Cdh5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdh5
Entrez Gene ID	307618
Full Name	cadherin 5
General protein information	Preferred Names cadherin 5 Names cadherin-5 VE-cadherin vascular endothelial cadherin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19p14

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107407.1	NP_001100877.1	cadherin-5

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Cdh5	NP_001100877.1
Gallus gallus (chicken)	CDH5	NP_989558.1
	CDH5	XP_001082641.1
Pan troglodytes (chimpanzee)	CDH5	XP_523383.3
Canis lupus familiaris (dog)	CDH5	XP_546894.2
Homo sapiens (human)	CDH5	NP_001786.2
Bos taurus (cattle)	CDH5	NP_001001601.1
Mus musculus (house mouse)	Cdh5	NP_033998.2
Danio rerio (zebrafish)	cdh5	NP_001003983.1
Xenopus tropicalis (tropical clawed frog)	cdh5	XP_002933718.2

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-22 regulates inflammation and angiogenesis via targeting VE-cadherin.
Gu W, Zhan H, Zhou XY, Yao L, Yan M, Chen A, Liu J, Ren X, Zhang X, Liu JX, Liu G
FEBS letters591(3)513-526(2017 02)

Defining the molecular basis of interaction between R3 receptor-type protein tyrosine phosphatases and VE-cadherin.
Dorofejeva O, Barr AJ
PloS one12(9)e0184574(2017)

Vascular endothelial-cadherin downregulation as a feature of endothelial transdifferentiation in monocrotaline-induced pulmonary hypertension.
Nikitopoulou I, Orfanos SE, Kotanidou A, Maltabe V, Manitsopoulos N, Karras P, Kouklis P, Armaganidis A, Maniatis NA
American journal of physiology. Lung cellular and molecular physiology311(2)L352-63(2016 Aug)

Cardiopulmonary bypass increases pulmonary microvascular permeability through the Src kinase pathway: Involvement of caveolin-1 and vascular endothelial cadherin.
Zhang J, Jiang Z, Bao C, Mei J, Zhu J
Molecular medicine reports13(3)2918-24(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Transcriptional repression of VE-cadherin by nitrosative stress is involved in endothelial-mesenchymal transdifferentiation in experimental pulmonary hypertension.
Title: Vascular endothelial-cadherin downregulation as a feature of endothelial transdifferentiation in monocrotaline-induced pulmonary hypertension.

Rab Gtpases regulate VE-cadherin levels at the cell surface to modulate the pulmonary endothelium.
Title: Select Rab GTPases Regulate the Pulmonary Endothelium via Endosomal Trafficking of Vascular Endothelial-Cadherin.

Changes in the SRC kinase mediated phosphorylation status of caveolin1 and VEcadherin may be involved in pulmonary microvascular permeability following cardiopulmonary bypass.
Title: Cardiopulmonary bypass increases pulmonary microvascular permeability through the Src kinase pathway: Involvement of caveolin-1 and vascular endothelial cadherin.

Nitric oxide increases arterial endotheial permeability through mediating VE-Cadherin expression during arteriogenesis.
Title: Nitric Oxide Increases Arterial Endotheial Permeability through Mediating VE-Cadherin Expression during Arteriogenesis.

Our studies indicate that diabetic conditions prime endothelial cells into a phenotype with increased susceptibility to inflammation without altering receptor expression and that the increased Rho activation.
Title: Enhanced permeability responses to inflammation in streptozotocin-induced diabetic rat venules: Rho-mediated alterations of actin cytoskeleton and VE-cadherin.

The following Cdh5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdh5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03440	NM_001107407.1 Latest version!	Rattus norvegicus cadherin 5 (Cdh5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$454.30 $649.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdh5 ( NM_001107407.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100877.1 Rattus norvegicus cadherin 5 (Cdh5), mRNA.

