGCA GCCCATCCTG AGACCTTCGA TCCATGCAGT CACTAAGGAG 
ATCCCCTTTG AGAAGAACTG TGGTGAGGAT AAGAAGTGTG AGGCAGACCT GGCCCTGTCA 
CCTCCTGCCA GATCCGGAGT CCTGCGTCTG ATGTCCTCTG CCAGCCTTGC TGTGGAGTGG 
ACACTGAGGA ACTTGGGAGA AGACGCTTAC TGGGTGCGAC TGGACCTGGA CTTCCCCCGG 
GGCCTCTCCT TCCGAAAAGT GGAGATGCTT CAGCCACACA GCCAAATACC TGTGAGCTGC 
GAGGAGCTCA CCGAGGAGTC GAGTCTCCTG ACTAAGACCC TGAAATGCAA TGTGAGCTCT 
CCCATCTTCA AAGCAGGCAA ACAGATGACC CTCCAGGTGA TGTTTAACAC GCTACTCAAC 
AGTTCCTGGG GAGATTTTGT CGAGCTGAAC GGCACTGTGC ACTGTGAGAA CGAGAACTCA 
AGCCTCGGGA AGGACAACTC AGCCACCACC CGCATTCCTG TCCTGTACCC TGTCAACATC 
CTTACTGAGG ACCAGGAGAA CTCCACACTC TATATCAGTT TCACCCCTAA AGGTCCCAAG 
ACTCAACAAG TCCAGCATAT CTACAAGGTG AGGATTCAGC CTTCTGCCTA TGACCACAAC 
ATGCCCGCAC TGGAGGCCTT GGTTGAGGTG CCGCAGCCTC ACAGCGAGGG CCCCATCGCA 
CACACATGGA CTGTGCATAC GGATCCCCTT GTCACTTGCC ACTGTGAGGA CCTGAAGAAG 
CCAACCAGGG AAGCTGAGCC CTGTCTGCCT GGAGTCCAGT TCCGCTGCCC AATTGTCTTC 
AGGCAAGAGA CCTTCATCCG AGTGGCCGGG ACTGTGGAAC TCTCAGAGAA AATCAAGGCC 
TCCTCCACAC TCAGCCTCTG CAGCTCGCTC TCAGTCTCCT TCAACAGCAG CAAGCATTTC 
CATTTGTATG GTAGCAAGGC CTCCAAGGCC CAGGTCCTCA TGAAGGTTGA CATGATCTAT 
GAGAAGGAGA TGCTTCACCT GTACGTGCTC AGCGGCATTG GGGGGCTATT GCTACTGTCC 
CTGATTTTCC TAGCGCTCTA CAAGGTTGGT TTCTTCAAAC GGAAGCTGAA GGAGAAGATG 
GAGGCGGATG GAGGTGTTCC AAATGGAAGC CCTGGCGAAG ACGCTGACCC TCTGGCAGTA 
CCTGGGGAAG AGACCAAAGA TATGGGCTGT CTAGAGCCCC TCCGTGAGAG TGACAAGGAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Itgal ( XM_006230269.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006230331.1 Rattus norvegicus integrin subunit alpha L (Itgal), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa23435
Clone ID Related Accession (Same CDS sequence)	XM_006230269.3
Accession Version	XM_006230269.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	integrin alpha-L isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006230269.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTTTCC GGATCCCTGG CCCCAGACTT CTGCTATTGG GGCTCCAGCT GTTTGTGAAT 
