Gene Symbol | CDH5 |
Entrez Gene ID | 414735 |
Full Name | cadherin 5 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » CDH5 cDNA ORF clone
Gene Symbol | CDH5 |
Entrez Gene ID | 414735 |
Full Name | cadherin 5 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
NM_001001601.1 | NP_001001601.1 | cadherin-5 precursor |
XM_024977976.1 | XP_024833744.1 | cadherin-5 isoform X1 |
Rattus norvegicus (Norway rat) | Cdh5 | NP_001100877.1 |
Gallus gallus (chicken) | CDH5 | NP_989558.1 |
CDH5 | XP_001082641.1 | |
Pan troglodytes (chimpanzee) | CDH5 | XP_523383.3 |
Canis lupus familiaris (dog) | CDH5 | XP_546894.2 |
Homo sapiens (human) | CDH5 | NP_001786.2 |
Bos taurus (cattle) | CDH5 | NP_001001601.1 |
Mus musculus (house mouse) | Cdh5 | NP_033998.2 |
Danio rerio (zebrafish) | cdh5 | NP_001003983.1 |
Xenopus tropicalis (tropical clawed frog) | cdh5 | XP_002933718.2 |
A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)
Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton.
Gray DS, Liu WF, Shen CJ, Bhadriraju K, Nelson CM, Chen CS
Experimental cell research314(15)2846-54(2008 Sep)
Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells.
Liu WF, Nelson CM, Tan JL, Chen CS
Circulation research101(5)e44-52(2007 Aug)
Hydrostatic pressure influences morphology and expression of VE-cadherin of vascular endothelial cells.
Ohashi T, Sugaya Y, Sakamoto N, Sato M
Journal of biomechanics40(11)2399-405(2007)
VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin.
Gavard J, Gutkind JS
Nature cell biology8(11)1223-34(2006 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
In all, these results demonstrate that cell-cell contact signals through VE-cadherin, RhoA, and intracellular tension in the actin cytoskeleton to regulate proliferation.
Title: Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton.
exposure of BAECs to hydrostatic pressure (PHYSIOLOGIC PRESSURE) may downregulate the expression of VE-cadherin, resulting in loss of contact inhibition followed by increased proliferation and formation of a multilayered structure
Title: Hydrostatic pressure influences morphology and expression of VE-cadherin of vascular endothelial cells.
results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network
Title: Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras.
a VE-cadherin-dependent pathway may link T2-TrpRS to inhibition of new blood vessel formation
Title: VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function.
Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA
Title: Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA.
The following CDH5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDH5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa43878 | |
Clone ID Related Accession (Same CDS sequence) | NM_001001601.1 | |
Accession Version | NM_001001601.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2352bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Bos taurus(cattle) | |
Product | cadherin-5 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY363224.1. ##Evidence-Data-START## Transcript exon combination :: AY363224.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145414 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCAGGCAC TCGTGATGCT GCTGGCCACG GGGGCCACCT ACTACCTGGG CCTGCTGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001001601.1 |
CDS | 58..2409 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001001601.1 |
1 | ATGCAGGCAC TCGTGATGCT GCTGGCCACG GGGGCCACCT ACTACCTGGG CCTGCTGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa224822 | |
Clone ID Related Accession (Same CDS sequence) | XM_024977976.1 | |
Accession Version | XM_024977976.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2352bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | cadherin-5 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037345.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAGGCAC TCGTGATGCT GCTGGCCACG GGGGCCACCT ACTACCTGGG CCTGCTGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024833744.1 |
CDS | 163..2514 |
Translation |
Target ORF information:
Target ORF information:
|
XM_024977976.1 |
1 | ATGCAGGCAC TCGTGATGCT GCTGGCCACG GGGGCCACCT ACTACCTGGG CCTGCTGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A whole-genome assembly of the domestic cow, Bos taurus. |
Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton. |
Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. |
Hydrostatic pressure influences morphology and expression of VE-cadherin of vascular endothelial cells. |
VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin. |