Price & Availability↑

CloneID	ORa03440
Clone ID Related Accession (Same CDS sequence)	NM_001107407.1
Accession Version	NM_001107407.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2331bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	cadherin-5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474006.1. On or before Oct 4, 2007 this sequence version replaced XM_001057656.1, XM_226213.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCAGAGGC TCACAGAGCT GGCCACTGCT TTGGGCACCT TCTTGGGCCT GCTGGCAGTG 
GCAGCGATGG CAGGCCCCAA CATGCTGCCT GTCCACCAGC GCCAAAAGAG AGACTGGATT 
TGGAATCAAA TGCACATAGA TGAAGAGAAA AATGAGTCGC TGCCCCACTA TGTGGGAAAG 
ATCAAGTCCA ATGTGAACCG TCAGAATGCT AAGTATGTGC TCCAAGGAGA ACAAGCTGGC 
AAGATCTTCA GGGTCGATGC TGACACAGGG GATGTGCTTG CCTATGAGAG GTTAGACCGG 
GAAAAAGTCT CTGAGTACTT CCTTACTGCC CTCATTGTGG ACAAGAAGAC CAACAAAAAC 
CTGGAACAAC CTTCCAGCTT CACTGTCAAG GTGCATGATG TAAATGACAA CTGGCCTGTG 
TTTACGCACC AGGTATTCAA CGCATCTGTG CCCGAGATGT CAGCTATAGG GACCTCTGTC 
ATCCGTGTGA CAGCAACGGA TGCAGATGAC CCTACGGTGG CTGGCCACGC CACTGTCTTG 
TACCAAATGG TGAAAGGAAA TGAGTACTTC GCCATCGACA ATTCTGGACT CATTTTCACA 
AAGGACAAAA ACTTGGACAG AGAGACACGG GCTGAATACA AGATCGTGGT GGAAGCACAA 
GATGCCCAGG GTCTGCGGGG AGAGTCAGGC ACAGCCACTG TGCTGATCAG ATTGGAAGAC 
ATCAATGACA ACTTCCCCAT CTTTACTCAG TCCACATACA CATTTTCGGT GCCTGAAGAT 
ATCCGTGTGG GCAAGCCCTT GGGCTCTCTC TCTGTTGAGG ACCCAGATGA GCCTCAGAAC 
CGGATGACCA AATATAGCAT CATGCAGGGC GAGTACAGGG ACACCTTCAC CATTGAGACA 
GACCCCGACC GTAATGAGGG TATCATCAAA CCCACAAAGC CCCTGGACTA TGAACTCATC 
CAGCAGTACA CGTTCCACAT CGAGGCCACA GACCCCACTA TCAGACTCGG ATACCTGAGC 
AGCACTGCGG GCAAAAACAA AGCCAAGATC ATCATCAATG TCCTAGATGT GGATGAGCCC 
CCTGTCTTCC AGCGACGCTT CTACCACTTC CACCTGCCCG AAAACAAGAA GAAACCACTG 
ATTGGCACTG TGGTGGCCAA AGACCCCGAC AAGGCTCAAC GCAGCATAGG ATACTCCATC 
CGCAAGACCA GTGACAGAGG CCAATACTTC CGAATAACCA AACAAGGGAA CATCTATAAT 
GAGAAAGAAC TGGACAGAGA AACCCACGCC TGGTATAACC TGACTGTGGA GGCCAACGAA 
TTGGATTCTA GGGGTAACCC TGTAGGTAAA GAATCCATTG TACAGATTTA CATTGAAGTT 