GCCTGGAGCT ACAACCTGGA CACGCGGCAT GCGCAGAGCT TCTTGACACA AGCTGGAAGA 
CATTTTGGGT ACCAGGTCTT GCAGTTTGGA GATGGGGTTG TCGTGGGAGC TCCAGGAGAG 
GGGAACAGCA CAGGAAGCCT CTATCACTGT CACCCAAGCA GCGGCTCCTG CCAGCCAGTC 
CACCTAGGTT CTAACCATAC CTCCAAATAC TTGGGAATGA CCATGGTGAC AGATGCTGCC 
AAGGGAAGCC TTTTGGCCTG TGATCCTGGA CTGTCTCGGA CCTGTGATCA GAACCCCTAC 
CTCAGTGGGC TGTGCTACTT ATTTTCCCAG AGCCTGGGGA AACCTATATT ACAAAATCGT 
CCTGCTTATC AGGAATGTAT GAAGGGCAAT GTCGACCTAG TGTTTCTGTT CGATGGCTCA 
CAGAGCTTGG ATAAAAAGGA CTTTGAAAAA ATCGTGGACT TCATGAAGGA TGTGATGAGG 
AAACTCAGCA ACACTTCCTA CCAGTTTGCT GCTGTTCAGT TTTCCACAGA GTGCAAAACA 
GAATTTACTT TCTTGGACTA CATCAAGCTA AACAAGAATC CTGATGTTCT GCTAGGCAAC 
GTGACGCCCA TGTTCTTGCT GACCAATACC TTCCGTGCCA TCAACTACGT GGTGACACAC 
GTGTTCAAAG AAGAGTCTGG TGCCAGGCCA GATGCTACCA AGGTGCTTGT CATCATTACA 
GACGGGGAAG CAAGTGACAA TGGCAACATC GATGCAGCCC AAGACATAAC CCGCTATATC 
ATCGGGATTG GCAAGCATTT TTCAACCACA CAAAAGCAGG AGAAACTCCA CATATTTGCC 
TCAAAACCTG TAGAGGAATT TGTCAAGATT CTGGACACAT TTGAGAAGCT GAAGGATCTG 
TTTACTGATC TGCAGAGGAA GATTTATGCC ATTGAGGGCA CAAGCAAACA GGACCTGGCA 
TCCTTTAATA TGGAACTCTC CTCCAGCGGG ATCAGCGCAG ACCTCAGCAA GGGCCATGCG 
GTTGTTGGAG CCGTTGGGGC TAAGGATTGG GCTGGGGGCT TTCTGGACCT GCATGAAGAC 
CTGGAGGGTG CCACATTTGT TGGGCAGGAA CCGCTGACCT CAGATGAGAG AGGAGGTTAT 
CTGGGTTACA CTGTGGCCTG GCTGACCTCC CGGAGCTCTA GACCACTGCT GGCAGCAGGA 
GCTCCGCGGT ACCAGCATGT GGGACAAGTG CTGCTTTTCC AAGCCCCAGA GGCTGGAGGA 
CATTGGAACC AGACTCAGAA GATAGAAGGG ACTCAGATCG GATCTTACTT TGGTGGGGAG 
CTATGTAGCG TTGACCTGCA CCAAGATGGC GAGACAGATC TGCTGCTGAT TGGAGCGCCC 
CTCTTCTACG GGGAGCAGAG AGGAGGCCGA GTGTCCGTTT ACCAGAGAAG ACGGTCACTG 
TTCGAAATGG TCTCAGAGCT GCAGGGTGAC CCAGGCTACC CGCTTGGTCG GTTTGGAGCT 
GCCATAAGTG CCCTGACAGA CATCAATGGG GATGGGCTGA CTGATGTGGC CGTGGGAGCC 
CCTCTGGAGG AGCAGGGGGC TGTGTATATC TTCAATGGGA AGCCTGGTGG GTTCAGTTCC 
CAGTCAAGTC AGCGTATACC AGGAACCCAG GTGTCCCCGG GAGTCCGGTG GTTTGGACGC 
TCCATCCATG GGGTGAAGGA CCTTGGAGGG GACAGGCTGG CAGATGTGGT TGTAGGAGCT 
GAGGGCCAGG TGATTGTGCT GAGCTCAAGG CCGGTGGTGG ATATTGTCAC TGAGCTGTCC 