TTGGATGAGA ATGACAACGC CCCAGAATTT GCCCAGCCCT ACGAACCTAA AGTATGTGAG 
AATGCTGCCC AGGGCAAGCT GGTAGTACAG ATCTCTGCAA CAGACAAGGA CGTGGTGCCA 
GTAAACACAA AGTTCAAGTT TGCCCTGAAG AACGAGGACA GCAACTTCAC CCTCATCAAC 
AACCACGACA ATACCGCCAA CATCACAGTC AAGTATGGAC AGTTTAATCG GGAGCATACC 
AAGTTCCACT ACCTGCCTGT GCTCATCTCC GACAATGGGA TGCCCAGCCT GACTGGAACC 
GGCACGCTAA CAGTGGCTGT GTGCAAATGC AACGAACAGG GCGAGTTCAC CTTCTGTGAG 
GAGATGGCCG CACAGGCGGG TGTCAGCATC CAGGCACTGG TAGCCATCTT TCTGTGCATC 
CTCACCATCA CAGTGATCAC CTTGCTGATC TTCCTGCGGA GGCGGCTCCG GAAGCAGGCG 
CATGCTCATA GCAAGAGTGC GCTTGAGATT CATGAGCAGT TGGTCACCTA CGACGAGGAG 
GGCGGTGGCG AGATGGACAC CACAAGCTAC GACGTGTCTG TGCTTAATTC TGTGCGCACC 
GGCTCCAACA AGCCTCTGCG GTCCACGATG GATGCCCGGC CAGCAGTATA CACACAGGTG 
CAGAAGCCTC CACGACTGGC GCCTAGCCTG CACGGAGGGC CCAGAGAGAT GGCCACCATG 
ATCGAGGTGA AGAAAGAAGA GGCAGACAAT GATGGCGGTG GTCCCCCCTA CGATACACTG 
CACATCTACG GCTACGAGGG CACAGAGTCC ATCGCAGAGT CCCTCAGCTC CCTGAGCACC 
AATTCCTCCG ACTCTGACAT CGACTATGAC TTCCTCAATG ACTGGGGACC CAGGTTCAAG 
ATGCTGGCAG AGCTGTATGG CTCAGATCCT CAGGAAGAGC TCATCATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100877.1
CDS	62..2392
Translation	MQRLTELATALGTFLGLLAVAAMAGPNMLPVHQRQKRDWIWNQMHIDEEKNESLPHYVGKIKSNVNRQNAKYVLQGEQAGKIFRVDADTGDVLAYERLDREKVSEYFLTALIVDKKTNKNLEQPSSFTVKVHDVNDNWPVFTHQVFNASVPEMSAIGTSVIRVTATDADDPTVAGHATVLYQMVKGNEYFAIDNSGLIFTKDKNLDRETRAEYKIVVEAQDAQGLRGESGTATVLIRLEDINDNFPIFTQSTYTFSVPEDIRVGKPLGSLSVEDPDEPQNRMTKYSIMQGEYRDTFTIETDPDRNEGIIKPTKPLDYELIQQYTFHIEATDPTIRLGYLSSTAGKNKAKIIINVLDVDEPPVFQRRFYHFHLPENKKKPLIGTVVAKDPDKAQRSIGYSIRKTSDRGQYFRITKQGNIYNEKELDRETHAWYNLTVEANELDSRGNPVGKESIVQIYIEVLDENDNAPEFAQPYEPKVCENAAQGKLVVQISATDKDVVPVNTKFKFALKNEDSNFTLINNHDNTANITVKYGQFNREHTKFHYLPVLISDNGMPSLTGTGTLTVAVCKCNEQGEFTFCEEMAAQAGVSIQALVAIFLCILTITVITLLIFLRRRLRKQAHAHSKSALEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRTGSNKPLRSTMDARPAVYTQVQKPPRLAPSLHGGPREMATMIEVKKEEADNDGGGPPYDTLHIYGYEGTESIAESLSSLSTNSSDSDIDYDFLNDWGPRFKMLAELYGSDPQEELII

Target ORF information:

RefSeq Version	NM_001107407.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cadherin 5 (Cdh5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107407.1

ORF Insert Sequence:

ATGCAGAGGC TCACAGAGCT GGCCACTGCT TTGGGCACCT TCTTGGGCCT GCTGGCAGTG 
GCAGCGATGG CAGGCCCCAA CATGCTGCCT GTCCACCAGC GCCAAAAGAG AGACTGGATT 
TGGAATCAAA TGCACATAGA TGAAGAGAAA AATGAGTCGC TGCCCCACTA TGTGGGAAAG 
ATCAAGTCCA ATGTGAACCG TCAGAATGCT AAGTATGTGC TCCAAGGAGA ACAAGCTGGC 
AAGATCTTCA GGGTCGATGC TGACACAGGG GATGTGCTTG CCTATGAGAG GTTAGACCGG 
GAAAAAGTCT CTGAGTACTT CCTTACTGCC CTCATTGTGG ACAAGAAGAC CAACAAAAAC 
CTGGAACAAC CTTCCAGCTT CACTGTCAAG GTGCATGATG TAAATGACAA CTGGCCTGTG 
TTTACGCACC AGGTATTCAA CGCATCTGTG CCCGAGATGT CAGCTATAGG GACCTCTGTC 
ATCCGTGTGA CAGCAACGGA TGCAGATGAC CCTACGGTGG CTGGCCACGC CACTGTCTTG 
TACCAAATGG TGAAAGGAAA TGAGTACTTC GCCATCGACA ATTCTGGACT CATTTTCACA 
AAGGACAAAA ACTTGGACAG AGAGACACGG GCTGAATACA AGATCGTGGT GGAAGCACAA 
GATGCCCAGG GTCTGCGGGG AGAGTCAGGC ACAGCCACTG TGCTGATCAG ATTGGAAGAC 
ATCAATGACA ACTTCCCCAT CTTTACTCAG TCCACATACA CATTTTCGGT GCCTGAAGAT 
ATCCGTGTGG GCAAGCCCTT GGGCTCTCTC TCTGTTGAGG ACCCAGATGA GCCTCAGAAC 
CGGATGACCA AATATAGCAT CATGCAGGGC GAGTACAGGG ACACCTTCAC CATTGAGACA 
GACCCCGACC GTAATGAGGG TATCATCAAA CCCACAAAGC CCCTGGACTA TGAACTCATC 
CAGCAGTACA CGTTCCACAT CGAGGCCACA GACCCCACTA TCAGACTCGG ATACCTGAGC 
AGCACTGCGG GCAAAAACAA AGCCAAGATC ATCATCAATG TCCTAGATGT GGATGAGCCC 
CCTGTCTTCC AGCGACGCTT CTACCACTTC CACCTGCCCG AAAACAAGAA GAAACCACTG 
ATTGGCACTG TGGTGGCCAA AGACCCCGAC AAGGCTCAAC GCAGCATAGG ATACTCCATC 
CGCAAGACCA GTGACAGAGG CCAATACTTC CGAATAACCA AACAAGGGAA CATCTATAAT 
GAGAAAGAAC TGGACAGAGA AACCCACGCC TGGTATAACC TGACTGTGGA GGCCAACGAA 
TTGGATTCTA GGGGTAACCC TGTAGGTAAA GAATCCATTG TACAGATTTA CATTGAAGTT 
TTGGATGAGA ATGACAACGC CCCAGAATTT GCCCAGCCCT ACGAACCTAA AGTATGTGAG 
AATGCTGCCC AGGGCAAGCT GGTAGTACAG ATCTCTGCAA CAGACAAGGA CGTGGTGCCA 
GTAAACACAA AGTTCAAGTT TGCCCTGAAG AACGAGGACA GCAACTTCAC CCTCATCAAC 
AACCACGACA ATACCGCCAA CATCACAGTC AAGTATGGAC AGTTTAATCG GGAGCATACC 
AAGTTCCACT ACCTGCCTGT GCTCATCTCC GACAATGGGA TGCCCAGCCT GACTGGAACC 
GGCACGCTAA CAGTGGCTGT GTGCAAATGC AACGAACAGG GCGAGTTCAC CTTCTGTGAG 
GAGATGGCCG CACAGGCGGG TGTCAGCATC CAGGCACTGG TAGCCATCTT TCTGTGCATC 
CTCACCATCA CAGTGATCAC CTTGCTGATC TTCCTGCGGA GGCGGCTCCG GAAGCAGGCG 
CATGCTCATA GCAAGAGTGC GCTTGAGATT CATGAGCAGT TGGTCACCTA CGACGAGGAG 
GGCGGTGGCG AGATGGACAC CACAAGCTAC GACGTGTCTG TGCTTAATTC TGTGCGCACC 
GGCTCCAACA AGCCTCTGCG GTCCACGATG GATGCCCGGC CAGCAGTATA CACACAGGTG 
CAGAAGCCTC CACGACTGGC GCCTAGCCTG CACGGAGGGC CCAGAGAGAT GGCCACCATG 
ATCGAGGTGA AGAAAGAAGA GGCAGACAAT GATGGCGGTG GTCCCCCCTA CGATACACTG 
CACATCTACG GCTACGAGGG CACAGAGTCC ATCGCAGAGT CCCTCAGCTC CCTGAGCACC 
AATTCCTCCG ACTCTGACAT CGACTATGAC TTCCTCAATG ACTGGGGACC CAGGTTCAAG 
ATGCTGGCAG AGCTGTATGG CTCAGATCCT CAGGAAGAGC TCATCATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-22 regulates inflammation and angiogenesis via targeting VE-cadherin.
FEBS letters591(3)513-526(2017 02)
Gu W,Zhan H,Zhou XY,Yao L,Yan M,Chen A,Liu J,Ren X,Zhang X,Liu JX,Liu G

Defining the molecular basis of interaction between R3 receptor-type protein tyrosine phosphatases and VE-cadherin.
PloS one12(9)e0184574(2017)
Dorofejeva O,Barr AJ

Vascular endothelial-cadherin downregulation as a feature of endothelial transdifferentiation in monocrotaline-induced pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology311(2)L352-63(2016 Aug)
Nikitopoulou I,Orfanos SE,Kotanidou A,Maltabe V,Manitsopoulos N,Karras P,Kouklis P,Armaganidis A,Maniatis NA

Cardiopulmonary bypass increases pulmonary microvascular permeability through the Src kinase pathway: Involvement of caveolin-1 and vascular endothelial cadherin.
Molecular medicine reports13(3)2918-24(2016 Mar)
Zhang J,Jiang Z,Bao C,Mei J,Zhu J

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Cdh5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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