TTCTCCCCAG ACGAAATCCC AGTGCATGAG GTGGAGTGCT CCTACTCAGC CAGTCAGGAG 
CAGAAGGAAG GCGTCAAGCT CAAGGTGTGC TTCCAGATCC GCCCCCTTAC GTCTCAGTTT 
CAAGGTCGCC TGCTTGCCAA CCTCAGCTAC ACCCTGCAGC TGGACGGCCA TCGGACAAGG 
AGCCGAGGTC TGTTCCCAGG AGGAAGCCGT GAGCTCGGCG GAAACACATC TGTCACCCCA 
GATAAGTCCT GCATGGACTT CCACTTCCAC TTCCCAATCT GCATTCAAGA CCTCATCTCC 
CCTATCAATG TCTCTCTGAA TTTCTCTCTT TTGGAGGAAG AAGGATCACC AAGGGACCAA 
AAGGGGGGCA GGGACATGCA GCCCATCCTG AGACCTTCGA TCCATGCAGT CACTAAGGAG 
ATCCCCTTTG AGAAGAACTG TGGTGAGGAT AAGAAGTGTG AGGCAGACCT GGCCCTGTCA 
CCTCCTGCCA GATCCGGAGT CCTGCGTCTG ATGTCCTCTG CCAGCCTTGC TGTGGAGTGG 
ACACTGAGGA ACTTGGGAGA AGACGCTTAC TGGGTGCGAC TGGACCTGGA CTTCCCCCGG 
GGCCTCTCCT TCCGAAAAGT GGAGATGCTT CAGCCACACA GCCAAATACC TGTGAGCTGC 
GAGGAGCTCA CCGAGGAGTC GAGTCTCCTG ACTAAGACCC TGAAATGCAA TGTGAGCTCT 
CCCATCTTCA AAGCAGGCAA ACAGATGACC CTCCAGGTGA TGTTTAACAC GCTACTCAAC 
AGTTCCTGGG GAGATTTTGT CGAGCTGAAC GGCACTGTGC ACTGTGAGAA CGAGAACTCA 
AGCCTCGGGA AGGACAACTC AGCCACCACC CGCATTCCTG TCCTGTACCC TGTCAACATC 
CTTACTGAGG ACCAGGAGAA CTCCACACTC TATATCAGTT TCACCCCTAA AGGTCCCAAG 
ACTCAACAAG TCCAGCATAT CTACAAGGTG AGGATTCAGC CTTCTGCCTA TGACCACAAC 
ATGCCCGCAC TGGAGGCCTT GGTTGAGGTG CCGCAGCCTC ACAGCGAGGG CCCCATCGCA 
CACACATGGA CTGTGCATAC GGATCCCCTT GTCACTTGCC ACCGTGAGGA CCTGAAGAAG 
CCAACCAGGG AAGCTGAGCA GCCCTGTCTG CCTGGAGTCC AGTTCCGCTG CCCAATTGTC 
TTCAGGCAAG AGACCTTCAT CCGAGTGGCC GGGACTGTGG AACTCTCAGA GAAAATCAAG 
GCCTCCTCCA CACTCAGCCT CTGCAGCTCG CTCTCAGTCT CCTTCAACAG CAGCAAGCAT 
TTCCATTTGT ATGGTAGCAA GGCCTCCAAG GCCCAGGTCC TCATGAAGGT TGACATGATC 
TATGAGAAGG AGATGCTTCA CCTGTACGTG CTCAGCGGCA TTGGGGGGCT ATTGCTACTG 
TCCCTGATTT TCCTAGCGCT CTACAAGGTT GGTTTCTTCA AACGGAAGCT GAAGGAGAAG 
ATGGAGGCGG ATGGAGGTGT TCCAAATGGA AGCCCTGGCG AAGACGCTGA CCCTCTGGCA 
GTACCTGGGG AAGAGACCAA AGATATGGGC TGTCTAGAGC CCCTCCGTGA GAGTGACAAG 
GACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006230331.1
CDS	217..3702
Translation	MSFRIPGPRLLLLGLQLFVNAWSYNLDTRHAQSFLTQAGRHFGYQVLQFGDGVVVGAPGEGNSTGSLYHCHPSSGSCQPVHLGSNHTSKYLGMTMVTDAAKGSLLACDPGLSRTCDQNPYLSGLCYLFSQSLGKPILQNRPAYQECMKGNVDLVFLFDGSQSLDKKDFEKIVDFMKDVMRKLSNTSYQFAAVQFSTECKTEFTFLDYIKLNKNPDVLLGNVTPMFLLTNTFRAINYVVTHVFKEESGARPDATKVLVIITDGEASDNGNIDAAQDITRYIIGIGKHFSTTQKQEKLHIFASKPVEEFVKILDTFEKLKDLFTDLQRKIYAIEGTSKQDLASFNMELSSSGISADLSKGHAVVGAVGAKDWAGGFLDLHEDLEGATFVGQEPLTSDERGGYLGYTVAWLTSRSSRPLLAAGAPRYQHVGQVLLFQAPEAGGHWNQTQKIEGTQIGSYFGGELCSVDLHQDGETDLLLIGAPLFYGEQRGGRVSVYQRRRSLFEMVSELQGDPGYPLGRFGAAISALTDINGDGLTDVAVGAPLEEQGAVYIFNGKPGGFSSQSSQRIPGTQVSPGVRWFGRSIHGVKDLGGDRLADVVVGAEGQVIVLSSRPVVDIVTELSFSPDEIPVHEVECSYSASQEQKEGVKLKVCFQIRPLTSQFQGRLLANLSYTLQLDGHRTRSRGLFPGGSRELGGNTSVTPDKSCMDFHFHFPICIQDLISPINVSLNFSLLEEEGSPRDQKGGRDMQPILRPSIHAVTKEIPFEKNCGEDKKCEADLALSPPARSGVLRLMSSASLAVEWTLRNLGEDAYWVRLDLDFPRGLSFRKVEMLQPHSQIPVSCEELTEESSLLTKTLKCNVSSPIFKAGKQMTLQVMFNTLLNSSWGDFVELNGTVHCENENSSLGKDNSATTRIPVLYPVNILTEDQENSTLYISFTPKGPKTQQVQHIYKVRIQPSAYDHNMPALEALVEVPQPHSEGPIAHTWTVHTDPLVTCHREDLKKPTREAEQPCLPGVQFRCPIVFRQETFIRVAGTVELSEKIKASSTLSLCSSLSVSFNSSKHFHLYGSKASKAQVLMKVDMIYEKEMLHLYVLSGIGGLLLLSLIFLALYKVGFFKRKLKEKMEADGGVPNGSPGEDADPLAVPGEETKDMGCLEPLRESDKD

Target ORF information:

RefSeq Version	XM_006230269.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus integrin subunit alpha L (Itgal), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006230269.3

ORF Insert Sequence:

ATGAGTTTCC GGATCCCTGG CCCCAGACTT CTGCTATTGG GGCTCCAGCT GTTTGTGAAT 
GCCTGGAGCT ACAACCTGGA CACGCGGCAT GCGCAGAGCT TCTTGACACA AGCTGGAAGA 
CATTTTGGGT ACCAGGTCTT GCAGTTTGGA GATGGGGTTG TCGTGGGAGC TCCAGGAGAG 
GGGAACAGCA CAGGAAGCCT CTATCACTGT CACCCAAGCA GCGGCTCCTG CCAGCCAGTC 
CACCTAGGTT CTAACCATAC CTCCAAATAC TTGGGAATGA CCATGGTGAC AGATGCTGCC 
AAGGGAAGCC TTTTGGCCTG TGATCCTGGA CTGTCTCGGA CCTGTGATCA GAACCCCTAC 
CTCAGTGGGC TGTGCTACTT ATTTTCCCAG AGCCTGGGGA AACCTATATT ACAAAATCGT 
CCTGCTTATC AGGAATGTAT GAAGGGCAAT GTCGACCTAG TGTTTCTGTT CGATGGCTCA 
CAGAGCTTGG ATAAAAAGGA CTTTGAAAAA ATCGTGGACT TCATGAAGGA TGTGATGAGG 
AAACTCAGCA ACACTTCCTA CCAGTTTGCT GCTGTTCAGT TTTCCACAGA GTGCAAAACA 
GAATTTACTT TCTTGGACTA CATCAAGCTA AACAAGAATC CTGATGTTCT GCTAGGCAAC 
GTGACGCCCA TGTTCTTGCT GACCAATACC TTCCGTGCCA TCAACTACGT GGTGACACAC 
GTGTTCAAAG AAGAGTCTGG TGCCAGGCCA GATGCTACCA AGGTGCTTGT CATCATTACA 
GACGGGGAAG CAAGTGACAA TGGCAACATC GATGCAGCCC AAGACATAAC CCGCTATATC 
ATCGGGATTG GCAAGCATTT TTCAACCACA CAAAAGCAGG AGAAACTCCA CATATTTGCC 
TCAAAACCTG TAGAGGAATT TGTCAAGATT CTGGACACAT TTGAGAAGCT GAAGGATCTG 
TTTACTGATC TGCAGAGGAA GATTTATGCC ATTGAGGGCA CAAGCAAACA GGACCTGGCA 
TCCTTTAATA TGGAACTCTC CTCCAGCGGG ATCAGCGCAG ACCTCAGCAA GGGCCATGCG 
GTTGTTGGAG CCGTTGGGGC TAAGGATTGG GCTGGGGGCT TTCTGGACCT GCATGAAGAC 
CTGGAGGGTG CCACATTTGT TGGGCAGGAA CCGCTGACCT CAGATGAGAG AGGAGGTTAT 
CTGGGTTACA CTGTGGCCTG GCTGACCTCC CGGAGCTCTA GACCACTGCT GGCAGCAGGA 
GCTCCGCGGT ACCAGCATGT GGGACAAGTG CTGCTTTTCC AAGCCCCAGA GGCTGGAGGA 
CATTGGAACC AGACTCAGAA GATAGAAGGG ACTCAGATCG GATCTTACTT TGGTGGGGAG 
CTATGTAGCG TTGACCTGCA CCAAGATGGC GAGACAGATC TGCTGCTGAT TGGAGCGCCC 
CTCTTCTACG GGGAGCAGAG AGGAGGCCGA GTGTCCGTTT ACCAGAGAAG ACGGTCACTG 
TTCGAAATGG TCTCAGAGCT GCAGGGTGAC CCAGGCTACC CGCTTGGTCG GTTTGGAGCT 
GCCATAAGTG CCCTGACAGA CATCAATGGG GATGGGCTGA CTGATGTGGC CGTGGGAGCC 
CCTCTGGAGG AGCAGGGGGC TGTGTATATC TTCAATGGGA AGCCTGGTGG GTTCAGTTCC 
CAGTCAAGTC AGCGTATACC AGGAACCCAG GTGTCCCCGG GAGTCCGGTG GTTTGGACGC 
TCCATCCATG GGGTGAAGGA CCTTGGAGGG GACAGGCTGG CAGATGTGGT TGTAGGAGCT 
GAGGGCCAGG TGATTGTGCT GAGCTCAAGG CCGGTGGTGG ATATTGTCAC TGAGCTGTCC 
TTCTCCCCAG ACGAAATCCC AGTGCATGAG GTGGAGTGCT CCTACTCAGC CAGTCAGGAG 
CAGAAGGAAG GCGTCAAGCT CAAGGTGTGC TTCCAGATCC GCCCCCTTAC GTCTCAGTTT 
CAAGGTCGCC TGCTTGCCAA CCTCAGCTAC ACCCTGCAGC TGGACGGCCA TCGGACAAGG 
AGCCGAGGTC TGTTCCCAGG AGGAAGCCGT GAGCTCGGCG GAAACACATC TGTCACCCCA 
GATAAGTCCT GCATGGACTT CCACTTCCAC TTCCCAATCT GCATTCAAGA CCTCATCTCC 
CCTATCAATG TCTCTCTGAA TTTCTCTCTT TTGGAGGAAG AAGGATCACC AAGGGACCAA 
AAGGGGGGCA GGGACATGCA GCCCATCCTG AGACCTTCGA TCCATGCAGT CACTAAGGAG 
ATCCCCTTTG AGAAGAACTG TGGTGAGGAT AAGAAGTGTG AGGCAGACCT GGCCCTGTCA 
CCTCCTGCCA GATCCGGAGT CCTGCGTCTG ATGTCCTCTG CCAGCCTTGC TGTGGAGTGG 
ACACTGAGGA ACTTGGGAGA AGACGCTTAC TGGGTGCGAC TGGACCTGGA CTTCCCCCGG 
GGCCTCTCCT TCCGAAAAGT GGAGATGCTT CAGCCACACA GCCAAATACC TGTGAGCTGC 
GAGGAGCTCA CCGAGGAGTC GAGTCTCCTG ACTAAGACCC TGAAATGCAA TGTGAGCTCT 
CCCATCTTCA AAGCAGGCAA ACAGATGACC CTCCAGGTGA TGTTTAACAC GCTACTCAAC 
AGTTCCTGGG GAGATTTTGT CGAGCTGAAC GGCACTGTGC ACTGTGAGAA CGAGAACTCA 
AGCCTCGGGA AGGACAACTC AGCCACCACC CGCATTCCTG TCCTGTACCC TGTCAACATC 
CTTACTGAGG ACCAGGAGAA CTCCACACTC TATATCAGTT TCACCCCTAA AGGTCCCAAG 
ACTCAACAAG TCCAGCATAT CTACAAGGTG AGGATTCAGC CTTCTGCCTA TGACCACAAC 
ATGCCCGCAC TGGAGGCCTT GGTTGAGGTG CCGCAGCCTC ACAGCGAGGG CCCCATCGCA 
CACACATGGA CTGTGCATAC GGATCCCCTT GTCACTTGCC ACCGTGAGGA CCTGAAGAAG 
CCAACCAGGG AAGCTGAGCA GCCCTGTCTG CCTGGAGTCC AGTTCCGCTG CCCAATTGTC 
TTCAGGCAAG AGACCTTCAT CCGAGTGGCC GGGACTGTGG AACTCTCAGA GAAAATCAAG 
GCCTCCTCCA CACTCAGCCT CTGCAGCTCG CTCTCAGTCT CCTTCAACAG CAGCAAGCAT 
TTCCATTTGT ATGGTAGCAA GGCCTCCAAG GCCCAGGTCC TCATGAAGGT TGACATGATC 
TATGAGAAGG AGATGCTTCA CCTGTACGTG CTCAGCGGCA TTGGGGGGCT ATTGCTACTG 
TCCCTGATTT TCCTAGCGCT CTACAAGGTT GGTTTCTTCA AACGGAAGCT GAAGGAGAAG 
ATGGAGGCGG ATGGAGGTGT TCCAAATGGA AGCCCTGGCG AAGACGCTGA CCCTCTGGCA 
GTACCTGGGG AAGAGACCAA AGATATGGGC TGTCTAGAGC CCCTCCGTGA GAGTGACAAG 
GACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines.
Immunology141(1)39-51(2014 Jan)
Roberts LL,Robinson CM

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Nature immunology14(8)858-66(2013 Aug)
Liang Y,Cucchetti M,Roncagalli R,Yokosuka T,Malzac A,Bertosio E,Imbert J,Nijman IJ,Suchanek M,Saito T,W?lfing C,Malissen B,Malissen M

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

Forced swimming test decreases chemotactic responsiveness and expression of CD11a in rat monocytes.
Neuroimmunomodulation17(6)369-78(2010)
Brice?o F,Arcaya JL,Carrizo E,Rinc?n J,Mosquera J

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Itgal cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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